9c24833a5a5a200d82e09639a41f4678  Dupilumab_sustains_efficacy_in_patients.pdf
3412cdd464a8ae6b116f46486f03b0e402c7abf3  Dupilumab_sustains_efficacy_in_patients.pdf
14191bb0d9258d663f5b56a7d66b4fbddbefe0f49e00df349f68e2fa9e78bdd1  Dupilumab_sustains_efficacy_in_patients.pdf

Title:           Dupilumab sustains efficacy in patients with moderate‐to‐severe type 2 asthma regardless of inhaled corticosteroids dose
Subject:         Allergy 2023.78:2921-2932
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText 4.2.0 by 1T3XT
CreationDate:    Tue Oct 24 15:00:02 2023 CEST
ModDate:         Tue May 14 16:03:21 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           12
Encrypted:       no
Page size:       595.276 x 782.362 pts
Page rot:        0
File size:       1610351 bytes
Optimized:       no
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
RESMMP+STIX-Regular                  Type 1C           Custom           yes yes yes     47  0
VCXPQH+Lato-Regular                  TrueType          WinAnsi          yes yes yes     48  0
LAZHGB+Lato-Regular                  CID TrueType      Identity-H       yes yes yes     49  0
CXHAKT+Lato-Bold                     TrueType          WinAnsi          yes yes yes     51  0
UQKJCJ+Lato-Italic                   TrueType          WinAnsi          yes yes yes    115  0
MMHIUZ+Lato-Bold                     CID TrueType      Identity-H       yes yes yes     52  0
GLIYOL+Lato-Black                    TrueType          WinAnsi          yes yes yes     50  0
Times-Roman                          Type 1            WinAnsi          no  no  no       5  0
UVAZHJ+Lato-Regular-SC700            TrueType          WinAnsi          yes yes yes    349  0
VCXPQH+Lato-Regular                  TrueType          WinAnsi          yes yes yes    350  0
UVAZHJ+Lato-Regular-SC700            TrueType          WinAnsi          yes yes yes    351  0
VCXPQH+Lato-Regular                  TrueType          WinAnsi          yes yes yes    352  0
BBVUWV+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     162  0
CFFAKT+ArialMT                       Type 1C           WinAnsi          yes yes no     163  0
CFFAKT+ArialMT                       Type 1C           Custom           yes yes no     183  0
BBVUWV+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     184  0
CFFAKT+ArialMT                       Type 1C           WinAnsi          yes yes no     185  0
BBVUWV+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     215  0
CFFAKT+ArialMT                       Type 1C           WinAnsi          yes yes no     216  0
BBVUWV+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     237  0
CFFAKT+ArialMT                       Type 1C           WinAnsi          yes yes no     238  0
BBVUWV+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     251  0
BBVUWV+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     252  0
CFFAKT+ArialMT                       Type 1C           Custom           yes yes no     253  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-05-15 02:42:17 CEST
 RepresentationInformation: Dupilumab_sustains_efficacy_in_patients.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-05-14 16:11:12 CEST
  Size: 1610351
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
    Language: en-US
    Outlines: 
     Item: 
      Title: Dupilumab sustains efficacy in patients with moderate-­to-­severe type 2 asthma regardless of inhaled corticosteroids dose
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: 1|INTRODUCTION
       Item: 
        Title: 2|METHODS
        Children: 
         Item: 
          Title: 2.1|Study design and patients
         Item: 
          Title: 2.2|Study endpoints
         Item: 
          Title: 2.3|Statistical analysis
       Item: 
        Title: 3|RESULTS
        Children: 
         Item: 
          Title: 3.1|Patients
         Item: 
          Title: 3.2|Annualized rate of severe asthma exacerbations
         Item: 
          Title: 3.3|Pre-­bronchodilator FEV1
         Item: 
          Title: 3.4|Asthma control (ACQ-­5 scores)
         Item: 
          Title: 3.5|ACQ-­5 responder analysis
         Item: 
          Title: 3.6|Biomarkers
       Item: 
        Title: 4|DISCUSSION
       Item: 
        Title: 5|CONCLUSIONS
       Item: 
        Title: AUTHOR CONTRIBUTIONS
       Item: 
        Title: ACKNOWLEDGMENTS
       Item: 
        Title: CONFLICT OF INTEREST STATEMENT
        Children: 
         Item: 
          Title: DATA AVAILABILITY STATEMENT
       Item: 
        Title: REFERENCES
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 4088
      ImageHeight: 2726
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 123
