fea515c412008784edb90032a3d145fd b-Catenin_activity.pdf 044cb4a0e664333af291628d1d8085ae0d0fa051 b-Catenin_activity.pdf e3b13918942927e8ba7623d2a755ddd8b4608a24a94f3aabb0c029aedbe00053 b-Catenin_activity.pdf Title: β‐catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia Creator: Arbortext Advanced Print Publisher 9.1.531/W Unicode Producer: Acrobat Distiller 15.0 (Windows) CreationDate: Mon Jan 30 04:00:54 2023 CET ModDate: Mon Jan 30 04:00:54 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2724757 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EEKDBI+AdvOT55ce2142 Type 1C WinAnsi yes yes no 1085 0 EEKFAF+AdvPSMP11 Type 1C WinAnsi yes yes no 1147 0 EEKFAG+AdvStPro-SB Type 1C WinAnsi yes yes no 1086 0 EEKFAH+AdvOT11e7dc17 Type 1C WinAnsi yes yes no 1087 0 EEKFAI+AdvOT61678bbb.B Type 1C WinAnsi yes yes no 1148 0 EEKFBJ+AdvStPro-B Type 1C WinAnsi yes yes no 1149 0 EEKFBK+AdvSlimb-BK Type 1C WinAnsi yes yes no 1150 0 EEKFBL+AdvSlim-BKI Type 1C WinAnsi yes yes no 1151 0 EEKFCM+AdvOTa293a443+20 Type 1C WinAnsi yes yes no 1152 0 EEKFCN+AdvTTec369687 Type 1C WinAnsi yes yes no 1153 0 EEKFCO+AdvTTec369687+20 Type 1C WinAnsi yes yes no 1154 0 EEKDOE+AdvPSMP13 Type 1C WinAnsi yes yes no 1155 0 EEKFDO+AdvPSSym Type 1C Custom yes yes no 1156 0 EEKFDP+AdvOT5199123b Type 1C WinAnsi yes yes no 1157 0 EEKFEA+AdvStPro-R Type 1C WinAnsi yes yes no 1158 0 EEKDPF+AdvOTf1351f0c Type 1C WinAnsi yes yes no 1159 0 EEKDPG+AdvOTa293a443 Type 1C WinAnsi yes yes no 1160 0 EEKDPH+AdvP4C4E59 Type 1C Custom yes yes no 1161 0 EEKDPI+AdvOTa293a443+01 Type 1C MacRoman yes yes no 1088 0 EEKDPJ+AdvStPro-L Type 1C WinAnsi yes yes no 1162 0 EEKDPK+AdvTimes Type 1C WinAnsi yes yes no 1089 0 EEKFAE+AdvOT5581a231 Type 1C WinAnsi yes yes no 1163 0 EEKFIA+AdvTT3713a231+25 Type 1C Custom yes yes yes 755 0 EEKFJA+AdvP4C4E74 Type 1C Custom yes yes no 756 0 EEKFKB+AdvOT36088c38.B Type 1C WinAnsi yes yes no 757 0 EEKFKC+AdvP4C4E5E Type 1C Custom yes yes no 758 0 EEKFLD+AdvOT5199123b+01 Type 1C MacRoman yes yes no 759 0 EEKHGJ+HelveticaLTStd-Bold Type 1C WinAnsi yes yes no 760 0 EEKHHK+ArialMT Type 1C Custom yes yes yes 761 0 EEKHOI+MyriadPro-Regular Type 1C Custom yes yes yes 45 0 EEKIPD+AdvTTec369687+03 Type 1C Custom yes yes yes 115 0 EEKPAO+Arial-BoldMT Type 1C Custom yes yes yes 762 0 EELDIE+Arial-ItalicMT Type 1C Custom yes yes no 763 0 EELEGP+AdvTTec369687+22 Type 1C Custom yes yes yes 595 0 EEMHMJ+Calibri Type 1C WinAnsi yes yes no 606 0 EEMMEP+AdvTT3713a231+20 Type 1C WinAnsi yes yes no 764 0 EEMMFP+AdvOT61678bbb.B+01 Type 1C MacRoman yes yes no 765 0 EEMMIP+AdvTT689d5d16.B Type 1C WinAnsi yes yes no 741 0 EEMMNO+AdvStPro-LI Type 1C WinAnsi yes yes no 748 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-29 02:34:10 CET RepresentationInformation: b-Catenin_activity.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-28 18:33:15 CET Size: 2724757 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'lemmm202216554-supitem' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'lemmm202216554-fig-0005ev' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'lemmm202216554-fig-0004ev' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'lemmm202216554-fig-0001ev' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'lemmm202216554-fig-0002ev' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'lemmm202216554-fig-0003ev' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lemmm202216554-supitem' cannot be found ID: PDF-HUL-122 Offset: 2696491 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lemmm202216554-fig-0001ev' cannot be found ID: PDF-HUL-122 Offset: 2696491 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lemmm202216554-fig-0003ev' cannot be found ID: PDF-HUL-122 Offset: 2696491 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lemmm202216554-fig-0004ev' cannot be found ID: PDF-HUL-122 Offset: 2696491 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lemmm202216554-fig-0005ev' cannot be found ID: PDF-HUL-122 Offset: 2696491 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lemmm202216554-fig-0002ev' cannot be found ID: PDF-HUL-122 Offset: 2696491 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1200 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: head2_1045324 Item: Title: Intro„duc„tion Destination: head3_1045324 Item: Title: Results Destination: head4_1400000 Children: Item: Title: beta-Catenin is recruited to the pro„moter regions of RNA pro„cess„ing-re„lated fac„tors in T-ALL cells Destination: head5_1519430 Item: Title: emmm202216554-fig-0001 Destination: lemmm202216554-fig-0001 Item: Title: beta-Catenin reg„u„lates expres„sion of RNA-pro„cess„ing and