88982a137d9cb7a034aaa2cd89a82fa9 300788.pdf d1d1a73ca87a5d8ebe49478bececb0613f20c688 300788.pdf acc3b0de7cb35d86af54208277ab72118f83f227fa60a1b427b85a17a615f596 300788.pdf Title: Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease Subject: Biomedicine & Pharmacotherapy, 167 (2023) 115469. doi:10.1016/j.biopha.2023.115469 Keywords: Lysyl oxidase,Cardiovascular calcification,Atherosclerosis,Extracellular matrix remodeling Author: Carme Ballester-Servera Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Oct 11 14:58:15 2023 CEST ModDate: Wed Oct 11 15:54:11 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 19797230 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SYBCVF+CharisSIL CID TrueType Identity-H yes yes yes 1059 0 XKYYNI+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 1064 0 IRJBBD+STIX-Regular Type 1C Custom yes yes yes 1069 0 VXCJFZ+Univers Type 1C Builtin yes yes yes 1074 0 VTBHHF+CharisSIL-Bold CID TrueType Identity-H yes yes yes 1078 0 NNLAUQ+TeX_CM_Roman Type 1C Builtin yes yes yes 1083 0 TBNJIY+STIX-Italic Type 1C Custom yes yes yes 1087 0 NRBIIM+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1092 0 BUTOJT+CharisSIL CID TrueType Identity-H yes yes yes 1050 0 QBKAFZ+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 470 0 OIPKTS+CharisSIL-Italic CID TrueType Identity-H yes yes yes 463 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 475 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-09-19 02:50:46 CEST RepresentationInformation: 300788.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-18 11:35:53 CEST Size: 19797230 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'cor1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'sec0130' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found ID: PDF-HUL-122 Offset: 19735273 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0130' cannot be found ID: PDF-HUL-122 Offset: 19735273 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1181 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Material and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Human samples Destination: mk:H2_1 Item: Title: 2.2 Isolation and culture of VICs Destination: mk:H2_2 Item: Title: 2.3 Calcium assessment in cell culture Destination: mk:H2_3 Item: Title: 2.4 Real-time PCR Destination: mk:H2_4 Item: Title: 2.5 Western blotting Destination: mk:H2_5 Item: Title: 2.6 LOX silencing and lentiviral overexpression of human LOX in VICs Destination: mk:H2_6 Item: Title: 2.7 Generation of decellularized VICs-derived ECM scaffolds Destination: mk:H2_7 Item: Title: 2.8 Animal handling Destination: mk:H2_8 Item: Title: 2.9 Ultrasound imaging Destination: mk:H2_9 Item: Title: 2.10 Plasma analysis Destination: mk:H2_10 Item: Title: 2.11 Oil Red O (ORO) staining of en face aortas Destination: mk:H2_11 Item: Title: 2.12 Analysis of macroscopic calcification by Near-Infrared Fluorescence (NIRF) imaging Destination: mk:H2_12 Item: Title: 2.13 Histology and immunohistochemistry Destination: mk:H2_13 Item: Title: 2.14 Immunocytochemistry Destination: mk:H2_14 Item: Title: 2.15 Statistical analysis Destination: mk:H2_15 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 LOX is upregulated in calcified valves Destination: mk:H2_16 Item: Title: 3.2 LOX is increased in calcifying VICs and exacerbates calcium deposition Destination: mk:H2_17 Item: Title: 3.3 LOX is highly expressed in calcified human atherosclerotic lesions and colocalizes with RUNX2 Destination: mk:H2_18 Item: Title: 3.4 LOX overexpression in VSMC aggravates atherosclerosis and vascular calcification Destination: mk:H2_19 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: CRediT authorship contribution statement Destination: mk:H1_5 Item: Title: Declaration of Competing Interest Destination: mk:HH1_3 Item: Title: Data Availability Destination: datalink4 Item: Title: Acknowledgments Destination: mk:HH1_5 Item: Title: Appendix A Supporting