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Title: Introduction Destination: s1 Item: Title: Materials and methods Destination: s2 Children: Item: Title: Study design and patients Destination: s2_1 Item: Title: IHC analysis Destination: s2_2 Item: Title: RNA isolation and gene expression analysis Destination: s2_3 Item: Title: Statistical analyses Destination: s2_4 Item: Title: Results Destination: s3 Children: Item: Title: Patient characteristics Destination: s3_1 Item: Title: Integrated signature and outcome Destination: s3_2 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Keywords: bladder cancer, integrated signature, mRNA expression, neoadjuvant 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FontDescriptor: FontName: MEGALF+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MEGAPI+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: MEGAPI+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding XMP: Albert Font Montserrat Domenech Jose Luis Ramirez Miriam Marqués Raquel Benítez Vicenç Ruiz de Porras José L. Gago Cristina Carrato Francesc Sant Hector Lopez Daniel Castellano Nuria Malats M. Luz Calle Francisco X. Real Font A, Domenech M, Ramirez JL, Marqués M, Benítez R, Ruiz de Porras V, Gago JL, Carrato C, Sant F, Lopez H, Castellano D, Malats N, Calle ML and Real FX (2023) Predictive signature of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer integrating mRNA expression, taxonomic subtypes, and clinicopathological features. Front. Oncol. 13:1155244 Copyright © 2023 Font, Domenech, Ramirez, Marqués, Benítez, Ruiz de Porras, Gago, Carrato, Sant, Lopez, Castellano, Malats, Calle and Real. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. bladder cancer integrated signature mRNA expression neoadjuvant chemotherapy pathological response taxonomical classification Predictive signature of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer integrating mRNA expression, taxonomic subtypes, and clinicopathological features bladder cancer, integrated signature, mRNA expression, neoadjuvant chemotherapy, pathological response, taxonomical classification True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 673, 533, 694 Annotation: Subtype: Link Rect: 222, 648, 538, 669 Annotation: Subtype: Link Rect: 222, 623, 528, 644 Annotation: Subtype: Link Rect: 222, 598, 509, 619 Annotation: Subtype: Link Rect: 222, 573, 464, 594 Annotation: Subtype: Link Rect: 222, 548, 490, 569 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link 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