mitotic-re„lated genes in an oppo„site man„ner Destination: head6_520000 Item: Title: emmm202216554-fig-0002 Destination: lemmm202216554-fig-0002 Item: Title: beta-Catenin tran„scrip„tional tar„get gene sig„na„ture iden„ti„fied T-ALL refrac„tory patients with worst out„come Destination: head7_270000 Item: Title: A beta-catenin-de„pen„dent RNA pro„cess„ing sig„na„ture pre„dicts response to ther„apy in T-ALL patients at diag„no„sis Destination: head8_1480000 Item: Title: emmm202216554-fig-0003 Destination: lemmm202216554-fig-0003 Item: Title: emmm202216554-fig-0004 Destination: lemmm202216554-fig-0004 Item: Title: Inhi„bi„tion of beta-catenin improves response to chemother„apy in T-ALL in vitro and in vivo Destination: head9_800000 Item: Title: emmm202216554-fig-0005 Destination: lemmm202216554-fig-0005 Item: Title: Dis„cus„sion Destination: head10_400000 Children: Item: Title: emmm202216554-fig-0006 Destination: lemmm202216554-fig-0006 Item: Title: Mate„ri„als and Meth„ods Destination: head11_640000 Children: Item: Title: Cell lines Destination: head12_759430 Item: Title: Reagents Destination: head13_1119230 Item: Title: RNA iso„la„tion and sequenc„ing Destination: head14_1479030 Item: Title: Chro„matin immuno„pre„cip„i„ta„tion and anal„y„sis Destination: head15_2158830 Item: Title: Len„tivi„ral pro„duc„tion Destination: head16_1640000 Item: Title: Genetic edit„ing Destination: head17_1959800 Item: Title: Western blot„ting (WB) Destination: head18_270000 Item: Title: RNA and pro„tein syn„the„sis anal„y„sis Destination: head19_519800 Item: Title: Cell cycle anal„y„sis Destination: head20_879600 Item: Title: Gene expres„sion in T-ALL pri„mary sam„ples Destination: head21_1399400 Item: Title: Sin„gle-sam„ple gene set enrich„ment anal„y„sis (ssGSEA) Destination: head22_1200000 Item: Title: Che„mother„apy response-as„says Destination: head23_1639800 Item: Title: In vitro drug recov„ery assays Destination: head24_2119600 Item: Title: Ani„mal stud„ies Destination: head25_400000 Item: Title: Flow cytom„e„try anal„y„sis of mice organs Destination: head26_1639800 Item: Title: Colony quan„tifi„ca„tion in HandE stain„ings Destination: head27_1879600 Item: Title: Sta„tis„ti„cal anal„y„sis Destination: head28_2239400 Item: Title: Data avail„abil„ity Destination: head29_1360000 Item: Title: Acknowl„edge„ments Destination: head30_1959530 Item: Title: Author contributions Destination: head31_2439530 Item: Title: Dis„clo„sure and com„pet„ing inter„ests state„ment Destination: head32_840000 Item: Title: Ref„er„ences Destination: head33_960000 Children: Item: Title: emmm202216554-bib-0001 Destination: lemmm202216554-bib-0001 Item: Title: emmm202216554-bib-0002 Destination: lemmm202216554-bib-0002 Item: Title: emmm202216554-bib-0003 Destination: lemmm202216554-bib-0003 Item: Title: emmm202216554-bib-0004 Destination: lemmm202216554-bib-0004 Item: Title: emmm202216554-bib-0005 Destination: lemmm202216554-bib-0005 Item: Title: emmm202216554-bib-0006 Destination: lemmm202216554-bib-0006 Item: Title: emmm202216554-bib-0007 Destination: lemmm202216554-bib-0007 Item: Title: emmm202216554-bib-0008 Destination: lemmm202216554-bib-0008 Item: Title: emmm202216554-bib-0009 Destination: lemmm202216554-bib-0009 Item: Title: emmm202216554-bib-0010 Destination: lemmm202216554-bib-0010 Item: Title: emmm202216554-bib-0011 Destination: lemmm202216554-bib-0011 Item: Title: emmm202216554-bib-0012 Destination: lemmm202216554-bib-0012 Item: Title: emmm202216554-bib-0013 Destination: lemmm202216554-bib-0013 Item: Title: emmm202216554-bib-0014 Destination: lemmm202216554-bib-0014 Item: Title: emmm202216554-bib-0015 Destination: lemmm202216554-bib-0015 Item: Title: emmm202216554-bib-0016 Destination: lemmm202216554-bib-0016 Item: Title: emmm202216554-bib-0017 Destination: lemmm202216554-bib-0017 Item: Title: emmm202216554-bib-0018 Destination: lemmm202216554-bib-0018 Item: Title: emmm202216554-bib-0019 Destination: lemmm202216554-bib-0019 Item: Title: emmm202216554-bib-0020 Destination: lemmm202216554-bib-0020 Item: Title: emmm202216554-bib-0021 Destination: lemmm202216554-bib-0021 Item: Title: emmm202216554-bib-0022 Destination: lemmm202216554-bib-0022 Item: Title: emmm202216554-bib-0023 Destination: lemmm202216554-bib-0023 Item: Title: emmm202216554-bib-0024 Destination: lemmm202216554-bib-0024 Item: Title: emmm202216554-bib-0025 Destination: lemmm202216554-bib-0025 Item: Title: emmm202216554-bib-0026 Destination: lemmm202216554-bib-0026 Item: Title: emmm202216554-bib-0027 Destination: lemmm202216554-bib-0027 Item: Title: emmm202216554-bib-0028 Destination: lemmm202216554-bib-0028 Item: Title: emmm202216554-bib-0029 