f0710c4e052fc5ec268d494a26c4043f 289749.pdf 788480b00f44e8096bee120191ccd872daa86d55 289749.pdf a678f379f6a31fc96cd8bf87c47ed4700393e93d71a2ddc15e9bf99fb0e9e2e4 289749.pdf Title: Current Approach in the Management of Secondary Immunodeficiency in Patients with Hematological Malignancies: Spanish Expert Consensus Recommendations Subject: A Delphi-based survey was designed to assess the opinions of clinical hematologists (n = 17) and clinical immunologists (n = 18) from across Spain on secondary immunodeficiencies (SID) in the management of oncohematological patients. There was 100% agreement on the need to have available guidelines for the management of immunodeficiency in hematological patients; to perform a baseline immunological evaluation in patients with chronic lymphocytic leukemia (CLL), multiple myeloma (MM), lymphoma and hematopoietic stem cell transplantation (HSCT) recipients; and to quantify serum IgG, IgA and IgM levels when SID is suspected. More than 90% agreed on the need for active immunization against seasonal influenza and H1N1, pneumococcus and Haemophilus influenzae. There was a consensus on the monitoring of IgG levels every 3 months (83%) and the need to have available a clinical protocol for the use of IVIG in the management of SID (94%), to monitor trough IgG levels to determine the correct IVIG dose (86%) and to discontinue IVIG after the recovery of IgG levels after 12 months of follow-up (77%). The findings of the present survey may be useful recommendations for hematologists and immunologists to improve the management of SID in daily practice. Keywords: secondary immunodeficiency; B-cell lymphoproliferative disorders (BCLPD); infections; hypogammaglobulinemia; intravenous IgG Author: Concepción Boqué, Silvia Sánchez-Ramón, Raúl Córdoba, Carol Moreno and Elena Cabezudo Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Oct 4 09:35:41 2023 CEST ModDate: Wed Oct 4 09:47:42 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 686472 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ACKGZT+VnURWPalladioL Type 1 Custom yes yes no 10 0 FPBAME+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 BAUTEK+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 ECTCXU+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 YUQXUW+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 49 0 OMKPPC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 84 0 OMKPPD+PalatinoLinotype CID TrueType Identity-H yes yes yes 87 0 OMKPPE+PalatinoLinotype TrueType WinAnsi yes yes no 93 0 OMKPPG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 96 0 OMLAND+PalatinoLinotype TrueType MacRoman yes yes no 99 0 GFAWRG+CMSY10 Type 1 Builtin yes yes no 109 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-06 02:32:09 CET RepresentationInformation: 289749.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-05 13:59:07 CET Size: 686472 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 278 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Survey Design Destination: subsection.2.1 Item: Title: Survey Questionnaire and Participants Destination: subsection.2.2 Item: Title: Assessment Destination: subsection.2.3 Item: Title: Results Destination: section.3 Children: Item: Title: General Characteristics of Participants Destination: subsection.3.1 Item: Title: Current Clinical Practice Destination: subsection.3.2 Children: Item: Title: Baseline Immunological Assessment Destination: subsubsection.3.2.1 Item: Title: Prophylaxis of Infection Destination: subsubsection.3.2.2 Item: Title: Treatment with IVIG and Follow-Up Destination: subsubsection.3.2.3 Item: Title: Recommendations Destination: subsection.3.3 Children: Item: Title: Baseline Immunological Evaluation Destination: subsubsection.3.3.1 Item: Title: Prophylaxis of Infection Destination: subsubsection.3.3.2 Item: Title: Use of IVIG and Follow-Up Destination: subsubsection.3.3.3 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: section.A. Info: Title: Current Approach in the Management of Secondary Immunodeficiency in Patients with Hematological Malignancies: Spanish Expert Consensus Recommendations Author: Concepción Boqué, Silvia Sánchez-Ramón, Raúl Córdoba, Carol Moreno and Elena Cabezudo Subject: A Delphi-based survey was designed to assess the opinions of clinical hematologists (n = 17) and clinical immunologists (n = 18) from across Spain on secondary immunodeficiencies (SID) in the management of oncohematological patients. There was 100% agreement on the need to have available guidelines for the management of immunodeficiency in hematological patients; to perform a baseline immunological evaluation in patients with chronic lymphocytic leukemia (CLL), multiple myeloma (MM), lymphoma and hematopoietic stem cell transplantation (HSCT) recipients; and to quantify serum IgG, IgA and IgM levels when SID is suspected. More than 90% agreed on the need for active immunization against seasonal influenza and H1N1, pneumococcus and Haemophilus influenzae. There was a consensus on the monitoring of IgG levels every 3 months (83%) and the need to have available a clinical protocol for the use of IVIG in the management of SID (94%), to monitor trough IgG levels to determine the correct IVIG dose (86%) and to discontinue IVIG after the recovery of IgG levels after 12 months of follow-up (77%). The findings of the present survey may be useful recommendations for hematologists and immunologists to improve the management of SID in daily practice. 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