information Destination: mk:H1_6 Item: Title: References Destination: mk:HH2_1 Info: Title: Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease Author: Carme Ballester-Servera Subject: Biomedicine & Pharmacotherapy, 167 (2023) 115469. doi:10.1016/j.biopha.2023.115469 Keywords: Lysyl oxidase,Cardiovascular calcification,Atherosclerosis,Extracellular matrix remodeling Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Oct 11 14:58:15 CEST 2023 ModDate: Wed Oct 11 15:54:11 CEST 2023 ID: 0x98c7c28424c2089ea6397b9efba7f87f, 0x552c6200d80839e8d5d059079860768a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: SYBCVF+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: NRBIIM+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: VTBHHF+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: XKYYNI+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: VXCJFZ+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: VXCJFZ+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: QBKAFZ+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: QBKAFZ+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NNLAUQ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NNLAUQ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NTMBZO+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: NTMBZO+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: IRJBBD+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 13 FontDescriptor: FontName: IRJBBD+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TBNJIY+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: TBNJIY+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: SYBCVF+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SYBCVF+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: NRBIIM+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NRBIIM+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: VTBHHF+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VTBHHF+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: XKYYNI+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: XKYYNI+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true XMP: application/pdf 10.1016/j.biopha.2023.115469 Elsevier Masson SAS Biomedicine & Pharmacotherapy, 167 (2023) 115469. doi:10.1016/j.biopha.2023.115469 Lysyl oxidase Cardiovascular calcification Atherosclerosis Extracellular matrix remodeling Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease Carme Ballester-Servera Judith Alonso Laia Cañes Paula Vázquez-Sufuentes Lídia Puertas-Umbert Amaya Fernández-Celis Manel Taurón Antonio Rodríguez-Sinovas Natalia López-Andrés Cristina Rodríguez José Martínez-González journal Biomedicine & Pharmacotherapy © 2023 The Authors. Published by Elsevier Masson SAS. 0753-3322 167 1 November 2023 2023-11-01 115469 115469 10.1016/j.biopha.2023.115469 https://doi.org/10.1016/j.biopha.2023.115469 2010-04-23 true 10.1016/j.biopha.2023.115469 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by-nc-nd/4.0/ VoR 10.1016/j.biopha.2023.115469 noindex 2010-04-23 true 11th October 2023 sciencedirect.com elsevier.com Elsevier 2023-10-11T13:54:11 2023-10-11T12:58:15 2023-10-11T13:54:11 True 11th October 2023 Acrobat Distiller 8.1.0 (Windows) Lysyl oxidase,Cardiovascular calcification,Atherosclerosis,Extracellular matrix remodeling uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 151, 576, 158, 587 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 158, 576, 165, 587 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 166, 571, 243, 582 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 243, 576, 249, 587 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 250, 576, 257, 587 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 258, 571, 320, 582 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 320, 576, 326, 587 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 327, 576, 333, 587 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 334, 571, 463, 582 