f40ecda3e706311cd102ad8d06b7dd45 PIIS1081120623001801.pdf 97687ea001e2d495d9d02b73b5a73ff5fa5841e7 PIIS1081120623001801.pdf 40cd2f1ed15be0e49c9160c94acb9cdd3abd5915a4b42ba5017fa886e99f0c5a PIIS1081120623001801.pdf Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Fri Jun 9 04:59:30 2023 CEST ModDate: Fri Jun 9 04:59:54 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 585.071 x 782.929 pts Page rot: 0 File size: 1980093 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OLEFMI+AdvOT5fa4e291 Type 1C WinAnsi yes yes no 727 0 OLEMKF+AdvOTb0c9bf5d+22 Type 1C Custom yes yes yes 730 0 OLEMKG+AdvOTb0c9bf5d Type 1C WinAnsi yes yes no 724 0 OLEMKH+AdvTT488bbd95+22 Type 1C Custom yes yes no 714 0 OLENCE+AdvPAC3D Type 1C WinAnsi yes yes no 665 0 OLEMHN+AdvP4C4E74 Type 1C Custom yes yes yes 740 0 OLEMIO+AdvTT488bbd95+01 Type 1C Custom yes yes yes 655 0 OLEMIP+AdvOTf2586c63 Type 1C WinAnsi yes yes no 721 0 OLEMJA+AdvOTf2586c63+20 Type 1C WinAnsi yes yes no 652 0 OLEMJB+AdvP4C4E59 Type 1C Custom yes yes no 648 0 OLEMKC+AdvOTf2586c63+fb Type 1C Custom yes yes yes 660 0 OLEMKD+AdvTTb83ee1dd.B Type 1C WinAnsi yes yes no 718 0 OLEMKE+AdvOT5fa4e291+fb Type 1C Custom yes yes yes 735 0 OLENJD+AdvTT488bbd95+20 Type 1C Custom yes yes yes 304 0 OLENKD+AdvP49A570 Type 1C WinAnsi yes yes no 309 0 OLENLE+AdvOT5fa4e291+20 Type 1C WinAnsi yes yes no 312 0 OLENME+AdvP4C9543 Type 1C WinAnsi yes yes no 49 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-16 02:38:20 CEST RepresentationInformation: PIIS1081120623001801.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-15 18:42:16 CEST Size: 1980093 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 766 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Dupilumab pharmacokinetics and effect on type 2 biomarkers in children with moderate-to-severe asthma Destination: Head1 Children: Item: Title: Introduction Destination: Head2 Item: Title: Methods Destination: Head3 Children: Item: Title: Study Design Destination: Head4 Item: Title: Pharmacokinetic Analysis Destination: Head5 Item: Title: Pharmacodynamic Biomarker Analysis Destination: Head6 Item: Title: Statistical Analysis of Biomarkers Levels Over Time Destination: Head7 Item: Title: Results Destination: Head8 Children: Item: Title: Demographics Destination: Head9 Item: Title: Pharmacokinetics Destination: Head10 Item: Title: Pharmacodynamics Destination: Head11 Item: Title: Serum Total Immunoglobulin E Destination: Head12 Item: Title: Serum Thymus and Activation-Regulated Chemokine Destination: Head13 Item: Title: Blood Eosinophil Counts Destination: Head14 Item: Title: Fractional Exhaled Nitric Oxide Destination: Head15 Item: Title: Discussion Destination: Head16 Item: Title: Conclusion Destination: Head17 Item: Title: Acknowledgments Destination: Head18 Item: Title: Supplementary Data Destination: Head19 Item: Title: References Destination: Head20 Info: Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Fri Jun 09 05:29:30 CEST 2023 ModDate: Fri Jun 09 05:29:54 CEST 2023 ID: 0x89094bf7e9a8392d94fbc7281e31191a, 0x7f1f10207a4810250027adc50130545b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 235 