02683e499dfe949a1bb57247a5f2931a Characterization_of_Patient-Derived.pdf 897451646ae90652c1286c68a25d9ad30d35d867 Characterization_of_Patient-Derived.pdf 4625aafb9feaa969566b996b4ff055cbb6b96cd2984f333b404454545b9f4482 Characterization_of_Patient-Derived.pdf Title: Characterization of Patient-Derived GNAQ Mutated Endothelial Cells from Capillary Malformations Subject: Journal of Investigative Dermatology, Corrected proof. doi:10.1016/j.jid.2023.10.033 Author: Ginger Beau Langbroek Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Dec 15 14:11:45 2023 CET ModDate: Fri Dec 15 14:12:52 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 593.972 x 782.986 pts Page rot: 0 File size: 4128443 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AKHIHO+AdvPSOP-B Type 1C MacRoman yes yes no 790 0 AKHJMI+AdvPSOPT-BI Type 1C WinAnsi yes yes no 792 0 AKHJMJ+AdvPS8C2A Type 1C MacRoman yes yes no 794 0 AKHJMK+AdvPSA536 Type 1C MacRoman yes yes no 796 0 AKHJNK+AdvPSA537 Type 1C WinAnsi yes yes no 805 0 AKHJNL+AdvPSOPT-I Type 1C WinAnsi yes yes no 800 0 AKHJNM+AdvPS480274 Type 1C WinAnsi yes yes no 803 0 AKHJNN+AdvPS44A44B Type 1C WinAnsi yes yes no 806 0 AKHKBO+AdvPSSym Type 1C WinAnsi yes yes no 813 0 AKHKCP+AdvP4C4E51 Type 1C WinAnsi yes yes no 521 0 AKHKCO+AdvP4C4E74 Type 1C Custom yes yes yes 518 0 AKIMIP+AdvPS3F4C13 Type 1C WinAnsi yes yes no 535 0 AKKDJD+AdvPS7DED Type 1C WinAnsi yes yes no 545 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-09 02:33:59 CET RepresentationInformation: Characterization_of_Patient-Derived.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-08 16:14:57 CET Size: 4128443 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 4100783 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 880 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Characterization of Patient-Derived GNAQ Mutated Endothelial Cells from Capillary Malformations Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: Patient characteristics Destination: slink1 Item: Title: Genetic and histological analysis Destination: slink2 Item: Title: Isolation and expansion of patient-derived primary endothelial cells Destination: slink3 Item: Title: Angiogenic sprouting capacity of patient-derived GNAQ (p.R183G) endothelial cells Destination: slink4 Item: Title: Discussion Destination: flink3 Children: Item: Title: Expansion of patient-derived primary cells Destination: slink5 Item: Title: Genetic mutations Destination: slink6 Item: Title: Patient study limitations Destination: slink7 Item: Title: Materials and Methods Destination: flink4 Children: Item: Title: Study design Destination: slink8 Item: Title: Participants Destination: slink9 Item: Title: Study outcomes Destination: slink10 Item: Title: Data and sample collection Destination: slink11 Item: Title: Next-generation sequencing for genetic analysis Destination: slink12 Item: Title: Histological analysis Destination: slink13 Item: Title: Endothelial cell isolation and culture Destination: slink14 Item: Title: Immunofluorescence stainings Destination: slink15 Item: Title: Microscopy Destination: slink16 Item: Title: Sprouting assay Destination: slink17 Item: Title: Statistical analysis Destination: slink18 Item: Title: Data availability statement Destination: slink19 Item: Title: ORCIDs Destination: flink5 Item: Title: Conflict of Interest Destination: flink6 Item: Title: Acknowledgments Destination: acklink1 Item: Title: Author Contributions Destination: flink7 Item: Title: Supplementary Material Destination: flink8 Item: Title: References Destination: blink2 Children: Item: Title: Supplementary File S1. Gene panel applied for next-generation sequencing Destination: slink20 Info: Title: Characterization of Patient-Derived GNAQ Mutated Endothelial Cells from Capillary Malformations Author: Ginger Beau Langbroek Subject: Journal of Investigative Dermatology, Corrected proof. doi:10.1016/j.jid.2023.10.033 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Dec 15 14:41:45 CET 2023 ModDate: Fri Dec 15 14:42:52 CET 2023 ID: 0x971a454d8341ed7859f9271131d1332d, 0xa98ab7c8f4446347878cb9acf542e31d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2103 ImageHeight: 1987 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1644 ImageHeight: 2086 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2093 ImageHeight: 840 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: AKHJNL+AdvPSOPT-I FontSubset: true FirstChar: 40 LastChar: 180 FontDescriptor: FontName: AKHJNL+AdvPSOPT-I Flags: Nonsymbolic FontBBox: -72, -260, 1114, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKKDJD+AdvPS7DED FontSubset: true FirstChar: 51 LastChar: 51 FontDescriptor: FontName: AKKDJD+AdvPS7DED Flags: Nonsymbolic FontBBox: -20, -229, 927, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKHJNM+AdvPS480274 FontSubset: true FirstChar: 45 LastChar: 45 FontDescriptor: FontName: AKHJNM+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKHJNK+AdvPSA537 FontSubset: true FirstChar: 49 LastChar: 81 FontDescriptor: FontName: AKHJNK+AdvPSA537 Flags: Nonsymbolic FontBBox: -114, -260, 1041, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKHJNN+AdvPS44A44B FontSubset: true FirstChar: 101 LastChar: 101 FontDescriptor: FontName: AKHJNN+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKHKCO+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: AKHKCO+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AKHKCP+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: AKHKCP+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKHKBO+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: AKHKBO+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKHIHO+AdvPSOP-B FontSubset: true FirstChar: 40 LastChar: 223 FontDescriptor: FontName: AKHIHO+AdvPSOP-B Flags: Nonsymbolic FontBBox: -93, -260, 1000, 750 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: AKIMIP+AdvPS3F4C13 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: AKIMIP+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKHJMI+AdvPSOPT-BI FontSubset: true FirstChar: 65 LastChar: 114 FontDescriptor: FontName: AKHJMI+AdvPSOPT-BI Flags: Nonsymbolic FontBBox: -93, -260, 1114, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKHJMJ+AdvPS8C2A FontSubset: true FirstChar: 37 LastChar: 245 FontDescriptor: FontName: AKHJMJ+AdvPS8C2A Flags: Nonsymbolic FontBBox: -72, -260, 1000, 750 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: AKHJMK+AdvPSA536 FontSubset: true FirstChar: 40 LastChar: 222 FontDescriptor: FontName: AKHJMK+AdvPSA536 Flags: Serif, Nonsymbolic FontBBox: -156, -270, 1000, 760 FontFile3: true Encoding: MacRomanEncoding XMP: application/pdf doi:10.1016/j.jid.2023.10.033 Characterization of Patient-Derived GNAQ Mutated Endothelial Cells from Capillary Malformations Ginger Beau Langbroek Merel L.E. Stor Vera Janssen Annett de Haan Sophie E.R. Horbach Mariona Graupera Carel J.M. van Noesel Chantal M.A.M. van der Horst Albert Wolkerstorfer Stephan Huveneers Angiogenesis Endothelial cells Port-wine stains Sturge-Weber syndrome Vascular malformations Journal of Investigative Dermatology, Corrected proof. doi:10.1016/j.jid.2023.10.033 The Authors journal Journal of Investigative Dermatology © 2023 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. 