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 463, 576, 470, 587 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 470, 571, 477, 582 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 139, 563, 146, 574 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 146, 563, 152, 574 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 153, 558, 276, 569 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 276, 558, 354, 569 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 354, 563, 361, 574 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 361, 563, 367, 574 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 368, 558, 373, 569 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 166, 550, 173, 561 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 174, 545, 286, 556 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 286, 545, 386, 556 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 386, 550, 392, 561 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 393, 550, 399, 561 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 400, 550, 407, 561 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 407, 553, 411, 558 Flags: Print Destination: null Annotation: Subtype: Link Rect: 407, 550, 414, 561 Flags: Print Destination: null Annotation: Subtype: Link Rect: 414, 545, 422, 556 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 150, 537, 156, 548 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 157, 537, 164, 548 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 164, 537, 170, 548 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 171, 540, 175, 545 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 175, 540, 179, 545 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 171, 537, 181, 548 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 182, 532, 187, 543 Flags: Print Destination: 1035 Annotation: Subtype: Link Rect: 103, 114, 183, 121 Flags: Print Annotation: Subtype: Link Rect: 236, 114, 320, 121 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 274, 667, 397, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 188, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 212, 748, 381, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 40, 48, 206, 59 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 155, 626, 173, 634 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 108, 605, 126, 613 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 169, 563, 187, 571 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 138, 479, 157, 487 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 37, 437, 61, 445 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 259, 385, 286, 393 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 119, 364, 142, 372 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 257, 333, 286, 341 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 186, 302, 212, 309 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 37, 228, 66, 236 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 127, 218, 156, 226 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 137, 207, 164, 215 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 167, 197, 196, 205 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 128, 186, 155, 194 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 270, 165, 286, 173 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 171, 134, 187, 142 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 342, 269, 358, 277 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 539, 196, 555, 204 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 530, 71, 545, 79 Flags: Print Destination: 203 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 118, 699, 133, 707 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 235, 155, 288, 163 Flags: Print Destination: null Annotation: Subtype: Link Rect: 37, 144, 66, 152 Flags: Print Destination: null Annotation: Subtype: Link Rect: 71, 