e2b7049195db2154ec7b8564e7a9f2d5 Genetic_variants_of_CTLA4.pdf 03761fcc957cb5282ca5edb1f210bf09a9903b7a Genetic_variants_of_CTLA4.pdf 5e5d2b4a32ce787c4c265464503916b04f626b76c3d84d4f11976a5579a780b0 Genetic_variants_of_CTLA4.pdf Title: Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma Subject: Gonzalez-Montes Y, Rodriguez-Romanos R, Villavicencio A, Osca-Gelis G, González-Bártulos M, Llopis F, Clapes V, Oriol A, Sureda A, Escoda L, Sarrà J, Garzó A, Lloveras N, Díez I, Granada I and Gallardo D (2023) Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma. Front. Immunol. 14:1158105 Keywords: CTLA4 polymorphisms, multiple myeloma, immune checkpoint, bone marrow microenvironment, cytogenetics and molecular genetics Author: Yolanda Gonzalez-Montes CreationDate: Mon Apr 10 02:16:54 2023 CEST ModDate: Mon Apr 10 02:16:54 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 1248274 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DEJJGL+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 713 0 DEJJGM+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 714 0 DEJJGN+AdvPSA18C Type 1C WinAnsi yes yes no 715 0 DEJJGO+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 716 0 DEJJHO+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 717 0 DEJJHP+AdvPSA323 Type 1C WinAnsi yes yes no 718 0 DEJJIA+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 724 0 DEJJIB+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 725 0 DEJKPJ+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 728 0 DEJKPK+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 730 0 DEJLDK+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 210 0 DEJLFK+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 215 0 DEJLGL+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 218 0 DEJLGM+AdvOTd877c31c+21 Type 1C WinAnsi yes yes no 219 0 DEJLGN+AdvOTd877c31c Type 1C WinAnsi yes yes no 202 0 DEJLHO+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 203 0 DEJLDJ+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 213 0 DEJLIO+AdvOT46dcae81 Type 1C WinAnsi yes yes no 224 0 DEJLIP+AdvOT46dcae81+01 Type 1C Custom yes yes no 223 0 DEJLKA+AdvOTb65e897d.B+01 Type 1C Custom yes yes no 229 0 DEJLKB+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 230 0 DEJLMB+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 232 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 235 0 DEKBIN+AdvTT58d178b9+03 Type 1C Custom yes yes yes 240 0 DEKBJO+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 241 0 DEKBKO+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 242 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-01 02:35:25 CET RepresentationInformation: Genetic_variants_of_CTLA4.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-29 16:16:07 CET Size: 1248274 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 789 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma Destination: bmark_-1881520564 Children: Item: Title: Introduction Destination: s1 Item: Title: Patients and methods Destination: s2 Children: Item: Title: Genotype analysis Destination: s2_1 Item: Title: Statistical analyses Destination: s2_2 Item: Title: Results Destination: s3 Children: Item: Title: CTLA4, BTLA, CD28, PDCD1 and LAG3 genotype distribution. Destination: s3_1 Item: Title: Homogeneity between genotype groups Destination: s3_2 Item: Title: Correlation between immune checkpoint molecules genotype and progression to symptomatic myeloma Destination: s3_3 Item: Title: Immune checkpoint molecules genotype and clinical outcome after treatment Destination: s3_4 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Title: Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma Author: Yolanda Gonzalez-Montes Subject: Gonzalez-Montes Y, Rodriguez-Romanos R, Villavicencio A, Osca-Gelis G, González-Bártulos M, Llopis F, Clapes V, Oriol A, Sureda A, Escoda L, Sarrà J, Garzó A, Lloveras N, Díez I, Granada I and Gallardo D (2023) Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma. Front. Immunol. 