9fb7b3481493d6864a5b78a372760bd5  292241.pdf
9269081ba7b20ae2de42803ab0e3f9d02b900d7d  292241.pdf
f3d27b129f21512c7e4e1d5cf3b96aa4c92b6553df4ed5c4a7e20d2eef0b8b87  292241.pdf

Title:           Influence of cannabis use on incidence of psychosis in people at clinical high risk
Keywords:        clinical high-risk, longitudinal, psychotic disorders, substance use, THC
Author:          Lucy A. Chester, Lucia R. Valmaggia, Matthew J. Kempton, Edward Chesney, Dominic Oliver, Emily P. Hedges, Elise Klatsa, Daniel Stahl, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Patrick McGorry, G. Paul Amminger, Anita Riecher-Rössler, Erich Studerus, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Birte Glenthøj, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Philip McGuire
Creator:         Antenna House Formatter V7.3 MR1 Linux : 7.3.2.60453 (2023-03-06T13:41+09)
Producer:        Antenna House PDF Output Library 7.3.1863
CreationDate:    Tue Jan 30 04:06:10 2024 CET
ModDate:         Tue Jan 30 04:06:10 2024 CET
Custom Metadata: no
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           19
Encrypted:       no
Page size:       612 x 792 pts (letter)
Page rot:        0
File size:       613343 bytes
Optimized:       no
PDF version:     1.5


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
Helvetica-Bold                       Type 1            Custom           no  no  yes     11  0
Helvetica                            Type 1            Custom           no  no  yes     14  0
Times-Roman                          Type 1            Custom           no  no  yes     61  0
Times-Bold                           Type 1            Custom           no  no  yes     67  0
Helvetica-BoldOblique                Type 1            Standard         no  no  no      72  0
HUEGJY+Code2000                      CID TrueType      Identity-H       yes yes yes    278  0
Times-BoldItalic                     Type 1            Standard         no  no  no     563  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-05-25 02:36:14 CEST
 RepresentationInformation: 292241.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-05-24 12:28:40 CEST
  Size: 613343
  Format: PDF
  Version: 1.5
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 0
   FreeObjects: 495
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Abstract
     Item: 
      Title: Methods
      Children: 
       Item: 
        Title: Recruitment of participants
       Item: 
        Title: Inclusion and exclusion criteria
       Item: 
        Title: Ethics statement
       Item: 
        Title: Baseline assessments
       Item: 
        Title: Assessment of clinical outcomes
       Item: 
        Title: Statistical analysis
     Item: 
      Title: Results
      Children: 
       Item: 
        Title: Comparison of CHR and HC populations
       Item: 
        Title: Cannabis use and clinical outcomes
       Item: 
        Title: Onset of psychosis
       Item: 
        Title: Persistence of symptoms
       Item: 
        Title: Level of functioning at follow-up
     Item: 
      Title: Discussion
     Item: 
      Title: Conclusions
     Item: 
      Title: References
     Item: 
      Title: Figure 1
     Item: 
      Title: Table 1
     Item: 
      Title: Table 2
     Item: 
      Title: Table 3
     Item: 
      Title: Table 4
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1680
      ImageHeight: 2099
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 16
      ImageHeight: 16
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type0: 
     Font: 
      BaseFont: HUEGJY+Code2000
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: Times-Bold
      FirstChar: 32
      LastChar: 128
      FontDescriptor: 
       FontName: Times-Bold
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: Times-BoldItalic
     Font: 
      BaseFont: Helvetica-BoldOblique
     Font: 
      BaseFont: Helvetica-Bold
      FirstChar: 32
      LastChar: 130
      FontDescriptor: 
       FontName: Helvetica-Bold
       Flags: Nonsymbolic
       FontBBox: -170, -228, 1003, 962
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: Times-Roman
      FirstChar: 32
      LastChar: 145
      FontDescriptor: 
       FontName: Times-Roman
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 898
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: Helvetica
      FirstChar: 32
      LastChar: 137
      FontDescriptor: 
       FontName: Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: HUEGJY+Code2000
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: HUEGJY+Code2000
       Flags: Symbolic
       FontBBox: -1111, -295, 2107, 977
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:dc="http://purl.org/dc/elements/1.1/">
<xmp:CreateDate>2024-01-29T22:06:10-05:00</xmp:CreateDate>
<xmp:ModifyDate>2024-01-29T22:06:10-05:00</xmp:ModifyDate>
<dc:format>application/pdf</dc:format>
<pdf:Producer>Antenna House PDF Output Library 7.3.1863</pdf:Producer>
<pdf:Keywords>clinical high-risk, longitudinal, psychotic disorders, substance use, THC</pdf:Keywords>
<xmp:CreatorTool>Antenna House Formatter V7.3 MR1 Linux : 7.3.2.60453 (2023-03-06T13:41+09)</xmp:CreatorTool>
<xmp:MetadataDate>2024-01-29T22:06:10-05:00</xmp:MetadataDate>
<dc:title><rdf:Alt><rdf:li xml:lang="x-default">Influence of cannabis use on incidence of psychosis in people at clinical high risk</rdf:li></rdf:Alt></dc:title>
<dc:creator><rdf:Seq><rdf:li>Lucy A. Chester, Lucia R. Valmaggia, Matthew J. Kempton, Edward Chesney, Dominic Oliver, Emily P. Hedges, Elise Klatsa, Daniel Stahl, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Patrick McGorry, G. Paul Amminger, Anita Riecher-Rössler, Erich Studerus, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Birte Glenthøj, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Philip McGuire</rdf:li></rdf:Seq></dc:creator>
<dc:subject><rdf:Bag><rdf:li>clinical high-risk</rdf:li><rdf:li>longitudinal</rdf:li><rdf:li>psychotic disorders</rdf:li><rdf:li>substance use</rdf:li><rdf:li>THC</rdf:li></rdf:Bag></dc:subject>
</rdf:Description></rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: BY 4.0
       Rect: 185, 156, 209, 164
       LastModified: D:20240129220610-05'00'
    Page: 
     Sequence: 2
    Page: 
     Sequence: 3
    Page: 
     Sequence: 4
    Page: 
     Sequence: 5
    Page: 
     Sequence: 6
    Page: 
     Sequence: 7
    Page: 
     Sequence: 8
    Page: 
     Sequence: 9
    Page: 
     Sequence: 10
    Page: 
     Sequence: 11
    Page: 
     Sequence: 12
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: https://www.earlypsychosis.ca/what-causes-psychosis/ 
       Rect: 432, 116, 457, 125
       LastModified: D:20240129220610-05'00'
      Annotation: 
       Subtype: Link
       Contents: www.earlypsychosis.ca/what-causes-psychosis/ 
       Rect: 165, 105, 336, 114
       LastModified: D:20240129220610-05'00'
    Page: 
     Sequence: 14
    Page: 
     Sequence: 15
    Page: 
     Sequence: 16
    Page: 
     Sequence: 17
    Page: 
     Sequence: 18
    Page: 
     Sequence: 19
  Checksum: cc7ea27d
   Type: CRC32
  Checksum: 9fb7b3481493d6864a5b78a372760bd5
   Type: MD5
  Checksum: 9269081ba7b20ae2de42803ab0e3f9d02b900d7d
   Type: SHA-1
  Checksum: f3d27b129f21512c7e4e1d5cf3b96aa4c92b6553df4ed5c4a7e20d2eef0b8b87
   Type: SHA-256