ImageHeight: 299 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1041 ImageHeight: 213 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1587 ImageHeight: 1104 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1552 ImageHeight: 1079 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: OLEMHN+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 123 FontDescriptor: FontName: OLEMHN+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OLEMJB+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OLEMJB+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: OLEMKH+AdvTT488bbd95+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: OLEMKH+AdvTT488bbd95+22 Flags: Nonsymbolic FontBBox: 9, -312, 1208, 927 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OLEMJA+AdvOTf2586c63+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: OLEMJA+AdvOTf2586c63+20 Flags: Nonsymbolic FontBBox: -41, -208, 885, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OLEMKD+AdvTTb83ee1dd.B FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: OLEMKD+AdvTTb83ee1dd.B Flags: Serif, Nonsymbolic FontBBox: -93, -250, 1041, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OLEMIO+AdvTT488bbd95+01 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OLEMIO+AdvTT488bbd95+01 Flags: Symbolic FontBBox: -41, -218, 1156, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OLENJD+AdvTT488bbd95+20 FontSubset: true FirstChar: 1 LastChar: 132 FontDescriptor: FontName: OLENJD+AdvTT488bbd95+20 Flags: Symbolic FontBBox: -1468, -416, 1208, 1281 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OLEMIP+AdvOTf2586c63 FontSubset: true FirstChar: 38 LastChar: 237 FontDescriptor: FontName: OLEMIP+AdvOTf2586c63 Flags: Serif, Nonsymbolic FontBBox: -135, -229, 1052, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OLENME+AdvP4C9543 FontSubset: true FirstChar: 167 LastChar: 167 FontDescriptor: FontName: OLENME+AdvP4C9543 Flags: Nonsymbolic FontBBox: 0, -947, 1041, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OLEMKG+AdvOTb0c9bf5d FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OLEMKG+AdvOTb0c9bf5d Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OLEMKC+AdvOTf2586c63+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OLEMKC+AdvOTf2586c63+fb Flags: Symbolic FontBBox: -114, -208, 833, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OLENKD+AdvP49A570 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: OLENKD+AdvP49A570 Flags: Nonsymbolic FontBBox: -20, -208, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OLEFMI+AdvOT5fa4e291 FontSubset: true FirstChar: 35 LastChar: 169 FontDescriptor: FontName: OLEFMI+AdvOT5fa4e291 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 1041, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OLENLE+AdvOT5fa4e291+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: OLENLE+AdvOT5fa4e291+20 Flags: Nonsymbolic FontBBox: 19, -208, 947, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OLENCE+AdvPAC3D FontSubset: true FirstChar: 67 LastChar: 118 FontDescriptor: FontName: OLENCE+AdvPAC3D Flags: Nonsymbolic FontBBox: -166, -239, 989, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OLEMKF+AdvOTb0c9bf5d+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OLEMKF+AdvOTb0c9bf5d+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OLEMKE+AdvOT5fa4e291+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OLEMKE+AdvOT5fa4e291+fb Flags: Symbolic FontBBox: 40, 0, 572, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2012-08-24T16:03:10+05:30 Elsevier 2013-02-20T16:20:50+05:30 2013-02-20T16:20:50+05:30 Acrobat Distiller 9.0.0 (Windows) application/pdf doi:10.1016/j.anai.2023.03.014 Dupilumab pharmacokinetics and effect on type 2 biomarkers in children with moderate-to-severe asthma Daniel J. Jackson MD Leonard B. Bacharier MD Wanda Phipatanakul MD Lawrence Sher MD Christian Domingo MD Nikolaos Papadopoulos MD Brian Modena MD Ning Li MS Changming Xia PhD Mohamed A. Kamal PharmD, PhD Myles Dillon PhD Kelley Wolfe MSc Rebecca Gall MD Nikhil Amin MD Leda P. Mannent MD Elizabeth Laws PhD Paul J. Rowe MD Juby A. Jacob-Nara MD Yamo Deniz MD David J. Lederer MD Megan Hardin MD Christine Xu PhD Annals of Allergy, Asthma & Immunology, 131 (2023) 44-51.e4. doi:10.1016/j.anai.2023.03.014 Elsevier Inc. uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:d56e5e26-6274-4fa7-ad08-30fc2ecddb91 journal © 2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. Annals of Allergy, Asthma & Immunology 1081-1206 131 1 10.1016/j.anai.2023.03.014 https://doi.org/10.1016/j.anai.2023.03.014 44 51.e4 44-51.e4 July 2023 7.0 2010-04-23 true http://creativecommons.org/licenses/by-nc-nd/4.0/ VoR 10.1016/j.anai.2023.03.014 noindex sciencedirect.com elsevier.com sciencedirect.com elsevier.com true 2010-04-23 10.1016/j.anai.2023.03.014 sciencedirect.com elsevier.com True Pages: Page: Label: 44 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 473, 589, 551, 604 Annotation: Subtype: Link Rect: 131, 543, 136, 554 Destination: 623 Annotation: Subtype: Link Rect: 263, 549, 266, 556 Destination: 623 Annotation: Subtype: Link Rect: 395, 549, 398, 556 Destination: 623 Annotation: Subtype: Link Rect: 124, 536, 127, 543 Destination: 623 Annotation: Subtype: Link Rect: 246, 535, 249, 546 Destination: 623 Annotation: Subtype: Link Rect: 389, 536, 394, 543 Destination: 623 Annotation: Subtype: Link Rect: 121, 522, 126, 533 Destination: 623 Annotation: Subtype: Link Rect: 186, 517, 191, 528 Destination: 623 Annotation: Subtype: Link Rect: 191, 517, 195, 528 Destination: 623 Annotation: Subtype: Link Rect: 299, 523, 302, 530 Destination: 623 Annotation: Subtype: Link Rect: 302, 523, 306, 530 Destination: 623 Annotation: Subtype: Link Rect: 194, 510, 197, 517 Destination: 623 Annotation: Subtype: Link Rect: 197, 510, 201, 517 Destination: 623 Annotation: Subtype: Link Rect: 292, 510, 296, 517 Destination: 623 Annotation: Subtype: Link Rect: 296, 510, 299, 517 Destination: 623 Annotation: Subtype: Link Rect: 392, 510, 395, 517 Destination: 623 Annotation: Subtype: Link Rect: 395, 510, 399, 517 Destination: 623 Annotation: Subtype: Link Rect: 114, 497, 117, 504 Destination: 623 Annotation: Subtype: Link Rect: 117, 497, 121, 504 Destination: 623 Annotation: Subtype: Link Rect: 207, 497, 210, 504 Destination: 623 Annotation: Subtype: Link Rect: 210, 497, 214, 504 Destination: 623 Annotation: Subtype: Link Rect: 322, 497, 325, 504 Destination: 623 Annotation: Subtype: Link Rect: 325, 497, 329, 504 Destination: 623 Annotation: Subtype: Link Rect: 431, 497, 434, 504 Destination: 623 Annotation: Subtype: Link Rect: 434, 497, 438, 504 Destination: 623 Annotation: Subtype: Link Rect: 112, 484, 115, 491 Destination: 623 Annotation: Subtype: Link Rect: 115, 484, 119, 491 Destination: 623 Annotation: Subtype: Link Rect: 235, 484, 239, 491 Destination: 623 Annotation: Subtype: Link Rect: 239, 484, 242, 491 Destination: 623 Annotation: Subtype: Link Rect: 328, 484, 332, 491 Destination: 623 Annotation: Subtype: Link Rect: 332, 484, 335, 491 Destination: 623 Annotation: Subtype: Link Rect: 439, 484, 442, 491 Destination: 623 Annotation: Subtype: Link Rect: 442, 484, 446, 491 Destination: 623 Annotation: Subtype: Link Rect: 122, 470, 129, 481 Destination: 623 Annotation: Subtype: Link Rect: 219, 472, 222, 478 Destination: 623 Annotation: Subtype: Link Rect: 222, 472, 226, 478 Destination: 623 Annotation: Subtype: Link Rect: 54, 172, 120, 178 Annotation: Subtype: Link Rect: 31, 36, 154, 42 Annotation: Subtype: Link Rect: 34, 18, 182, 25 Annotation: Subtype: Link Rect: 221, 730, 362, 737 Annotation: Subtype: Link Rect: 316, 703, 367, 710 Page: Label: 45 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 303, 626, 471, 633 Annotation: Subtype: Link Rect: 92, 556, 104, 563 Destination: 130 Annotation: Subtype: Link Rect: 48, 545, 51, 553 Destination: 130 Annotation: Subtype: Link Rect: 61, 535, 64, 543 Destination: 130 Annotation: Subtype: Link Rect: 186, 514, 190, 522 Destination: 130 Annotation: Subtype: Link Rect: 187, 493, 190, 501 Destination: 161 Annotation: Subtype: Link Rect: 109, 482, 112, 490 Destination: 161 Annotation: Subtype: Link Rect: 155, 472, 170, 480 Destination: 161 Annotation: Subtype: Link Rect: 144, 440, 159, 448 Destination: 161 Annotation: Subtype: Link Rect: 136, 420, 143, 428 Destination: 161 Annotation: Subtype: Link Rect: 192, 409, 198, 417 Destination: 161 Annotation: Subtype: Link Rect: 200, 409, 207, 417 Destination: 161 Annotation: Subtype: Link Rect: 156, 367, 163, 375 Destination: 161 Annotation: Subtype: Link Rect: 165, 367, 171, 375 Destination: 161 Annotation: Subtype: Link Rect: 201, 346, 208, 354 Destination: 161 Annotation: Subtype: Link Rect: 82, 315, 88, 323 Destination: 161 Annotation: Subtype: Link Rect: 90, 315, 97, 323 Destination: 161 Annotation: Subtype: Link Rect: 226, 284, 233, 292 Destination: 161 Annotation: Subtype: Link Rect: 235, 284, 242, 292 Destination: 161 Annotation: Subtype: Link Rect: 131, 242, 138, 250 Destination: 161 Annotation: Subtype: Link Rect: 75, 179, 82, 187 Destination: 161 Annotation: Subtype: Link Rect: 55, 148, 62, 156 Destination: 161 Annotation: Subtype: Link Rect: 134, 106, 141, 114 Destination: 161 Annotation: Subtype: Link Rect: 142, 106, 149, 114 Destination: 161 Annotation: Subtype: Link Rect: 466, 550, 473, 558 Destination: 161 Annotation: Subtype: Link Rect: 510, 310, 517, 318 Destination: 161 Annotation: Subtype: Link Rect: 518, 310, 525, 318 