83618a2864daa1205e01cd74a448aa27 humgen_a2023v17a20iENG.pdf 2ca8b171dcb4c9f7e55a42e5f031e71cdd2cd6b1 humgen_a2023v17a20iENG.pdf e81698133b01af01ed672a42f0b3a6b8f9a02fdcf64af5f76a9cdea8fc1c9d8b humgen_a2023v17a20iENG.pdf Title: A crowdsourcing database for the copy-number variation of the Spanish population Subject: Human Genomics, https://doi.org/10.1186/s40246-023-00466-8 Author: Daniel López-López Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Mar 8 16:59:32 2023 CET ModDate: Thu Mar 9 05:30:28 2023 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1644142 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 53 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 56 0 MyriadPro-It Type 1C Custom yes no yes 55 0 MyriadPro-Regular2 Type 1C WinAnsi yes no no 379 0 MyriadPro-Light Type 1C Custom yes no yes 57 0 MyriadPro-Semibold Type 1C Custom yes no yes 54 0 WarnockPro-It Type 1C WinAnsi yes no yes 58 0 WarnockPro-Regular Type 1C Custom yes no yes 59 0 MyriadPro-Regular3 Type 1C WinAnsi yes no yes 338 0 TUIXKI+MyriadPro-LightIt Type 1C WinAnsi yes yes yes 119 0 TLLKAO+MTSY Type 1C Custom yes yes yes 141 0 SSCEFN+STIXMath-Regular Type 1C WinAnsi yes yes yes 268 0 CCKHIK+OpenSans-Extrabold Type 1C WinAnsi yes yes no 310 0 CCKHIK+OpenSans-Bold Type 1C WinAnsi yes yes no 317 0 CCKHIK+OpenSans-Light Type 1C Custom yes yes no 314 0 CCKHIK+OregonLDOBookSinistral Type 1C WinAnsi yes yes no 320 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-07-25 02:41:59 CEST RepresentationInformation: humgen_a2023v17a20iENG.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-07-08 16:14:51 CEST Size: 1644142 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 473 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: A crowdsourcing database for the copy-number variation of the Spanish population Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Results Item: Title: Conclusion Item: Title: Background Item: Title: Implementation Children: Item: Title: Data Item: Title: Sample locality and potential kinship Item: Title: Copy number variation predictions Item: Title: Pharmacogenomic analysis of the Spanish population Item: Title: Gene-phenotype associations Item: Title: CNV annotations Item: Title: Statistical methods Item: Title: Results Children: Item: Title: SPACNACS content description Item: Title: SPACNACS architecture Item: Title: SPACNACS functionality Item: Title: The SPACNACS beacon Item: Title: Impact of CNV in human phenotype Item: Title: Impact of CNVs on genes relevant in pharmacogenomics Item: Title: Discussion Item: Title: Anchor 23 Item: Title: Acknowledgements Item: Title: References Info: Title: A crowdsourcing database for the copy-number variation of the Spanish population Author: Daniel López-López Subject: Human Genomics, https://doi.org/10.1186/s40246-023-00466-8 Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Mar 08 16:59:32 CET 2023 ModDate: Thu Mar 09 05:30:28 CET 2023 ID: 0x407ad61f80d34a72f7bfa45a642e8180, 0xb315ccf071410223aef88c6319a07c30 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 39 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 81 ImageHeight: 84 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 74 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1595 ImageHeight: 1178 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1961 ImageHeight: 1044 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1595 ImageHeight: 917 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TUIXKI+MyriadPro-LightIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: TUIXKI+MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -221, -533, 1474, 950 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Regular2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular2 Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SSCEFN+STIXMath-Regular FontSubset: true FirstChar: 32 LastChar: 174 FontDescriptor: FontName: SSCEFN+STIXMath-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -524, 3238, 2566 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TLLKAO+MTSY FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: TLLKAO+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2023-03-08T15:59:32 Adobe InDesign 15.1 (Windows) 2023-03-09T05:30:28+01:00 2023-03-09T05:30:28+01:00 application/pdf https://doi.org/10.1186/s40246-023-00466-8 BioMed Central Human Genomics, https://doi.org/10.1186/s40246-023-00466-8 A crowdsourcing database for the copy-number variation of the Spanish population Daniel López-López Gema Roldán Jose L. Fernández-Rueda Gerrit Bostelmann Rosario Carmona Virginia Aquino Javier Perez-Florido Francisco Ortuño Guillermo Pita Rocío Núñez-Torres Anna González-Neira Angel Alonso Josefa Salgado-Garrido Sara Pasalodos-Sanchez Carmen Ayuso Pablo Minguez Almudena Avila-Fernandez Marta Corton Rafael Artuch Salud Borrego Guillermo Antiñolo Angel Carracedo Jorge Amigo Luis Antonio Castaño Isabel Tejada Aitor Delmiro Carmina Espinos Daniel Grinberg Encarnación Guillén Pablo Lapunzina Jose Antonio Lopez-Escámez Alvaro Gallego-Martinez Ramón Martí Eulalia Rovira José Mª Millán Miguel Angel Moreno Matías Morin Antonio Moreno-Galdó Mónica Fernández-Cancio Beatriz Morte Victoriano Mulero Diana García Virginia Nunes Francesc Palau Belén Perez Luis Pérez Jurado Rosario Perona Aurora Pujol Feliciano Ramos Esther Lopez Antonia Ribes Jordi Rosell Jordi Surrallés María Peña-Chilet Joaquin Dopazo 10.1186/s40246-023-00466-8 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s40246-023-00466-8 10.1186/s40246-023-00466-8 1479-7364 journal Human Genomics The Author(s) 2010-04-23 true 10.1186/s40246-023-00466-8 noindex springer.com springerlink.com Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) False uuid:70523eea-75b4-4df5-b5eb-13a066c9a805 uuid:5a3d1cd4-69a7-4417-8f13-ffdceac1d6f7 default 1 converted uuid:70523eea-75b4-4df5-b5eb-13a066c9a805 converted to PDF/A-2b pdfToolbox 2023-03-09T04:08:06Z 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 212, 66, 330, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 486, 