      ImageHeight: 123
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: LAZHGB+Lato-Regular
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: MMHIUZ+Lato-Bold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: BBVUWV+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: BBVUWV+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CFFAKT+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: CFFAKT+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBVUWV+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: BBVUWV+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CFFAKT+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: CFFAKT+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: RESMMP+STIX-Regular
      FontSubset: true
      FirstChar: 29
      LastChar: 61
      FontDescriptor: 
       FontName: RESMMP+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CFFAKT+ArialMT
      FontSubset: true
      FirstChar: 31
      LastChar: 177
      FontDescriptor: 
       FontName: CFFAKT+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: BBVUWV+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: BBVUWV+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBVUWV+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: BBVUWV+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CFFAKT+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 177
      FontDescriptor: 
       FontName: CFFAKT+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CFFAKT+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 177
      FontDescriptor: 
       FontName: CFFAKT+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBVUWV+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: BBVUWV+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BBVUWV+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: BBVUWV+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CFFAKT+ArialMT
      FontSubset: true
      FirstChar: 31
      LastChar: 177
      FontDescriptor: 
       FontName: CFFAKT+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
    TrueType: 
     Font: 
      BaseFont: VCXPQH+Lato-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 174
      FontDescriptor: 
       FontName: VCXPQH+Lato-Regular
       Flags: Nonsymbolic
       FontBBox: -546, -268, 1342, 1079
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: GLIYOL+Lato-Black
      FontSubset: true
      FirstChar: 32
      LastChar: 84
      FontDescriptor: 
       FontName: GLIYOL+Lato-Black
       Flags: Nonsymbolic
       FontBBox: -654, -299, 1356, 1117
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: UQKJCJ+Lato-Italic
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: UQKJCJ+Lato-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -501, -268, 1290, 1077
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: CXHAKT+Lato-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 124
      FontDescriptor: 
       FontName: CXHAKT+Lato-Bold
       Flags: Nonsymbolic
       FontBBox: -603, -285, 1344, 1100
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: MMHIUZ+Lato-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: MMHIUZ+Lato-Bold
       Flags: Symbolic
       FontBBox: -603, -285, 1344, 1100
       FontFile2: true
     Font: 
      BaseFont: LAZHGB+Lato-Regular
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: LAZHGB+Lato-Regular
       Flags: Symbolic
       FontBBox: -546, -268, 1342, 1079
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>doi:10.1111/all.15792</dc:identifier></rdf:Description>
<rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"><prism:doi>10.1111/all.15792</prism:doi><prism:url>https://doi.org/10.1111/all.15792</prism:url></rdf:Description>
<rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2023-07-11</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>onlinelibrary.wiley.com</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1111/all.15792</crossmark:DOI></rdf:Description>
<rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>onlinelibrary.wiley.com</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:doi>10.1111/all.15792</pdfx:doi><pdfx:CrossmarkMajorVersionDate>2023-07-11</pdfx:CrossmarkMajorVersionDate></rdf:Description>
<rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/"><jav:journal_article_version>VoR</jav:journal_article_version></rdf:Description>
</rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Label: 2921
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 416, 34, 519, 25
      Annotation: 
       Subtype: Link
       Rect: 116, 584, 116, 568
      Annotation: 
       Subtype: Link
       Rect: 116, 584, 121, 568
