aa4baa0546b36b91ed2e1666c4cf94d2 Characterization_and_Factors.pdf 3d278f5f71719d5eaaa899b36b1500f2a3195d02 Characterization_and_Factors.pdf cab1f11558db2da4a71ce26fa7e03e3c8dbe519682cdcd7d970ceb5d422b7303 Characterization_and_Factors.pdf Title: Characterization and Factors Associated with Poor Asthma Control in Adults with Severe Eosinophilic Asthma Subject: A study was conducted in 98 adult patients diagnosed with severe eosinophilic asthma (73.5% women, mean age 47.2 years) and followed prospectively for 1 year. The aim of the study was to characterize this population and to identify factors associated with poor prognosis at 1 year of follow-up. At the initial visit, uncontrolled severe asthma was diagnosed in 87.7% of patients. Allergic sensitization was observed in 81.7% (polysensitization in 17.3%), with clinically significant allergic asthma in 45%. The mean percentage of sputum eosinophils was 4.7% (standard deviation(SD) 6.3%) and the mean (SD) blood eosinophil count 467 (225) cells/L. Almost half of the patients (48.3%) had sputum eosinophilia (>3% eosinophils). Sputum eosinophils correlated significantly with peripheral eosinophilia (p = 0.004) and, to a lesser extent, with fractional exhaled nitric oxide (FeNO) (p = 0.04). After 1 year, 48 patients (49%) had uncontrolled asthma in all visits, and 50 (51%) had controlled asthma in some visits. Airway obstruction (FEV1 < 80% predicted) was the main reason for uncontrolled asthma. In the multivariate analysis, an obstructive pattern (odds ratio (OR) 7.45, 95% confidence interval (CI) 2.41–23.03, p < 0.0001) and the patient’s age (OR 1.045, 95% CI 1.005–1.086, p = 0.026) were independent predictors of poor asthma control. In adult-onset and long-standing asthma, serum interleukin (IL) IL-17 was higher in the uncontrolled asthma group. This study contributes to characterizing patients with severe eosinophilic asthma in real-world clinical practice. Keywords: eosinophilic asthma; biomarkers; blood eosinophils; fractional exhaled nitric oxide; asthma control; periostin Author: Clara Padró-Casas, María Basagaña, María Luisa Rivera-Ortún, Ignasi García-Olivé, Carlos Pollan-Guisasola, Aina Teniente-Serra, Eva Martínez-Cáceres, José-Tomás Navarro, Jorge Abad-Capa, Antoni Rosell, Albert Roger and Carlos Martínez-Rivera Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Jul 22 11:15:31 2023 CEST ModDate: Sat Jul 22 11:16:47 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1158289 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZXDKIP+EURM10 Type 1 Builtin yes yes no 10 0 SGPLNR+URWPalladioL-Bold Type 1 Custom yes yes no 14 0 WZDWPP+URWPalladioL-Roma Type 1 Custom yes yes no 19 0 QKINXM+URWPalladioL-Ital Type 1 Custom yes yes no 23 0 VJAUGW+VnURWPalladioL Type 1 Custom yes yes no 27 0 DGBDNV+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 UIJACC+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 50 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 53 0 EILUJF+CMSY10 Type 1 Builtin yes yes no 70 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 98 0 BOJJCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 114 0 BOJJCD+PalatinoLinotype CID TrueType Identity-H yes yes yes 117 0 BOJJCE+PalatinoLinotype TrueType WinAnsi yes yes no 123 0 BOJJCG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 126 0 BOJKEA+PalatinoLinotype TrueType MacRoman yes yes no 129 0 BOJJCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 144 0 BOJJCD+PalatinoLinotype CID TrueType Identity-H yes yes yes 147 0 BOJJCE+PalatinoLinotype TrueType WinAnsi yes yes no 153 0 BOJJCG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 156 0 BOJKEA+PalatinoLinotype TrueType MacRoman yes yes no 159 0 BOJJCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 171 0 BOJJCD+PalatinoLinotype CID TrueType Identity-H yes yes yes 174 0 BOJJCE+PalatinoLinotype TrueType WinAnsi yes yes no 180 0 BOJJCG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 183 0 BOJKEA+PalatinoLinotype TrueType MacRoman yes yes no 186 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-09 02:33:54 CET RepresentationInformation: Characterization_and_Factors.