Destination: lemmm202216554-bib-0029 Item: Title: emmm202216554-bib-0030 Destination: lemmm202216554-bib-0030 Item: Title: emmm202216554-bib-0031 Destination: lemmm202216554-bib-0031 Item: Title: emmm202216554-bib-0032 Destination: lemmm202216554-bib-0032 Item: Title: emmm202216554-bib-0033 Destination: lemmm202216554-bib-0033 Item: Title: emmm202216554-bib-0034 Destination: lemmm202216554-bib-0034 Item: Title: emmm202216554-bib-0035 Destination: lemmm202216554-bib-0035 Item: Title: emmm202216554-bib-0036 Destination: lemmm202216554-bib-0036 Item: Title: emmm202216554-bib-0037 Destination: lemmm202216554-bib-0037 Item: Title: emmm202216554-bib-0038 Destination: lemmm202216554-bib-0038 Item: Title: emmm202216554-bib-0039 Destination: lemmm202216554-bib-0039 Item: Title: emmm202216554-bib-0040 Destination: lemmm202216554-bib-0040 Item: Title: emmm202216554-bib-0041 Destination: lemmm202216554-bib-0041 Item: Title: emmm202216554-bib-0042 Destination: lemmm202216554-bib-0042 Item: Title: emmm202216554-bib-0043 Destination: lemmm202216554-bib-0043 Item: Title: emmm202216554-bib-0044 Destination: lemmm202216554-bib-0044 Item: Title: emmm202216554-bib-0045 Destination: lemmm202216554-bib-0045 Item: Title: emmm202216554-bib-0046 Destination: lemmm202216554-bib-0046 Item: Title: emmm202216554-bib-0047 Destination: lemmm202216554-bib-0047 Item: Title: emmm202216554-bib-0048 Destination: lemmm202216554-bib-0048 Item: Title: emmm202216554-bib-0049 Destination: lemmm202216554-bib-0049 Item: Title: emmm202216554-bib-0050 Destination: lemmm202216554-bib-0050 Item: Title: emmm202216554-bib-0051 Destination: lemmm202216554-bib-0051 Item: Title: emmm202216554-bib-0052 Destination: lemmm202216554-bib-0052 Item: Title: emmm202216554-bib-0053 Destination: lemmm202216554-bib-0053 Item: Title: emmm202216554-bib-0054 Destination: lemmm202216554-bib-0054 Item: Title: emmm202216554-bib-0055 Destination: lemmm202216554-bib-0055 Info: Title: β‐catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia Creator: Arbortext Advanced Print Publisher 9.1.531/W Unicode Producer: Acrobat Distiller 15.0 (Windows) CreationDate: Mon Jan 30 04:30:54 CET 2023 ModDate: Mon Jan 30 04:30:54 CET 2023 ID: 0x04387bac60382f364d8e2ddfb2f45c7a, 0xd6559883ea3ec01c78a252c6d30ddad9 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 143 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 144 ImageHeight: 798 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 143 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 144 ImageHeight: 798 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 143 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 101 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 88 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 144 ImageHeight: 798 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 144 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 93 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 236 ImageHeight: 96 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 215 ImageHeight: 84 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 106 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 110 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 197 ImageHeight: 105 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 99 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 198 ImageHeight: 230 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 154 ImageHeight: 239 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 151 ImageHeight: 235 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 146 ImageHeight: 807 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 146 ImageHeight: 807 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 145 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 146 ImageHeight: 807 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 145 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 144 ImageHeight: 798 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 144 ImageHeight: 798 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 143 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 439 ImageHeight: 253 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1 ImageHeight: 300 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1 ImageHeight: 300 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 153 ImageHeight: 14 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 128 ImageHeight: 111 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1 ImageHeight: 10 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 108 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 77 ImageHeight: 95 