92, 86, 100 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 539, 657, 555, 665 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 396, 405, 434, 413 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 354, 228, 381, 236 Flags: Print Destination: 203 Page: Label: 4 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 187, 615, 273, 623 Flags: Print Destination: null Annotation: Subtype: Link Rect: 270, 594, 286, 602 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 229, 563, 251, 571 Flags: Print Destination: 43 Annotation: Subtype: Link Rect: 126, 532, 208, 540 Flags: Print Destination: null Annotation: Subtype: Link Rect: 150, 500, 239, 508 Flags: Print Destination: null Annotation: Subtype: Link Rect: 168, 385, 188, 393 Flags: Print Destination: 89 Annotation: Subtype: Link Rect: 259, 364, 286, 372 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 188, 354, 204, 362 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 228, 333, 248, 341 Flags: Print Destination: 89 Annotation: Subtype: Link Rect: 40, 281, 62, 289 Flags: Print Destination: 89 Annotation: Subtype: Link Rect: 74, 281, 159, 289 Flags: Print Destination: null Annotation: Subtype: Link Rect: 187, 270, 270, 278 Flags: Print Destination: null Annotation: Subtype: Link Rect: 444, 730, 464, 738 Flags: Print Destination: 89 Annotation: Subtype: Link Rect: 473, 730, 552, 738 Flags: Print Destination: null Annotation: Subtype: Link Rect: 334, 626, 355, 633 Flags: Print Destination: 89 Annotation: Subtype: Link Rect: 309, 615, 332, 623 Flags: Print Destination: 89 Annotation: Subtype: Link Rect: 309, 605, 329, 613 Flags: Print Destination: 89 Annotation: Subtype: Link Rect: 392, 594, 412, 602 Flags: Print Destination: 89 Annotation: Subtype: Link Rect: 478, 563, 500, 571 Flags: Print Destination: 100 Annotation: Subtype: Link Rect: 527, 552, 547, 560 Flags: Print Destination: 100 Annotation: Subtype: Link Rect: 376, 531, 459, 539 Flags: Print Destination: null Annotation: Subtype: Link Rect: 402, 479, 422, 487 Flags: Print Destination: 100 Annotation: Subtype: Link Rect: 394, 469, 475, 477 Flags: Print Destination: null Annotation: Subtype: Link Rect: 487, 458, 508, 466 Flags: Print Destination: 118 Annotation: Subtype: Link Rect: 489, 427, 509, 435 Flags: Print Destination: 118 Annotation: Subtype: Link Rect: 438, 395, 458, 403 Flags: Print Destination: 118 Annotation: Subtype: Link Rect: 437, 301, 453, 309 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 420, 259, 440, 267 Flags: Print Destination: 125 Annotation: Subtype: Link Rect: 421, 228, 441, 236 Flags: Print Destination: 125 Annotation: Subtype: Link Rect: 441, 113, 457, 121 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 379, 102, 462, 110 Flags: Print Destination: null Annotation: Subtype: Link Rect: 504, 92, 557, 100 Flags: Print Destination: null Annotation: Subtype: Link Rect: 306, 81, 335, 89 Flags: Print Destination: null Annotation: Subtype: Link Rect: 436, 71, 521, 79 Flags: Print Destination: null Annotation: Subtype: Link Rect: 470, 60, 554, 68 Flags: Print Destination: null Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 90, 66, 174, 74 Flags: Print Destination: null Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 40, 217, 129, 225 Flags: Print Destination: null Annotation: Subtype: Link Rect: 235, 206, 288, 214 Flags: Print Destination: null Annotation: Subtype: Link Rect: 37, 196, 69, 204 Flags: Print Destination: null Annotation: Subtype: Link Rect: 40, 164, 61, 172 Flags: Print Destination: 143 Annotation: Subtype: Link Rect: 92, 123, 112, 131 Flags: Print Destination: 143 Annotation: Subtype: Link Rect: 117, 91, 196, 99 Flags: Print Destination: null Annotation: Subtype: Link Rect: 328, 185, 409, 193 Flags: Print Destination: null Annotation: Subtype: Link Rect: 411, 154, 426, 162 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 506, 133, 527, 141 Flags: Print Destination: 159 Annotation: Subtype: Link