Destination: 161 Annotation: Subtype: Link Rect: 526, 310, 533, 318 Destination: 161 Annotation: Subtype: Link Rect: 534, 171, 552, 179 Destination: 161 Annotation: Subtype: Link Rect: 546, 98, 552, 106 Destination: 161 Page: Label: 46 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 346, 459, 373, 467 Destination: 34 Annotation: Subtype: Link Rect: 394, 459, 412, 467 Destination: 42 Annotation: Subtype: Link Rect: 123, 212, 126, 219 Destination: 34 Annotation: Subtype: Link Rect: 135, 50, 140, 56 Destination: 161 Annotation: Subtype: Link Rect: 141, 39, 165, 45 Destination: 282 Page: Label: 47 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 72, 238, 90, 246 Destination: 42 Annotation: Subtype: Link Rect: 108, 238, 138, 246 Destination: 282 Annotation: Subtype: Link Rect: 155, 118, 173, 126 Destination: 70 Annotation: Subtype: Link Rect: 261, 97, 277, 105 Destination: 70 Annotation: Subtype: Link Rect: 122, 29, 154, 37 Destination: 104 Annotation: Subtype: Link Rect: 172, 29, 176, 37 Destination: 130 Annotation: Subtype: Link Rect: 329, 191, 346, 199 Destination: 104 Annotation: Subtype: Link Rect: 355, 191, 384, 199 Destination: 287 Annotation: Subtype: Link Rect: 493, 170, 510, 178 Destination: 130 Annotation: Subtype: Link Rect: 519, 170, 548, 178 Destination: 287 Annotation: Subtype: Link Rect: 488, 139, 507, 147 Destination: 104 Annotation: Subtype: Link Rect: 517, 139, 548, 147 Destination: 287 Annotation: Subtype: Link Rect: 453, 118, 469, 126 Destination: 130 Annotation: Subtype: Link Rect: 478, 118, 507, 126 Destination: 287 Annotation: Subtype: Link Rect: 353, 50, 372, 58 Destination: 104 Annotation: Subtype: Link Rect: 381, 50, 413, 58 Destination: 287 Annotation: Subtype: Link Rect: 357, 266, 363, 272 Destination: 161 Page: Label: 48 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 61, 60, 80, 68 Destination: 130 Annotation: Subtype: Link Rect: 91, 60, 123, 68 Destination: 287 Annotation: Subtype: Link Rect: 34, 29, 52, 37 Destination: 130 Annotation: Subtype: Link Rect: 61, 29, 92, 37 Destination: 287 Annotation: Subtype: Link Rect: 475, 698, 492, 706 Destination: 104 Annotation: Subtype: Link Rect: 501, 698, 531, 706 Destination: 287 Annotation: Subtype: Link Rect: 390, 639, 409, 647 Destination: 104 Annotation: Subtype: Link Rect: 419, 639, 451, 647 Destination: 287 Annotation: Subtype: Link Rect: 488, 597, 506, 605 Destination: 130 Annotation: Subtype: Link Rect: 515, 597, 547, 605 Destination: 287 Annotation: Subtype: Link Rect: 303, 524, 320, 532 Destination: 130 Annotation: Subtype: Link Rect: 329, 524, 359, 532 Destination: 287 Annotation: Subtype: Link Rect: 410, 444, 427, 452 Destination: 104 Annotation: Subtype: Link Rect: 437, 444, 468, 452 Destination: 287 Annotation: Subtype: Link Rect: 410, 402, 427, 410 Destination: 130 Annotation: Subtype: Link Rect: 437, 402, 467, 410 Destination: 287 Annotation: Subtype: Link Rect: 330, 381, 347, 389 Destination: 104 Annotation: Subtype: Link Rect: 365, 329, 382, 337 Destination: 130 Annotation: Subtype: Link Rect: 385, 329, 416, 337 Destination: 287 Annotation: Subtype: Link Rect: 303, 287, 328, 295 Destination: 293 