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-08 17:50:51 CET Size: 1158289 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 360 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Design and Participants Destination: subsection.2.1 Item: Title: Study Procedures Destination: subsection.2.2 Item: Title: Study Outcomes Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Characteristics of Patients Destination: subsection.3.1 Item: Title: Sputum and Peripheral Blood Eosinophils Destination: subsection.3.2 Item: Title: Inflammatory- and Immune-Related Parameters Destination: subsection.3.3 Item: Title: Asthma Control at Follow-Up Destination: subsection.3.4 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.A. Info: Title: Characterization and Factors Associated with Poor Asthma Control in Adults with Severe Eosinophilic Asthma Author: Clara Padró-Casas, María Basagaña, María Luisa Rivera-Ortún, Ignasi García-Olivé, Carlos Pollan-Guisasola, Aina Teniente-Serra, Eva Martínez-Cáceres, José-Tomás Navarro, Jorge Abad-Capa, Antoni Rosell, Albert Roger and Carlos Martínez-Rivera Subject: A study was conducted in 98 adult patients diagnosed with severe eosinophilic asthma (73.5% women, mean age 47.2 years) and followed prospectively for 1 year. The aim of the study was to characterize this population and to identify factors associated with poor prognosis at 1 year of follow-up. At the initial visit, uncontrolled severe asthma was diagnosed in 87.7% of patients. Allergic sensitization was observed in 81.7% (polysensitization in 17.3%), with clinically significant allergic asthma in 45%. The mean percentage of sputum eosinophils was 4.7% (standard deviation(SD) 6.3%) and the mean (SD) blood eosinophil count 467 (225) cells/L. Almost half of the patients (48.3%) had sputum eosinophilia (>3% eosinophils). Sputum eosinophils correlated significantly with peripheral eosinophilia (p = 0.004) and, to a lesser extent, with fractional exhaled nitric oxide (FeNO) (p = 0.04). After 1 year, 48 patients (49%) had uncontrolled asthma in all visits, and 50 (51%) had controlled asthma in some visits. Airway obstruction (FEV1 < 80% predicted) was the main reason for uncontrolled asthma. In the multivariate analysis, an obstructive pattern (odds ratio (OR) 7.45, 95% confidence interval (CI) 2.41 23.03, p < 0.0001) and the patient’s age (OR 1.045, 95% CI 1.005 1.086, p = 0.026) were independent predictors of poor asthma control. In adult-onset and long-standing asthma, serum interleukin (IL) IL-17 was higher in the uncontrolled asthma group. This study contributes to characterizing patients with severe eosinophilic asthma in real-world clinical practice. Keywords: eosinophilic asthma; biomarkers; blood eosinophils; fractional exhaled nitric oxide; asthma control; periostin Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Jul 22 11:15:31 CEST 2023 ModDate: Sat Jul 22 11:16:47 CEST 2023 ID: 0x9c43db37f888c323f947659c5387873e, 0x9c43db37f888c323f947659c5387873e Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: DGBDNV+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 243 FontDescriptor: FontName: DGBDNV+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QLBIEB+URWPalladioL-BoldItal FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: QLBIEB+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: WZDWPP+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: WZDWPP+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EILUJF+CMSY10 FontSubset: true FirstChar: 0 LastChar: 21 FontDescriptor: FontName: EILUJF+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: QKINXM+URWPalladioL-Ital FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: QKINXM+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZXDKIP+EURM10 FontSubset: true FirstChar: 11 LastChar: 22 FontDescriptor: FontName: ZXDKIP+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: VJAUGW+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: VJAUGW+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: SGPLNR+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: SGPLNR+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 82, 293, 152, 302 Annotation: Subtype: Link Rect: 34, 281, 103, 290 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 176, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 539, 68, 546, 76 ActionDest: 201 Annotation: Subtype: Link Rect: 549, 67, 556, 76 ActionDest: 201 Annotation: Subtype: Link Rect: 130, 17, 268, 28 Annotation: Subtype: Link Rect: 423, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 414, 87, 433 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 549, 710, 556, 719 ActionDest: 201 Annotation: Subtype: Link Rect: 205, 685, 212, 694 ActionDest: 201 Annotation: Subtype: Link Rect: 291, 648, 297, 657 ActionDest: 201 Annotation: Subtype: Link Rect: 298, 647, 305, 657 ActionDest: 201 Annotation: Subtype: Link Rect: 497, 635, 504, 644 ActionDest: 201 Annotation: Subtype: Link Rect: 360, 623, 367, 631 ActionDest: 201 Annotation: Subtype: Link Rect: 360, 547, 367, 556 ActionDest: 201 Annotation: Subtype: Link Rect: 529, 497, 536, 506 ActionDest: 201 Annotation: Subtype: Link Rect: 272, 459, 284, 468 ActionDest: 201 Annotation: Subtype: Link Rect: 233, 434, 245, 443 ActionDest: 201 Annotation: Subtype: Link Rect: 246, 434, 258, 443 ActionDest: 201 Annotation: Subtype: Link Rect: 290, 409, 302, 418 ActionDest: 201 Annotation: Subtype: Link Rect: 244, 245, 251, 254 ActionDest: 201 Annotation: Subtype: Link Rect: 300, 232, 312, 241 ActionDest: 201 Annotation: Subtype: Link Rect: 461, 207, 473, 216 ActionDest: 201 Annotation: Subtype: Link Rect: 233, 144, 240, 153 ActionDest: 201 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 387, 695, 399, 704 ActionDest: 201 Annotation: Subtype: Link Rect: 510, 682, 522, 691 ActionDest: 201 Annotation: Subtype: Link Rect: 549, 632, 556, 641 ActionDest: 201 Annotation: Subtype: Link Rect: 262, 607, 269, 616 ActionDest: 201 Annotation: Subtype: Link Rect: 256, 469, 268, 478 ActionDest: 201 Annotation: Subtype: Link Rect: 190, 343, 202, 352 ActionDest: 204 Annotation: Subtype: Link Rect: 300, 343, 311, 352 ActionDest: 204 Annotation: Subtype: Link Rect: 441, 331, 453, 340 ActionDest: 204 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 327, 279, 333, 289 ActionDest: 80 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 552, 240, 559, 252 ActionDest: 83 Annotation: Subtype: Link Rect: 508, 89, 515, 101 ActionDest: 83 Page: Sequence: 6 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 515, 705, 522, 717 ActionDest: 83 Annotation: Subtype: Link Rect: 380, 680, 387, 692 ActionDest: 92 Annotation: Subtype: Link Rect: 449, 667, 456, 679 ActionDest: 83 Annotation: Subtype: Link Rect: 231, 80, 238, 92 ActionDest: 95 Page: Sequence: 8 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 492, 532, 499, 544 ActionDest: 102 Annotation: Subtype: Link Rect: 200, 519, 207, 531 ActionDest: 134 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 220, 380, 227, 392 ActionDest: 134 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 462, 635, 469, 644 ActionDest: 201 Annotation: Subtype: Link Rect: 337, 610, 344, 619 ActionDest: 201 Annotation: Subtype: Link Rect: 543, 597, 555, 606 ActionDest: 204 Annotation: Subtype: Link Rect: 242, 321, 254, 330 ActionDest: 204 Annotation: Subtype: Link Rect: 257, 296, 269, 305 ActionDest: 204 Annotation: Subtype: Link Rect: 371, 284, 383, 293 ActionDest: 204 Annotation: Subtype: Link Rect: 232, 258, 244, 267 ActionDest: 204 Annotation: Subtype: Link Rect: 325, 196, 337, 205 ActionDest: 204 Annotation: Subtype: Link Rect: 326, 183, 338, 192 ActionDest: 204 Annotation: Subtype: Link Rect: 463, 170, 475, 180 ActionDest: 204 Annotation: Subtype: Link Rect: 475, 170, 487, 180 ActionDest: 204 Annotation: Subtype: Link Rect: 352, 158, 364, 167 ActionDest: 204 Annotation: Subtype: Link Rect: 420, 133, 432, 142 ActionDest: 204 Annotation: Subtype: Link Rect: 433, 133, 445, 142 ActionDest: 204 Annotation: Subtype: Link Rect: 323, 83, 335, 92 ActionDest: 201 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 