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Title:           Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
Subject:         Nature Communications, doi:10.1038/s41467-023-41562-6
Keywords:        
Author:          Cirino Botta
Creator:         Springer
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      Title: Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: The T cell compartment in healthy, benign, and malignant bone marrow
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         Item: 
          Title: The phenotype of clonal T’cells during disease progression
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         Item: 
          Title: ICB combination therapy tailored to the phenotype of large T cell clones
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         Item: 
          Title: T cell markers of clonality and prognosis in MM
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        Title: Discussion
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       Item: 
        Title: Methods
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         Item: 
          Title: Patients and treatment
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         Item: 
          Title: Combined single-cell RNA and TCR sequencing (scRNA/TCR-seq)
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         Item: 
          Title: Multidimensional flow cytometry (MFC)
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         Item: 
          Title: Computational flow cytometry
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         Item: 
          Title: RNA sequencing (RNA-seq)
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         Item: 
          Title: Whole-exome sequencing (WES)
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         Item: 
          Title: Mouse model of MM for scRNAseq + scTCRseq analysis
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         Item: 
          Title: In vivo pre-clinical trial in a syngeneic MM model using immune checkpoint inhibitors
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          Title: 3D cultures
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          Title: Statistical analysis
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