931509085e87d0edfe008d836190ad3b  301128.pdf
363716ce67ee23139d0f90ae01e7ff5c8c161c86  301128.pdf
f50839213541f3a2c6f6aecc3bf1ab08f0f4add81a85f8e7de5334fc6000ab3b  301128.pdf

Title:           Moving from serotonin to serotonin-norepinephrine enhancement with increasing venlafaxine dose: clin
Keywords:        Venlafaxine; major depressive disorder; monoamines; symptom clusters; depression; anxiety
Creator:         PTC Arbortext Publishing Engine
Producer:        PDFlib+PDI 9.2.0 (C++/Win64)
CreationDate:    Tue Aug 29 22:24:37 2023 CEST
ModDate:         Tue Aug 29 22:24:37 2023 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           10
Encrypted:       no
Page size:       634.32 x 833.04 pts
Page rot:        0
File size:       1447770 bytes
Optimized:       no
PDF version:     1.5


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
ECEDBC+OpenSans-Semibold             CID TrueType      Identity-H       yes yes yes   1122  0
ECEDBB+OpenSans                      CID TrueType      Identity-H       yes yes yes   1123  0
WQULKP+MyriadPro-Regular             Type 1C           Custom           yes yes yes   1129  0
EYQFAY+MyriadPro-Semibold            Type 1C           Custom           yes yes yes   1130  0
HIAXKI+MyriadPro-SemiCn              Type 1C           Custom           yes yes yes   1131  0
AJOMIE+MyriadPro-Black               Type 1C           Custom           yes yes yes   1132  0
UOZWBM+MyriadPro-Bold                Type 1C           Custom           yes yes yes   1133  0
OBLMWH+MyriadPro-It                  Type 1C           Custom           yes yes yes   1142  0
YXBPSS+MyriadPro-SemiboldSemiCn      Type 1C           Custom           yes yes yes   1143  0
PUQVQO+ArialUnicodeMS                CID TrueType      Identity-H       yes yes yes   1144  0
MAOFLA+MyriadPro-BoldIt              Type 1C           Custom           yes yes yes   1153  0
BWVAEJ+MyriadPro-SemiboldIt          Type 1C           Custom           yes yes yes   1157  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-09-27 02:41:39 CEST
 RepresentationInformation: 301128.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-09-26 11:01:50 CEST
  Size: 1447770
  Format: PDF
  Version: 1.5
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  InfoMessage: File header gives version as 1.4, but catalog dictionary gives version as 1.5
   ID: PDF-HUL-87
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 1239
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
    Language: English
    Outlines: 
     Item: 
      Title: Abstract
      Destination: 1
     Item: 
      Title: 1.  Introduction
      Destination: 1
     Item: 
      Title: 2.  Pharmacodynamics of venlafaxine
      Destination: 1
     Item: 
      Title: 3.  Symptom clusters in MDD
      Destination: 1
     Item: 
      Title: 4.  Efficacy of venlafaxine in patients with MDD with low energy
      Destination: 1
     Item: 
      Title: 5.  Conclusions
      Destination: 1
     Item: 
      Title: 6.  Clinical practice
      Destination: 1
      Children: 
       Item: 
        Title: 6.1.  Case 1 - low-dose venlafaxine XR
        Destination: 1
        Children: 
         Item: 
          Title: 6.1.1.  Expert comment
          Destination: 1
       Item: 
        Title: 6.2.  Case 2   high-dose venlafaxine
        Destination: 1
        Children: 
         Item: 
          Title: 6.2.1.  Expert comment
          Destination: 1
       Item: 
        Title: 6.3.  Case 3   sequential treatment
        Destination: 1
        Children: 
         Item: 
          Title: 6.3.1.  Expert comment
          Destination: 1
     Item: 
      Title: 7.  Expert opinion
      Destination: 1
     Item: 
      Title: Funding
      Destination: 1
     Item: 
      Title: Declaration of interest
      Destination: 1
     Item: 
      Title: Reviewer disclosures
      Destination: 1
     Item: 
      Title: Acknowledgments
      Destination: 1
     Item: 
      Title: References
      Destination: 1
   Info: 
    Title: Moving from serotonin to serotonin-norepinephrine enhancement with increasing venlafaxine dose: clin
    Keywords: Venlafaxine; major depressive disorder; monoamines; symptom clusters; depression; anxiety
    Creator: PTC Arbortext Publishing Engine
    Producer: PDFlib+PDI 9.2.0 (C++/Win64)
    CreationDate: Tue Aug 29 22:54:37 CEST 2023
    ModDate: Tue Aug 29 22:54:37 CEST 2023
   ID: 0x7c8e7bda94e19bea962ab356815155bc, 0x7c8e7bda94e19bea962ab356815155bc
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 512
      ImageHeight: 346
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im10
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 694
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im13
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 694
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im14
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 448
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im11
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 448
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im12
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 600
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im17
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 600
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im18
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 674
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im15
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 674
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im16
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 200
      ImageHeight: 261
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Name: Im1
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 1010
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im3
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 3150