14:1158105 Keywords: CTLA4 polymorphisms, multiple myeloma, immune checkpoint, bone marrow microenvironment, cytogenetics and molecular genetics CreationDate: Mon Apr 10 02:16:54 CEST 2023 ModDate: Mon Apr 10 02:16:54 CEST 2023 ID: 0x42e2366c4ffea586c5c9f23001cebc27, 0x06e82de64909cb44a327fc727388c759 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1263 ImageHeight: 2219 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1476 ImageHeight: 1286 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1476 ImageHeight: 1286 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: DEJJGL+AdvTTd3a5f740 FontSubset: true FirstChar: 42 LastChar: 242 FontDescriptor: FontName: DEJJGL+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJJGM+AdvTTd3a5f740+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: DEJJGM+AdvTTd3a5f740+01 Flags: Nonsymbolic FontBBox: -52, -208, 947, 885 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: DEJLGN+AdvOTd877c31c FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: DEJLGN+AdvOTd877c31c Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJJGN+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: DEJJGN+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJLHO+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DEJLHO+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEJJGO+AdvTT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 232 FontDescriptor: FontName: DEJJGO+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJJHO+AdvTT9b12cd41+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: DEJJHO+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJJHP+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: DEJJHP+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJLDK+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DEJLDK+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEJJIA+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DEJJIA+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEJJIB+AdvTT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: DEJJIB+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJLDJ+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: DEJLDJ+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJLFK+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: DEJLFK+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJKPJ+AdvTT9b12cd41+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: DEJKPJ+AdvTT9b12cd41+01 Flags: Nonsymbolic FontBBox: -52, -208, 958, 875 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: DEJKPK+AdvTTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: DEJKPK+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJLGL+AdvOT7d6df7ab.I FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: DEJLGL+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJLGM+AdvOTd877c31c+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: DEJLGM+AdvOTd877c31c+21 Flags: Nonsymbolic FontBBox: -10, -250, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJLIP+AdvOT46dcae81+01 FontSubset: true FirstChar: 20 LastChar: 20 FontDescriptor: FontName: DEJLIP+AdvOT46dcae81+01 Flags: Nonsymbolic FontBBox: -41, -218, 854, 864 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DEJLIO+AdvOT46dcae81 FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: DEJLIO+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEJLKA+AdvOTb65e897d.B+01 FontSubset: true FirstChar: 20 LastChar: 20 FontDescriptor: FontName: DEJLKA+AdvOTb65e897d.B+01 Flags: Nonsymbolic FontBBox: -41, -260, 979, 875 