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 111 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 108 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 79 ImageHeight: 111 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 153 ImageHeight: 5 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 79 ImageHeight: 111 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 10 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 79 ImageHeight: 111 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 108 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 158 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 79 ImageHeight: 111 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 5 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 158 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1 ImageHeight: 5 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 108 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 77 ImageHeight: 94 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 77 ImageHeight: 94 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 108 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 155 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 108 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 94 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 108 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 78 ImageHeight: 108 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 155 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 77 ImageHeight: 108 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 640 ImageHeight: 481 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 386 ImageHeight: 481 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 313 ImageHeight: 236 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Intent: Perceptual Fonts: Type1: Font: BaseFont: EEKFCM+AdvOTa293a443+20 FontSubset: true FirstChar: 145 LastChar: 146 FontDescriptor: FontName: EEKFCM+AdvOTa293a443+20 Flags: Nonsymbolic FontBBox: -114, -187, 1125, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKDPI+AdvOTa293a443+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: EEKDPI+AdvOTa293a443+01 Flags: Nonsymbolic FontBBox: -72, -208, 854, 989 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EEKFCN+AdvTTec369687 FontSubset: true FirstChar: 43 LastChar: 215 FontDescriptor: FontName: EEKFCN+AdvTTec369687 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKDPK+AdvTimes FontSubset: true FirstChar: 134 LastChar: 135 FontDescriptor: FontName: EEKDPK+AdvTimes Flags: Nonsymbolic FontBBox: -217, -212, 1005, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKFCO+AdvTTec369687+20 FontSubset: true FirstChar: 134 LastChar: 150 FontDescriptor: FontName: EEKFCO+AdvTTec369687+20 Flags: Nonsymbolic FontBBox: -208, -208, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKDOE+AdvPSMP13 FontSubset: true FirstChar: 98 LastChar: 108 FontDescriptor: FontName: EEKDOE+AdvPSMP13 Flags: Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKFDO+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EEKFDO+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: EEKFDP+AdvOT5199123b FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: EEKFDP+AdvOT5199123b Flags: Nonsymbolic FontBBox: -125, -197, 968, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKFEA+AdvStPro-R FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: EEKFEA+AdvStPro-R Flags: Nonsymbolic FontBBox: -114, -197, 1187, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKDPF+AdvOTf1351f0c FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: EEKDPF+AdvOTf1351f0c Flags: Nonsymbolic FontBBox: -41, -197, 1000, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKDPG+AdvOTa293a443 FontSubset: true FirstChar: 35 LastChar: 124 FontDescriptor: FontName: EEKDPG+AdvOTa293a443 Flags: Nonsymbolic FontBBox: -41, -197, 968, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKDPH+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EEKDPH+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: EEKDPJ+AdvStPro-L FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: EEKDPJ+AdvStPro-L Flags: Nonsymbolic FontBBox: -114, -197, 1125, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKFAE+AdvOT5581a231 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: EEKFAE+AdvOT5581a231 Flags: Nonsymbolic FontBBox: -41, -197, 1031, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EELEGP+AdvTTec369687+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EELEGP+AdvTTec369687+22 Flags: Symbolic FontBBox: -156, -208, 802, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEMHMJ+Calibri FontSubset: true