Annotation: Subtype: Link Rect: 331, 287, 336, 295 Destination: 293 Annotation: Subtype: Link Rect: 340, 287, 370, 295 Destination: 290 Annotation: Subtype: Link Rect: 465, 179, 472, 187 Destination: 161 Annotation: Subtype: Link Rect: 448, 106, 455, 114 Destination: 161 Annotation: Subtype: Link Rect: 455, 64, 461, 72 Destination: 161 Annotation: Subtype: Link Rect: 463, 64, 470, 72 Destination: 161 Annotation: Subtype: Link Rect: 471, 64, 478, 72 Destination: 161 Page: Label: 49 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 220, 294, 227, 302 Destination: 161 Annotation: Subtype: Link Rect: 228, 294, 235, 302 Destination: 161 Annotation: Subtype: Link Rect: 236, 294, 243, 302 Destination: 161 Annotation: Subtype: Link Rect: 170, 221, 176, 229 Destination: 161 Annotation: Subtype: Link Rect: 178, 221, 185, 229 Destination: 161 Annotation: Subtype: Link Rect: 229, 137, 236, 145 Destination: 161 Annotation: Subtype: Link Rect: 69, 95, 84, 103 Destination: 161 Annotation: Subtype: Link Rect: 148, 64, 155, 72 Destination: 161 Annotation: Subtype: Link Rect: 73, 43, 80, 51 Destination: 161 Annotation: Subtype: Link Rect: 248, 32, 255, 40 Destination: 161 Annotation: Subtype: Link Rect: 489, 294, 512, 302 Destination: 161 Annotation: Subtype: Link Rect: 427, 242, 434, 250 Destination: 161 Annotation: Subtype: Link Rect: 319, 210, 326, 218 Destination: 161 Annotation: Subtype: Link Rect: 342, 189, 349, 197 Destination: 161 Annotation: Subtype: Link Rect: 349, 158, 367, 166 Destination: 161 Annotation: Subtype: Link Rect: 331, 85, 338, 93 Destination: 161 Annotation: Subtype: Link Rect: 340, 85, 358, 93 Destination: 161 Annotation: Subtype: Link Rect: 395, 64, 402, 72 Destination: 161 Annotation: Subtype: Link Rect: 431, 53, 446, 61 Destination: 161 Page: Label: 50 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 56, 263, 71, 271 Destination: 161 Annotation: Subtype: Link Rect: 125, 231, 140, 239 Destination: 161 Annotation: Subtype: Link Rect: 156, 200, 179, 208 Destination: 161 Annotation: Subtype: Link Rect: 524, 212, 551, 220 Annotation: Subtype: Link Rect: 300, 201, 427, 209 Annotation: Subtype: Link Rect: 313, 157, 551, 163 Annotation: Subtype: Link Rect: 313, 149, 386, 155 Annotation: Subtype: Link Rect: 313, 141, 549, 147 Annotation: Subtype: Link Rect: 313, 133, 551, 139 Annotation: Subtype: Link Rect: 313, 125, 353, 131 Annotation: Subtype: Link Rect: 512, 117, 551, 123 Annotation: Subtype: Link Rect: 313, 109, 365, 115 Annotation: Subtype: Link Rect: 313, 101, 551, 107 Annotation: Subtype: Link Rect: 313, 93, 551, 99 Annotation: Subtype: Link Rect: 313, 85, 514, 91 Annotation: Subtype: Link Rect: 313, 77, 551, 83 Annotation: Subtype: Link Rect: 313, 69, 551, 76 Annotation: Subtype: Link Rect: 313, 61, 551, 68 Annotation: Subtype: Link Rect: 313, 53, 368, 60 Annotation: Subtype: Link Rect: 313, 45, 551, 52 Annotation: Subtype: Link Rect: 313, 37, 551, 44 Annotation: Subtype: Link Rect: 313, 29, 493, 36 Page: Label: 51 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 45, 709, 283, 716 Annotation: Subtype: Link Rect: 45, 701, 283, 708 Annotation: Subtype: Link Rect: 45, 693, 100, 