aef0b71d95a55c076a44e489f4cffecc 289545.pdf 2c0e5894d9928adb6d51c83ee912be7d13aac10e 289545.pdf 95dafe61be438f4b37be2e1334881b7236dd23884ad191190442db31cfc2f726 289545.pdf Keywords: bioinformatics and computational biology, immunology and infectious diseases, vaccine development, antibody therapeutics, epitope prediction and antigenicity prediction Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 2217796 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HKKEBG+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 1350 0 HKKEBH+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 1351 0 HKKDPM+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 1324 0 HKKDPN+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 1325 0 HKKDPO+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 1326 0 HKKDPP+AdvPSA18C Type 1C WinAnsi yes yes no 1327 0 HKKEAA+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 1328 0 HKKEAB+AdvPSA323 Type 1C WinAnsi yes yes no 1329 0 HKKEAC+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 1330 0 HKKEAD+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 1331 0 HKKEBD+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 1332 0 HKKEBE+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 1333 0 HKKEBF+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 1352 0 HKKIDP+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 330 0 HKKIEA+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 334 0 HKKIFB+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 339 0 HKKIJA+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 340 0 HKKIKB+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 341 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 342 0 HKKOAC+AdvTT9b12cd41+22 Type 1C Custom yes yes yes 343 0 HKMBFM+AdvTT2c8ce45a+fb Type 1C Custom yes yes yes 351 0 HKMINP+AdvTT58d178b9+03 Type 1C Custom yes yes yes 352 0 HKMJBO+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 358 0 HKMJBP+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 357 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-01 02:35:27 CET RepresentationInformation: 289545.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-29 13:35:19 CET Size: 2217796 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1426 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Brewpitopes: a pipeline to refine B-cell epitope predictions during public health emergencies Destination: bmark_587863231 Children: Item: Title: Introduction Destination: s1 Item: Title: Materials and methods Destination: s2 Children: Item: Title: Dataset curation Destination: s3_1 Item: Title: Linear epitope predictions Destination: s3_2 Item: Title: Structural epitope predictions Destination: s3_3 Item: Title: Epitope extraction and integration Destination: s3_4 Item: Title: Subcellular location predictions Destination: s3_5 Item: Title: Glycosylation predictions Destination: s3_6 Item: Title: Accessibility predictions Destination: s3_7 Item: Title: Variants of concern analysis Destination: s3_8 Item: Title: Results Destination: s3 Children: Item: Title: Brewpitopes, a pipeline to curate B-cell epitope predictions based on determinant features for in vivo antibody recognition Destination: s4_1 Item: Title: Bioinformatic validation of Brewpitopes in the proteome of SARS-CoV-2 Destination: s4_2 Item: Title: Analysis of epitope conservation in the S protein of variants of concern Destination: s4_3 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Author contributions Destination: s6 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Keywords: bioinformatics and computational biology, immunology and infectious diseases, vaccine development, antibody therapeutics, epitope prediction and antigenicity prediction ID: 0xfca56834f76ee1cf16ce20b7b282a480, 0xba0973182b668744a7e5207500428a5b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3281 