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Title:           Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation
Subject:         Nature Communications, doi:10.1038/s41467-023-43896-7
Keywords:        
Author:          M. C. Martinez-Campanario
Creator:         Springer
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     Item: 
      Title: Atherosclerotic plaque development in mice’is enhanced by myeloid ZEB1 downregulation
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       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Ubiquitous downregulation of Zeb1 increases plaque formation
          Destination: B1
         Item: 
          Title: Downregulation of Zeb1 expression in myeloid cells increases plaque formation
          Destination: B2
         Item: 
          Title: Zeb1∆M/ApoeKO mice exhibit systemic inflammation and lipid accumulation
          Destination: B3
         Item: 
          Title: ZEB1 inhibits lipid accumulation in macrophages
          Destination: B4
         Item: 
          Title: ZEB1 promotes cholesterol efflux in macrophages through upregulation of ABCA1 and’ABCG1
          Destination: B5
         Item: 
          Title: ZEB1 inhibits lipid accumulation in macrophages through activation of AMPK signaling
          Destination: B6
         Item: 
          Title: ZEB1 regulates the expression of genes involved in the intracellular trafficking of’lipids
          Destination: B7
         Item: 
          Title: Zeb1 deletion hinders the intracellular traffic of’lipids
          Destination: B8
         Item: 
          Title: Macrophage-targeted nanoparticles expressing ZEB1 reduce lipid accumulation and enhance cholesterol’efflux
          Destination: B9
         Item: 
          Title: In vivo use of macrophage-targeted nanoparticles expressing ZEB1 reduces atherosclerotic plaque formation
          Destination: B10
         Item: 
          Title: Low levels of ZEB1 in human endarterectomies are associated with a higher incidence of plaque rupture and cardiovascular’events
          Destination: B11
       Item: 
        Title: Discussion
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       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Research ethics statement
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         Item: 
          Title: Plasmids
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         Item: 
          Title: Human samples
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         Item: 
          Title: Generation of the conditional Zeb1WT and Zeb1∆M’mice
          Destination: B15
         Item: 
          Title: Atherosclerosis mouse model and experimental mice used in the’study
          Destination: B16
         Item: 
          Title: Mouse aortic root preparation and tissue staining
          Destination: B17
         Item: 
          Title: In situ atherosclerotic plaque efferocytosis’assay
          Destination: B18
         Item: 
          Title: LDL isolation and oxidation
          Destination: B19
         Item: 
          Title: Isolation and culture of peritoneal macrophages
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         Item: 
          Title: Isolation of aortic plaque macrophages
          Destination: B21
         Item: 
          Title: Isolation of liver macrophages
          Destination: B22
         Item: 
          Title: Isolation of white adipose tissue macrophages
          Destination: B23
         Item: 
          Title: Determination of peripheral blood cell populations
          Destination: B24
         Item: 
          Title: Assessment of cell surface protein expression analysis and cell sorting by flow cytometry’(FACS)
          Destination: B25
         Item: 
          Title: Assessment of protein expression by immunofluorescence
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         Item: 
          Title: Assessment of protein expression by western’blot
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         Item: 
          Title: RNA extraction and assessment of gene expression by quantitative real-time’PCR
          Destination: B28
         Item: 
          Title: RNA sequencing and data analysis
          Destination: B29
         Item: 
          Title: Analysis of single-cell RNAseq datasets
          Destination: B30
         Item: 
          Title: Ultrastructure of the atherosclerotic plaque by electron transmission microscopy
          Destination: B31
         Item: 
          Title: Ultrastructure of macrophages by electron transmission microscopy
          Destination: B32
         Item: 
          Title: Determination of lipids, albumin, total protein, and transaminases in’serum
          Destination: B33
         Item: 
          Title: Determination of serum glucose and glucose tolerance’test
          Destination: B34
         Item: 
          Title: Ex vivo cholesterol efflux capacity
          Destination: B35
         Item: 
          Title: pHrodo™ Green-LDL and DiI-oxLDL intracellular trafficking
          Destination: B36
         Item: 
          Title: Atto-655-oxLDL uptake’assay
          Destination: B37
         Item: 
          Title: Determination of cytokines by bead-based multiplex’array
          Destination: B38
         Item: 
          Title: Determination of leptin by’ELISA
          Destination: B39
         Item: 
          Title: Synthesis, functionalization, and characterization of dendrimer-graphene nanostars
          Destination: B40
         Item: 
          Title: Ex vivo delivery of DGNS into macrophages
          Destination: B41
         Item: 
          Title: In vivo delivery of DGNS into’mice
          Destination: B42
         Item: 
          Title: Statistical analysis
          Destination: B43
         Item: 
          Title: Reporting summary
          Destination: B44
       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Competing interests
        Destination: A7
       Item: 
        Title: Additional information
        Destination: M3
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    Author: M. C. Martinez-Campanario
    Subject: Nature Communications, doi:10.1038/s41467-023-43896-7
    Keywords: 
    Creator: Springer
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