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DEJLKB+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DEJLKB+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEJLMB+AdvOT65f8a23b.I FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: DEJLMB+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HelveticaNeueLTStd-Bd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKBIN+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: DEKBIN+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEKBJO+AdvTTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: DEKBJO+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEKBKO+AdvOT1ef757c0+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: DEKBKO+AdvOT1ef757c0+01 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: MacRomanEncoding XMP: application/pdf Yolanda Gonzalez-Montes Rocío Rodriguez-Romanos Alicia Villavicencio Gemma Osca-Gelis Marta González-Bártulos Francesca Llopis Victòria Clapes Albert Oriol Anna Sureda Lourdes Escoda Josep Sarrà Ana Garzó Natàlia Lloveras Isabel Díez Isabel Granada David Gallardo Gonzalez-Montes Y, Rodriguez-Romanos R, Villavicencio A, Osca-Gelis G, González-Bártulos M, Llopis F, Clapes V, Oriol A, Sureda A, Escoda L, Sarrà J, Garzó A, Lloveras N, Díez I, Granada I and Gallardo D (2023) Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma. Front. Immunol. 14:1158105 Copyright © 2023 Gonzalez-Montes, Rodriguez-Romanos, Villavicencio, Osca-Gelis, González-Bártulos, Llopis, Clapes, Oriol, Sureda, Escoda, Sarrà, Garzó, Lloveras, Díez, Granada and Gallardo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. CTLA4 polymorphisms multiple myeloma immune checkpoint bone marrow microenvironment cytogenetics and molecular genetics Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma CTLA4 polymorphisms, multiple myeloma, immune checkpoint, bone marrow microenvironment, cytogenetics and molecular genetics True https://www.frontiersin.org/legal/copyright-statement 2023-04-10T08:16:54+08:00 2023-04-10T08:16:54+08:00 2023-04-10T08:16:54+08:00 uuid:8e8ea7b1-0a2d-4285-81eb-c5df61f89767 uuid:9d294781-7f00-43a1-908b-ea7f683248a2 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 511, 707 Annotation: Subtype: Link Rect: 222, 661, 451, 682 Annotation: Subtype: Link Rect: 222, 636, 467, 657 Annotation: Subtype: Link Rect: 222, 611, 396, 632 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 691, 125, 706 Annotation: Subtype: Link Rect: 60, 538, 146, 545 Annotation: Subtype: Link Rect: 49, 329, 157, 336 Annotation: Subtype: Link Rect: 89, 252, 182, 259 Annotation: Subtype: Link Rect: 49, 243, 99, 250 Annotation: Subtype: Link Rect: 454, 802, 510, 809 Annotation: Subtype: Link Rect: 471, 793, 512, 800 Annotation: Subtype: Link Rect: 451, 783, 543, 790 Annotation: Subtype: Link Rect: 49, 797, 233, 813 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 221, 618, 226, 627 Destination: 122 Annotation: Subtype: Link Rect: 233, 618, 237, 627 Destination: 122 Annotation: Subtype: Link Rect: 248, 556, 252, 565 Destination: 122 Annotation: Subtype: Link Rect: 156, 368, 160, 377 Destination: 122 Annotation: Subtype: Link Rect: 52, 306, 57, 315 Destination: 122 Annotation: Subtype: Link Rect: 258, 256, 262, 265 Destination: 122 Annotation: Subtype: Link Rect: 267, 256, 271, 265 Destination: 122 Annotation: Subtype: Link Rect: 226, 231, 231, 240 Destination: 122 Annotation: Subtype: Link Rect: 98, 181, 103, 190 Destination: 122 Annotation: Subtype: Link Rect: 108, 181, 117, 190 Destination: 122 Annotation: Subtype: Link Rect: 245, 181, 253, 190 Destination: 122 Annotation: Subtype: Link Rect: 259, 181, 268, 190 Destination: 122 Annotation: Subtype: Link Rect: 74, 168, 83, 177 Destination: 122 Annotation: Subtype: Link Rect: 88, 168, 97, 177 Destination: 122 