ImageHeight: 903 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2205 ImageHeight: 947 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1789 ImageHeight: 2218 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3298 ImageHeight: 1479 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1789 ImageHeight: 2219 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: HKMINP+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: HKMINP+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKMJBP+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HKMJBP+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKKEBG+AdvOTb65e897d.B FontSubset: true FirstChar: 45 LastChar: 118 FontDescriptor: FontName: HKKEBG+AdvOTb65e897d.B Flags: Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKMJBO+AdvOT3f84ef53 FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: HKMJBO+AdvOT3f84ef53 Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKEBH+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: HKKEBH+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKEBF+AdvTT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: HKKEBF+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKIDP+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HKKIDP+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKKDPM+AdvTTd3a5f740 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: HKKDPM+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKDPN+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HKKDPN+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKKDPO+AdvTTd3a5f740+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: HKKDPO+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKIEA+AdvOT1ef757c0+20 FontSubset: true FirstChar: 133 LastChar: 150 FontDescriptor: FontName: HKKIEA+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKDPP+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: HKKDPP+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKEAA+AdvTT9b12cd41 FontSubset: true FirstChar: 40 LastChar: 232 FontDescriptor: FontName: HKKEAA+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKEAB+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: HKKEAB+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKEAC+AdvTT9b12cd41+20 FontSubset: true FirstChar: 134 LastChar: 148 FontDescriptor: FontName: HKKEAC+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKEAD+AdvTT9b12cd41+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: HKKEAD+AdvTT9b12cd41+01 Flags: Nonsymbolic FontBBox: -52, -208, 958, 875 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: HKKIFB+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: HKKIFB+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKEBD+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HKKEBD+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKKIJA+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: HKKIJA+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKKEBE+AdvTTd168d80a.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: HKKEBE+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKIKB+AdvTT749c1f5a.I FontSubset: true FirstChar: 105 LastChar: 118 FontDescriptor: FontName: HKKIKB+AdvTT749c1f5a.I Flags: Nonsymbolic FontBBox: -145, -208, 989, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HelveticaNeueLTStd-Bd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKKOAC+AdvTT9b12cd41+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HKKOAC+AdvTT9b12cd41+22 Flags: Symbolic FontBBox: 0, -156, 552, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKMBFM+AdvTT2c8ce45a+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HKMBFM+AdvTT2c8ce45a+fb Flags: Symbolic FontBBox: 0, 0, 947, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: Roc Farriol-Duran Ruben López-Aladid Eduard Porta-Pardo Antoni Torres Laia Fernández-Barat Farriol-Duran R, López-Aladid R, Porta-Pardo E, Torres A and Fernández-Barat L (2023) Brewpitopes: a pipeline to refine B-cell epitope predictions during public health emergencies. Front. Immunol. 