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microsatellite instability from microarray DNA methylation tumor profiles Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: Model development and optimization Destination: slink1 Item: Title: Underlying features of the MSIMEP model Destination: slink2 Item: Title: External validation of MSIMEP models Destination: slink3 Item: Title: Comparison of MSIMEP models with a MLH1 promoter methylation-based model Destination: slink4 Item: Title: Discussion Destination: flink3 Children: Item: Title: Limitations of the study Destination: slink5 Item: Title: Supplemental information Destination: falink4 Item: Title: Acknowledgments Destination: acklink1 Item: Title: Author contributions Destination: flink5 Item: Title: Declaration of interests Destination: flink6 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink7 Children: Item: Title: Key resources table Destination: slink6 Item: Title: Resource availability Destination: slink7 Children: Item: Title: Lead contact Destination: tlink1 Item: Title: Materials availability Destination: tlink2 Item: Title: Data and code availability Destination: tlink3 Item: Title: Experimental model and subject details Destination: slink8 Children: Item: Title: TCGA cohorts Destination: tlink4 Item: Title: External cohorts Destination: tlink5 Children: Item: Title: External cohort I Destination: ftlink6 Item: Title: External cohort II Destination: ftlink7 Item: Title: External cohort III Destination: ftlink8 Item: Title: External cohort IV Destination: ftlink9 Item: Title: Method details Destination: slink9 Children: Item: Title: TCGA datasets annotation Destination: tlink10 Item: Title: Analysis of DNA methylation arrays Destination: tlink11 Item: Title: Machine-learning predictive models Destination: tlink12 Item: Title: Model description Destination: tlink13 Item: Title: MSIMEP exploratory analysis in alternative 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FontDescriptor: FontName: OFMOIH+Avenir-Black Flags: Nonsymbolic FontBBox: -161, -240, 1135, 954 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFNAFM+AdvPSA5BD FontSubset: true FirstChar: 67 LastChar: 117 FontDescriptor: FontName: OFNAFM+AdvPSA5BD Flags: Nonsymbolic FontBBox: -156, -239, 1166, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFNCGB+AdvPS480274 FontSubset: true FirstChar: 43 LastChar: 66 FontDescriptor: FontName: OFNCGB+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFNCGC+AdvPSMPi6 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: OFNCGC+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.isci.2023.106127 MSIMEP: Predicting microsatellite instability from microarray DNA methylation tumor profiles Martín Santamarina-García Jenifer Brea-Iglesias Jesper Bertram Bramsen Mar Fuentes-Losada Francisco Javier Caneiro-Gómez José Ángel Vázquez-Bueno Héctor Lázare-Iglesias Natalia Fernández-Díaz Laura Sánchez-Rivadulla Yoel Z. Betancor Miriam Ferreiro-Pantín Pablo Conesa-Zamora José Ramón Antúnez-López Masahito Kawazu Manel Esteller Claus Lindbjerg Andersen Jose M.C. Tubio Rafael López-López Juan Ruiz-Bañobre Medical informatics Genomic analysis Cancer systems biology ISCIENCE, 26 (2023) 106127. doi:10.1016/j.isci.2023.106127 The Author(s) journal ISCIENCE © 2023 The Author(s). 2589-0042 26 3 17 March 2023 2023-03-17 106127 106127 10.1016/j.isci.2023.106127 https://doi.org/10.1016/j.isci.2023.106127 2010-04-23 true 10.1016/j.isci.2023.106127 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.isci.2023.106127 noindex true 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-02-16T00:58:07+05:30 2023-02-16T00:59:25+05:30 2023-02-16T00:59:25+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:0446aa26-4bbb-4822-871f-b9b1bb41b2fc uuid:fc38aaa0-05df-488a-9713-846dfa6ba78c http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 455, 423, 534, 429 Annotation: Subtype: Link Rect: 455, 405, 533, 411 Annotation: Subtype: Link Rect: 455, 68, 520, 74 Annotation: Subtype: Link Rect: 455, 60, 503, 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