0022-202X 10.1016/j.jid.2023.10.033 https://doi.org/10.1016/j.jid.2023.10.033 P 7.0 10.1016/j.jid.2023.10.033 noindex Elsevier 2023-12-15T18:41:45+05:30 2023-12-15T18:42:52+05:30 2023-12-15T18:42:52+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:c3390e56-2841-449d-9488-2524508ce435 uuid:58c4a94c-1f7d-41d3-b322-5be941fb954a http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 154, 623, 154, 625 Annotation: Subtype: Link Rect: 154, 626, 159, 637 Destination: 701 Annotation: Subtype: Link Rect: 161, 626, 165, 637 Destination: 701 Annotation: Subtype: Link Rect: 168, 626, 172, 637 Destination: 701 Annotation: Subtype: Link Rect: 248, 623, 248, 625 Annotation: Subtype: Link Rect: 248, 626, 252, 637 Destination: 701 Annotation: Subtype: Link Rect: 255, 626, 259, 637 Destination: 701 Annotation: Subtype: Link Rect: 324, 623, 324, 625 Annotation: Subtype: Link Rect: 324, 626, 329, 637 Destination: 701 Annotation: Subtype: Link Rect: 410, 623, 410, 625 Annotation: Subtype: Link Rect: 410, 626, 414, 637 Destination: 701 Annotation: Subtype: Link Rect: 519, 623, 519, 625 Annotation: Subtype: Link Rect: 519, 626, 524, 637 Destination: 701 Annotation: Subtype: Link Rect: 129, 610, 129, 612 Annotation: Subtype: Link Rect: 129, 614, 133, 624 Destination: 701 Annotation: Subtype: Link Rect: 136, 614, 140, 624 Destination: 701 Annotation: Subtype: Link Rect: 142, 614, 147, 624 Destination: 701 Annotation: Subtype: Link Rect: 254, 610, 254, 612 Annotation: Subtype: Link Rect: 254, 614, 259, 624 Destination: 701 Annotation: Subtype: Link Rect: 405, 610, 405, 612 Annotation: Subtype: Link Rect: 405, 614, 410, 624 Destination: 701 Annotation: Subtype: Link Rect: 511, 610, 511, 612 Annotation: Subtype: Link Rect: 511, 614, 515, 624 Destination: 701 Annotation: Subtype: Link Rect: 518, 614, 527, 624 Destination: 701 Annotation: Subtype: Link Rect: 155, 597, 155, 600 Annotation: Subtype: Link Rect: 155, 601, 160, 612 Destination: 701 Annotation: Subtype: Link Rect: 162, 601, 171, 612 Destination: 701 Annotation: Subtype: Link Rect: 221, 387, 318, 395 Annotation: Subtype: Link Rect: 416, 365, 503, 374 Destination: 141 Annotation: Subtype: Link Rect: 510, 365, 550, 374 Destination: 404 Annotation: Subtype: Link Rect: 303, 353, 348, 363 Destination: 404 Annotation: Subtype: Link Rect: 333, 319, 445, 329 Destination: 141 Annotation: Subtype: Link Rect: 449, 319, 550, 329 Destination: 141 Annotation: Subtype: Link Rect: 303, 308, 324, 317 Destination: 141 Annotation: Subtype: Link Rect: 329, 308, 419, 317 Destination: 404 Annotation: Subtype: Link Rect: 380, 273, 491, 283 Destination: 141 Annotation: Subtype: Link Rect: 496, 273, 550, 283 Destination: 141 Annotation: Subtype: Link Rect: 303, 262, 324, 271 Destination: 141 Annotation: Subtype: Link Rect: 414, 227, 472, 237 Destination: 141 Annotation: Subtype: Link Rect: 477, 227, 550, 237 Destination: 404 Annotation: Subtype: Link Rect: 303, 216, 324, 225 Destination: 404 Annotation: Subtype: Link Rect: 349, 159, 448, 168 Destination: 141 Annotation: Subtype: Link Rect: 453, 159, 539, 168 Destination: 404 Annotation: Subtype: Link Rect: 430, 113, 513, 122 Destination: 141 Annotation: Subtype: Link Rect: 397, 67, 470, 77 Destination: 141 Annotation: Subtype: Link Rect: 475, 67, 496, 77 Destination: 141 Annotation: Subtype: Link Rect: 502, 67, 550, 77 Destination: 141 Annotation: Subtype: Link Rect: 303, 56, 324, 65 Destination: 141 Annotation: Subtype: Link Rect: 330, 56, 414, 65 Destination: 141 Annotation: Subtype: Link Rect: 420, 56, 496, 65 Destination: 404 Annotation: Subtype: Link Rect: 502, 56, 550, 65 Destination: 404 Annotation: Subtype: Link Rect: 303, 44, 324, 54 Destination: 404 Annotation: Subtype: Link Rect: 332, 44, 438, 54 Destination: 404 Annotation: Subtype: Link Rect: 194, 104, 289, 112 Annotation: Subtype: Link Rect: 42, 95, 49, 103 Annotation: Subtype: Link Rect: 150, 16, 290, 23 Annotation: Subtype: Link Rect: 487, 16, 551, 24 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 122, 485, 199, 495 Destination: 141 Annotation: Subtype: Link Rect: 205, 485, 287, 495 Destination: 141 Annotation: Subtype: Link Rect: 42, 474, 116, 483 Destination: 404 Annotation: Subtype: Link Rect: 67, 440, 141, 449 Destination: 141 Annotation: Subtype: Link Rect: 147, 440, 227, 449 Destination: 141 Annotation: Subtype: Link Rect: 233, 440, 289, 449 Destination: 141 Annotation: Subtype: Link Rect: 42, 428, 63, 438 Destination: 141 Annotation: Subtype: Link Rect: 45, 246, 78, 255 Destination: 1 Annotation: Subtype: Link Rect: 52, 200, 82, 210 Destination: 26 Annotation: Subtype: Link Rect: 467, 663, 545, 672 Destination: 404 Annotation: Subtype: Link Rect: 306, 560, 340, 569 Destination: 50 Annotation: Subtype: Link Rect: 306, 474, 391, 483 Destination: 141 Annotation: Subtype: Link Rect: 328, 393, 409, 403 Destination: 141 Annotation: Subtype: Link Rect: 414, 336, 447, 345 Destination: 50 Annotation: Subtype: Link Rect: 451, 164, 486, 174 Destination: 64 Annotation: Subtype: Link Rect: 401, 67, 484, 76 Destination: 141 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 104, 700, 111, 703 Destination: 40 Annotation: Subtype: Link Rect: 123, 700, 130, 703 Destination: 40 Annotation: Subtype: Link Rect: 410, 700, 416, 703 Destination: 40 Annotation: Subtype: Link Rect: 487, 15, 551, 23 Rotate: 90 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 170, 701, 177, 704 Destination: 40 Rotate: 90 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 364, 126, 397, 136 Destination: 75 Annotation: Subtype: Link Rect: 487, 15, 551, 23 Page: Label: 6 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 187, 308, 284, 318 Destination: 141 Annotation: Subtype: Link Rect: 78, 274, 226, 283 Destination: 141 Annotation: Subtype: Link Rect: 145, 79, 223, 88 Destination: 404 Annotation: Subtype: Link Rect: 230, 79, 289, 88 Destination: 404 Annotation: Subtype: Link Rect: 42, 67, 63, 77 Destination: 404 Annotation: Subtype: Link Rect: 397, 377, 472, 386 Destination: 141 Annotation: Subtype: Link Rect: 477, 377, 550, 386 Destination: 404 Annotation: Subtype: Link Rect: 303, 365, 324, 375 Destination: 404 Annotation: Subtype: Link Rect: 382, 216, 458, 225 Destination: 141 Annotation: Subtype: Link Rect: 465, 216, 545, 225 Destination: 404 Annotation: Subtype: Link Rect: 306, 136, 382, 145 Destination: 404 Annotation: Subtype: Link Rect: 401, 67, 475, 76 Destination: 141 Annotation: Subtype: Link Rect: 481, 67, 502, 76 Destination: 141 Annotation: Subtype: Link Rect: 508, 67, 550, 76 Destination: 141 Annotation: Subtype: Link Rect: 303, 55, 324, 65 Destination: 141 Annotation: Subtype: Link Rect: 330, 55, 405, 65 Destination: 