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Item: Title: When to begin surveillance? Item: Title: Who should coordinate screening? Item: Title: Management Item: Title: Future directions Item: Title: Acknowledgements Item: Title: References Info: Title: SEOM clinical guideline on heritable TP53-related cancer syndrome (2022) Author: Ana Beatriz Sánchez-Heras Subject: Clinical and Translational Oncology, https://doi.org/10.1007/s12094-023-03202-9 Keywords: Li-Fraumeni syndrome; TP53; Cancer; Pathogenic variants Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Thu Apr 27 10:56:11 CEST 2023 ModDate: Wed Aug 09 13:51:52 CEST 2023 ID: 0x2eb2fb70a1c27c4b9c8637744f3c0891, 0x9de2efc47903b6429eed4892ec523a18 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2032 ImageHeight: 1164 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: SNQRKI+MyriadPro-Bold FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: SNQRKI+MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BKMMBQ+STIX-Regular FontSubset: true FirstChar: 27 LastChar: 243 FontDescriptor: FontName: BKMMBQ+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: STIX-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MWVNNQ+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MWVNNQ+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: NDTPUE+STIX-Bold FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: NDTPUE+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2023-04-27T13:56:11+05:30 Springer 2023-08-09T16:51:52+05:30 2023-08-09T16:51:52+05:30 Acrobat Distiller 10.1.8 (Windows) Li-Fraumeni syndrome; TP53; Cancer; Pathogenic variants application/pdf https://doi.org/10.1007/s12094-023-03202-9 Springer International Publishing Clinical and Translational Oncology, https://doi.org/10.1007/s12094-023-03202-9 Li-Fraumeni syndrome TP53 Cancer Pathogenic variants SEOM clinical guideline on heritable TP53-related cancer syndrome (2022) Ana Beatriz Sánchez-Heras Teresa Ramon y Cajal Marta Pineda Elena Aguirre Begoña Graña Isabel Chirivella Judit Balmaña Joan Brunet 10.1007/s12094-023-03202-9 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s12094-023-03202-9 10.1007/s12094-023-03202-9 1699-3055 25 9 2627 2633 journal Clinical and Translational Oncology The Author(s) 2010-04-23 true 10.1007/s12094-023-03202-9 noindex springer.com springerlink.com VoR uuid:805f9c84-ba6a-4e72-b3dc-3e3daaf18e09 uuid:c00be4dc-2a9d-4b4c-b6bb-5f4f4f36f3f9 default 1 converted uuid:2ba7d0b3-2ee2-491f-b3d6-8a6d14794a13 converted to PDF/A-2b pdfToolbox 2023-08-09T16:51:16+05:30 converted uuid:c28933a8-3027-40a5-a384-d5252e296391 converted to PDF/A-2b pdfToolbox 2023-08-09T16:51:52+05:30 2 B Ana Beatriz Sánchez-Heras http://orcid.org/0000-0003-1742-5374 Teresa Ramon y Cajal http://orcid.org/0000-0003-3490-3585 Marta Pineda http://orcid.org/0000-0002-5403-5845 Elena Aguirre http://orcid.org/0000-0002-2999-5959 Begoña Graña http://orcid.org/0000-0003-2008-8188 Isabel Chirivella http://orcid.org/0000-0002-0733-3276 Judit Balmaña http://orcid.org/0000-0002-0762-6415 Joan Brunet http://orcid.org/0000-0003-1945-3512 http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. 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