66, 530, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 58, 276, 50 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 683, 540, 650 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 405, 600, 522, 589 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 63, 588, 103, 577 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 59, 462, 64, 450 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 70, 462, 75, 450 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 105, 414, 110, 402 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 92, 390, 97, 378 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 103, 390, 107, 378 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 141, 330, 146, 318 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 121, 318, 126, 306 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 185, 318, 190, 306 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 222, 222, 232, 210 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 165, 210, 174, 198 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 223, 174, 233, 162 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 139, 102, 149, 90 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 483, 354, 493, 342 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 441, 330, 451, 318 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 450, 306, 461, 294 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 452, 258, 462, 246 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 351, 246, 361, 234 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 308, 234, 318, 222 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 374, 234, 384, 222 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 512, 234, 522, 222 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 446, 210, 456, 198 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 427, 186, 437, 174 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 376, 162, 386, 150 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 509, 102, 518, 90 Flags: Print AppearanceDictionary: true Destination: 275 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 59, 655, 69, 643 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 192, 619, 196, 607 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 201, 619, 211, 607 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 277, 583, 287, 571 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 112, 559, 122, 547 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 128, 559, 138, 547 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 212, 475, 222, 463 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 82, 415, 92, 403 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 275, 391, 285, 379 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 139, 367, 149, 355 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 201, 331, 211, 319 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 222, 319, 232, 307 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 275, 271, 285, 259 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 126, 247, 135, 235 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 185, 223, 195, 211 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 133, 199, 143, 187 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 277, 175, 287, 163 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 180, 163, 190, 151 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 489, 656, 494, 644 Flags: Print AppearanceDictionary: true Destination: 217 Annotation: Subtype: Link Rect: 448, 644, 458, 632 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 463, 644, 473, 632 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 331, 632, 341, 620 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 402, 632, 411, 620 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 486, 558, 496, 546 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 389, 510, 399, 498 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 442, 510, 452, 498 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 525, 510, 535, 498 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 345, 412, 355, 400 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 463, 376, 473, 364 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 307, 316, 317, 304 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 324, 316, 334, 304 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 425, 292, 435, 280 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 307, 244, 317, 232 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 307, 196, 317, 184 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 523, 196, 533, 184 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 330, 148, 340, 136 Flags: Print AppearanceDictionary: true Destination: 275 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 144, 295, 154, 283 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 137, 173, 142, 161 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 76, 137, 81, 125 Flags: Print AppearanceDictionary: true Destination: 107 Annotation: Subtype: Link Rect: 280, 77, 285, 65 Flags: Print AppearanceDictionary: true Destination: 107 Annotation: Subtype: Link Rect: 496, 331, 501, 319 Flags: Print AppearanceDictionary: true Destination: 107 Annotation: Subtype: Link Rect: 366, 151, 371, 139 Flags: Print AppearanceDictionary: true Destination: 217 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 283, 465, 288, 452 Flags: Print AppearanceDictionary: true Destination: 217 Annotation: Subtype: Link Rect: 507, 681, 517, 668 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 522, 681, 532, 668 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 439, 645, 449, 632 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 506, 573, 516, 560 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 523, 573, 533, 560 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 304, 441, 466, 428 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 340, 417, 350, 404 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 