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Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: Generation of a high-resolution all-to-all interaction map of the Igh locus Destination: slink3 Item: Title: Igh harbors two key anchors mediating multiple CTCF-driven long-range interactions Destination: slink4 Item: Title: Polymer modeling reveals a heterogeneous ensemble of Igh single conformations Destination: slink5 Item: Title: Interactions within the Igh locus are focused over distal VH genes Destination: slink6 Item: Title: A network of interchromosomal interactions enriched in B lineage genes may drive B cell development Destination: slink7 Item: Title: The Igh locus is in spatial proximity to key B lineage genes more frequently in B cells than in thymocytes Destination: slink8 Item: Title: Discussion Destination: flink9 Children: Item: Title: A new model of lineage-determining genomic interaction networks Destination: slink10 Item: Title: Limitations of the study Destination: slink11 Item: Title: Supplemental information Destination: falink12 Item: Title: Acknowledgments Destination: acklink1 Item: Title: Author contributions Destination: acklink2 Item: Title: Declaration of interests Destination: acklink3 Item: Title: Inclusion and diversity Destination: acklink4 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink13 Children: Item: Title: Key resources table Destination: slink14 Item: Title: Resource availability Destination: slink15 Children: Item: Title: Lead contact Destination: tlink1 Item: Title: Materials availability Destination: tlink2 Item: Title: Data and code availability Destination: tlink3 Item: Title: Experimental model and study participant details Destination: slink16 Children: Item: Title: Mice Destination: tlink4 Item: Title: Method details Destination: slink17 Children: Item: Title: Primary cells Destination: tlink5 Item: Title: Hi-C Destination: tlink6 Item: Title: Capture HiC Destination: tlink7 Children: Item: Title: Capture baits Destination: ftlink1 Item: Title: Capture Hi-C procedure Destination: ftlink2 Item: Title: Polymer modeling Destination: tlink8 Item: Title: 3D DNA fluorescence in situ hybridization (FISH) Destination: tlink9 Children: Item: Title: Fluorescent signal acquisition using Metacyte and analysis in Metafer Destination: ftlink3 Item: Title: Quantification and statistical analysis Destination: slink18 Children: Item: Title: Hi-C and Capture Hi-C analysis Destination: tlink10 Children: Item: Title: Generation of custom genome datasets Destination: ftlink4 Item: Title: Matrix normalization in HOMER Destination: ftlink5 Item: Title: Subdomain calling in HiCSeg Destination: ftlink6 Item: Title: Identification of significant inter-chromosomal interactions Destination: ftlink7 Item: Title: A/B compartment analysis Destination: ftlink8 Item: Title: Hierarchical clustering Destination: ftlink9 Item: Title: Polymer 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CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UPJDXP+Cambria-Bold Flags: Serif, Symbolic FontBBox: -1110, -299, 1373, 1047 FontFile2: true Font: BaseFont: BHZYRB+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: BHZYRB+TimesNewRomanPSMT Flags: Serif, Symbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Font: BaseFont: YPNEGH+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YPNEGH+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile2: true XMP: application/pdf doi:10.1016/j.celrep.2023.113074 Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes Olga Mielczarek Carolyn H. Rogers Yinxiu Zhan Louise S. Matheson Michael J.T. Stubbington Stefan Schoenfelder Daniel J. Bolland Biola M. Javierre Steven W. Wingett Csilla Várnai Anne Segonds-Pichon Simon J. Conn Felix Krueger Simon Andrews Peter Fraser Luca Giorgetti Anne E. Corcoran immunoglobin locus Capture Hi-C polymer modeling 3D immunoglobulin structure genome organization interchromosomal CellReports, 42 (2023) 113074. doi:10.1016/j.celrep.2023.113074 The Authors journal CellReports © 2023 The Authors. 2211-1247 42 9 26 September 2023 2023-09-26 113074 113074 10.1016/j.celrep.2023.113074 https://doi.org/10.1016/j.celrep.2023.113074 2010-04-23 true 10.1016/j.celrep.2023.113074 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.celrep.2023.113074 noindex true 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-09-22T00:31:09+05:30 2023-09-22T00:32:47+05:30 2023-09-22T00:32:47+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:5068481b-41c9-4917-83cd-4c0aa0e83631 uuid:b7127f51-1361-404a-b20d-aec5949d99dc http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 354, 510, 503, 520 Annotation: Subtype: Link Rect: 100, 48, 273, 56 Annotation: Subtype: Link Rect: 53, 58, 69, 74 Page: Label: 2 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