a829b0dd5cedab88df6cca73028e9339 300815.pdf 7c5545a31d3c82eeec4ace739ee193f8522e2bda 300815.pdf e8b2edfcc1b88e56ae010c6cf4d0161c2bf5f351839c1fe5387573562ade28fd 300815.pdf Title: Impact of Baseline Anemia in Patients Undergoing Transcatheter Aortic Valve Replacement: A Prognostic Systematic Review and Meta-Analysis Subject: Transcatheter aortic valve replacement (TAVR) is currently the treatment of choice for patients aged 75 years with severe aortic stenosis. Preoperative anemia is present in a large proportion of patients and may increase the risk of post-procedural complications. The purpose of this prognostic systematic review was to analyze the impact of baseline anemia on short- and mid-term outcomes following TAVR. A computerized search was performed on PubMed and Web of Science databases for studies published between January 2013 and December 2022. Primary outcomes were 30-day need for transfusion, acute renal failure, 30-day and mid-term mortality, and readmission during the first year post-TAVR. Data were analyzed via random effects model using inverse variance method with 95% confidence intervals. Eleven observational studies met our eligibility criteria and included a total of 12,588 patients. The prevalence of baseline anemia ranged between 39% and 72%, with no relevant sex differences. Patients with preprocedural anemia received more blood transfusions [OR: 2.95 (2.13–4.09)]), and exhibited increased rates of acute kidney injury [OR:1.74 (1.45–2.10)], short-term mortality [OR: 1.47 (1.07–2.01], and mid-term [OR: 1.89 (1.58–2.25)] mortality following TAVR compared with those without anemia. Baseline anemia determined an increased risk for blood transfusion, acute kidney injury, and short/mid-term mortality among TAVR recipients. Keywords: anemia; aortic stenosis; transcatheter aortic valve replacement; TAVR Author: Elena Jiménez-Xarrié, Lluis Asmarats, Marta Roqué-Figuls, Xavier Millán, Chi Hion Pedro Li, Estefanía Fernández-Peregrina, Juan Sánchez-Ceña, Albert Massó van Roessel, M. Luz Maestre Hittinger, Pilar Paniagua and Dabit Arzamendi Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Sep 26 06:37:32 2023 CEST ModDate: Tue Sep 26 06:43:22 2023 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1829687 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DWHBJD+VnURWPalladioL Type 1 Custom yes yes no 10 0 ZHTFDZ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 JXPIKP+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 NZLNYJ+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 TNBSFT+CMSY10 Type 1 Builtin yes yes no 28 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 50 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 53 0 CKINGG+PalatinoLinotype TrueType MacRoman yes yes no 81 0 CKIMGD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 84 0 CKIMGE+PalatinoLinotype CID TrueType Identity-H yes yes yes 87 0 CKIMGF+PalatinoLinotype TrueType WinAnsi yes yes no 93 0 CKIMGH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 96 0 CKINGF+Symbol Type 1C Custom yes yes yes 109 0 CKINGG+PalatinoLinotype TrueType MacRoman yes yes no 114 0 CKIMGD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 117 0 CKIMGF+PalatinoLinotype TrueType WinAnsi yes yes no 120 0 CKIMGH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 123 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 131 0 CKINGG+PalatinoLinotype TrueType MacRoman yes yes no 144 0 CKJFBH+Symbol CID TrueType Identity-H yes yes yes 147 0 CKIMGD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 153 0 CKIMGE+PalatinoLinotype CID TrueType Identity-H yes yes yes 156 0 CKIMGF+PalatinoLinotype TrueType WinAnsi yes yes no 162 0 CKIMGH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 165 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-09-21 02:53:51 CEST RepresentationInformation: 300815.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-20 12:05:07 CEST Size: 1829687 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 355 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Search Strategy Destination: subsection.2.1 Item: Title: Inclusion and Exclusion Criteria Destination: subsection.2.2 Item: Title: Risk of Bias Assessment Destination: subsection.2.3 Item: Title: Endpoints Destination: subsection.2.4 Item: Title: Statistical Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: Search Results Destination: subsection.3.1 Item: Title: Risk of Bias Assessment Destination: subsection.3.2 Item: Title: Clinical Characteristics Destination: subsection.3.3 Item: Title: Need for Transfusion Destination: subsection.3.4 Item: Title: Acute Kidney Injury Destination: subsection.3.5 Item: Title: Mortality Destination: subsection.3.6 Item: Title: Rehospitalization Destination: subsection.3.7 Item: Title: Discussion Destination: section.4 Children: Item: Title: Clinical Impact Destination: subsection.4.1 Item: Title: Pre-TAVR Anemia Optimization Destination: subsection.4.2 Item: Title: Limitations Destination: section.5 Item: Title: Conclusions Destination: section.6 Item: Title: References Destination: section.A. Info: Title: Impact of Baseline Anemia in Patients Undergoing Transcatheter Aortic Valve Replacement: A Prognostic Systematic Review and Meta-Analysis Author: Elena Jiménez-Xarrié, Lluis Asmarats, Marta Roqué-Figuls, Xavier Millán, Chi Hion Pedro Li, Estefanía Fernández-Peregrina, Juan Sánchez-Ceña, Albert Massó van Roessel, M. Luz Maestre Hittinger, Pilar Paniagua and Dabit Arzamendi Subject: Transcatheter aortic valve replacement (TAVR) is currently the treatment of choice for patients aged 75 years with severe aortic stenosis. Preoperative anemia is present in a large proportion of patients and may increase the risk of post-procedural complications. The purpose of this prognostic systematic review was to analyze the impact of baseline anemia on short- and mid-term outcomes following TAVR. A computerized search was performed on PubMed and Web of Science databases for studies published between January 2013 and December 2022. Primary outcomes were 30-day need for transfusion, acute renal failure, 30-day and mid-term mortality, and readmission during the first year post-TAVR. Data were analyzed via random effects model using inverse variance method with 95% confidence intervals. Eleven observational studies met our eligibility criteria and included a total of 12,588 patients. The prevalence of baseline anemia ranged between 39% and 72%, with no relevant sex differences. Patients with preprocedural anemia received more blood transfusions [OR: 2.95 (2.13 4.09)]), and exhibited increased rates of acute kidney injury [OR:1.74 (1.45 2.10)], short-term mortality [OR: 1.47 (1.07 2.01], and mid-term [OR: 1.89 (1.58 2.25)] mortality following TAVR compared with those without anemia. Baseline anemia determined an increased risk for blood transfusion, acute kidney injury, and short/mid-term mortality among TAVR recipients. 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