1500640e3c03726269301551d19ec840 Opportunities_for_CAR-T_Cell.pdf 1ebb9b4abc08efbdcf9abaf5da2c363026bfee77 Opportunities_for_CAR-T_Cell.pdf df8b9e078429994c05b00edad25afd7432925a548bb9d5683877ff58b9f996b7 Opportunities_for_CAR-T_Cell.pdf Title: Opportunities for CAR-T Cell Immunotherapy in HIV Cure Subject: Chimeric antigen receptor (CAR) technology is having a huge impact in the blood malignancy field and is becoming a well-established therapy for many types of leukaemia. In recent decades, efforts have been made to demonstrate that CAR-T cells have potential as a therapy to achieve a sterilizing cure for human immunodeficiency virus (HIV) infection. However, translation of this technology to the HIV scenario has not been easy, as many challenges have appeared along the way that hinder the consolidation of CAR-T cells as a putative therapy. Here, we review the origin and development of CAR-T cells, describe the advantages of CAR-T cell therapy in comparison with other therapies, and describe the major obstacles currently faced regarding application of this technology in the HIV field, specifically, viral escape, CAR-T cell infectivity, and accessibility to hidden reservoirs. Nonetheless, promising results in successfully tackling some of these issues that have been obtained in clinical trials suggest a bright future for CAR-T cells as a consolidated therapy. Keywords: CAR-T cells; chimeric antigen receptor; immunotherapy; HIV; HIV reservoir; latency reversal agents Author: Gerard Campos-Gonzalez, Javier Martinez-Picado, Talia Velasco-Hernandez and Maria Salgado Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Mar 22 11:05:41 2023 CET ModDate: Wed Mar 22 12:01:13 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2349340 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DEWXFO+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 XOGIRN+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 WVMEKU+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 HOWKDX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 37 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 59 0 CRVHMC+EURM10 Type 1 Builtin yes yes no 63 0 BBZZZZ+Roboto-Bold CID TrueType Identity-H yes yes yes 94 0 EZZZZZ+Carlito CID TrueType Identity-H yes yes yes 99 0 JZZZZZ+Roboto-Regular CID TrueType Identity-H yes yes yes 104 0 SYVAVM+VnURWPalladioL-Italic Type 1 Custom yes yes no 124 0 HCGKFY+VnURWPalladioL Type 1 Custom yes yes no 129 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-09 02:34:01 CET RepresentationInformation: Opportunities_for_CAR-T_Cell.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-08 14:24:14 CET Size: 2349340 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 393 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Development of the CAR Technology Destination: section.2 Children: Item: Title: Early Studies of CAR-T Cells Destination: subsection.2.1 Item: Title: New Generations of CARs-T Cells Destination: subsection.2.2 Item: Title: Translation of the CAR-T Cell Technology to the Clinic Destination: subsection.2.3 Item: Title: Difficulties and New Strategies to Achieve HIV Cure with CAR-T Cells Destination: section.3 Children: Item: Title: Avoiding CAR-T Cell Infection Destination: subsection.3.1 Item: Title: Reducing Viral Escape Destination: subsection.3.2 Item: Title: Targeting HIV Infected Cells Destination: subsection.3.3 Item: Title: Conclusions Destination: section.4 Item: Title: References Destination: section.4 Info: Title: Opportunities for CAR-T Cell Immunotherapy in HIV Cure Author: Gerard Campos-Gonzalez, Javier Martinez-Picado, Talia Velasco-Hernandez and Maria Salgado Subject: Chimeric antigen receptor (CAR) technology is having a huge impact in the blood malignancy field and is becoming a well-established therapy for many types of leukaemia. In recent decades, efforts have been made to demonstrate that CAR-T cells have potential as a therapy to achieve a sterilizing cure for human immunodeficiency virus (HIV) infection. However, translation of this technology to the HIV scenario has not been easy, as many challenges have appeared along the way that hinder the consolidation of CAR-T cells as a putative therapy. Here, we review the origin and development of CAR-T cells, describe the advantages of CAR-T cell therapy in comparison with other therapies, and describe the major obstacles currently faced regarding application of this technology in the HIV field, specifically, viral escape, CAR-T cell infectivity, and accessibility to hidden reservoirs. Nonetheless, promising results in successfully tackling some of these issues that have been obtained in clinical trials suggest a bright future for CAR-T cells as a consolidated therapy. 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