f63c961aca48c3876557e36566c4618c Characterization_of_a_cohort.pdf e9a39c5ead3ef416ba2287e01f1d8043620dc00c Characterization_of_a_cohort.pdf 0aa30170de503fd8b38c9019dd49dc8a43807b7a551c7436c2484ca86b516a71 Characterization_of_a_cohort.pdf Title: Characterization of a cohort of metastatic lung cancer patients harboring KRAS mutations treated with immunotherapy: differences according to KRAS G12C vs. non-G12C Subject: Approximately 20% of lung adenocarcinomas harbor activating mutations at KRAS, an oncogene with the ability to alter the tumor immune microenvironment. Keywords: non-small cell lung cancer, lung adenocarcinoma, KRAS, PD-L1, immunotherapy Author: Lucía Notario CreationDate: Thu Oct 12 08:07:09 2023 CEST ModDate: Thu Oct 12 08:07:09 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 6 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 891416 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PDFFLC+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 282 0 PDFFMD+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 283 0 PDFFME+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 284 0 PDFFMF+AdvPSA18C Type 1C WinAnsi yes yes no 285 0 PDFFMG+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 286 0 PDFFMH+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 293 0 PDFFMI+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 294 0 PDFGKD+AdvPSA323 Type 1C MacRoman yes yes no 295 0 PDFGKE+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 299 0 PDFGOF+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 105 0 PDFGOG+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 106 0 PDFGOH+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 100 0 PDFGNE+AdvOTb1404cd8+20 Type 1C WinAnsi yes yes no 103 0 PDFGNF+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 104 0 PDFGPI+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 115 0 PDFHBI+AdvTTc8b77491.I Type 1C WinAnsi yes yes no 124 0 PDFHBJ+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 123 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 118 0 PDFHPG+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 121 0 PDFJJM+AdvTT9b12cd41+22 Type 1C Custom yes yes yes 125 0 PDFJKM+AdvTT58d178b9+03 Type 1C Custom yes yes yes 127 0 PDFJKN+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 126 0 PDFJKO+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 128 0 PDFJLP+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 129 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-02 02:33:38 CET RepresentationInformation: Characterization_of_a_cohort.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-01 16:21:31 CET Size: 891416 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 355 FreeObjects: 3 IncrementalUpdates: 3 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Characterization of a cohort of metastatic lung cancer patients harboring KRAS mutations treated with immunotherapy: differences according to KRAS G12C vs. non-G12C Destination: bmark_2034931509 Children: Item: Title: Highlights Destination: s1 Item: Title: Introduction Destination: s2 Item: Title: Methods Destination: s3 Children: Item: Title: Study population Destination: s3_1 Item: Title: Molecular analysis and PD-L1 expression Destination: s3_2 Item: Title: Statistical analysis Destination: s3_3 Item: Title: Results Destination: s4 Children: Item: Title: Clinical and molecular characteristics according to KRAS mut type Destination: s4_1 Item: Title: Clinical outcomes in KRAS mutant patients treated with IT Destination: s4_2 Item: Title: Discussion Destination: s5 Item: Title: Data availability statement Destination: s6 Item: Title: Ethics statement Destination: s7 Item: Title: Author contributions Destination: s8 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: References Destination: bmark_2090415954 Info: Title: Characterization of a cohort of metastatic lung cancer patients harboring KRAS mutations treated with immunotherapy: differences according to KRAS G12C vs. non-G12C Author: Lucía Notario Subject: Approximately 20% of lung adenocarcinomas harbor activating mutations at KRAS, an oncogene with the ability to alter the tumor immune microenvironment. 