e80c0b61b33b7775bb9ac45500887538 The_KMT2A_recombinome.pdf 0406e14e4738b1a2aaffb188882d96404b1e78f2 The_KMT2A_recombinome.pdf d05a0140ae9a4072824a0ff1a7449616c7dda526669f4e04681c12b45d7a64b5 The_KMT2A_recombinome.pdf Title: The KMT2A recombinome of acute leukemias in 2023 Subject: Leukemia, doi:10.1038/s41375-023-01877-1 Keywords: Author: C. Meyer Creator: Springer CreationDate: Fri Apr 28 06:26:15 2023 CEST ModDate: Fri Apr 28 06:26:57 2023 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 3916466 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IICMAF+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 808 0 IIDDEC+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 826 0 IIDDED+AdvMyriad_I Type 1C WinAnsi yes yes no 827 0 IIDDEE+AdvMyriad_R Type 1C WinAnsi yes yes no 828 0 IIDDHE+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 829 0 IIDDIF+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 843 0 Arial-BoldMT Type 1C WinAnsi yes no no 809 0 IICMMD+AdvOTce3d9a73 Type 1C WinAnsi yes yes no 814 0 IICMME+AdvOT46dcae81 Type 1C WinAnsi yes yes no 815 0 IICMNE+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 816 0 IICMNF+AdvTT6780a46b Type 1C WinAnsi yes yes no 817 0 IICPPD+AdvTT6780a46b+01 Type 1C Custom yes yes yes 822 0 IIDDDA+AdvTT2876772e+27 Type 1C Custom yes yes yes 830 0 IIDDEB+AdvOT46dcae81+fb Type 1C Custom yes yes yes 831 0 IIDEBC+AdvTTab7e17fd Type 1C WinAnsi yes yes no 271 0 IIDECD+AdvOT46dcae81+22 Type 1C Custom yes yes yes 278 0 IIDJJC+AdvOT919a0533.B Type 1C WinAnsi yes yes no 280 0 IIDLPF+AdvTT6780a46b+fb Type 1C Custom yes yes yes 279 0 IIDMJC+AdvTT6780a46b+20 Type 1C WinAnsi yes yes no 272 0 IIDMJD+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 274 0 IIDNHO+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 284 0 IIDNHP+AdvOTd0125be5.BI Type 1C WinAnsi yes yes no 283 0 IIGNFK+AdvOT3b30f6db.B+20 Type 1C WinAnsi yes yes no 335 0 IIIDOB+AdvOT46dcae81+01 Type 1C Custom yes yes yes 386 0 IIIEGP+AdvOT46dcae81+03 Type 1C Custom yes yes yes 392 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-14 02:36:37 CET RepresentationInformation: The_KMT2A_recombinome.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-13 15:30:20 CET Size: 3916466 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 995 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: The KMT2A recombinome of acute leukemias in 2023 Destination: title_link Children: Item: Title: Introduction Destination: A1 Item: Title: Methods Destination: A2 Children: Item: Title: Patient material Destination: B1 Item: Title: Detection of chromosomal breakpoints by LDI-PCR, LD multiplex PCR, and targeted NGS Destination: B2 Item: Title: Data evaluation and statistical analyses Destination: B3 Item: Title: Nomenclature Destination: B4 Item: Title: Results Destination: A3 Children: Item: Title: The study cohort Destination: B5 Item: Title: Age distribution according to clinical subtypes Destination: B6 Item: Title: Identification of KMT2A rearrangements and their distribution in clinical subgroups Destination: B7 Item: Title: Breakpoint distribution according to clinical subtypes Destination: B8 Item: Title: The minor BCR of KMT2A Destination: B9 Item: Title: T-ALL cases Destination: B10 Item: Title: Therapy-induced leukemia Destination: B11 Item: Title: Spliced fusions Destination: B12 Item: Title: The KMT2A recombinome Destination: B13 Item: Title: Novel translocation partner genes Destination: B14 Item: Title: Novel in-frame fusions to KMT2A Destination: B15 Item: Title: Novel out-of-frame fusions to KMT2A Destination: B16 Item: Title: Discussion Destination: A4 Item: Title: Data availablility Destination: A5 Item: Title: Acknowledgements Destination: A6 Item: Title: Author contributions Destination: A7 Item: Title: Funding Destination: A8 Item: Title: Competing interests Destination: A9 Item: Title: ADDITIONAL INFORMATION Destination: M1 Info: Title: The KMT2A recombinome of acute leukemias in 2023 Author: C. 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FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/s41375-023-01877-1 The KMT2A recombinome of acute leukemias in 2023 C. Meyer P. Larghero B. Almeida Lopes T. Burmeister D. Gröger R. Sutton N. C. Venn G. Cazzaniga L. Corral Abascal G. Tsaur L. Fechina M. Emerenciano M. S. Pombo-de-Oliveira T. Lund-Aho T. Lundán M. Montonen V. Juvonen J. Zuna J. Trka P. Ballerini H. Lapillonne V. H. J. Velden E. Sonneveld E. Delabesse R. R. C. Matos M. L. M. Silva S. Bomken K. Katsibardi M. Keernik N. Grardel J. Mason R. Price J. Kim C. Eckert L. Lo Nigro C. Bueno P. Menendez U. zur Stadt P. Gameiro L. Sedék T. Szczepański A. Bidet V. Marcu K. Shichrur S. Izraeli H. O. Madsen B. W. Schäfer S. Kubetzko R. Kim E. Clappier H. Trautmann M. Brüggemann P. Archer J. Hancock J. Alten A. Möricke M. Stanulla J. Lentes A. K. Bergmann S. Strehl S. Köhrer K. Nebral M. N. Dworzak O. A. Haas C. Arfeuille A. Caye-Eude H. Cavé R. 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