Annotation: Subtype: Link Rect: 265, 143, 274, 152 Destination: 122 Annotation: Subtype: Link Rect: 278, 143, 287, 152 Destination: 122 Annotation: Subtype: Link Rect: 162, 118, 171, 127 Destination: 122 Annotation: Subtype: Link Rect: 465, 506, 492, 515 Destination: 29 Annotation: Subtype: Link Rect: 450, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 63, 93, 92, 102 Destination: 29 Annotation: Subtype: Link Rect: 333, 256, 366, 265 Destination: 122 Annotation: Subtype: Link Rect: 370, 256, 379, 265 Destination: 122 Annotation: Subtype: Link Rect: 450, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 241, 556, 267, 565 Destination: 43 Annotation: Subtype: Link Rect: 392, 744, 423, 753 Destination: 52 Annotation: Subtype: Link Rect: 495, 569, 521, 578 Destination: 52 Annotation: Subtype: Link Rect: 450, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 453, 744, 483, 753 Destination: 78 Annotation: Subtype: Link Rect: 307, 681, 338, 690 Destination: 78 Annotation: Subtype: Link Rect: 386, 531, 390, 540 Destination: 122 Annotation: Subtype: Link Rect: 368, 506, 377, 515 Destination: 122 Annotation: Subtype: Link Rect: 531, 506, 540, 515 Destination: 122 Annotation: Subtype: Link Rect: 406, 494, 414, 503 Destination: 122 Annotation: Subtype: Link Rect: 532, 494, 540, 503 Destination: 122 Annotation: Subtype: Link Rect: 338, 469, 347, 478 Destination: 122 Annotation: Subtype: Link Rect: 479, 456, 487, 465 Destination: 122 Annotation: Subtype: Link Rect: 410, 406, 418, 415 Destination: 122 Annotation: Subtype: Link Rect: 422, 406, 431, 415 Destination: 122 Annotation: Subtype: Link Rect: 378, 356, 387, 365 Destination: 122 Annotation: Subtype: Link Rect: 492, 356, 500, 365 Destination: 122 Annotation: Subtype: Link Rect: 450, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 127, 394, 135, 403 Destination: 122 Annotation: Subtype: Link Rect: 176, 394, 184, 403 Destination: 122 Annotation: Subtype: Link Rect: 181, 331, 189, 340 Destination: 122 Annotation: Subtype: Link Rect: 201, 306, 210, 315 Destination: 122 Annotation: Subtype: Link Rect: 225, 231, 234, 240 Destination: 172 Annotation: Subtype: Link Rect: 239, 231, 247, 240 Destination: 172 Annotation: Subtype: Link Rect: 52, 194, 56, 203 Destination: 122 Annotation: Subtype: Link Rect: 62, 194, 71, 203 Destination: 122 Annotation: Subtype: Link Rect: 218, 169, 222, 178 Destination: 122 Annotation: Subtype: Link Rect: 227, 169, 235, 178 Destination: 172 Annotation: Subtype: Link Rect: 70, 131, 78, 140 Destination: 172 Annotation: Subtype: Link Rect: 378, 494, 386, 503 Destination: 172 Annotation: Subtype: Link Rect: 345, 444, 354, 453 Destination: 172 Annotation: Subtype: Link Rect: 360, 444, 369, 453 Destination: 172 Annotation: Subtype: Link Rect: 361, 406, 370, 415 Destination: 172 Annotation: Subtype: Link Rect: 336, 369, 345, 378 Destination: 172 Annotation: Subtype: Link Rect: 392, 319, 396, 328 Destination: 122 Annotation: Subtype: Link Rect: 400, 319, 409, 328 Destination: 172 Annotation: Subtype: Link Rect: 470, 244, 479, 253 Destination: 172 Annotation: Subtype: Link Rect: 325, 94, 333, 103 Destination: 172 Annotation: Subtype: Link Rect: 338, 94, 346, 103 Destination: 172 Annotation: Subtype: Link Rect: 450, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 236, 656, 245, 665 Destination: 172 Annotation: Subtype: Link Rect: 251, 656, 260, 665 Destination: 172 Annotation: Subtype: Link Rect: 85, 581, 93, 590 Destination: 172 Annotation: Subtype: Link Rect: 100, 581, 109, 590 Destination: 172 Annotation: Subtype: Link Rect: 195, 394, 204, 403 Destination: 172 Annotation: Subtype: Link Rect: 233, 331, 242, 340 Destination: 172 Annotation: Subtype: Link Rect: 128, 231, 137, 240 Destination: 172 Annotation: Subtype: Link Rect: 275, 