FirstChar: 45 LastChar: 101 FontDescriptor: FontName: EEMHMJ+Calibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMMIP+AdvTT689d5d16.B FontSubset: true FirstChar: 243 LastChar: 243 FontDescriptor: FontName: EEMMIP+AdvTT689d5d16.B Flags: Nonsymbolic FontBBox: -20, -208, 989, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMMNO+AdvStPro-LI FontSubset: true FirstChar: 51 LastChar: 51 FontDescriptor: FontName: EEMMNO+AdvStPro-LI Flags: Nonsymbolic FontBBox: -197, -197, 1104, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKHOI+MyriadPro-Regular FontSubset: true FirstChar: 2 LastChar: 117 FontDescriptor: FontName: EEKHOI+MyriadPro-Regular Flags: Symbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEKFIA+AdvTT3713a231+25 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EEKFIA+AdvTT3713a231+25 Flags: Symbolic FontBBox: -10, -302, 989, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEKIPD+AdvTTec369687+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EEKIPD+AdvTTec369687+03 Flags: Symbolic FontBBox: -437, -229, 875, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEKFJA+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EEKFJA+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: EEKFKB+AdvOT36088c38.B FontSubset: true FirstChar: 66 LastChar: 118 FontDescriptor: FontName: EEKFKB+AdvOT36088c38.B Flags: Nonsymbolic FontBBox: -114, -197, 1052, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKFKC+AdvP4C4E5E FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EEKFKC+AdvP4C4E5E Flags: Symbolic FontBBox: -52, -239, 1114, 750 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: EEKFLD+AdvOT5199123b+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: EEKFLD+AdvOT5199123b+01 Flags: Nonsymbolic FontBBox: -125, -208, 895, 968 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EEKHGJ+HelveticaLTStd-Bold FontSubset: true FirstChar: 65 LastChar: 73 FontDescriptor: FontName: EEKHGJ+HelveticaLTStd-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKHHK+ArialMT FontSubset: true FirstChar: 2 LastChar: 185 FontDescriptor: FontName: EEKHHK+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEKPAO+Arial-BoldMT FontSubset: true FirstChar: 2 LastChar: 177 FontDescriptor: FontName: EEKPAO+Arial-BoldMT Flags: Symbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEKFAF+AdvPSMP11 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: EEKFAF+AdvPSMP11 Flags: Nonsymbolic FontBBox: 0, -302, 989, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EELDIE+Arial-ItalicMT FontSubset: true FirstChar: 21 LastChar: 121 FontDescriptor: FontName: EELDIE+Arial-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -517, -325, 1359, 998 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EEKFAI+AdvOT61678bbb.B FontSubset: true FirstChar: 38 LastChar: 122 FontDescriptor: FontName: EEKFAI+AdvOT61678bbb.B Flags: Nonsymbolic FontBBox: -41, -197, 1062, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMMEP+AdvTT3713a231+20 FontSubset: true FirstChar: 129 LastChar: 151 FontDescriptor: FontName: EEMMEP+AdvTT3713a231+20 Flags: Nonsymbolic FontBBox: -468, -208, 1708, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKFBJ+AdvStPro-B FontSubset: true FirstChar: 48 LastChar: 54 FontDescriptor: FontName: EEKFBJ+AdvStPro-B Flags: Nonsymbolic FontBBox: -114, -197, 1302, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKDBI+AdvOT55ce2142 FontSubset: true FirstChar: 65 LastChar: 116 FontDescriptor: FontName: EEKDBI+AdvOT55ce2142 Flags: Nonsymbolic FontBBox: -114, -197, 1000, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMMFP+AdvOT61678bbb.B+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: EEMMFP+AdvOT61678bbb.B+01 Flags: Nonsymbolic FontBBox: -62, -250, 916, 1041 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EEKFAG+AdvStPro-SB FontSubset: true FirstChar: 48 LastChar: 52 FontDescriptor: FontName: EEKFAG+AdvStPro-SB Flags: Nonsymbolic FontBBox: -114, -197, 1250, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKFBK+AdvSlimb-BK FontSubset: true FirstChar: 35 LastChar: 148 FontDescriptor: FontName: EEKFBK+AdvSlimb-BK Flags: Serif, Nonsymbolic FontBBox: -62, -239, 1062, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKFAH+AdvOT11e7dc17 FontSubset: true FirstChar: 105 LastChar: 118 FontDescriptor: FontName: EEKFAH+AdvOT11e7dc17 Flags: Nonsymbolic FontBBox: -114, -197, 1020, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEKFBL+AdvSlim-BKI FontSubset: true FirstChar: 78 LastChar: 118 FontDescriptor: FontName: EEKFBL+AdvSlim-BKI Flags: Serif, Nonsymbolic FontBBox: -72, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding XMP: VoR 10.15252/emmm.202216554 