9e8543ab7a32e40a9bf7564881f1817d 300806.pdf 14f4335a258f750d6662b2a8c30d02aa71b6350c 300806.pdf ffe2e51e12a03dc1b30d71c1eeb538ae23bc9368d0b4bb93312eab21b399b327 300806.pdf Title: SEOM-GEIS clinical guideline for gastrointestinal stromal tumors (2022) Subject: Clinical and Translational Oncology, https://doi.org/10.1007/s12094-023-03177-7 Keywords: GIST; Imatinib; Ripretinib; Avapritinib Author: César Serrano Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Sat Apr 29 05:07:56 2023 CEST ModDate: Wed Aug 9 13:24:49 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1051892 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C WinAnsi yes no yes 336 0 MyriadPro-Semibold Type 1C Custom yes no yes 337 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 346 0 MyriadPro-Bold Type 1C Custom yes no yes 347 0 ULHVFZ+STIX-Regular Type 1C Custom yes yes yes 348 0 TOEQDN+Wingdings-Regular Type 1C WinAnsi yes yes yes 359 0 TXRKKQ+MyriadPro-SemiCn2 Type 1C WinAnsi yes yes yes 385 0 Springnew-Regular Type 1C WinAnsi yes no yes 370 0 KANDSW+STIX-Italic Type 1C WinAnsi yes yes yes 139 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 179 0 UAIUMG+MyriadPro-SemiboldSemiCnIt Type 1C WinAnsi yes yes yes 279 0 STIX-Bold Type 1C WinAnsi yes no yes 297 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-09-20 02:50:50 CEST RepresentationInformation: 300806.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-19 12:00:31 CEST Size: 1051892 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 449 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: SEOM-GEIS clinical guideline for gastrointestinal stromal tumors (2022) Children: Item: Title: Abstract Item: Title: Incidence and epidemiology Item: Title: Methodology Item: Title: Diagnosis, pathology, and molecular biology Children: Item: Title: Diagnostic evaluation Item: Title: Pathology Item: Title: Molecular biology Item: Title: Recommendations for the diagnostic work-up Item: Title: Staging and risk assessment in localized GIST Item: Title: Management of local and locoregional disease Children: Item: Title: Surgery Item: Title: Adjuvant treatment with imatinib Item: Title: Neoadjuvant treatment with imatinib Item: Title: Recommendations for the management of localized disease Item: Title: Management of advanced and metastatic disease Children: Item: Title: Surgery and other local treatments for metastatic disease Item: Title: KIT- and PDGFRA-mutant GIST Children: Item: Title: First-line treatment with imatinib Item: Title: Systemic treatment following imatinib failure Item: Title: Treatment of other GIST molecular subtypes Children: Item: Title: GISTs harboring the PDGFRA exon 18 D842V mutation Item: Title: SDH-deficient GIST Item: Title: Other molecular drivers in KITPDGFRA WT GIST Item: Title: Recommendations for metastatic disease Item: Title: Follow-up, long-term implications, and survivorship Item: Title: Acknowledgments Item: Title: References Info: Title: SEOM-GEIS clinical guideline for gastrointestinal stromal tumors (2022) Author: César Serrano Subject: Clinical and Translational Oncology, https://doi.org/10.1007/s12094-023-03177-7 Keywords: GIST; Imatinib; Ripretinib; Avapritinib Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Sat Apr 29 05:37:56 CEST 2023 ModDate: Wed Aug 09 13:54:49 CEST 2023 ID: 0x6118d2838902454d84667d478e233935, 0xdf0f3c896c99c04bab2e05662cda5208 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TOEQDN+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: TOEQDN+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: UAIUMG+MyriadPro-SemiboldSemiCnIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: UAIUMG+MyriadPro-SemiboldSemiCnIt Flags: Nonsymbolic, Italic FontBBox: -156, -250, 1096, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: STIX-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KANDSW+STIX-Italic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: KANDSW+STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: ULHVFZ+STIX-Regular FontSubset: true FirstChar: 25 LastChar: 243 FontDescriptor: FontName: ULHVFZ+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2023-04-29T08:37:56+05:30 Springer 2023-08-09T16:54:49+05:30 2023-08-09T16:54:49+05:30 Acrobat Distiller 10.1.8 (Windows) GIST; 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