      ImageHeight: 746
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im2
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 641
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im5
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 1010
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im4
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 470
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im7
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 641
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im6
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 512
      ImageHeight: 346
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im9
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 470
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im8
   Fonts: 
    Type0: 
     Font: 
      BaseFont: ECEDBC+OpenSans-Semibold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: ECEDBB+OpenSans
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: PUQVQO+ArialUnicodeMS
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: MAOFLA+MyriadPro-BoldIt
      FontSubset: true
      FirstChar: 1
      LastChar: 30
      FontDescriptor: 
       FontName: MAOFLA+MyriadPro-BoldIt
       Flags: Nonsymbolic, Italic, ForceBold
       FontBBox: -201, -250, 1225, 987
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BWVAEJ+MyriadPro-SemiboldIt
      FontSubset: true
      FirstChar: 1
      LastChar: 16
      FontDescriptor: 
       FontName: BWVAEJ+MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -103, -250, 1165, 882
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OBLMWH+MyriadPro-It
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: OBLMWH+MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: YXBPSS+MyriadPro-SemiboldSemiCn
      FontSubset: true
      FirstChar: 1
      LastChar: 19
      FontDescriptor: 
       FontName: YXBPSS+MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WQULKP+MyriadPro-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 87
      FontDescriptor: 
       FontName: WQULKP+MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EYQFAY+MyriadPro-Semibold
      FontSubset: true
      FirstChar: 1
      LastChar: 25
      FontDescriptor: 
       FontName: EYQFAY+MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HIAXKI+MyriadPro-SemiCn
      FontSubset: true
      FirstChar: 1
      LastChar: 81
      FontDescriptor: 
       FontName: HIAXKI+MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AJOMIE+MyriadPro-Black
      FontSubset: true
      FirstChar: 1
      LastChar: 16
      FontDescriptor: 
       FontName: AJOMIE+MyriadPro-Black
       Flags: Nonsymbolic, ForceBold
       FontBBox: -166, -251, 1313, 1005
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: UOZWBM+MyriadPro-Bold
      FontSubset: true
      FirstChar: 1
      LastChar: 56
      FontDescriptor: 
       FontName: UOZWBM+MyriadPro-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: ECEDBC+OpenSans-Semibold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: ECEDBC+OpenSans-Semibold
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -583, -282, 1261, 1048
       FontFile2: true
     Font: 
      BaseFont: ECEDBB+OpenSans
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: ECEDBB+OpenSans
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -549, -270, 1204, 1047
       FontFile2: true
     Font: 
      BaseFont: PUQVQO+ArialUnicodeMS
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: PUQVQO+ArialUnicodeMS
       Flags: Nonsymbolic
       FontBBox: -1011, -330, 2260, 1078
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/"
           x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
      <rdf:Description rdf:about="">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1080/14656566.2023.2242264</dc:identifier>
         <dc:title>Moving from serotonin to serotonin-norepinephrine enhancement with increasing venlafaxine dose: clinical implications and strategies for a successful outcome in major depressive disorder</dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Andrea Fagiolini</rdf:li>
               <rdf:li>Narcis Cardoner</rdf:li>
               <rdf:li>Sebnem Pirildar</rdf:li>
               <rdf:li>Pichai Ittsakul</rdf:li>
               <rdf:li>Bernardo Ng</rdf:li>
               <rdf:li>Kalil Duailibi</rdf:li>
               <rdf:li>Nasser El Hindy</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>Taylor &amp; Francis</dc:publisher>
         <dc:description>Expert Opinion on Pharmacotherapy, 2023. doi:10.1080/14656566.2023.2242264</dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Venlafaxine</rdf:li>
               <rdf:li>major depressive disorder</rdf:li>
               <rdf:li>monoamines</rdf:li>
               <rdf:li>symptom clusters</rdf:li>
               <rdf:li>depression</rdf:li>
               <rdf:li>anxiety</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:lang>en</dc:lang>
         <prism:aggregationType>Journal</prism:aggregationType>
         <prism:publicationName>Expert Opinion on Pharmacotherapy</prism:publicationName>
         <prism:copyright>© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group.</prism:copyright>
         <prism:issn>1465-6566</prism:issn>
         <prism:elssn>1744-7666</prism:elssn>
         <prism:volume>24</prism:volume>
         <prism:number>15</prism:number>
         <prism:issueName/>
         <prism:startingPage>1715</prism:startingPage>
         <prism:endingPage>1724</prism:endingPage>
         <prism:doi>10.1080/14656566.2023.2242264</prism:doi>
         <prism:url>https://doi.org/10.1080/14656566.2023.2242264</prism:url>
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description xmlns:crossmark="http://crossref.org/crossmark/1.0/" rdf:about="">