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 121, 582, 134, 569
      Annotation: 
       Subtype: Link
       Rect: 237, 584, 242, 568
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 242, 582, 254, 569
      Annotation: 
       Subtype: Link
       Rect: 340, 584, 345, 568
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 345, 582, 357, 569
      Annotation: 
       Subtype: Link
       Rect: 476, 584, 481, 568
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 481, 582, 493, 569
      Annotation: 
       Subtype: Link
       Rect: 134, 566, 139, 550
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 139, 564, 151, 551
      Annotation: 
       Subtype: Link
       Rect: 260, 566, 265, 550
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 265, 564, 277, 551
      Annotation: 
       Subtype: Link
       Rect: 364, 566, 369, 550
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 369, 564, 382, 551
      Annotation: 
       Subtype: Link
       Rect: 495, 566, 500, 550
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 500, 564, 512, 551
      Annotation: 
       Subtype: Link
       Rect: 149, 548, 153, 532
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 153, 546, 166, 533
      Annotation: 
       Subtype: Link
       Rect: 248, 548, 253, 532
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 341, 548, 346, 532
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 445, 548, 450, 532
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 130, 530, 135, 514
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 135, 528, 147, 515
      Annotation: 
       Subtype: Link
       Rect: 242, 530, 247, 514
       ActionDest: 363
      Annotation: 
       Subtype: Link
       Rect: 247, 528, 260, 515
      Annotation: 
       Subtype: Link
       Rect: 211, 74, 395, 65
      Annotation: 
       Subtype: Link
       Rect: 66, 239, 147, 230
      Annotation: 
       Subtype: Link
       Rect: 519, 782, 595, 767
    Page: 
     Label: 2922
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 131, 172, 139, 162
       ActionDest: 260
      Annotation: 
       Subtype: Link
       Rect: 101, 94, 109, 84
       ActionDest: 260
      Annotation: 
       Subtype: Link
       Rect: 485, 211, 493, 201
       ActionDest: 260
      Annotation: 
       Subtype: Link
       Rect: 425, 185, 440, 175
       ActionDest: 260
      Annotation: 
       Subtype: Link
       Rect: 529, 159, 535, 149
       ActionDest: 260
      Annotation: 
       Subtype: Link
       Rect: 505, 133, 512, 123
       ActionDest: 260
      Annotation: 
       Subtype: Link
       Rect: 456, 81, 483, 71
       ActionDest: 260
      Annotation: 
       Subtype: Link
       Rect: 496, 68, 510, 58
       ActionDest: 341
    Page: 
     Label: 2923
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 198, 718, 213, 708
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 159, 614, 166, 604
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 102, 523, 109, 513
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 167, 458, 173, 448
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 105, 250, 114, 240
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 281, 224, 288, 214
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 147, 211, 154, 201
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 128, 185, 135, 175
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 82, 81, 89, 71
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 420, 419, 426, 409
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 467, 302, 473, 292
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 538, 94, 547, 84
       ActionDest: 341
    Page: 
     Label: 2924
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 160, 679, 169, 667
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 197, 432, 201, 422
       ActionDest: 152
      Annotation: 
       Subtype: Link
       Rect: 185, 393, 190, 383
       ActionDest: 152
      Annotation: 
       Subtype: Link
       Rect: 117, 289, 122, 279
       ActionDest: 159
      Annotation: 
       Subtype: Link
       Rect: 71, 146, 82, 136
       ActionDest: 159
      Annotation: 
       Subtype: Link
       Rect: 207, 68, 217, 58
       ActionDest: 159
      Annotation: 
       Subtype: Link
       Rect: 383, 718, 392, 708
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 410, 718, 419, 708
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 437, 679, 447, 669
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 535, 536, 545, 526
       ActionDest: 181
      Annotation: 
       Subtype: Link
       Rect: 535, 406, 545, 396
       ActionDest: 181
      Annotation: 
       Subtype: Link
       Rect: 443, 380, 453, 370
