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Keywords:       CD176, Thomsen-Friedenreich antigen, pan-tumor antigen, carbohydrate antigen, CAR-T cell therapy, immunotherapy, cancer, solid tumors
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      Title: CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors
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       Item: 
        Title: 1 Introduction
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       Item: 
        Title: 2 Materials and methods
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         Item: 
          Title: 2.1 Human sample materials
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         Item: 
          Title: 2.2 Immunohistochemistry
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         Item: 
          Title: 2.3 Construction of CD176-CAR vectors
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         Item: 
          Title: 2.4 Generation and titration of lentiviral particles
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          Title: 2.5 Reporter assay to determine CD176-CAR signaling
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          Title: 2.6 Generation of primary CD176-CAR-Ts
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         Item: 
          Title: 2.7 Evaluation of CD176-CAR-T functionality
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          Title: 2.8 Flow cytometry
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         Item: 
          Title: 2.9 Multiplex cytokine analysis
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          Title: 2.10 Cytotoxicity
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          Title: 2.11 Statistical analysis
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        Title: 3 Results
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          Title: 3.1 Specific expression of CD176 on malignant cells from different blood and solid cancers
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          Title: 3.2 CD176-CARs mediate T-cell signaling upon specific recognition of unmasked CD176 or CD176+ cell lines from various solid and blood cancer entities
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          Title: 3.3 CD176-CAR-Ts are activated and release IFN-γ upon recognition of CD176+ cell lines from solid and blood cancer entities
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          Title: 3.4 CD176-CAR-Ts mediate cytotoxicity and release effector molecules upon recognition of CD176+ cell lines from solid and blood cancer entities
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          Title: 3.5 CD176-CAR-Ts proliferate, release cytokines and mediate cytotoxicity in long-term co-cultures with CD176+ cells
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          Title: 3.6 CD176-CAR-Ts proliferate and persist upon repetitive antigen stimulation
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        Title: 4 Discussion
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        Title: Data availability statement
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       Item: 
        Title: Ethics statement
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        Title: Author contributions
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       Item: 
        Title: Funding
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Supplementary material
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       Item: 
        Title: References
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   Type: CRC32
  Checksum: 5f2d080fb1c00e6465574e576ea8973e
   Type: MD5
  Checksum: 61029f50fc17ddbc813dd4fc30779c16d110a6ef
   Type: SHA-1
  Checksum: 82f375df0ef69ac7e36dd46062636a8a77bb86a87f8eaa12f6cd0f5728980019
   Type: SHA-256