540b54e3897c6443ff10efd4efe2bcac The_relapsed_acute_lymphoblastic_leukemia.pdf 55c9fccfc2e4e79b6d1716f2d632511f9ae768d9 The_relapsed_acute_lymphoblastic_leukemia.pdf 62d3123950ff8a6f55fd0d4e87af03fff8a97ec77e938524184e437aabcf78a7 The_relapsed_acute_lymphoblastic_leukemia.pdf Title: The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) Subject: Velasco P, Bautista F, Rubio A, Aguilar Y, Rives S, Dapena JL, Pérez A, Ramirez M, Saiz-Ladera C, Izquierdo E, Escudero A, Camós M, Vega-García N, Ortega M, Hidalgo-Gómez G, Palacio C, Menéndez P, Bueno C, Montero J, Romecín PA, Zazo S, Alvarez F, Parras J, Ortega-Sabater C, Chulián S, Rosa María, Cirillo D, García E, García J, Manzano-Muñoz A, Minguela A and Fuster JL (2023) The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP). Front. Pediatr. 11:1269560. doi: 10.3389/fped.2023.1269560 Keywords: relapsed acute lymphoblastic leukemia; precision medicine; cancer registry; artificial intelligence; functional assay Author: Pablo Velasco Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Sep 14 12:30:44 2023 CEST ModDate: Fri Sep 15 03:22:10 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 702653 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AOJIHF+AdvOT2c8ce45a Type 1C WinAnsi yes yes no 320 0 AOJIHG+AdvOT9b12cd41 Type 1C WinAnsi yes yes no 321 0 AOJIHH+AdvOT9b12cd41+20 Type 1C WinAnsi yes yes no 322 0 AOJIJI+AdvOTd3a5f740 Type 1C WinAnsi yes yes no 328 0 AOJILI+AdvOT9b12cd41+fb Type 1C Custom yes yes yes 142 0 AOJILJ+AdvOTd3a5f740+fb Type 1C Custom yes yes yes 145 0 AOJILK+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 152 0 AOJILL+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 150 0 AOJILM+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 149 0 AOJIMM+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 160 0 AOJINN+AdvOT46dcae81 Type 1C WinAnsi yes yes no 163 0 AOJIOO+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 166 0 AOJJGM+AdvOTd3a5f740+20 Type 1C WinAnsi yes yes no 167 0 AOJJGN+AdvOT7d6df7ab.I+20 Type 1C WinAnsi yes yes no 168 0 AOJJGO+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 169 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-07 02:35:42 CET RepresentationInformation: The_relapsed_acute_lymphoblastic_leukemia.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-06 19:05:28 CET Size: 702653 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 387 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) Destination: head1 Children: Item: Title: Introduction Destination: head2 Item: Title: Relapse and refractory ALL national registry Destination: head3 Item: Title: ReALL board Destination: head4 Item: Title: Platform for shipping, analysis, and biobanking of samples Destination: head5 Item: Title: Oncogenomic testing Destination: head6 Item: Title: Functional assays Destination: head7 Children: Item: Title: Dynamic BH3 profiling Destination: head8 Item: Title: Drug response profiling Destination: head9 Item: Title: Data and computational science Destination: head10 Children: Item: Title: Data science Destination: head11 Item: Title: Clinical trial decision maker Destination: head12 Item: Title: Implementation and funding Destination: head13 Item: Title: Conclusion Destination: head14 Item: Title: Data availability statement Destination: head15 Item: Title: Ethics statement Destination: head16 Item: Title: Author contributions Destination: head17 Item: Title: Funding Destination: head18 Item: Title: Acknowledgments Destination: head19 Item: Title: Conflict of interest Destination: head20 Item: Title: Publisher's note Destination: head21 Item: Title: References Destination: head22 Info: Title: The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) Author: Pablo Velasco Subject: Velasco P, Bautista F, Rubio A, Aguilar Y, Rives S, Dapena JL, Pérez A, Ramirez M, Saiz-Ladera C, Izquierdo E, Escudero A, Camós M, Vega-García N, Ortega M, Hidalgo-Gómez G, Palacio C, Menéndez P, Bueno C, Montero J, Romecín PA, Zazo S, Alvarez F, Parras J, Ortega-Sabater C, Chulián S, Rosa María, Cirillo D, García E, García J, Manzano-Muñoz A, Minguela A and Fuster JL (2023) The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP). Front. Pediatr. 