c5b568018b077dfd4e2ba92cdbd6b69f 296622.pdf 1fca08ba710bb36613cb1820691c59dce6516cb6 296622.pdf ef93e875c0b66081e2d31c8c21297ecf60ed6634af494b3ec262da6943814e86 296622.pdf Title: Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019–2021): A Population-Based Epidemiological Study Subject: In countries with low tuberculosis (TB) incidence, the systematic testing and treatment of latent TB infection (LTBI) in contacts of pulmonary TB index cases is the standard of care. The objective of this study, conducted in Catalonia over 2019–2021, was to assess the factors associated with LTBI treatment prescription to close contacts of pulmonary TB index cases. In this population-based epidemiological study of LTBI prevalence among pulmonary TB contacts between 2019 and 2021, multiple logistic backward stepwise regression was used to identify the factors associated with treatment prescription, for which the adjusted odds ratio (aOR) and 95% confidence intervals (CI) were calculated. A total of 1487 LTBI contacts of 542 pulmonary TB index cases were studied, 80.6% of whom received a prescription. The factors associated with LTBI treatment prescription were exposure 6 h/day (aOR 14.20; 95% CI 5.22–38.66) and exposure <6 h/day (aOR 7.32, 95% CI 2.48–21.64), whereas the factors associated with no LTBI treatment prescription were age 55 years (aOR 0.22, 95% CI 0.08–0.64) and bacillus Calmette–Guerin vaccination (aOR 0.38, 95% CI 0.16–0.90). Crucial to LTBI treatment prescription is information on the contact’s duration of exposure to pulmonary TB, not only for contacts exposed for 6 h/day, but also for contacts with lower daily exposure levels. Keywords: contact tracing; tuberculosis; latent TB infection; treatment; prescription; prevention Author: Ángela Domínguez, Núria Soldevila, Diana Toledo, Ignasi Parrón, Joan-Pau Millet, Irene Barrabeig, Pere Godoy and on behalf of Transmission of Tuberculosis in Catalonia (Spain) Working Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Dec 1 10:05:56 2023 CET ModDate: Fri Dec 1 10:30:17 2023 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 842944 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DCXXPC+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 CNRZPM+VnURWPalladioL Type 1 Custom yes yes no 15 0 MYIZYA+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 YAQNBH+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 MVHGAC+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 IKKWKP+CMSY10 Type 1 Builtin yes yes no 32 0 DFKKLH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 75 0 DFKKLI+PalatinoLinotype CID TrueType Identity-H yes yes yes 78 0 DFKKLJ+PalatinoLinotype TrueType WinAnsi yes yes no 84 0 DFKKLL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 87 0 DFKKLH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 110 0 DFKKLI+PalatinoLinotype CID TrueType Identity-H yes yes yes 113 0 DFKKLJ+PalatinoLinotype TrueType WinAnsi yes yes no 119 0 DFKKLL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 122 0 DFKLFI+PalatinoLinotype TrueType MacRoman yes yes no 125 0 QCCTFG+VnURWPalladioL-Italic Type 1 Custom yes yes no 138 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-07-20 02:46:46 CEST RepresentationInformation: 296622.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-07-19 13:05:39 CEST Size: 842944 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 255 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Children: Item: Title: Characteristics of Infected Contacts Destination: subsection.3.1 Item: Title: Characteristics of Pulmonary TB Index Cases Destination: subsection.3.2 Item: Title: Factors Associated with Treatment Prescription to Infected Contacts Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019 2021): A Population-Based Epidemiological Study Author: Ángela Domínguez, Núria Soldevila, Diana Toledo, Ignasi Parrón, Joan-Pau Millet, Irene Barrabeig, Pere Godoy and on behalf of Transmission of Tuberculosis in Catalonia (Spain) Working Group Subject: In countries with low tuberculosis (TB) incidence, the systematic testing and treatment of latent TB infection (LTBI) in contacts of pulmonary TB index cases is the standard of care. The objective of this study, conducted in Catalonia over 2019 2021, was to assess the factors associated with LTBI treatment prescription to close contacts of pulmonary TB index cases. In this population-based epidemiological study of LTBI prevalence among pulmonary TB contacts between 2019 and 2021, multiple logistic backward stepwise regression was used to identify the factors associated with treatment prescription, for which the adjusted odds ratio (aOR) and 95% confidence intervals (CI) were calculated. A total of 1487 LTBI contacts of 542 pulmonary TB index cases were studied, 80.6% of whom received a prescription. The factors associated with LTBI treatment prescription were exposure 6 h/day (aOR 14.20; 95% CI 5.22 38.66) and exposure <6 h/day (aOR 7.32, 95% CI 2.48 21.64), whereas the factors associated with no LTBI treatment prescription were age 55 years (aOR 0.22, 95% CI 0.08 0.64) and bacillus Calmette Guerin vaccination (aOR 0.38, 95% CI 0.16 0.90). Crucial to LTBI treatment prescription is information on the contact’s duration of exposure to pulmonary TB, not only for contacts exposed for 6 h/day, but also for contacts with lower daily exposure levels. 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