14:1278534 Copyright © 2023 Farriol-Duran, López-Aladid, Porta-Pardo, Torres and Fernández-Barat. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. bioinformatics and computational biology immunology and infectious diseases vaccine development antibody therapeutics epitope prediction and antigenicity prediction Brewpitopes: a pipeline to refine B-cell epitope predictions during public health emergencies bioinformatics and computational biology, immunology and infectious diseases, vaccine development, antibody therapeutics, epitope prediction and antigenicity prediction True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 537, 707 Annotation: Subtype: Link Rect: 222, 661, 542, 682 Annotation: Subtype: Link Rect: 222, 636, 478, 657 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 691, 125, 706 Annotation: Subtype: Link Rect: 60, 520, 125, 527 Annotation: Subtype: Link Rect: 60, 500, 115, 507 Annotation: Subtype: Link Rect: 60, 480, 144, 487 Annotation: Subtype: Link Rect: 49, 330, 158, 337 Annotation: Subtype: Link Rect: 121, 280, 180, 287 Annotation: Subtype: Link Rect: 49, 271, 133, 278 Annotation: Subtype: Link Rect: 450, 802, 506, 809 Annotation: Subtype: Link Rect: 466, 793, 529, 800 Annotation: Subtype: Link Rect: 446, 783, 539, 790 Annotation: Subtype: Link Rect: 49, 797, 233, 813 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 150, 715, 154, 724 Destination: 245 Annotation: Subtype: Link Rect: 225, 690, 229, 699 Destination: 245 Annotation: Subtype: Link Rect: 246, 615, 271, 624 Destination: 1 Annotation: Subtype: Link Rect: 279, 578, 287, 587 Destination: 245 Annotation: Subtype: Link Rect: 52, 565, 78, 574 Destination: 1 Annotation: Subtype: Link Rect: 223, 528, 248, 537 Destination: 1 Annotation: Subtype: Link Rect: 257, 528, 265, 537 Destination: 245 Annotation: Subtype: Link Rect: 269, 528, 277, 537 Destination: 245 Annotation: Subtype: Link Rect: 112, 503, 120, 512 Destination: 245 Annotation: Subtype: Link Rect: 187, 503, 191, 512 Destination: 245 Annotation: Subtype: Link Rect: 246, 503, 250, 512 Destination: 245 Annotation: Subtype: Link Rect: 136, 490, 162, 499 Destination: 1 Annotation: Subtype: Link Rect: 170, 490, 174, 499 Destination: 245 Annotation: Subtype: Link Rect: 178, 490, 182, 499 Destination: 245 Annotation: Subtype: Link Rect: 186, 490, 190, 499 Destination: 245 Annotation: Subtype: Link Rect: 195, 490, 203, 499 Destination: 245 Annotation: Subtype: Link Rect: 133, 440, 141, 449 Destination: 245 Annotation: Subtype: Link Rect: 180, 428, 188, 437 Destination: 245 Annotation: Subtype: Link Rect: 232, 365, 236, 374 Destination: 245 Annotation: Subtype: Link Rect: 240, 365, 248, 374 Destination: 245 Annotation: Subtype: Link Rect: 127, 69, 136, 78 Destination: 245 Annotation: Subtype: Link Rect: 364, 755, 370, 758 Destination: 245 Annotation: Subtype: Link Rect: 387, 749, 393, 752 Destination: 245 Annotation: Subtype: Link Rect: 387, 755, 393, 758 Destination: 245 Annotation: Subtype: Link Rect: 402, 749, 408, 752 Destination: 245 Annotation: Subtype: Link Rect: 402, 755, 408, 758 Destination: 245 Annotation: Subtype: Link Rect: 417, 749, 423, 752 Destination: 245 Annotation: Subtype: Link Rect: 417, 755, 423, 758 Destination: 245 Annotation: Subtype: Link Rect: 432, 749, 438, 752 Destination: 245 Annotation: Subtype: Link Rect: 432, 755, 438, 758 Destination: 245 Annotation: Subtype: Link Rect: 455, 746, 461, 749 Destination: 245 Annotation: Subtype: Link Rect: 455, 752, 461, 758 Destination: 245 Annotation: Subtype: Link Rect: 471, 752, 476, 758 Destination: 245 Annotation: Subtype: Link Rect: 494, 752, 500, 758 Destination: 245 Annotation: Subtype: Link Rect: 509, 