10.15252/emmm.202216554 10.1002/(ISSN)1757-4684 3 β‐catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 181, 572, 184, 584 Annotation: Subtype: Link Rect: 181, 574, 184, 586 Annotation: Subtype: Link Rect: 184, 572, 189, 583 Annotation: Subtype: Link Rect: 126, 555, 129, 567 Annotation: Subtype: Link Rect: 126, 557, 129, 569 Annotation: Subtype: Link Rect: 129, 555, 135, 566 Annotation: Subtype: Link Rect: 221, 555, 224, 567 Annotation: Subtype: Link Rect: 221, 557, 224, 569 Annotation: Subtype: Link Rect: 224, 555, 230, 566 Annotation: Subtype: Link Rect: 325, 555, 328, 567 Annotation: Subtype: Link Rect: 325, 557, 328, 569 Annotation: Subtype: Link Rect: 328, 555, 334, 566 Annotation: Subtype: Link Rect: 417, 555, 420, 567 Annotation: Subtype: Link Rect: 417, 557, 420, 569 Annotation: Subtype: Link Rect: 420, 555, 425, 566 Annotation: Subtype: Link Rect: 122, 520, 125, 532 Annotation: Subtype: Link Rect: 122, 522, 125, 534 Annotation: Subtype: Link Rect: 125, 521, 131, 532 Annotation: Subtype: Link Rect: 227, 520, 230, 532 Annotation: Subtype: Link Rect: 227, 522, 230, 534 Annotation: Subtype: Link Rect: 230, 521, 235, 532 Annotation: Subtype: Link Rect: 326, 350, 343, 359 Destination: 738 Annotation: Subtype: Link Rect: 331, 214, 349, 222 Destination: 744 Annotation: Subtype: Link Rect: 331, 158, 348, 166 Destination: 738 Annotation: Subtype: Link Rect: 331, 146, 348, 154 Destination: 738 Annotation: Subtype: Link Rect: 404, 146, 421, 154 Destination: 738 Annotation: Subtype: Link Rect: 490, 146, 507, 154 Destination: 738 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 268, 669, 285, 677 Destination: 744 Annotation: Subtype: Link Rect: 198, 635, 215, 643 Destination: 738 Annotation: Subtype: Link Rect: 174, 613, 191, 621 Destination: 744 Annotation: Subtype: Link Rect: 243, 556, 260, 564 Destination: 744 Annotation: Subtype: Link Rect: 199, 511, 217, 519 Destination: 744 Annotation: Subtype: Link Rect: 268, 511, 285, 519 Destination: 738 Annotation: Subtype: Link Rect: 375, 669, 423, 677 Destination: null Annotation: Subtype: Link Rect: 342, 635, 362, 643 Destination: null Annotation: Subtype: Link Rect: 524, 590, 533, 598 Destination: 1 Annotation: Subtype: Link Rect: 336, 579, 350, 587 Destination: null Annotation: Subtype: Link Rect: 323, 567, 343, 575 Destination: null Annotation: Subtype: Link Rect: 391, 545, 400, 553 Destination: 1 Annotation: Subtype: Link Rect: 421, 545, 440, 553 Destination: null Annotation: Subtype: Link Rect: 451, 511, 470, 519 Destination: null Annotation: Subtype: Link Rect: 518, 511, 532, 519 Destination: null Annotation: Subtype: Link Rect: 446, 488, 466, 496 Destination: null Annotation: Subtype: Link Rect: 527, 465, 536, 473 Destination: 1 Annotation: Subtype: Link Rect: 335, 454, 349, 462 Destination: null Annotation: Subtype: Link Rect: 492, 442, 509, 451 Destination: 744 Annotation: Subtype: Link Rect: 397, 408, 417, 417 Destination: null Annotation: Subtype: Link Rect: 488, 386, 505, 394 Destination: 738 Annotation: Subtype: Link Rect: 534, 340, 548, 349 Destination: 1 Annotation: Subtype: Link Rect: 534, 340, 552, 349 Destination: 1 Annotation: Subtype: Link Rect: 321, 329, 342, 337 Destination: null Annotation: Subtype: Link Rect: 391, 329, 406, 337 Destination: null Annotation: Subtype: Link Rect: 489, 284, 506, 292 Destination: 744 Annotation: Subtype: Link Rect: 346, 272, 364, 281 Destination: null Thumb: true Page: Label: 3 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 60, 692, 70, 700 Destination: 1 Annotation: Subtype: Link Rect: 269, 692, 286, 700 Destination: null Annotation: Subtype: Link Rect: 161, 669, 171, 677 Destination: 1 Annotation: Subtype: Link Rect: 80, 522, 100, 530 Destination: null Annotation: Subtype: Link Rect: 187, 443, 221, 451 Destination: 82 Annotation: Subtype: Link Rect: 269, 443, 283, 451 Destination: null Annotation: Subtype: Link Rect: 60, 397, 69, 405 Destination: 82 Annotation: Subtype: Link Rect: 119, 397, 134, 405 Destination: null Annotation: Subtype: Link Rect: 104, 352, 114, 360 Destination: 82 Annotation: Subtype: Link Rect: 162, 352, 176, 360 Destination: null Annotation: Subtype: Link Rect: 179, 318, 188, 326 Destination: 82 Annotation: Subtype: Link Rect: 190, 295, 208, 303 Destination: 738 Annotation: Subtype: Link Rect: 64, 284, 81, 292 Destination: 738 Annotation: Subtype: Link Rect: 221, 284, 230, 292 Destination: 82 Annotation: Subtype: Link Rect: 252, 284, 289, 292 Destination: null Annotation: Subtype: Link Rect: 42, 272, 47, 281 Destination: null Annotation: Subtype: Link Rect: 353, 681, 367, 689 Destination: 1 Annotation: Subtype: Link Rect: 353, 