404 Annotation: Subtype: Link Rect: 487, 15, 551, 23 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 215, 686, 284, 695 Destination: 141 Annotation: Subtype: Link Rect: 129, 605, 192, 615 Destination: 141 Annotation: Subtype: Link Rect: 234, 571, 289, 580 Destination: 141 Annotation: Subtype: Link Rect: 42, 560, 63, 569 Destination: 141 Annotation: Subtype: Link Rect: 70, 560, 155, 569 Destination: 141 Annotation: Subtype: Link Rect: 465, 491, 498, 500 Destination: 75 Annotation: Subtype: Link Rect: 388, 249, 447, 257 Destination: 141 Annotation: Subtype: Link Rect: 477, 78, 504, 87 Destination: 1 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 138, 319, 195, 328 Destination: 141 Annotation: Subtype: Link Rect: 201, 319, 268, 328 Destination: 141 Annotation: Subtype: Link Rect: 273, 319, 289, 328 Destination: 141 Annotation: Subtype: Link Rect: 42, 308, 83, 316 Destination: 141 Annotation: Subtype: Link Rect: 88, 308, 154, 316 Destination: 141 Annotation: Subtype: Link Rect: 159, 308, 227, 316 Destination: 404 Annotation: Subtype: Link Rect: 235, 308, 289, 316 Destination: null Annotation: Subtype: Link Rect: 42, 296, 67, 305 Destination: null Annotation: Subtype: Link Rect: 100, 193, 177, 201 Destination: 141 Annotation: Subtype: Link Rect: 487, 15, 551, 23 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 255, 698, 289, 706 Destination: 141 Annotation: Subtype: Link Rect: 42, 686, 99, 695 Destination: 141 Annotation: Subtype: Link Rect: 105, 686, 200, 695 Destination: 404 Annotation: Subtype: Link Rect: 166, 652, 243, 661 Destination: 141 Annotation: Subtype: Link Rect: 124, 524, 247, 531 Annotation: Subtype: Link Rect: 97, 515, 221, 522 Annotation: Subtype: Link Rect: 87, 506, 211, 513 Annotation: Subtype: Link Rect: 98, 497, 222, 504 Annotation: Subtype: Link Rect: 117, 488, 240, 496 Annotation: Subtype: Link Rect: 107, 479, 230, 487 Annotation: Subtype: Link Rect: 121, 470, 244, 478 Annotation: Subtype: Link Rect: 151, 461, 274, 469 Annotation: Subtype: Link Rect: 112, 452, 236, 460 Annotation: Subtype: Link Rect: 110, 443, 233, 451 Annotation: Subtype: Link Rect: 270, 262, 289, 270 Annotation: Subtype: Link Rect: 42, 254, 84, 261 Annotation: Subtype: Link Rect: 111, 254, 242, 261 Annotation: Subtype: Link Rect: 42, 224, 289, 231 Annotation: Subtype: Link Rect: 50, 215, 289, 222 Annotation: Subtype: Link Rect: 50, 206, 289, 213 Annotation: Subtype: Link Rect: 50, 197, 235, 204 Annotation: Subtype: Link Rect: 240, 197, 248, 204 Annotation: Subtype: Link Rect: 42, 185, 289, 192 Annotation: Subtype: Link Rect: 50, 176, 289, 183 Annotation: Subtype: Link Rect: 50, 167, 63, 174 Annotation: Subtype: Link Rect: 68, 167, 77, 174 Annotation: Subtype: Link Rect: 42, 155, 289, 162 Annotation: Subtype: Link Rect: 50, 146, 289, 153 Annotation: Subtype: Link Rect: 50, 137, 91, 145 Annotation: Subtype: Link Rect: 97, 137, 101, 145 Annotation: Subtype: Link Rect: 42, 125, 289, 133 Annotation: Subtype: Link Rect: 50, 116, 289, 124 Annotation: Subtype: Link Rect: 50, 107, 217, 115 Annotation: Subtype: Link Rect: 222, 107, 226, 115 Annotation: Subtype: Link Rect: 42, 95, 289, 103 Annotation: Subtype: Link Rect: 50, 86, 289, 94 Annotation: Subtype: Link Rect: 50, 77, 226, 85 Annotation: Subtype: Link Rect: 231, 77, 243, 85 Annotation: Subtype: Link Rect: 42, 65, 258, 73 Annotation: Subtype: Link Rect: 264, 65, 268, 73 Annotation: Subtype: Link Rect: 42, 53, 289, 61 Annotation: Subtype: Link Rect: 50, 44, 289, 52 