404, 710, 416, 719 ActionDest: 204 Annotation: Subtype: Link Rect: 320, 673, 332, 682 ActionDest: 204 Annotation: Subtype: Link Rect: 333, 673, 345, 682 ActionDest: 204 Annotation: Subtype: Link Rect: 348, 673, 360, 682 ActionDest: 204 Annotation: Subtype: Link Rect: 224, 635, 236, 644 ActionDest: 204 Annotation: Subtype: Link Rect: 529, 522, 541, 531 ActionDest: 204 Annotation: Subtype: Link Rect: 214, 472, 226, 481 ActionDest: 204 Annotation: Subtype: Link Rect: 413, 396, 425, 406 ActionDest: 204 Annotation: Subtype: Link Rect: 459, 321, 471, 330 ActionDest: 207 Annotation: Subtype: Link Rect: 346, 283, 358, 293 ActionDest: 207 Annotation: Subtype: Link Rect: 225, 196, 232, 205 ActionDest: 201 Annotation: Subtype: Link Rect: 232, 196, 244, 205 ActionDest: 204 Annotation: Subtype: Link Rect: 278, 108, 290, 117 ActionDest: 207 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 379, 522, 391, 531 ActionDest: 201 Annotation: Subtype: Link Rect: 505, 182, 560, 193 Annotation: Subtype: Link Rect: 165, 170, 336, 181 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 501, 526, 560, 537 Annotation: Subtype: Link Rect: 56, 514, 119, 525 Annotation: Subtype: Link Rect: 59, 480, 96, 491 Annotation: Subtype: Link Rect: 102, 480, 138, 491 Annotation: Subtype: Link Rect: 333, 457, 370, 468 Annotation: Subtype: Link Rect: 59, 423, 96, 433 Annotation: Subtype: Link Rect: 415, 399, 452, 410 Annotation: Subtype: Link Rect: 208, 377, 245, 387 Annotation: Subtype: Link Rect: 251, 377, 287, 387 Annotation: Subtype: Link Rect: 185, 342, 222, 353 Annotation: Subtype: Link Rect: 228, 342, 264, 353 Annotation: Subtype: Link Rect: 459, 319, 497, 330 Annotation: Subtype: Link Rect: 203, 296, 240, 307 Annotation: Subtype: Link Rect: 247, 296, 283, 307 Annotation: Subtype: Link Rect: 467, 272, 504, 284 Annotation: Subtype: Link Rect: 511, 272, 547, 284 Annotation: Subtype: Link Rect: 144, 239, 182, 249 Annotation: Subtype: Link Rect: 59, 204, 96, 214 Annotation: Subtype: Link Rect: 121, 181, 157, 191 Annotation: Subtype: Link Rect: 264, 146, 301, 157 Annotation: Subtype: Link Rect: 135, 112, 173, 122 Annotation: Subtype: Link Rect: 228, 89, 266, 99 Annotation: Subtype: Link Rect: 272, 89, 308, 99 Annotation: Subtype: Link Rect: 418, 65, 456, 76 Annotation: Subtype: Link Rect: 462, 65, 498, 76 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 223, 710, 261, 721 Annotation: Subtype: Link Rect: 267, 710, 303, 721 Annotation: Subtype: Link Rect: 155, 687, 192, 698 Annotation: Subtype: Link Rect: 198, 687, 234, 698 Annotation: Subtype: Link Rect: 438, 629, 475, 640 Annotation: Subtype: Link Rect: 385, 606, 423, 617 Annotation: Subtype: Link Rect: 104, 538, 141, 548 Annotation: Subtype: Link Rect: 148, 538, 184, 548 Annotation: Subtype: Link Rect: 113, 515, 151, 525 Annotation: Subtype: Link Rect: 157, 515, 193, 525 Annotation: Subtype: Link Rect: 324, 491, 361, 502 Annotation: Subtype: Link Rect: 59, 458, 96, 468 Annotation: Subtype: Link Rect: 518, 434, 555, 445 Annotation: Subtype: Link Rect: 86, 412, 124, 422 Annotation: Subtype: Link Rect: 441, 388, 478, 399 Annotation: Subtype: Link Rect: 407, 365, 444, 376 Annotation: Subtype: Link Rect: 148, 331, 185, 341 Annotation: Subtype: Link Rect: 315, 307, 353, 318 Annotation: Subtype: Link Rect: 59, 274, 96, 284 Annotation: Subtype: Link Rect: 102, 274, 138, 284 Annotation: Subtype: Link Rect: 157, 228, 194, 238 Annotation: Subtype: Link Rect: 59, 193, 96, 203 Annotation: Subtype: Link Rect: 102, 193, 138, 203 Annotation: Subtype: Link Rect: 430, 123, 468, 134 Annotation: Subtype: Link Rect: 474, 123, 510, 134 Annotation: Subtype: Link Rect: 59, 101, 96, 111 Annotation: Subtype: Link Rect: 102, 101, 138, 111 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 393, 733, 430, 744 Annotation: Subtype: Link Rect: 285, 710, 323, 721 Checksum: 382fc9e9 Type: CRC32 Checksum: aa4baa0546b36b91ed2e1666c4cf94d2 Type: MD5 Checksum: 3d278f5f71719d5eaaa899b36b1500f2a3195d02 Type: SHA-1 Checksum: cab1f11558db2da4a71ce26fa7e03e3c8dbe519682cdcd7d970ceb5d422b7303 Type: SHA-256