         <crossmark:DOI>10.1080/14656566.2023.2242264</crossmark:DOI>
         <crossmark:MajorVersionDate>2023-08-07</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>www.tandfonline.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" rdf:about="">
         <pdfx:doi>10.1080/14656566.2023.2242264</pdfx:doi>
         <pdfx:CrossmarkMajorVersionDate>2023-08-07</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>True</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>www.tandfonline.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 155, 42, 478, 51
      Annotation: 
       Subtype: Link
       Rect: 283, 688, 431, 696
      Annotation: 
       Subtype: Link
       Rect: 292, 421, 446, 431
      Annotation: 
       Subtype: Link
       Rect: 202, 401, 427, 411
      Annotation: 
       Subtype: Link
       Rect: 106, 302, 124, 311
      Annotation: 
       Subtype: Link
       Rect: 131, 302, 286, 311
      Annotation: 
       Subtype: Link
       Rect: 106, 255, 122, 264
      Annotation: 
       Subtype: Link
       Rect: 131, 259, 230, 268
      Annotation: 
       Subtype: Link
       Rect: 326, 252, 344, 261
      Annotation: 
       Subtype: Link
       Rect: 351, 259, 452, 268
      Annotation: 
       Subtype: Link
       Rect: 106, 213, 124, 222
      Annotation: 
       Subtype: Link
       Rect: 131, 216, 292, 225
    Page: 
     Label: 1
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 120, 625, 124, 636
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 124, 625, 124, 636
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 200, 625, 204, 636
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 280, 625, 283, 636
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 350, 625, 354, 636
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 417, 625, 420, 636
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 481, 625, 483, 636
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 137, 613, 141, 624
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 113, 260, 118, 270
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 218, 224, 223, 234
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 225, 224, 230, 234
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 264, 188, 269, 197
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 270, 188, 275, 197
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 237, 151, 247, 160
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 247, 151, 257, 160
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 230, 127, 240, 136
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 242, 127, 252, 136
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 313, 264, 323, 273
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 325, 264, 334, 273
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 353, 226, 363, 236
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 365, 226, 375, 236
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 377, 226, 386, 236
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 335, 202, 345, 211
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 347, 202, 357, 211
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 546, 104, 556, 113
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 459, 744, 561, 751
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 702, 561, 714
       Flags: Print
    Page: 
     Label: 2
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 128, 471, 138, 480
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 135, 446, 140, 456
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 50, 409, 60, 418
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 62, 409, 72, 418
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 74, 409, 89, 418
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 89, 409, 99, 418
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 76, 384, 86, 394
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 284, 384, 293, 394
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 129, 347, 139, 356
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 141, 347, 151, 356
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 167, 310, 176, 319
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 260, 297, 270, 307
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 313, 695, 323, 704
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 325, 695, 334, 704
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 368, 647, 382, 656
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 382, 647, 392, 656
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 357, 575, 367, 584
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 522, 563, 558, 572
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 313, 551, 323, 560
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 325, 551, 334, 560
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 419, 515, 429, 524
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 424, 491, 434, 500
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 389, 467, 404, 476
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 404, 467, 414, 476
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 490, 443, 500, 452
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 494, 419, 504, 428
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 364, 383, 374, 392
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 376, 383, 386, 392
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 388, 383, 398, 392
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 547, 323, 556, 332
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 472, 38, 479, 46
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 481, 38, 488, 46
       Flags: Print
       Destination: 1
    Page: 
     Label: 3
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 235, 719, 245, 728