700 Annotation: Subtype: Link Rect: 45, 685, 283, 692 Annotation: Subtype: Link Rect: 45, 677, 225, 684 Annotation: Subtype: Link Rect: 45, 669, 283, 676 Annotation: Subtype: Link Rect: 45, 661, 283, 668 Annotation: Subtype: Link Rect: 45, 653, 119, 660 Annotation: Subtype: Link Rect: 45, 645, 283, 652 Annotation: Subtype: Link Rect: 45, 638, 277, 644 Annotation: Subtype: Link Rect: 45, 630, 283, 636 Annotation: Subtype: Link Rect: 45, 622, 128, 628 Annotation: Subtype: Link Rect: 45, 614, 283, 620 Annotation: Subtype: Link Rect: 45, 606, 283, 612 Annotation: Subtype: Link Rect: 45, 598, 129, 604 Annotation: Subtype: Link Rect: 45, 590, 283, 596 Annotation: Subtype: Link Rect: 45, 582, 283, 588 Annotation: Subtype: Link Rect: 45, 574, 227, 580 Annotation: Subtype: Link Rect: 45, 566, 283, 572 Annotation: Subtype: Link Rect: 45, 558, 283, 564 Annotation: Subtype: Link Rect: 45, 550, 118, 556 Annotation: Subtype: Link Rect: 45, 542, 283, 548 Annotation: Subtype: Link Rect: 45, 534, 283, 540 Annotation: Subtype: Link Rect: 45, 526, 137, 532 Annotation: Subtype: Link Rect: 45, 518, 283, 524 Annotation: Subtype: Link Rect: 45, 510, 283, 516 Annotation: Subtype: Link Rect: 45, 502, 153, 508 Annotation: Subtype: Link Rect: 45, 494, 283, 500 Annotation: Subtype: Link Rect: 45, 486, 283, 492 Annotation: Subtype: Link Rect: 45, 478, 132, 484 Annotation: Subtype: Link Rect: 130, 462, 283, 469 Annotation: Subtype: Link Rect: 45, 454, 157, 461 Annotation: Subtype: Link Rect: 45, 446, 283, 453 Annotation: Subtype: Link Rect: 45, 438, 225, 445 Annotation: Subtype: Link Rect: 45, 430, 283, 437 Annotation: Subtype: Link Rect: 45, 422, 178, 429 Annotation: Subtype: Link Rect: 183, 422, 283, 429 Annotation: Subtype: Link Rect: 45, 414, 220, 421 Annotation: Subtype: Link Rect: 45, 406, 283, 413 Annotation: Subtype: Link Rect: 45, 398, 283, 405 Annotation: Subtype: Link Rect: 45, 390, 122, 397 Annotation: Subtype: Link Rect: 45, 382, 283, 389 Annotation: Subtype: Link Rect: 45, 374, 283, 381 Annotation: Subtype: Link Rect: 45, 367, 176, 373 Annotation: Subtype: Link Rect: 45, 359, 283, 365 Annotation: Subtype: Link Rect: 45, 351, 226, 357 Annotation: Subtype: Link Rect: 45, 343, 283, 349 Annotation: Subtype: Link Rect: 45, 335, 283, 341 Annotation: Subtype: Link Rect: 45, 327, 202, 333 Annotation: Subtype: Link Rect: 45, 319, 283, 325 Annotation: Subtype: Link Rect: 45, 311, 283, 317 Annotation: Subtype: Link Rect: 45, 303, 122, 309 Annotation: Subtype: Link Rect: 45, 295, 283, 301 Annotation: Subtype: Link Rect: 45, 287, 283, 293 Annotation: Subtype: Link Rect: 45, 279, 208, 285 Annotation: Subtype: Link Rect: 213, 279, 283, 285 Annotation: Subtype: Link Rect: 45, 271, 283, 277 Annotation: Subtype: Link Rect: 45, 263, 118, 269 Annotation: Subtype: Link Rect: 45, 231, 283, 237 Annotation: Subtype: Link Rect: 45, 223, 283, 229 Annotation: Subtype: Link Rect: 314, 709, 552, 716 Annotation: Subtype: Link Rect: 314, 701, 330, 708 Annotation: Subtype: Link Rect: 495, 677, 552, 684 Annotation: Subtype: Link Rect: 314, 669, 528, 676 Annotation: Subtype: Link Rect: 314, 653, 552, 660 Annotation: Subtype: Link Rect: 314, 645, 