11:1269560. doi: 10.3389/fped.2023.1269560 Keywords: relapsed acute lymphoblastic leukemia; precision medicine; cancer registry; artificial intelligence; functional assay Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Sep 14 13:00:44 CEST 2023 ModDate: Fri Sep 15 03:52:10 CEST 2023 ID: 0x56c65aae479ef78b8a0aaad4446280c0, 0xbf46afa5305b594fa0862cb549b85965 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: AOJIHF+AdvOT2c8ce45a FontSubset: true FirstChar: 44 LastChar: 117 FontDescriptor: FontName: AOJIHF+AdvOT2c8ce45a Flags: Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJIMM+AdvOTb65e897d.B FontSubset: true FirstChar: 49 LastChar: 117 FontDescriptor: FontName: AOJIMM+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJIHG+AdvOT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 250 FontDescriptor: FontName: AOJIHG+AdvOT9b12cd41 Flags: Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJIHH+AdvOT9b12cd41+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: AOJIHH+AdvOT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJINN+AdvOT46dcae81 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: AOJINN+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJIOO+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 241 FontDescriptor: FontName: AOJIOO+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJJGM+AdvOTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: AOJJGM+AdvOTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJIJI+AdvOTd3a5f740 FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: AOJIJI+AdvOTd3a5f740 Flags: Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJJGN+AdvOT7d6df7ab.I+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: AOJJGN+AdvOT7d6df7ab.I+20 Flags: Nonsymbolic FontBBox: -156, -177, 1000, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJJGO+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: AOJJGO+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -208, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJILI+AdvOT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AOJILI+AdvOT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AOJILJ+AdvOTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AOJILJ+AdvOTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AOJILM+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: AOJILM+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -218, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOJILL+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AOJILL+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AOJILK+AdvOT1ef757c0 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: AOJILK+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf 10.3389/fped.2023.1269560 en Pablo Velasco Francisco Bautista Alba Rubio Yurena Aguilar Susana Rives Jose L. Dapena Antonio Pérez Manuel Ramirez Cristina Saiz-Ladera Elisa Izquierdo Adela Escudero Mireia Camós Nerea Vega-García Margarita Ortega Gloria Hidalgo-Gómez Carlos Palacio Pablo Menéndez Clara Bueno Joan Montero PaolaA. Romecín Santiago Zazo Federico Alvarez Juan Parras Carmen Ortega-Sabater Salvador Chulián María Rosa Davide Cirillo Elena García Jorge García Albert Manzano-Muñoz Alfredo Minguela Jose L. Fuster The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) Velasco P, Bautista F, Rubio A, Aguilar Y, Rives S, Dapena JL, Pérez A, Ramirez M, Saiz-Ladera C, Izquierdo E, Escudero A, Camós M, Vega-García N, Ortega M, Hidalgo-Gómez G, Palacio C, Menéndez P, Bueno C, Montero J, Romecín PA, Zazo S, Alvarez F, Parras J, Ortega-Sabater C, Chulián S, Rosa María, Cirillo D, García E, García J, Manzano-Muñoz A, Minguela A and Fuster JL (2023) The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP). Front. Pediatr. 11:1269560. doi: 10.3389/fped.2023.1269560 Copyright © 2023 Velasco, Bautista, Rubio, Aguilar, Rives, Dapena, Pérez, Ramirez, Saiz-Ladera, Izquierdo, Escudero, Camós, Vega-Garcia, Ortega, Hidalgo-Gómez, Palacio, Menéndez, Bueno, Montero, Romecín, Zazo, Alvarez, Parras, Ortega-Sabater, Chulián, Rosa, Cirillo, García, García, Manzano-Muñoz, Minguela and Fuster. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. relapsed acute lymphoblastic leukemia precision medicine cancer registry artificial intelligence functional assay 2023-09-14T16:00:44+05:30 Arbortext Advanced Print Publisher 10.0.1465/W Unicode 2023-09-15T06:52:10+05:30 2023-09-15T06:52:10+05:30 Acrobat Distiller 8.1.0 (Windows) relapsed acute lymphoblastic leukemia; precision medicine; cancer registry; artificial intelligence; functional assay uuid:2d428831-200f-4116-b807-c154195d85bd uuid:023bf6df-235e-4f2e-a841-a135a1bf7725 Journal © 2023 Velasco, Bautista, Rubio, Aguilar, Rives, Dapena, Pérez, Ramirez, Saiz-Ladera, Izquierdo, Escudero, Camós, Vega-Garcia, Ortega, Hidalgo-Gómez, Palacio, Menéndez, Bueno, Montero, Romecín, Zazo, Alvarez, Parras, Ortega-Sabater, Chulián, Rosa, Cirillo, García, García, Manzano-Muñoz, Minguela and Fuster. 10.3389/fped.2023.1269560 https://doi.org/10.3389/fped.2023.1269560 True 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