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Title:          Advancing CART therapy for acute myeloid leukemia: recent breakthroughs and strategies for future development
Subject:        Pérez-Amill L, Bataller À, Delgado J, Esteve J, Juan M and Klein-González N (2023) Advancing CART therapy for acute myeloid leukemia: recent breakthroughs and strategies for future development. Front. Immunol. 14:1260470
Keywords:       acute myeloid leukemia, chimeric antigen receptor, myelotoxicity, hematologic toxicity, cytopenia, on-target/off-tumor toxicity
Author:         Lorena Pérez-Amill
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      Title: Advancing CART therapy for acute myeloid leukemia: recent breakthroughs and strategies for future development
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        Title: 1 Introduction
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          Title: 1.1 History of cancer immunotherapy
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          Title: 1.2 CAR structure
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          Title: 1.3 Clinical approved CART products
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       Item: 
        Title: 2 Design of CART therapy for AML
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         Item: 
          Title: 2.1 State of the art of AML treatment
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         Item: 
          Title: 2.2 Designing of CART for AML
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          Title: 2.3 Common antigens targeted by CART in AML
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         Item: 
          Title: 2.4 Future prospects of CART in AML
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            Title: 2.4.1 Strategies to enhance efficacy
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        Title: 3 Preclinical development of new CART therapies for AML
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          Title: 3.1 Engineering CARTs
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          Title: 3.2 Isolating, activating, and expanding effector cells
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          Title: 3.3 Gene-editing
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          Title: 3.4 In vitro efficacy testing
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          Title: 3.5 In vitro safety assessments
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         Item: 
          Title: 3.6 In vivo efficacy studies
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          Title: 3.7 In vivo safety studies
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        Title: 4 Translation of CART therapies for AML
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          Title: 4.1 GMP production of CART therapies
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          Title: 4.2 Monitoring patients treated with CART cells
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          Title: 4.3 Clinical trials utilizing CART cells in AML
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          Title: 4.4 Combining CART therapy and allogeneic HSCT: a dual immunotherapeutic strategy?
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        Title: 5 Discussion
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        Title: Author contributions
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       Item: 
        Title: Funding
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       Item: 
        Title: References
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    Author: Lorena Pérez-Amill
    Subject: Pérez-Amill L, Bataller À, Delgado J, Esteve J, Juan M and Klein-González N (2023) Advancing CART therapy for acute myeloid leukemia: recent breakthroughs and strategies for future development. Front. Immunol. 14:1260470
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