381, 405, 391, 392 Flags: Print AppearanceDictionary: true Destination: 275 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 59, 693, 69, 680 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 59, 669, 69, 656 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 103, 609, 108, 596 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 160, 597, 170, 584 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 216, 573, 226, 560 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 249, 561, 259, 548 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 226, 549, 236, 536 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 256, 525, 266, 512 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 125, 489, 130, 476 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 59, 333, 69, 320 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 123, 333, 133, 320 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 166, 321, 171, 308 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 260, 285, 290, 272 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 273, 227, 260 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 133, 177, 143, 164 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 512, 681, 538, 668 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 669, 538, 656 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 657, 538, 638 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 645, 538, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 633, 538, 614 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 621, 438, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 512, 549, 538, 530 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 537, 538, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 525, 538, 506 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 513, 538, 494 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 501, 494, 482 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 484, 465, 494, 452 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 458, 369, 463, 356 Flags: Print AppearanceDictionary: true Destination: 190 Annotation: Subtype: Link Rect: 483, 177, 493, 164 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 375, 81, 380, 68 Flags: Print AppearanceDictionary: true Destination: 190 Thumb: true Page: Sequence: 7 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 253, 294, 263, 282 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 280, 198, 285, 186 Flags: Print AppearanceDictionary: true Destination: 195 Annotation: Subtype: Link Rect: 449, 330, 459, 318 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 463, 282, 473, 270 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 479, 282, 489, 270 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 499, 222, 504, 210 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 510, 222, 515, 210 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 522, 222, 533, 210 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 470, 186, 480, 174 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 486, 186, 496, 174 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 347, 150, 357, 138 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 506, 126, 516, 114 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 522, 126, 533, 114 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 495, 102, 505, 90 Flags: Print AppearanceDictionary: true Destination: 275 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 176, 693, 186, 680 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 192, 693, 203, 680 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 120, 621, 130, 608 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 259, 573, 269, 560 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 274, 573, 284, 560 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 56, 561, 66, 548 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 219, 453, 229, 440 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 246, 441, 257, 428 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 274, 417, 284, 404 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 242, 177, 252, 164 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 253, 129, 258, 116 Flags: Print AppearanceDictionary: true Destination: 241 Annotation: Subtype: Link Rect: 247, 93, 256, 80 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 430, 669, 440, 656 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 496, 303, 529, 294 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 294, 404, 285 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 194, 298, 282, 290 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 289, 83, 281 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 499, 478, 521, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 469, 375, 461 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 453, 460, 531, 452 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 451, 348, 443 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 460, 442, 531, 434 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 433, 531, 425 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 424, 385, 416 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 161, 559, 285, 551 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 128, 550, 226, 542 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 268, 424, 287, 416 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 415, 230, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 98, 325, 211, 317 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 362, 361, 417, 353 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 332, 352, 475, 344 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 376, 316, 507, 308 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 12 Thumb: true Checksum: 74cc2a6b Type: CRC32 Checksum: 83618a2864daa1205e01cd74a448aa27 Type: MD5 Checksum: 2ca8b171dcb4c9f7e55a42e5f031e71cdd2cd6b1 Type: SHA-1 Checksum: e81698133b01af01ed672a42f0b3a6b8f9a02fdcf64af5f76a9cdea8fc1c9d8b Type: SHA-256