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Copyright © 2023 Notario, Cucurull, Cerdà, Sanz, Carcereny, Muñoz-Mármol, Hernández, Domènech, Morán, Sánchez-Céspedes, Costa, Mate, Esteve and Saigí. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Characterization of a cohort of metastatic lung cancer patients harboring KRAS mutations treated with immunotherapy: differences according to KRAS G12C vs. non-G12C non-small cell lung cancer lung adenocarcinoma KRAS PD-L1 immunotherapy non-small cell lung cancer, lung adenocarcinoma, KRAS, PD-L1, immunotherapy True https://www.frontiersin.org/legal/copyright-statement 2023-10-12T14:07:09+08:00 2023-10-12T14:07:09+08:00 2023-10-12T14:07:09+08:00 uuid:ef262e0b-1ee8-4680-b560-1dad891883c1 uuid:61e7f0a3-0f1f-416b-8742-46ca3c3b3f2c Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 523, 707 Annotation: Subtype: Link Rect: 222, 661, 526, 682 Annotation: Subtype: Link Rect: 222, 636, 476, 657 Annotation: Subtype: Link Rect: 222, 611, 506, 632 Annotation: Subtype: Link Rect: 222, 586, 514, 607 Annotation: Subtype: Link Rect: 222, 561, 412, 582 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 691, 125, 706 Annotation: Subtype: Link Rect: 60, 547, 134, 554 Annotation: Subtype: Link Rect: 49, 390, 153, 397 Annotation: Subtype: Link Rect: 89, 322, 182, 329 Annotation: Subtype: Link Rect: 49, 313, 99, 320 Annotation: Subtype: Link Rect: 458, 802, 527, 809 Annotation: Subtype: Link Rect: 474, 793, 528, 800 Annotation: Subtype: Link Rect: 454, 783, 542, 790 Annotation: Subtype: Link Rect: 49, 797, 221, 813 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 250, 453, 255, 462 Destination: 65 Annotation: Subtype: Link Rect: 108, 353, 113, 362 Destination: 65 Annotation: Subtype: Link Rect: 117, 303, 121, 312 Destination: 65 Annotation: Subtype: Link Rect: 255, 203, 260, 212 Destination: 65 Annotation: Subtype: Link Rect: 266, 203, 270, 212 Destination: 65 Annotation: Subtype: Link Rect: 281, 128, 285, 137 Destination: 65 Annotation: Subtype: Link Rect: 470, 656, 474, 665 Destination: 65 Annotation: Subtype: Link Rect: 454, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 261, 506, 288, 515 Destination: 29 Annotation: Subtype: Link Rect: 68, 294, 95, 303 Destination: 29 Annotation: Subtype: Link Rect: 65, 194, 95, 203 Destination: 29 Annotation: Subtype: Link Rect: 495, 744, 526, 753 Destination: 50 Annotation: Subtype: Link Rect: 527, 306, 532, 315 Destination: 65 Annotation: Subtype: Link Rect: 538, 306, 542, 315 Destination: 65 Annotation: Subtype: Link Rect: 430, 181, 434, 190 Destination: 65 Annotation: Subtype: Link Rect: 454, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 93, 279, 97, 288 Destination: 65 Annotation: Subtype: Link Rect: 472, 391, 481, 400 Destination: 65 Annotation: Subtype: Link Rect: 407, 191, 416, 200 Destination: 65 Annotation: Subtype: Link Rect: 454, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 197, 268, 206, 277 Destination: 65 Annotation: Subtype: Link Rect: 454, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 266, 495, 290, 502 Annotation: Subtype: Link Rect: 49, 487, 84, 494 Annotation: Subtype: Link Rect: 95, 452, 165, 459 Annotation: Subtype: Link Rect: 136, 417, 220, 424 Annotation: Subtype: Link Rect: 62, 390, 130, 397 Annotation: Subtype: Link Rect: 62, 355, 134, 362 Annotation: Subtype: Link Rect: 222, 328, 290, 335 Annotation: Subtype: Link Rect: 49, 320, 72, 327 Annotation: Subtype: Link Rect: 436, 487, 513, 494 Annotation: Subtype: Link Rect: 487, 452, 545, 459 Annotation: Subtype: Link Rect: 474, 425, 545, 432 Annotation: Subtype: Link Rect: 459, 390, 545, 397 Annotation: Subtype: Link Rect: 520, 363, 545, 370 Annotation: Subtype: Link Rect: 304, 355, 363, 362 Annotation: Subtype: Link Rect: 454, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: 87e88d0a Type: CRC32 Checksum: f63c961aca48c3876557e36566c4618c Type: MD5 Checksum: e9a39c5ead3ef416ba2287e01f1d8043620dc00c Type: SHA-1 Checksum: 0aa30170de503fd8b38c9019dd49dc8a43807b7a551c7436c2484ca86b516a71 Type: SHA-256