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Title:           ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
Subject:         Nature Communications, doi:10.1038/s41467-023-39097-x
Keywords:        
Author:          Nadia Mensali
Creator:         Springer
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      Title: ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: TP-1 and TP-3 antibodies recognize surface expressed ALPL-1
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         Item: 
          Title: ALPL-1 is highly expressed in sarcoma samples
          Destination: B2
         Item: 
          Title: TP-1 and TP-3 derived CARs redirect primary T cells
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         Item: 
          Title: OSCAR T’cells control tumor growth in human xenograft models
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         Item: 
          Title: Safety assessment of OSCARs
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        Title: Discussion
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        Title: Methods
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          Title: Cell lines, biopsies, reagents and media
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         Item: 
          Title: Osteosarcoma patient-derived xenografts (PDXs)
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         Item: 
          Title: Immunohistochemistry (IHC)
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         Item: 
          Title: DNA/RNA constructs
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         Item: 
          Title: Generation of ALPL knockout OHS cell line
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         Item: 
          Title: Generation of ALPL expressing HEK-293 cell line
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         Item: 
          Title: T cell transduction and expansion
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         Item: 
          Title: In vitro functional assay, antibodies, and flow cytometry
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         Item: 
          Title: Antigen density test
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         Item: 
          Title: In vitro cytotoxicity of OSCAR T’cells against OS primary cells
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         Item: 
          Title: Rechallenge assay
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          Title: CTV-based proliferation assay
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         Item: 
          Title: Colony-forming unit assay (CFU)
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          Title: OS multicellular spheroids
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         Item: 
          Title: Western blot
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         Item: 
          Title: Gene expression analysis
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         Item: 
          Title: Mouse xenograft studies
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         Item: 
          Title: Ca2+ flux analysis
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          Title: Statistical analysis
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          Title: Reporting summary
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        Title: Data availability
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        Title: References
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        Title: Acknowledgements
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        Title: Author contributions
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       Item: 
        Title: Competing interests
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       Item: 
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