Rect: 528, 81, 547, 89 Flags: Print Destination: 159 Annotation: Subtype: Link Rect: 466, 70, 488, 78 Flags: Print Destination: 159 Page: Label: 8 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 156, 282, 176, 290 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 236, 240, 283, 248 Flags: Print Destination: 159 Annotation: Subtype: Link Rect: 40, 209, 128, 217 Flags: Print Destination: null Annotation: Subtype: Link Rect: 37, 102, 64, 110 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 452, 272, 479, 280 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 478, 240, 494, 248 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 480, 178, 496, 186 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 448, 125, 464, 133 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 506, 115, 555, 123 Flags: Print Destination: 203 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 261, 201, 288, 209 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 37, 191, 49, 199 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 159, 149, 219, 157 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 127, 128, 143, 136 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 419, 233, 448, 241 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 488, 180, 503, 188 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 383, 149, 399, 157 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 527, 97, 543, 105 Flags: Print Destination: 203 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 69, 329, 84, 337 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 272, 329, 288, 337 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 156, 214, 194, 222 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 259, 120, 286, 128 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 400, 329, 416, 337 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 389, 288, 427, 295 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 458, 277, 474, 285 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 450, 256, 466, 264 Flags: Print Destination: 426 Annotation: Subtype: Link Rect: 488, 246, 504, 254 Flags: Print Destination: 426 Annotation: Subtype: Link Rect: 334, 183, 361, 191 Flags: Print Destination: 426 Annotation: Subtype: Link Rect: 374, 141, 412, 149 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 539, 89, 555, 97 Flags: Print Destination: 203 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 174, 360, 190, 368 Flags: Print Destination: 203 Annotation: Subtype: Link Rect: 368, 170, 493, 178 Flags: Print Annotation: Subtype: Link Rect: 322, 130, 554, 136 Flags: Print Annotation: Subtype: Link Rect: 322, 122, 553, 128 Flags: Print Annotation: Subtype: Link Rect: 322, 114, 512, 120 Flags: Print Annotation: Subtype: Link Rect: 322, 106, 555, 112 Flags: Print Annotation: Subtype: Link Rect: 322, 98, 555, 104 Flags: Print Annotation: Subtype: Link Rect: 322, 90, 555, 96 Flags: Print Annotation: Subtype: Link Rect: 322, 82, 445, 88 Flags: Print Annotation: Subtype: Link Rect: 322, 74, 542, 80 Flags: Print Annotation: Subtype: Link Rect: 322, 66, 503, 73 Flags: Print Annotation: Subtype: Link Rect: 322, 58, 550, 65 Flags: Print Annotation: Subtype: Link Rect: 322, 50, 525, 57 Flags: Print Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 53, 732, 253, 738 Flags: Print Annotation: Subtype: Link Rect: 53, 724, 286, 730 Flags: Print Annotation: Subtype: Link Rect: 53, 716, 279, 722 Flags: Print Annotation: Subtype: Link Rect: 53, 708, 267, 714 Flags: Print Annotation: Subtype: Link Rect: 53, 700, 85, 706 Flags: Print Annotation: Subtype: Link Rect: 53, 692, 286, 698 Flags: Print Annotation: Subtype: Link Rect: 53, 684, 286, 690 Flags: Print Annotation: Subtype: Link Rect: 53, 676, 284, 682 Flags: Print Annotation: Subtype: Link Rect: 53, 668, 166, 674 Flags: Print Annotation: Subtype: Link Rect: 53, 660, 286, 666 Flags: Print Annotation: Subtype: Link Rect: 53, 652, 273, 658 Flags: Print