552, 652 Annotation: Subtype: Link Rect: 314, 638, 371, 644 Annotation: Subtype: Link Rect: 376, 638, 552, 644 Annotation: Subtype: Link Rect: 314, 630, 471, 636 Annotation: Subtype: Link Rect: 314, 622, 552, 628 Annotation: Subtype: Link Rect: 314, 614, 461, 620 Annotation: Subtype: Link Rect: 513, 598, 552, 604 Annotation: Subtype: Link Rect: 314, 590, 493, 596 Annotation: Subtype: Link Rect: 314, 574, 552, 580 Annotation: Subtype: Link Rect: 314, 566, 552, 572 Annotation: Subtype: Link Rect: 314, 558, 545, 564 Annotation: Subtype: Link Rect: 314, 550, 552, 556 Annotation: Subtype: Link Rect: 314, 542, 552, 548 Annotation: Subtype: Link Rect: 314, 534, 363, 540 Annotation: Subtype: Link Rect: 314, 526, 552, 532 Annotation: Subtype: Link Rect: 314, 518, 508, 524 Annotation: Subtype: Link Rect: 314, 510, 552, 516 Annotation: Subtype: Link Rect: 314, 502, 552, 508 Annotation: Subtype: Link Rect: 314, 494, 489, 500 Annotation: Subtype: Link Rect: 314, 486, 552, 492 Annotation: Subtype: Link Rect: 314, 478, 453, 484 Annotation: Subtype: Link Rect: 314, 470, 552, 477 Annotation: Subtype: Link Rect: 314, 462, 552, 469 Annotation: Subtype: Link Rect: 314, 454, 387, 461 Annotation: Subtype: Link Rect: 314, 446, 552, 453 Annotation: Subtype: Link Rect: 314, 438, 541, 445 Annotation: Subtype: Link Rect: 314, 430, 552, 437 Annotation: Subtype: Link Rect: 314, 422, 552, 429 Annotation: Subtype: Link Rect: 314, 414, 330, 421 Annotation: Subtype: Link Rect: 314, 406, 552, 413 Annotation: Subtype: Link Rect: 314, 398, 552, 405 Annotation: Subtype: Link Rect: 314, 390, 552, 397 Annotation: Subtype: Link Rect: 314, 382, 330, 389 Annotation: Subtype: Link Rect: 314, 374, 552, 381 Annotation: Subtype: Link Rect: 314, 367, 446, 373 Annotation: Subtype: Link Rect: 314, 359, 552, 365 Annotation: Subtype: Link Rect: 314, 351, 537, 357 Annotation: Subtype: Link Rect: 314, 343, 552, 349 Annotation: Subtype: Link Rect: 314, 335, 552, 341 Annotation: Subtype: Link Rect: 314, 327, 552, 333 Annotation: Subtype: Link Rect: 314, 319, 458, 325 Annotation: Subtype: Link Rect: 314, 311, 552, 317 Annotation: Subtype: Link Rect: 314, 303, 465, 309 Annotation: Subtype: Link Rect: 314, 295, 552, 301 Annotation: Subtype: Link Rect: 314, 287, 552, 293 Annotation: Subtype: Link Rect: 314, 279, 552, 285 Annotation: Subtype: Link Rect: 314, 271, 424, 277 Annotation: Subtype: Link Rect: 314, 263, 552, 269 Annotation: Subtype: Link Rect: 314, 255, 552, 261 Annotation: Subtype: Link Rect: 314, 247, 493, 253 Annotation: Subtype: Link Rect: 314, 239, 552, 245 Annotation: Subtype: Link Rect: 314, 231, 552, 237 Annotation: Subtype: Link Rect: 314, 223, 330, 229 Page: Label: 52 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 123, 476, 126, 482 Destination: 282 Annotation: Subtype: Link Rect: 135, 305, 140, 311 Destination: 161 Page: Label: 53 Sequence: 10 Page: Label: 54 Sequence: 11 Page: Label: 55 Sequence: 12 Checksum: 43fdfa8b Type: CRC32 Checksum: f40ecda3e706311cd102ad8d06b7dd45 Type: MD5 Checksum: 97687ea001e2d495d9d02b73b5a73ff5fa5841e7 Type: SHA-1 Checksum: 40cd2f1ed15be0e49c9160c94acb9cdd3abd5915a4b42ba5017fa886e99f0c5a Type: SHA-256