f13909d4cf6f8b3e4bea90b64e2ab12c The_Molecular_Mechanism.pdf 52bbed6cd7d15cc4952969093e890dbe720244ba The_Molecular_Mechanism.pdf def47a2185335abd6136b056625a9f3a5a94c1570983b823332b181d0e0306a1 The_Molecular_Mechanism.pdf Title: The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks Subject: Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. The determining role that environmental factors such as diet and lifestyle play on health, life expectancy, and susceptibility to diseases, including cancer and neurodegenerative diseases, is wellestablished. In view of the growing interest in the beneficial effects of phytochemicals in the prevention of chronic diseases, several studies have been conducted, and they strongly suggest that the intake of dietary polyphenols may bring numerous benefits due to their antioxidant and anti-inflammatory properties, and their intake has been associated with impaired ageing in humans. Polyphenol intake has been shown to be effective in ameliorating several age-related phenotypes, including oxidative stress, inflammatory processes, impaired proteostasis, and cellular senescence, among other features, which contribute to an increased risk of ageing-associated diseases. This review aims to address, in a general way, the main findings described in the literature about the benefits of polyphenols in each of the hallmarks of ageing, as well as the main regulatory mechanisms responsible for the observed antiageing effects. Keywords: ageing hallmarks; polyphenols; molecular mechanisms Author: Quélita Cristina Pereira, Tanila Wood dos Santos, Isabela Monique Fortunato and Marcelo Lima Ribeiro Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Mar 14 04:24:32 2023 CET ModDate: Tue Mar 14 04:26:54 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 27 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4107737 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KZVALY+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 SULEAJ+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 TAJEOO+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 23 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 42 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 45 0 LHCXDL+EURM10 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Title: Effects of Polyphenols on Telomere Attrition Destination: section.4 Item: Title: Effects of Polyphenols on Proteostasis Loss Destination: section.5 Item: Title: Effects of Polyphenols on Deregulated Nutrient-Sensing Pathways Destination: section.6 Item: Title: Effects of Polyphenols on Mitochondrial Dysfunction Destination: section.7 Item: Title: Effects of Polyphenols on Cell Senescence Destination: section.8 Item: Title: Effects of Polyphenols on Stem Cell Exhaustion Destination: section.9 Item: Title: Effects of Polyphenols on Altered Intercellular Communication Destination: section.10 Item: Title: Polyphenols’ Regulation of Ageing A Clinical Perspective Destination: section.11 Item: Title: Conclusions Destination: section.12 Item: Title: References Destination: figure.caption.13 Info: Title: The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks Author: Quélita Cristina Pereira, Tanila Wood dos Santos, Isabela Monique Fortunato and Marcelo Lima Ribeiro Subject: Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. The determining role that environmental factors such as diet and lifestyle play on health, life expectancy, and susceptibility to diseases, including cancer and neurodegenerative diseases, is wellestablished. In view of the growing interest in the beneficial effects of phytochemicals in the prevention of chronic diseases, several studies have been conducted, and they strongly suggest that the intake of dietary polyphenols may bring numerous benefits due to their antioxidant and anti-inflammatory properties, and their intake has been associated with impaired ageing in humans. Polyphenol intake has been shown to be effective in ameliorating several age-related phenotypes, including oxidative stress, inflammatory processes, impaired proteostasis, and cellular senescence, among other features, which contribute to an increased risk of ageing-associated diseases. This review aims to address, in a general way, the main findings described in the literature about the benefits of polyphenols in each of the hallmarks of ageing, as well as the main regulatory mechanisms responsible for the observed antiageing effects. 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