Annotation: Subtype: Link Rect: 311, 722, 550, 729 Annotation: Subtype: Link Rect: 311, 713, 357, 720 Annotation: Subtype: Link Rect: 363, 713, 367, 720 Annotation: Subtype: Link Rect: 303, 701, 550, 708 Annotation: Subtype: Link Rect: 311, 692, 410, 699 Annotation: Subtype: Link Rect: 416, 692, 420, 699 Annotation: Subtype: Link Rect: 303, 680, 550, 687 Annotation: Subtype: Link Rect: 311, 671, 550, 678 Annotation: Subtype: Link Rect: 311, 662, 501, 669 Annotation: Subtype: Link Rect: 506, 662, 515, 669 Annotation: Subtype: Link Rect: 303, 650, 550, 657 Annotation: Subtype: Link Rect: 311, 641, 509, 649 Annotation: Subtype: Link Rect: 514, 641, 519, 649 Annotation: Subtype: Link Rect: 303, 629, 550, 637 Annotation: Subtype: Link Rect: 311, 620, 550, 628 Annotation: Subtype: Link Rect: 311, 611, 391, 619 Annotation: Subtype: Link Rect: 396, 611, 404, 619 Annotation: Subtype: Link Rect: 303, 599, 550, 607 Annotation: Subtype: Link Rect: 311, 590, 550, 598 Annotation: Subtype: Link Rect: 311, 581, 550, 589 Annotation: Subtype: Link Rect: 311, 572, 352, 580 Annotation: Subtype: Link Rect: 358, 572, 366, 580 Annotation: Subtype: Link Rect: 303, 560, 550, 568 Annotation: Subtype: Link Rect: 311, 551, 550, 559 Annotation: Subtype: Link Rect: 311, 542, 442, 550 Annotation: Subtype: Link Rect: 448, 542, 456, 550 Annotation: Subtype: Link Rect: 303, 530, 551, 538 Annotation: Subtype: Link Rect: 311, 521, 550, 529 Annotation: Subtype: Link Rect: 311, 513, 497, 520 Annotation: Subtype: Link Rect: 303, 501, 550, 508 Annotation: Subtype: Link Rect: 311, 492, 550, 499 Annotation: Subtype: Link Rect: 311, 483, 550, 490 Annotation: Subtype: Link Rect: 311, 474, 550, 481 Annotation: Subtype: Link Rect: 311, 465, 328, 472 Annotation: Subtype: Link Rect: 334, 465, 364, 472 Annotation: Subtype: Link Rect: 303, 453, 550, 460 Annotation: Subtype: Link Rect: 311, 444, 550, 451 Annotation: Subtype: Link Rect: 311, 435, 550, 442 Annotation: Subtype: Link Rect: 311, 426, 365, 433 Annotation: Subtype: Link Rect: 303, 414, 550, 421 Annotation: Subtype: Link Rect: 311, 405, 520, 412 Annotation: Subtype: Link Rect: 526, 405, 534, 412 Annotation: Subtype: Link Rect: 303, 393, 550, 400 Annotation: Subtype: Link Rect: 311, 384, 445, 391 Annotation: Subtype: Link Rect: 450, 384, 458, 391 Annotation: Subtype: Link Rect: 303, 372, 550, 380 Annotation: Subtype: Link Rect: 311, 363, 550, 371 Annotation: Subtype: Link Rect: 311, 354, 550, 362 Annotation: Subtype: Link Rect: 311, 345, 398, 353 Annotation: Subtype: Link Rect: 403, 345, 411, 353 Annotation: Subtype: Link Rect: 303, 333, 550, 341 Annotation: Subtype: Link Rect: 311, 324, 550, 332 Annotation: Subtype: Link Rect: 311, 315, 416, 323 Annotation: Subtype: Link Rect: 422, 315, 426, 323 Annotation: Subtype: Link Rect: 303, 303, 550, 311 Annotation: Subtype: Link Rect: 311, 294, 535, 302 Annotation: Subtype: Link Rect: 540, 294, 548, 302 Annotation: Subtype: Link Rect: 303, 282, 550, 290 Annotation: Subtype: Link Rect: 311, 273, 550, 281 Annotation: Subtype: Link Rect: 311, 264, 550, 272 Annotation: Subtype: Link Rect: 311, 255, 357, 263 Annotation: Subtype: Link Rect: 363, 255, 371, 263 Annotation: Subtype: Link Rect: 303, 243, 550, 250 Annotation: Subtype: Link Rect: 311, 234, 550, 241 Annotation: Subtype: Link Rect: 311, 225, 454, 232 Annotation: Subtype: Link Rect: 460, 225, 468, 232 Annotation: Subtype: Link Rect: 303, 212, 550, 219 Annotation: Subtype: Link Rect: 311, 203, 550, 210 Annotation: Subtype: Link Rect: 311, 194, 384, 201 Annotation: Subtype: Link Rect: 303, 181, 550, 188 Annotation: Subtype: Link Rect: 311, 172, 550, 179 Annotation: Subtype: Link Rect: 311, 163, 550, 170 Annotation: Subtype: Link Rect: 311, 154, 338, 161 Annotation: Subtype: Link Rect: 303, 141, 550, 148 Annotation: Subtype: Link Rect: 311, 132, 550, 139 Annotation: Subtype: Link Rect: 311, 123, 550, 130 Annotation: Subtype: Link Rect: 311, 114, 376, 122 Annotation: Subtype: Link Rect: 382, 114, 390, 122 Annotation: Subtype: Link Rect: 303, 103, 550, 111 Annotation: Subtype: Link Rect: 311, 94, 550, 102 Annotation: Subtype: Link Rect: 311, 85, 535, 93 Annotation: Subtype: Link Rect: 540, 85, 548, 93 Annotation: Subtype: Link Rect: 303, 71, 550, 79 Annotation: Subtype: Link Rect: 311, 62, 550, 70 Annotation: Subtype: Link Rect: 311, 53, 550, 61 Annotation: Subtype: Link Rect: 311, 44, 393, 52 Annotation: Subtype: Link Rect: 398, 44, 406, 52 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 42, 722, 289, 729 Annotation: Subtype: Link Rect: 50, 713, 289, 720 Annotation: Subtype: Link Rect: 50, 704, 253, 711 Annotation: Subtype: Link Rect: 42, 692, 289, 699 Annotation: Subtype: Link Rect: 50, 683, 216, 690 Annotation: Subtype: Link Rect: 222, 683, 230, 690 Annotation: Subtype: Link Rect: 42, 670, 289, 677 Annotation: Subtype: Link Rect: 50, 661, 289, 668 Annotation: Subtype: Link Rect: 50, 652, 248, 659 Annotation: Subtype: Link Rect: 42, 639, 289, 647 Annotation: Subtype: Link Rect: 50, 630, 289, 638 Annotation: Subtype: Link Rect: 50, 621, 182, 629 Annotation: Subtype: Link Rect: 187, 621, 192, 629 Annotation: Subtype: Link Rect: 42, 608, 289, 616 Annotation: Subtype: Link Rect: 50, 599, 289, 607 Annotation: Subtype: Link Rect: 50, 590, 214, 598 Annotation: Subtype: Link Rect: 219, 590, 228, 598 Annotation: Subtype: Link Rect: 42, 577, 289, 585 Annotation: Subtype: Link Rect: 50, 568, 141, 576 Annotation: Subtype: Link Rect: 147, 568, 155, 576 Annotation: Subtype: Link Rect: 42, 556, 289, 564 Annotation: Subtype: Link Rect: 50, 547, 289, 555 Annotation: Subtype: Link Rect: 50, 538, 59, 546 Annotation: Subtype: Link Rect: 64, 538, 68, 546 Annotation: Subtype: Link Rect: 303, 722, 550, 729 Annotation: Subtype: Link Rect: 311, 713, 550, 720 Annotation: Subtype: Link Rect: 311, 704, 550, 711 Annotation: Subtype: Link Rect: 311, 695, 345, 702 Annotation: Subtype: Link Rect: 303, 682, 550, 689 Annotation: Subtype: Link Rect: 311, 673, 550, 680 Annotation: Subtype: Link Rect: 311, 664, 550, 671 Annotation: Subtype: Link Rect: 311, 655, 328, 662 Annotation: Subtype: Link Rect: 334, 655, 338, 662 Annotation: Subtype: Link Rect: 303, 642, 550, 649 Annotation: Subtype: Link Rect: 311, 633, 550, 640 Annotation: Subtype: Link Rect: 311, 624, 522, 631 Annotation: Subtype: Link Rect: 528, 624, 536, 631 Annotation: Subtype: Link Rect: 303, 612, 550, 619 Annotation: Subtype: Link Rect: 311, 603, 550, 610 Annotation: Subtype: Link Rect: 311, 594, 550, 601 Annotation: Subtype: Link Rect: 311, 585, 372, 592 Annotation: Subtype: Link Rect: 377, 585, 386, 592 Annotation: Subtype: Link Rect: 431, 549, 550, 559 Annotation: Subtype: Link Rect: 303, 538, 369, 547 Annotation: Subtype: Link Rect: 487, 15, 551, 23 Page: Label: 12 Checksum: a85e43f6 Type: CRC32 Checksum: 02683e499dfe949a1bb57247a5f2931a Type: MD5 Checksum: 897451646ae90652c1286c68a25d9ad30d35d867 Type: SHA-1 Checksum: 4625aafb9feaa969566b996b4ff055cbb6b96cd2984f333b404454545b9f4482 Type: SHA-256