752, 515, 758 Destination: 245 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 170, 752, 176, 758 Destination: 245 Annotation: Subtype: Link Rect: 193, 755, 199, 758 Destination: 245 Annotation: Subtype: Link Rect: 217, 752, 222, 758 Destination: 245 Annotation: Subtype: Link Rect: 232, 752, 238, 758 Destination: 245 Annotation: Subtype: Link Rect: 255, 752, 261, 758 Destination: 245 Annotation: Subtype: Link Rect: 270, 752, 276, 758 Destination: 245 Annotation: Subtype: Link Rect: 285, 752, 291, 758 Destination: 245 Annotation: Subtype: Link Rect: 300, 752, 306, 758 Destination: 245 Annotation: Subtype: Link Rect: 315, 752, 321, 758 Destination: 245 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Rotate: 90 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 87, 706, 96, 715 Destination: 245 Annotation: Subtype: Link Rect: 157, 694, 166, 703 Destination: 245 Annotation: Subtype: Link Rect: 222, 694, 231, 703 Destination: 245 Annotation: Subtype: Link Rect: 89, 606, 98, 615 Destination: 245 Annotation: Subtype: Link Rect: 175, 606, 179, 615 Destination: 245 Annotation: Subtype: Link Rect: 264, 606, 273, 615 Destination: 245 Annotation: Subtype: Link Rect: 86, 581, 95, 590 Destination: 245 Annotation: Subtype: Link Rect: 210, 506, 215, 515 Destination: 245 Annotation: Subtype: Link Rect: 144, 387, 152, 396 Destination: 245 Annotation: Subtype: Link Rect: 202, 299, 211, 308 Destination: 245 Annotation: Subtype: Link Rect: 145, 212, 150, 221 Destination: 245 Annotation: Subtype: Link Rect: 122, 119, 127, 128 Destination: 245 Annotation: Subtype: Link Rect: 181, 119, 190, 128 Destination: 245 Annotation: Subtype: Link Rect: 283, 119, 287, 128 Destination: 245 Annotation: Subtype: Link Rect: 49, 69, 184, 78 Annotation: Subtype: Link Rect: 532, 716, 540, 725 Destination: 245 Annotation: Subtype: Link Rect: 393, 679, 397, 688 Destination: 245 Annotation: Subtype: Link Rect: 410, 666, 419, 675 Destination: 245 Annotation: Subtype: Link Rect: 475, 666, 484, 675 Destination: 245 Annotation: Subtype: Link Rect: 307, 654, 316, 663 Destination: 245 Annotation: Subtype: Link Rect: 363, 654, 372, 663 Destination: 245 Annotation: Subtype: Link Rect: 414, 654, 422, 663 Destination: 245 Annotation: Subtype: Link Rect: 468, 654, 477, 663 Destination: 245 Annotation: Subtype: Link Rect: 307, 641, 316, 650 Destination: 245 Annotation: Subtype: Link Rect: 356, 641, 365, 650 Destination: 245 Annotation: Subtype: Link Rect: 431, 641, 439, 650 Destination: 245 Annotation: Subtype: Link Rect: 376, 534, 384, 543 Destination: 245 Annotation: Subtype: Link Rect: 534, 534, 542, 543 Destination: 245 Annotation: Subtype: Link Rect: 476, 364, 484, 373 Destination: 245 Annotation: Subtype: Link Rect: 383, 219, 388, 228 Destination: 245 Annotation: Subtype: Link Rect: 532, 219, 540, 228 Destination: 245 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 189, 744, 220, 753 Destination: 1 Annotation: Subtype: Link Rect: 150, 656, 184, 665 Destination: 100 Annotation: Subtype: Link Rect: 83, 606, 116, 615 Destination: 100 Annotation: Subtype: Link Rect: 121, 606, 125, 615 Destination: 132 Annotation: Subtype: Link Rect: 72, 531, 100, 540 Destination: 1 Annotation: Subtype: Link Rect: 179, 519, 184, 528 Destination: 245 Annotation: Subtype: Link Rect: 248, 519, 256, 528 Destination: 245 Annotation: Subtype: Link Rect: 281, 506, 285, 515 Destination: 245 Annotation: Subtype: Link Rect: 140, 394, 170, 403 Destination: 100 Annotation: Subtype: Link Rect: 204, 381, 213, 390 Destination: 245 Annotation: Subtype: Link Rect: 433, 756, 442, 765 Destination: 245 Annotation: Subtype: Link Rect: 307, 681, 312, 690 Destination: 245 Annotation: Subtype: Link Rect: 464, 631, 493, 640 Destination: 100 Annotation: Subtype: Link Rect: 502, 631, 510, 640 Destination: 245 Annotation: Subtype: Link Rect: 534, 606, 542, 615 Destination: 245 