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Title:           An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma
Subject:         Nature Communications, doi:10.1038/s41467-023-36967-2
Keywords:        
Author:          Veronica Davalos
Creator:         Springer
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      Title: An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma
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       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: The NR2F2 locus becomes methylated during NCC-to-melanocyte differentiation, and de-methylated during metastatic melanoma progression
          Destination: B1
         Item: 
          Title: NR2F2 demethylation restores NR2F2-Iso2 expression during metastatic melanoma progression
          Destination: B2
         Item: 
          Title: NR2F2-Iso2 promotes melanoma cell survival and anchorage-independent growth
          Destination: B3
         Item: 
          Title: NR2F2-Iso2 enhances melanoma metastasis
          Destination: B4
         Item: 
          Title: NR2F2-Iso2 controls a pro-metastatic transcriptional program
          Destination: B5
         Item: 
          Title: NR2F2-Iso2 modulates NR2F2-Iso1 chromatin binding and target gene expression
          Destination: B6
         Item: 
          Title: NR2F2-Iso2 modifies NR2F2-Iso1 transcriptional regulation of metastasis and differentiation genes
          Destination: B7
         Item: 
          Title: Shifting the ratio of NR2F2 isoforms changes melanoma metastatic potential
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       Item: 
        Title: Methods
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         Item: 
          Title: Cell lines and culture
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         Item: 
          Title: Melanoma DNA methylation profiles
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         Item: 
          Title: DNA methylation analyses
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         Item: 
          Title: mRNA expression analysis
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         Item: 
          Title: RNA sequencing
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         Item: 
          Title: Protein expression analysis
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         Item: 
          Title: Subcellular fractionation
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         Item: 
          Title: Co-Immunoprecipitation
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         Item: 
          Title: Short hairpin interference and ectopic expression assays
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         Item: 
          Title: Chromatin Immunoprecipitation (ChIP) sequencing
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         Item: 
          Title: Proliferation assay
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         Item: 
          Title: Soft agar assay
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         Item: 
          Title: Melanosphere formation assay
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         Item: 
          Title: Mouse xenograft models
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         Item: 
          Title: Mouse housing conditions
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         Item: 
          Title: Statistical analysis
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         Item: 
          Title: Primers
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         Item: 
          Title: Plasmids
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         Item: 
          Title: Antibodies
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         Item: 
          Title: Reporting summary
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        Title: References
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        Title: Acknowledgements
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       Item: 
        Title: Competing interests
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