Annotation: Subtype: Link Rect: 53, 644, 276, 651 Flags: Print Annotation: Subtype: Link Rect: 53, 636, 278, 643 Flags: Print Annotation: Subtype: Link Rect: 53, 628, 275, 635 Flags: Print Annotation: Subtype: Link Rect: 53, 620, 100, 627 Flags: Print Annotation: Subtype: Link Rect: 53, 612, 268, 619 Flags: Print Annotation: Subtype: Link Rect: 53, 604, 284, 611 Flags: Print Annotation: Subtype: Link Rect: 54, 596, 284, 603 Flags: Print Annotation: Subtype: Link Rect: 54, 588, 268, 595 Flags: Print Annotation: Subtype: Link Rect: 54, 580, 286, 587 Flags: Print Annotation: Subtype: Link Rect: 54, 572, 260, 579 Flags: Print Annotation: Subtype: Link Rect: 54, 565, 197, 571 Flags: Print Annotation: Subtype: Link Rect: 54, 557, 286, 563 Flags: Print Annotation: Subtype: Link Rect: 54, 549, 286, 555 Flags: Print Annotation: Subtype: Link Rect: 54, 541, 155, 547 Flags: Print Annotation: Subtype: Link Rect: 54, 533, 286, 539 Flags: Print Annotation: Subtype: Link Rect: 54, 525, 284, 531 Flags: Print Annotation: Subtype: Link Rect: 54, 517, 284, 523 Flags: Print Annotation: Subtype: Link Rect: 54, 509, 284, 515 Flags: Print Annotation: Subtype: Link Rect: 54, 501, 286, 507 Flags: Print Annotation: Subtype: Link Rect: 54, 493, 279, 499 Flags: Print Annotation: Subtype: Link Rect: 54, 485, 256, 491 Flags: Print Annotation: Subtype: Link Rect: 54, 477, 286, 483 Flags: Print Annotation: Subtype: Link Rect: 54, 469, 271, 475 Flags: Print Annotation: Subtype: Link Rect: 54, 461, 263, 467 Flags: Print Annotation: Subtype: Link Rect: 54, 453, 286, 459 Flags: Print Annotation: Subtype: Link Rect: 54, 445, 278, 451 Flags: Print Annotation: Subtype: Link Rect: 54, 437, 286, 443 Flags: Print Annotation: Subtype: Link Rect: 54, 429, 78, 435 Flags: Print Annotation: Subtype: Link Rect: 54, 421, 271, 427 Flags: Print Annotation: Subtype: Link Rect: 54, 413, 276, 419 Flags: Print Annotation: Subtype: Link Rect: 54, 405, 284, 411 Flags: Print Annotation: Subtype: Link Rect: 54, 397, 286, 403 Flags: Print Annotation: Subtype: Link Rect: 54, 389, 286, 396 Flags: Print Annotation: Subtype: Link Rect: 54, 381, 255, 388 Flags: Print Annotation: Subtype: Link Rect: 54, 373, 193, 380 Flags: Print Annotation: Subtype: Link Rect: 54, 365, 276, 372 Flags: Print Annotation: Subtype: Link Rect: 54, 357, 284, 364 Flags: Print Annotation: Subtype: Link Rect: 54, 349, 284, 356 Flags: Print Annotation: Subtype: Link Rect: 54, 341, 286, 348 Flags: Print Annotation: Subtype: Link Rect: 54, 333, 269, 340 Flags: Print Annotation: Subtype: Link Rect: 54, 325, 78, 332 Flags: Print Annotation: Subtype: Link Rect: 54, 317, 273, 324 Flags: Print Annotation: Subtype: Link Rect: 54, 309, 254, 316 Flags: Print Annotation: Subtype: Link Rect: 54, 301, 260, 308 Flags: Print Annotation: Subtype: Link Rect: 54, 294, 282, 300 Flags: Print Annotation: Subtype: Link Rect: 54, 286, 254, 292 Flags: Print Annotation: Subtype: Link Rect: 54, 278, 286, 284 Flags: Print Annotation: Subtype: Link Rect: 54, 270, 284, 276 Flags: Print Annotation: Subtype: Link Rect: 54, 262, 252, 268 Flags: Print Annotation: Subtype: Link Rect: 54, 254, 284, 260 Flags: Print Annotation: Subtype: Link Rect: 54, 246, 199, 252 Flags: Print Annotation: Subtype: Link Rect: 54, 238, 286, 244 Flags: Print Annotation: Subtype: Link Rect: 54, 230, 272, 236 Flags: Print Annotation: Subtype: Link Rect: 54, 222, 261, 228 Flags: Print Annotation: Subtype: Link Rect: 54, 214, 266, 220 Flags: Print Annotation: Subtype: Link Rect: 54, 206, 278, 212 Flags: Print Annotation: Subtype: Link Rect: 54, 198, 229, 204 Flags: Print Annotation: Subtype: Link Rect: 54, 190, 260, 196 Flags: Print Annotation: Subtype: Link Rect: 54, 182, 279, 188 Flags: Print Annotation: Subtype: Link Rect: 54, 174, 286, 180 Flags: Print Annotation: Subtype: Link Rect: 54, 166, 78, 172 Flags: Print Annotation: Subtype: Link Rect: 54, 158, 268, 164 Flags: Print Annotation: Subtype: Link Rect: 54, 150, 286, 156 