681, 371, 689 Destination: 1 Annotation: Subtype: Link Rect: 485, 669, 502, 677 Destination: 744 Annotation: Subtype: Link Rect: 443, 624, 453, 632 Destination: 82 Annotation: Subtype: Link Rect: 384, 567, 403, 575 Destination: null Annotation: Subtype: Link Rect: 426, 567, 435, 575 Destination: 82 Annotation: Subtype: Link Rect: 492, 567, 506, 575 Destination: null Annotation: Subtype: Link Rect: 403, 488, 413, 496 Destination: 82 Annotation: Subtype: Link Rect: 540, 431, 547, 439 Destination: 82 Annotation: Subtype: Link Rect: 513, 408, 520, 417 Destination: 82 Annotation: Subtype: Link Rect: 328, 352, 344, 360 Destination: 738 Annotation: Subtype: Link Rect: 322, 306, 365, 315 Destination: null Annotation: Subtype: Link Rect: 329, 295, 346, 303 Destination: 744 Annotation: Subtype: Link Rect: 407, 284, 452, 292 Destination: null Thumb: true Page: Label: 5 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 239, 579, 256, 587 Destination: 744 Annotation: Subtype: Link Rect: 68, 567, 86, 576 Destination: 738 Annotation: Subtype: Link Rect: 186, 533, 197, 541 Destination: 82 Annotation: Subtype: Link Rect: 203, 522, 223, 530 Destination: null Annotation: Subtype: Link Rect: 177, 488, 220, 496 Destination: null Annotation: Subtype: Link Rect: 205, 454, 214, 462 Destination: null Annotation: Subtype: Link Rect: 269, 454, 283, 462 Destination: null Annotation: Subtype: Link Rect: 59, 397, 79, 405 Destination: null Annotation: Subtype: Link Rect: 59, 363, 80, 371 Destination: null Annotation: Subtype: Link Rect: 265, 352, 285, 360 Destination: null Annotation: Subtype: Link Rect: 90, 341, 111, 349 Destination: null Annotation: Subtype: Link Rect: 95, 318, 114, 326 Destination: null Annotation: Subtype: Link Rect: 231, 318, 250, 326 Destination: null Annotation: Subtype: Link Rect: 182, 250, 192, 258 Destination: 513 Annotation: Subtype: Link Rect: 228, 227, 261, 235 Destination: 513 Annotation: Subtype: Link Rect: 56, 204, 65, 213 Destination: 513 Annotation: Subtype: Link Rect: 217, 182, 237, 190 Destination: null Annotation: Subtype: Link Rect: 396, 658, 405, 666 Destination: 513 Annotation: Subtype: Link Rect: 400, 545, 410, 553 Destination: 513 Annotation: Subtype: Link Rect: 457, 545, 471, 553 Destination: null Annotation: Subtype: Link Rect: 387, 511, 402, 519 Destination: null Annotation: Subtype: Link Rect: 392, 465, 412, 473 Destination: null Annotation: Subtype: Link Rect: 463, 465, 477, 473 Destination: null Annotation: Subtype: Link Rect: 324, 397, 343, 405 Destination: null Annotation: Subtype: Link Rect: 391, 295, 408, 303 Destination: 738 Annotation: Subtype: Link Rect: 347, 238, 357, 247 Destination: 557 Annotation: Subtype: Link Rect: 365, 227, 384, 235 Destination: null Annotation: Subtype: Link Rect: 401, 182, 440, 190 Destination: 557 Thumb: true Page: Label: 7 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 433, 68, 467, 77 Destination: 557 Annotation: Subtype: Link Rect: 431, 46, 451, 54 Destination: null Annotation: Subtype: Link Rect: 263, 126, 269, 133 Destination: 513 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 64, 658, 81, 666 Destination: 738 Annotation: Subtype: Link Rect: 86, 590, 96, 598 Destination: 557 Annotation: Subtype: Link Rect: 60, 567, 79, 575 Destination: null Annotation: Subtype: Link Rect: 60, 397, 70, 405 Destination: 567 Annotation: Subtype: Link Rect: 90, 397, 110, 405 Destination: null Annotation: Subtype: Link Rect: 167, 363, 176, 371 Destination: 567 Annotation: Subtype: Link Rect: 195, 363, 214, 371 Destination: null Annotation: Subtype: Link Rect: 175, 318, 185, 326 Destination: 567 Annotation: Subtype: Link Rect: 176, 306, 196, 315 Destination: null Annotation: Subtype: Link Rect: 341, 647, 356, 655 Destination: 567 Annotation: Subtype: Link Rect: 341, 647, 360, 655 Destination: 567 Annotation: Subtype: Link Rect: 379, 590, 393, 598 Destination: 567 Annotation: Subtype: Link Rect: 379, 590, 396, 598 Destination: 567 Annotation: Subtype: Link Rect: 456, 567, 475, 575 Destination: null Annotation: Subtype: Link Rect: 391, 556, 411, 564 Destination: null Annotation: Subtype: Link Rect: 497, 465, 507, 473 Destination: 668 Annotation: Subtype: Link Rect: 359, 442, 369, 451 Destination: 668 Annotation: Subtype: Link Rect: 335, 374, 368, 383 Destination: 668 Annotation: Subtype: Link Rect: 474, 352, 484, 360 Destination: 668 Annotation: Subtype: Link Rect: 323, 329, 333, 337 Destination: 668 Annotation: Subtype: Link Rect: 494, 329, 504, 337 Destination: 668 Annotation: Subtype: Link Rect: 338, 318, 348, 326 Destination: 668 Annotation: Subtype: Link Rect: 472, 306, 503, 315 Destination: 668 Annotation: Subtype: Link Rect: 455, 185, 497, 192 Annotation: Subtype: Link Rect: 455, 139, 497, 146 Thumb: true Page: Label: 10 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 381, 635, 398, 643 Destination: 744 Annotation: Subtype: Link Rect: 450, 635, 467, 643 Destination: 738 Annotation: Subtype: Link Rect: 516, 635, 533, 643 Destination: 744 Annotation: Subtype: Link Rect: 408, 624, 425, 632 Destination: 738 Annotation: Subtype: Link Rect: 474, 624, 491, 632 Destination: 738 Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 144, 442, 161, 451 Destination: 744 Annotation: Subtype: Link Rect: 61, 318, 70, 326 Destination: 513 Annotation: Subtype: Link Rect: 87, 284, 104, 292 Destination: 738 Annotation: Subtype: Link Rect: 166, 284, 184, 292 Destination: 738 Annotation: Subtype: Link Rect: 163, 250, 173, 258 Destination: 513 Annotation: Subtype: Link Rect: 274, 227, 283, 235 Destination: 513 Annotation: Subtype: Link Rect: 269, 148, 286, 156 Destination: 744 Annotation: Subtype: Link Rect: 100, 136, 117, 145 Destination: 738 Annotation: Subtype: Link Rect: 154, 68, 172, 77 Destination: 738 Annotation: Subtype: Link Rect: 226, 68, 243, 77 Destination: 738 Annotation: Subtype: Link Rect: 492, 477, 509, 485 Destination: 744 Annotation: Subtype: Link Rect: 328, 136, 346, 145 Destination: 744 Annotation: Subtype: Link Rect: 418, 136, 495, 145 Annotation: Subtype: Link Rect: 468, 68, 485, 77 Destination: 738 Annotation: Subtype: Link Rect: 426, 624, 433, 631 Destination: 668 Annotation: Subtype: Link Rect: 85, 614, 93, 621 Destination: 668 Annotation: Subtype: Link Rect: 353, 555, 360, 562 Destination: 668 Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 152, 692, 170, 700 Destination: 738 Annotation: Subtype: Link Rect: 216, 692, 233, 700 Destination: 738 Annotation: Subtype: Link Rect: 122, 658, 131, 666 Destination: 1 Annotation: Subtype: Link Rect: 187, 658, 201, 666 Destination: null Annotation: Subtype: Link Rect: 101, 284, 110, 292 Destination: null Annotation: Subtype: Link Rect: 65, 193, 82, 202 Destination: 738 Annotation: Subtype: Link Rect: 229, 171, 246, 179 Destination: 738 Annotation: Subtype: Link Rect: 198, 114, 215, 122 Destination: 738 Annotation: Subtype: Link Rect: 476, 545, 484, 553 Destination: null Annotation: Subtype: Link Rect: 385, 477, 402, 485 Destination: 738 Annotation: Subtype: Link Rect: 475, 465, 492, 473 Destination: 744 Annotation: Subtype: Link Rect: 529, 454, 547, 462 Destination: 744 Annotation: Subtype: Link Rect: 386, 442, 404, 451 Destination: 744 Annotation: Subtype: Link Rect: 511, 420, 528, 428 Destination: 744 Annotation: Subtype: Link Rect: 328, 386, 345, 394 Destination: 738 Annotation: Subtype: Link Rect: 432, 374, 449, 383 Destination: 744 Annotation: Subtype: Link Rect: 321, 352, 338, 360 Destination: 738 Annotation: Subtype: Link Rect: 343, 352, 527, 360 Annotation: Subtype: Link Rect: 503, 182, 520, 190 Destination: 744 Annotation: Subtype: Link Rect: 365, 125, 374, 133 Destination: null Annotation: Subtype: Link Rect: 439, 102, 456, 111 Destination: 738 Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 146, 635, 154, 644 Destination: null Annotation: Subtype: Link Rect: 45, 295, 189, 304 Annotation: Subtype: Link Rect: 358, 669, 376, 677 Destination: 738 Annotation: Subtype: Link Rect: 480, 635, 497, 643 Destination: 744 Annotation: Subtype: Link Rect: 415, 454, 433, 462 Destination: 738 Annotation: Subtype: Link Rect: 509, 442, 526, 451 Destination: 744 Annotation: Subtype: Link Rect: 404, 352, 421, 360 Destination: 744 Annotation: Subtype: Link Rect: 459, 137, 495, 145 Destination: 567 Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 247, 443, 264, 451 Destination: 744 Annotation: Subtype: Link Rect: 92, 375, 102, 383 Destination: 668 Annotation: Subtype: Link Rect: 103, 261, 112, 269 Destination: null Annotation: Subtype: Link Rect: 314, 329, 522, 338 Annotation: Subtype: Link Rect: 311, 318, 351, 326 Annotation: Subtype: Link Rect: 481, 295, 552, 303 Annotation: Subtype: Link Rect: 311, 284, 423, 292 Annotation: Subtype: Link Rect: 467, 284, 552, 292 Annotation: Subtype: Link Rect: 311, 273, 369, 281 Annotation: Subtype: Link Rect: 433, 261, 552, 269 Annotation: Subtype: Link Rect: 311, 250, 504, 258 Annotation: Subtype: Link Rect: 445, 227, 464, 235 Thumb: true Page: Label: 16 Thumb: true Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 422, 227, 517, 235 Thumb: true Checksum: 3f2a17d2 Type: CRC32 Checksum: fea515c412008784edb90032a3d145fd Type: MD5 Checksum: 044cb4a0e664333af291628d1d8085ae0d0fa051 Type: SHA-1 Checksum: e3b13918942927e8ba7623d2a755ddd8b4608a24a94f3aabb0c029aedbe00053 Type: SHA-256