Annotation: Subtype: Link Rect: 369, 594, 378, 603 Destination: 245 Annotation: Subtype: Link Rect: 392, 494, 401, 503 Destination: 245 Annotation: Subtype: Link Rect: 411, 494, 442, 503 Destination: 100 Annotation: Subtype: Link Rect: 307, 431, 316, 440 Destination: 245 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 203, 138, 211, 147 Destination: 245 Annotation: Subtype: Link Rect: 521, 425, 530, 434 Destination: 245 Annotation: Subtype: Link Rect: 442, 363, 473, 372 Destination: 146 Annotation: Subtype: Link Rect: 450, 313, 480, 322 Destination: 154 Annotation: Subtype: Link Rect: 495, 263, 525, 272 Destination: 146 Annotation: Subtype: Link Rect: 341, 225, 350, 234 Destination: 245 Annotation: Subtype: Link Rect: 495, 113, 525, 122 Destination: 146 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 236, 231, 266, 240 Destination: 154 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 122, 488, 155, 497 Destination: 233 Annotation: Subtype: Link Rect: 162, 488, 195, 497 Destination: 180 Annotation: Subtype: Link Rect: 277, 450, 285, 459 Destination: 245 Annotation: Subtype: Link Rect: 120, 349, 145, 356 Annotation: Subtype: Link Rect: 120, 332, 145, 339 Annotation: Subtype: Link Rect: 120, 316, 145, 323 Annotation: Subtype: Link Rect: 120, 299, 145, 306 Annotation: Subtype: Link Rect: 120, 283, 145, 290 Annotation: Subtype: Link Rect: 120, 266, 145, 273 Annotation: Subtype: Link Rect: 120, 249, 145, 256 Annotation: Subtype: Link Rect: 120, 233, 145, 240 Annotation: Subtype: Link Rect: 120, 216, 145, 223 Annotation: Subtype: Link Rect: 120, 200, 145, 207 Annotation: Subtype: Link Rect: 120, 183, 145, 190 Annotation: Subtype: Link Rect: 120, 166, 144, 173 Annotation: Subtype: Link Rect: 120, 150, 145, 157 Annotation: Subtype: Link Rect: 120, 133, 145, 140 Annotation: Subtype: Link Rect: 120, 117, 145, 124 Annotation: Subtype: Link Rect: 120, 100, 145, 107 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 119, 172, 151, 181 Destination: 233 Annotation: Subtype: Link Rect: 158, 172, 193, 181 Destination: 233 Annotation: Subtype: Link Rect: 139, 147, 144, 156 Destination: 245 Annotation: Subtype: Link Rect: 428, 147, 464, 156 Destination: 233 Annotation: Subtype: Link Rect: 470, 147, 503, 156 Destination: 233 Annotation: Subtype: Link Rect: 337, 122, 369, 131 Destination: 195 Annotation: Subtype: Link Rect: 375, 122, 379, 131 Destination: 213 Annotation: Subtype: Link Rect: 275, 281, 300, 288 Destination: 132 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 52, 496, 79, 505 Destination: 213 Annotation: Subtype: Link Rect: 84, 496, 114, 505 Destination: 180 Annotation: Subtype: Link Rect: 89, 396, 116, 405 Destination: 225 Annotation: Subtype: Link Rect: 233, 283, 269, 292 Destination: 1 Annotation: Subtype: Link Rect: 401, 533, 432, 542 Destination: 1 Annotation: Subtype: Link Rect: 443, 533, 452, 542 Destination: 245 Annotation: Subtype: Link Rect: 457, 533, 466, 542 Destination: 245 Annotation: Subtype: Link Rect: 473, 533, 483, 542 Destination: 317 Annotation: Subtype: Link Rect: 489, 533, 499, 542 Destination: 317 Annotation: Subtype: Link Rect: 518, 158, 527, 167 Destination: 245 Annotation: Subtype: Link Rect: 513, 108, 543, 117 Destination: 146 Annotation: Subtype: Link Rect: 304, 96, 332, 105 Destination: 154 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Rotate: 90 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Rotate: 90 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 463, 419, 471, 428 Destination: 245 Annotation: Subtype: Link Rect: 389, 194, 397, 203 Destination: 317 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 275, 631, 284, 640 Destination: 317 Annotation: Subtype: Link Rect: 241, 619, 250, 628 Destination: 317 Annotation: Subtype: Link Rect: 102, 256, 191, 265 Destination: 233 Annotation: Subtype: Link Rect: 409, 628, 511, 637 