       ActionDest: 181
      Annotation: 
       Subtype: Link
       Rect: 367, 354, 376, 344
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 394, 354, 403, 344
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 376, 328, 385, 318
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 489, 289, 497, 279
       ActionDest: 341
    Page: 
     Label: 2925
     Sequence: 5
    Page: 
     Label: 2926
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 170, 68, 180, 58
       ActionDest: 213
      Annotation: 
       Subtype: Link
       Rect: 334, 81, 343, 71
       ActionDest: 213
      Annotation: 
       Subtype: Link
       Rect: 500, 68, 509, 58
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 526, 68, 534, 58
       ActionDest: 341
    Page: 
     Label: 2927
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 74, 211, 85, 201
       ActionDest: 235
      Annotation: 
       Subtype: Link
       Rect: 246, 198, 256, 188
       ActionDest: 235
      Annotation: 
       Subtype: Link
       Rect: 151, 172, 164, 162
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 182, 172, 195, 162
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 363, 367, 373, 357
       ActionDest: 249
      Annotation: 
       Subtype: Link
       Rect: 334, 289, 344, 279
       ActionDest: 249
      Annotation: 
       Subtype: Link
       Rect: 397, 276, 406, 266
       ActionDest: 249
      Annotation: 
       Subtype: Link
       Rect: 360, 107, 375, 97
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 360, 68, 376, 58
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 543, 55, 549, 45
       ActionDest: 341
    Page: 
     Label: 2928
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 58, 276, 107, 266
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 217, 133, 223, 123
       ActionDest: 260
      Annotation: 
       Subtype: Link
       Rect: 76, 68, 91, 58
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 470, 276, 477, 266
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 501, 250, 515, 240
       ActionDest: 341
      Annotation: 
       Subtype: Link
       Rect: 328, 185, 335, 175
       ActionDest: 341
    Page: 
     Label: 2929
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 220, 107, 247, 97
       ActionDest: 260
      Annotation: 
       Subtype: Link
       Rect: 249, 68, 264, 58
       ActionDest: 341
    Page: 
     Label: 2930
     Sequence: 10
    Page: 
     Label: 2931
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 62, 705, 122, 695
      Annotation: 
       Subtype: Link
       Rect: 79, 107, 156, 97
      Annotation: 
       Subtype: Link
       Rect: 91, 70, 103, 58
      Annotation: 
       Subtype: Link
       Rect: 103, 68, 251, 58
      Annotation: 
       Subtype: Link
       Rect: 99, 57, 112, 45
      Annotation: 
       Subtype: Link
       Rect: 112, 55, 260, 45
      Annotation: 
       Subtype: Link
       Rect: 348, 733, 361, 721
      Annotation: 
       Subtype: Link
       Rect: 361, 731, 510, 721
      Annotation: 
       Subtype: Link
       Rect: 370, 720, 382, 708
      Annotation: 
       Subtype: Link
       Rect: 382, 718, 531, 708
      Annotation: 
       Subtype: Link
       Rect: 363, 707, 376, 695
      Annotation: 
       Subtype: Link
       Rect: 376, 705, 522, 695
      Annotation: 
       Subtype: Link
       Rect: 364, 694, 377, 682
      Annotation: 
       Subtype: Link
       Rect: 377, 692, 526, 682
      Annotation: 
       Subtype: Link
       Rect: 350, 681, 363, 669
      Annotation: 
       Subtype: Link
       Rect: 363, 679, 510, 669
      Annotation: 
       Subtype: Link
       Rect: 367, 668, 379, 656
      Annotation: 
       Subtype: Link
       Rect: 379, 666, 526, 656
      Annotation: 
       Subtype: Link
       Rect: 373, 655, 385, 643
      Annotation: 
       Subtype: Link
       Rect: 385, 653, 532, 643
      Annotation: 
       Subtype: Link
       Rect: 361, 642, 373, 630
      Annotation: 
       Subtype: Link
       Rect: 373, 640, 522, 630
      Annotation: 
       Subtype: Link
       Rect: 355, 629, 367, 617
      Annotation: 
       Subtype: Link
       Rect: 367, 627, 514, 617
      Annotation: 
       Subtype: Link
       Rect: 478, 525, 549, 515
      Annotation: 
       Subtype: Link
       Rect: 324, 514, 366, 504
    Page: 
     Label: 2932
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 455, 399, 520, 388
  Checksum: b3a8fc48
   Type: CRC32
  Checksum: 9c24833a5a5a200d82e09639a41f4678
   Type: MD5
  Checksum: 3412cdd464a8ae6b116f46486f03b0e402c7abf3
   Type: SHA-1
  Checksum: 14191bb0d9258d663f5b56a7d66b4fbddbefe0f49e00df349f68e2fa9e78bdd1
   Type: SHA-256