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Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Systematic review with meta-analysis Destination: mk:H2_1 Item: Title: 2.2 Structured question and outcome prioritization Destination: mk:H2_2 Item: Title: 2.3 Search strategy and database Destination: mk:H2_3 Item: Title: 2.4 Inclusion and exclusion criteria Destination: mk:H2_4 Item: Title: 2.5 Study selection Destination: mk:H2_5 Item: Title: 2.6 Data extraction and risk of bias assessment Destination: mk:H2_6 Item: Title: 2.7 Assessment of the certainty of the evidence Destination: mk:H2_7 Item: Title: 2.8 Data analysis plan Destination: mk:H2_8 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Study Selection Destination: mk:H2_9 Item: Title: 3.2 Characteristics of Included Studies Destination: mk:H2_10 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: 5 Conclusions Destination: mk:H1_5 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