Annotation: Subtype: Link Rect: 319, 274, 545, 283 Annotation: Subtype: Link Rect: 304, 262, 440, 271 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 130, 715, 201, 722 Annotation: Subtype: Link Rect: 158, 688, 213, 695 Annotation: Subtype: Link Rect: 72, 661, 151, 668 Annotation: Subtype: Link Rect: 136, 650, 198, 657 Annotation: Subtype: Link Rect: 102, 623, 191, 630 Annotation: Subtype: Link Rect: 255, 604, 290, 611 Annotation: Subtype: Link Rect: 49, 596, 69, 603 Annotation: Subtype: Link Rect: 218, 585, 290, 592 Annotation: Subtype: Link Rect: 49, 577, 80, 584 Annotation: Subtype: Link Rect: 138, 550, 220, 557 Annotation: Subtype: Link Rect: 89, 523, 175, 530 Annotation: Subtype: Link Rect: 87, 496, 143, 503 Annotation: Subtype: Link Rect: 62, 442, 133, 449 Annotation: Subtype: Link Rect: 49, 415, 108, 422 Annotation: Subtype: Link Rect: 163, 388, 242, 395 Annotation: Subtype: Link Rect: 194, 361, 275, 368 Annotation: Subtype: Link Rect: 170, 334, 251, 341 Annotation: Subtype: Link Rect: 266, 299, 290, 306 Annotation: Subtype: Link Rect: 49, 291, 116, 298 Annotation: Subtype: Link Rect: 80, 264, 163, 271 Annotation: Subtype: Link Rect: 266, 237, 290, 244 Annotation: Subtype: Link Rect: 49, 229, 95, 236 Annotation: Subtype: Link Rect: 62, 194, 146, 201 Annotation: Subtype: Link Rect: 80, 167, 161, 174 Annotation: Subtype: Link Rect: 205, 148, 276, 155 Annotation: Subtype: Link Rect: 49, 113, 130, 120 Annotation: Subtype: Link Rect: 156, 86, 232, 93 Annotation: Subtype: Link Rect: 522, 715, 545, 722 Annotation: Subtype: Link Rect: 304, 707, 340, 714 Annotation: Subtype: Link Rect: 376, 680, 453, 687 Annotation: Subtype: Link Rect: 373, 653, 429, 660 Annotation: Subtype: Link Rect: 427, 642, 488, 649 Annotation: Subtype: Link Rect: 317, 615, 398, 622 Annotation: Subtype: Link Rect: 443, 596, 484, 603 Annotation: Subtype: Link Rect: 304, 569, 358, 576 Annotation: Subtype: Link Rect: 373, 550, 441, 557 Annotation: Subtype: Link Rect: 369, 523, 453, 530 Annotation: Subtype: Link Rect: 521, 504, 545, 511 Annotation: Subtype: Link Rect: 304, 496, 370, 503 Annotation: Subtype: Link Rect: 449, 477, 533, 484 Annotation: Subtype: Link Rect: 419, 458, 494, 465 Annotation: Subtype: Link Rect: 381, 431, 467, 438 Annotation: Subtype: Link Rect: 356, 404, 438, 411 Annotation: Subtype: Link Rect: 377, 377, 435, 384 Annotation: Subtype: Link Rect: 413, 350, 472, 357 Annotation: Subtype: Link Rect: 493, 331, 545, 338 Annotation: Subtype: Link Rect: 304, 323, 339, 330 Annotation: Subtype: Link Rect: 413, 296, 492, 303 Annotation: Subtype: Link Rect: 525, 285, 545, 292 Annotation: Subtype: Link Rect: 304, 277, 443, 284 Annotation: Subtype: Link Rect: 521, 250, 545, 257 Annotation: Subtype: Link Rect: 304, 242, 345, 249 Annotation: Subtype: Link Rect: 459, 231, 545, 238 Annotation: Subtype: Link Rect: 304, 223, 341, 230 Annotation: Subtype: Link Rect: 418, 212, 467, 219 Annotation: Subtype: Link Rect: 304, 185, 375, 192 Annotation: Subtype: Link Rect: 522, 166, 545, 173 Annotation: Subtype: Link Rect: 304, 158, 361, 165 Annotation: Subtype: Link Rect: 453, 139, 524, 146 Annotation: Subtype: Link Rect: 329, 112, 410, 119 Annotation: Subtype: Link Rect: 327, 85, 386, 92 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 266, 742, 290, 749 Annotation: Subtype: Link Rect: 49, 734, 103, 741 Annotation: Subtype: Link Rect: 62, 699, 144, 706 Annotation: Subtype: Link Rect: 520, 742, 545, 749 Annotation: Subtype: Link Rect: 304, 734, 366, 741 Annotation: Subtype: Link Rect: 519, 707, 545, 714 Annotation: Subtype: Link Rect: 304, 699, 375, 706 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: 096dd180 Type: CRC32 Checksum: aef0b71d95a55c076a44e489f4cffecc Type: MD5 Checksum: 2c0e5894d9928adb6d51c83ee912be7d13aac10e Type: SHA-1 Checksum: 95dafe61be438f4b37be2e1334881b7236dd23884ad191190442db31cfc2f726 Type: SHA-256