144, 285, 153 Destination: 172 Annotation: Subtype: Link Rect: 444, 427, 531, 436 Destination: 122 Annotation: Subtype: Link Rect: 450, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 304, 642, 545, 651 Annotation: Subtype: Link Rect: 304, 630, 401, 639 Annotation: Subtype: Link Rect: 109, 547, 203, 554 Annotation: Subtype: Link Rect: 115, 512, 190, 519 Annotation: Subtype: Link Rect: 194, 493, 287, 500 Annotation: Subtype: Link Rect: 104, 466, 180, 473 Annotation: Subtype: Link Rect: 266, 431, 290, 438 Annotation: Subtype: Link Rect: 49, 423, 88, 430 Annotation: Subtype: Link Rect: 180, 396, 267, 403 Annotation: Subtype: Link Rect: 147, 361, 202, 368 Annotation: Subtype: Link Rect: 266, 342, 290, 349 Annotation: Subtype: Link Rect: 49, 334, 104, 341 Annotation: Subtype: Link Rect: 221, 307, 272, 314 Annotation: Subtype: Link Rect: 247, 280, 290, 287 Annotation: Subtype: Link Rect: 49, 272, 101, 279 Annotation: Subtype: Link Rect: 99, 237, 187, 244 Annotation: Subtype: Link Rect: 49, 202, 144, 209 Annotation: Subtype: Link Rect: 186, 175, 281, 182 Annotation: Subtype: Link Rect: 95, 140, 173, 147 Annotation: Subtype: Link Rect: 121, 113, 170, 120 Annotation: Subtype: Link Rect: 49, 78, 100, 85 Annotation: Subtype: Link Rect: 415, 539, 496, 546 Annotation: Subtype: Link Rect: 349, 504, 437, 511 Annotation: Subtype: Link Rect: 357, 469, 435, 476 Annotation: Subtype: Link Rect: 304, 434, 363, 441 Annotation: Subtype: Link Rect: 418, 399, 504, 406 Annotation: Subtype: Link Rect: 489, 372, 545, 379 Annotation: Subtype: Link Rect: 304, 364, 338, 371 Annotation: Subtype: Link Rect: 304, 337, 386, 344 Annotation: Subtype: Link Rect: 452, 310, 507, 317 Annotation: Subtype: Link Rect: 518, 283, 545, 290 Annotation: Subtype: Link Rect: 304, 275, 362, 282 Annotation: Subtype: Link Rect: 304, 240, 392, 247 Annotation: Subtype: Link Rect: 451, 221, 538, 228 Annotation: Subtype: Link Rect: 522, 194, 545, 201 Annotation: Subtype: Link Rect: 304, 186, 358, 193 Annotation: Subtype: Link Rect: 352, 159, 435, 166 Annotation: Subtype: Link Rect: 471, 132, 545, 139 Annotation: Subtype: Link Rect: 418, 105, 476, 112 Annotation: Subtype: Link Rect: 439, 78, 534, 85 Annotation: Subtype: Link Rect: 450, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 109, 742, 190, 749 Annotation: Subtype: Link Rect: 122, 715, 195, 722 Annotation: Subtype: Link Rect: 222, 688, 290, 695 Annotation: Subtype: Link Rect: 49, 680, 72, 687 Annotation: Subtype: Link Rect: 188, 661, 268, 668 Annotation: Subtype: Link Rect: 212, 634, 280, 641 Annotation: Subtype: Link Rect: 175, 599, 266, 606 Annotation: Subtype: Link Rect: 172, 564, 263, 571 Annotation: Subtype: Link Rect: 186, 537, 286, 544 Annotation: Subtype: Link Rect: 266, 510, 290, 517 Annotation: Subtype: Link Rect: 49, 502, 113, 509 Annotation: Subtype: Link Rect: 179, 475, 266, 482 Annotation: Subtype: Link Rect: 521, 758, 545, 765 Annotation: Subtype: Link Rect: 304, 750, 358, 757 Annotation: Subtype: Link Rect: 422, 715, 492, 722 Annotation: Subtype: Link Rect: 354, 688, 422, 695 Annotation: Subtype: Link Rect: 304, 660, 384, 667 Annotation: Subtype: Link Rect: 361, 624, 451, 631 Annotation: Subtype: Link Rect: 518, 588, 545, 595 Annotation: Subtype: Link Rect: 304, 580, 386, 587 Annotation: Subtype: Link Rect: 351, 544, 427, 551 Annotation: Subtype: Link Rect: 304, 508, 375, 515 Annotation: Subtype: Link Rect: 522, 464, 545, 471 Annotation: Subtype: Link Rect: 304, 456, 393, 463 Annotation: Subtype: Link Rect: 450, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: 0cb85292 Type: CRC32 Checksum: e2b7049195db2154ec7b8564e7a9f2d5 Type: MD5 Checksum: 03761fcc957cb5282ca5edb1f210bf09a9903b7a Type: SHA-1 Checksum: 5e5d2b4a32ce787c4c265464503916b04f626b76c3d84d4f11976a5579a780b0 Type: SHA-256