Flags: Print Annotation: Subtype: Link Rect: 54, 142, 277, 148 Flags: Print Annotation: Subtype: Link Rect: 54, 134, 100, 140 Flags: Print Annotation: Subtype: Link Rect: 54, 126, 286, 133 Flags: Print Annotation: Subtype: Link Rect: 54, 118, 264, 125 Flags: Print Annotation: Subtype: Link Rect: 54, 110, 278, 117 Flags: Print Annotation: Subtype: Link Rect: 54, 102, 221, 109 Flags: Print Annotation: Subtype: Link Rect: 54, 94, 271, 101 Flags: Print Annotation: Subtype: Link Rect: 54, 86, 286, 93 Flags: Print Annotation: Subtype: Link Rect: 54, 78, 286, 85 Flags: Print Annotation: Subtype: Link Rect: 54, 70, 105, 77 Flags: Print Annotation: Subtype: Link Rect: 54, 62, 282, 69 Flags: Print Annotation: Subtype: Link Rect: 54, 54, 286, 61 Flags: Print Annotation: Subtype: Link Rect: 323, 732, 549, 738 Flags: Print Annotation: Subtype: Link Rect: 323, 724, 555, 730 Flags: Print Annotation: Subtype: Link Rect: 323, 716, 498, 722 Flags: Print Annotation: Subtype: Link Rect: 323, 708, 549, 714 Flags: Print Annotation: Subtype: Link Rect: 323, 700, 555, 706 Flags: Print Annotation: Subtype: Link Rect: 323, 692, 514, 698 Flags: Print Annotation: Subtype: Link Rect: 323, 684, 555, 690 Flags: Print Annotation: Subtype: Link Rect: 323, 676, 555, 682 Flags: Print Annotation: Subtype: Link Rect: 323, 668, 553, 674 Flags: Print Annotation: Subtype: Link Rect: 323, 660, 555, 666 Flags: Print Annotation: Subtype: Link Rect: 323, 652, 537, 658 Flags: Print Annotation: Subtype: Link Rect: 323, 644, 548, 651 Flags: Print Annotation: Subtype: Link Rect: 323, 636, 526, 643 Flags: Print Annotation: Subtype: Link Rect: 323, 628, 355, 635 Flags: Print Annotation: Subtype: Link Rect: 323, 620, 545, 627 Flags: Print Annotation: Subtype: Link Rect: 323, 612, 532, 619 Flags: Print Annotation: Subtype: Link Rect: 323, 604, 549, 611 Flags: Print Annotation: Subtype: Link Rect: 323, 596, 543, 603 Flags: Print Annotation: Subtype: Link Rect: 323, 588, 480, 595 Flags: Print Annotation: Subtype: Link Rect: 323, 580, 543, 587 Flags: Print Annotation: Subtype: Link Rect: 323, 572, 542, 579 Flags: Print Annotation: Subtype: Link Rect: 323, 565, 543, 571 Flags: Print Annotation: Subtype: Link Rect: 323, 557, 347, 563 Flags: Print Annotation: Subtype: Link Rect: 323, 549, 555, 555 Flags: Print Annotation: Subtype: Link Rect: 323, 541, 526, 547 Flags: Print Annotation: Subtype: Link Rect: 323, 533, 541, 539 Flags: Print Annotation: Subtype: Link Rect: 323, 525, 555, 531 Flags: Print Annotation: Subtype: Link Rect: 323, 517, 426, 523 Flags: Print Annotation: Subtype: Link Rect: 323, 509, 519, 515 Flags: Print Annotation: Subtype: Link Rect: 323, 501, 555, 507 Flags: Print Annotation: Subtype: Link Rect: 323, 493, 549, 499 Flags: Print Annotation: Subtype: Link Rect: 323, 485, 355, 491 Flags: Print Annotation: Subtype: Link Rect: 323, 477, 554, 483 Flags: Print Annotation: Subtype: Link Rect: 323, 469, 516, 475 Flags: Print Annotation: Subtype: Link Rect: 323, 461, 552, 467 Flags: Print Annotation: Subtype: Link Rect: 323, 453, 525, 459 Flags: Print Annotation: Subtype: Link Rect: 323, 445, 545, 451 Flags: Print Annotation: Subtype: Link Rect: 323, 437, 552, 443 Flags: Print Annotation: Subtype: Link Rect: 323, 429, 546, 435 Flags: Print Annotation: Subtype: Link Rect: 323, 421, 472, 427 Flags: Print Annotation: Subtype: Link Rect: 323, 413, 531, 419 Flags: Print Annotation: Subtype: Link Rect: 323, 405, 548, 411 Flags: Print Annotation: Subtype: Link Rect: 323, 397, 541, 403 Flags: Print Annotation: Subtype: Link Rect: 323, 389, 436, 396 Flags: Print Annotation: Subtype: Link Rect: 323, 381, 541, 388 Flags: Print Annotation: Subtype: Link Rect: 323, 373, 548, 380 Flags: Print Annotation: Subtype: Link Rect: 323, 365, 555, 372 Flags: Print Annotation: Subtype: Link Rect: 323, 357, 555, 364 Flags: Print Annotation: Subtype: Link Rect: 323, 349, 382, 356 Flags: Print Annotation: Subtype: Link Rect: 323, 341, 534, 348 Flags: Print Annotation: Subtype: Link Rect: 323, 333, 552, 340 Flags: Print Annotation: Subtype: Link Rect: 323, 325, 552, 332 Flags: Print Annotation: Subtype: Link Rect: 323, 317, 461, 324 Flags: Print Annotation: Subtype: Link Rect: 323, 309, 549, 316 Flags: Print Annotation: Subtype: Link Rect: 323, 301, 555, 308 Flags: Print Annotation: Subtype: Link Rect: 323, 294, 461, 300 Flags: Print Annotation: Subtype: Link Rect: 323, 286, 555, 292 Flags: Print Annotation: Subtype: Link Rect: 323, 278, 555, 284 Flags: Print Annotation: Subtype: Link Rect: 323, 270, 533, 276 Flags: Print Annotation: Subtype: Link Rect: 323, 262, 555, 268 Flags: Print Annotation: Subtype: Link Rect: 323, 254, 355, 260 Flags: Print Annotation: Subtype: Link Rect: 323, 246, 538, 252 Flags: Print Annotation: Subtype: Link Rect: 323, 238, 544, 244 Flags: Print Annotation: Subtype: Link Rect: 323, 230, 555, 236 Flags: Print Annotation: Subtype: Link Rect: 323, 222, 392, 228 Flags: Print Annotation: Subtype: Link Rect: 323, 214, 555, 220 Flags: Print Annotation: Subtype: Link Rect: 323, 206, 439, 212 Flags: Print Annotation: Subtype: Link Rect: 323, 198, 554, 204 Flags: Print Annotation: Subtype: Link Rect: 323, 190, 544, 196 Flags: Print Annotation: Subtype: Link Rect: 323, 182, 480, 188 Flags: Print Annotation: Subtype: Link Rect: 323, 174, 552, 180 Flags: Print Annotation: Subtype: Link Rect: 323, 166, 553, 172 Flags: Print Annotation: Subtype: Link Rect: 323, 158, 550, 164 Flags: Print Annotation: Subtype: Link Rect: 323, 150, 470, 156 Flags: Print Annotation: Subtype: Link Rect: 323, 142, 555, 148 Flags: Print Annotation: Subtype: Link Rect: 323, 134, 538, 140 Flags: Print Annotation: Subtype: Link Rect: 323, 126, 555, 133 Flags: Print Annotation: Subtype: Link Rect: 323, 118, 553, 125 Flags: Print Annotation: Subtype: Link Rect: 323, 110, 532, 117 Flags: Print Annotation: Subtype: Link Rect: 323, 102, 555, 109 Flags: Print Annotation: Subtype: Link Rect: 323, 94, 555, 101 Flags: Print Annotation: Subtype: Link Rect: 323, 86, 364, 93 Flags: Print Annotation: Subtype: Link Rect: 323, 78, 549, 85 Flags: Print Annotation: Subtype: Link Rect: 323, 70, 555, 77 Flags: Print Annotation: Subtype: Link Rect: 323, 62, 441, 69 Flags: Print Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 54, 732, 286, 738 Flags: Print Annotation: Subtype: Link Rect: 54, 724, 277, 730 Flags: Print Annotation: Subtype: Link Rect: 54, 716, 275, 722 Flags: Print Annotation: Subtype: Link Rect: 54, 708, 265, 714 Flags: Print Annotation: Subtype: Link Rect: 54, 700, 286, 706 Flags: Print Annotation: Subtype: Link Rect: 54, 692, 285, 698 Flags: Print Annotation: Subtype: Link Rect: 54, 684, 286, 690 Flags: Print Annotation: Subtype: Link Rect: 54, 676, 134, 682 Flags: Print Annotation: Subtype: Link Rect: 54, 668, 286, 674 Flags: Print Annotation: Subtype: Link Rect: 54, 660, 268, 666 Flags: Print Annotation: Subtype: Link Rect: 54, 652, 283, 658 Flags: Print Annotation: Subtype: Link Rect: 54, 644, 191, 651 Flags: Print Annotation: Subtype: Link Rect: 323, 732, 537, 738 Flags: Print Annotation: Subtype: Link Rect: 323, 724, 555, 730 Flags: Print Annotation: Subtype: Link Rect: 323, 716, 347, 722 Flags: Print Annotation: Subtype: Link Rect: 323, 708, 533, 714 Flags: Print Annotation: Subtype: Link Rect: 323, 700, 547, 706 Flags: Print Annotation: Subtype: Link Rect: 323, 692, 555, 698 Flags: Print Annotation: Subtype: Link Rect: 323, 684, 410, 690 Flags: Print Annotation: Subtype: Link Rect: 323, 676, 555, 682 Flags: Print Annotation: Subtype: Link Rect: 323, 668, 545, 674 Flags: Print Annotation: Subtype: Link Rect: 323, 660, 555, 666 Flags: Print Annotation: Subtype: Link Rect: 323, 652, 495, 658 Flags: Print Checksum: e6e3bd20 Type: CRC32 Checksum: 88982a137d9cb7a034aaa2cd89a82fa9 Type: MD5 Checksum: d1d1a73ca87a5d8ebe49478bececb0613f20c688 Type: SHA-1 Checksum: acc3b0de7cb35d86af54208277ab72118f83f227fa60a1b427b85a17a615f596 Type: SHA-256