b43d2cb74f998054fde45c44f507ff50 289896.pdf dfa38659ea0c5aac1d4e5b5bb3d55d7284fa6164 289896.pdf cd3e0e5e1151fb04de606969e9fbab0f17c10b2b64893598e7b9010cfc10daec 289896.pdf Title: Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution Subject: Nature Communications, doi:10.1038/s41467-023-35911-8 Keywords: Author: Laureano Tomás-Daza Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Jan 17 13:14:08 2023 CET ModDate: Tue Jan 17 14:45:25 2023 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 3586346 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JAOEGM+AdvOTdd63dae3+20 Type 1C Custom yes yes yes 64 0 JAOEIM+AdvOT0c200bf0 Type 1C WinAnsi yes yes no 608 0 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(liCHi-C) identifies promoter-enhancer interactions at high-„resolution Destination: title_link Children: Item: Title: Results Destination: A1 Children: Item: Title: Development and optimization of liCHi-C for low-input samples Destination: B1 Item: Title: Comparison of liCHi-C with other C-based methods for profiling promoter interactomes Destination: B2 Item: Title: liCHi-C efficiently captures promoter interactomes across different hematopoietic lineages Destination: B3 Item: Title: Promoter interactomes reshape transcriptional trajectories during in’vivo cell commitment Destination: B4 Item: Title: liCHi-C enables the discovery of disease-relevant cell types and disease-associated genes and pathways Destination: B5 Item: Title: liCHi-C can be used to simultaneously diagnose and discover translocations, copy number variations (CNVs) and topological alterations in tumoral samples Destination: B6 Item: Title: liCHi-C can be customized to improve its resolution Destination: B7 Item: Title: Discussion Destination: A2 Item: Title: Methods Destination: A3 Children: Item: Title: Cell isolation Destination: B8 Item: Title: Fixation and cell quantification Destination: B9 Item: Title: liCHi-C method Destination: B10 Item: Title: Sequencing Destination: B11 Item: Title: B-ALL cytogenetic and FISH analysis Destination: B12 Item: Title: liCHi-C processing Destination: B13 Item: Title: liCHi-C interaction calling Destination: B14 Item: Title: Loop calling using Hi-C, low-C, and TagHi-C Destination: B15 Item: Title: Clustering of promoter interactions Destination: B16 Item: Title: ChIP-seq processing Destination: B17 Item: Title: Histones mark enrichment at PIRs Destination: B18 Item: Title: Chromatin assortativity Destination: B19 Item: Title: Gene ontology and pathways enrichment analysis Destination: B20 Item: Title: Data visualization Destination: B21 Item: Title: GWAS summary statistics and imputation Destination: B22 Item: Title: GWAS enrichment at PIRs Destination: B23 Item: Title: liCHi-C GWAS prioritizing genes Destination: B24 Item: Title: SVs analysis Destination: B25 Item: Title: Institutional review board statement Destination: B26 Item: Title: Reporting summary Destination: B27 Item: Title: Data availability Destination: M1 Item: Title: Code availability Destination: M2 Item: Title: References Destination: A4 Item: Title: Acknowledgements Destination: A5 Item: Title: Author contributions Destination: A6 Item: Title: Competing interests Destination: A7 Item: Title: Additional information Destination: M3 Info: Title: Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution Author: Laureano Tomás-Daza Subject: Nature Communications, doi:10.1038/s41467-023-35911-8 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Jan 17 13:44:08 CET 2023 ModDate: Tue Jan 17 14:45:25 CET 2023 ID: 0x19997eb63e19522fd9d70380caf8a3a5, 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JAOENM+AdvOT3d287b35.B Flags: Serif, Nonsymbolic FontBBox: -125, -218, 1000, 958 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-023-35911-8 Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution Laureano Tomás-Daza Llorenç Rovirosa Paula López-Martí Andrea Nieto-Aliseda François Serra Ainoa Planas-Riverola Oscar Molina Rebecca McDonald Cedric Ghevaert Esther Cuatrecasas Dolors Costa Mireia Camós Clara Bueno Pablo Menéndez Alfonso Valencia Biola M. Javierre Springer US Nature Communications, doi:10.1038/s41467-023-35911-8 Springer 2023-01-17T14:45:25+01:00 2023-01-17T17:44:08+05:30 2023-01-17T14:45:25+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) uuid:3475a879-fd1e-4bdb-8809-028806d95da2 uuid:58654632-d5fc-4a88-8199-ac72540f9399 default 1 converted uuid:c1b36e74-7c88-48f9-abe8-c1ddad6c3772 converted to PDF/A-2b pdfToolbox 2023-01-17T17:45:03+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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