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 50, 671, 60, 680
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 62, 671, 72, 680
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 50, 647, 65, 656
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 65, 647, 74, 656
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 240, 479, 249, 488
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 242, 455, 251, 464
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 253, 455, 262, 464
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 260, 431, 270, 440
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 272, 431, 282, 440
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 284, 431, 294, 440
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 161, 359, 170, 368
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 172, 359, 182, 368
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 117, 287, 126, 296
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 155, 155, 165, 164
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 50, 119, 60, 128
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 210, 59, 220, 68
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 547, 731, 556, 740
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 464, 671, 474, 680
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 514, 647, 524, 656
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 525, 647, 535, 656
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 405, 563, 415, 572
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 417, 563, 427, 572
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 476, 515, 486, 524
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 488, 515, 498, 524
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 532, 419, 547, 428
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 547, 419, 556, 428
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 547, 371, 556, 380
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 313, 287, 323, 296
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 489, 203, 499, 212
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 475, 179, 485, 188
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 476, 143, 506, 152
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 395, 71, 405, 80
       Flags: Print
       Destination: 1
    Page: 
     Label: 4
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 84, 503, 93, 512
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 244, 431, 254, 440
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 256, 431, 266, 440
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 267, 431, 277, 440
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 187, 347, 196, 356
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 197, 143, 230, 152
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 264, 723, 271, 731
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 273, 723, 281, 731
       Flags: Print
       Destination: 1
    Page: 
     Label: 5
     Sequence: 6
    Page: 
     Label: 6
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 331, 503, 362, 512
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 491, 455, 521, 464
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 348, 383, 381, 392
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 524, 299, 556, 308
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 382, 203, 413, 212
       Flags: Print
       Destination: 1
    Page: 
     Label: 7
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 498, 695, 531, 704
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 540, 695, 550, 704
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 468, 563, 477, 572
       Flags: Print
       Destination: 1
    Page: 
     Label: 8
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 121, 545, 138, 553
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 270, 545, 298, 553
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 72, 535, 151, 543
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 204, 495, 220, 503
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 243, 465, 260, 473
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 155, 425, 298, 433
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 72, 415, 125, 423
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 226, 385, 298, 393
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 72, 375, 298, 383
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 72, 365, 108, 373
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 116, 335, 133, 343
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 229, 335, 298, 343
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 72, 325, 99, 333
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 247, 305, 263, 313
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 98, 265, 115, 273
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 98, 235, 114, 243
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 123, 205, 139, 213
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 214, 205, 298, 213
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 226, 185, 242, 193
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 282, 145, 298, 153
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 131, 115, 147, 123
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 220, 115, 286, 123
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 149, 75, 165, 83
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 208, 45, 225, 53
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 88, 35, 185, 43
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 498, 712, 514, 720
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 367, 702, 451, 710
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 407, 672, 423, 680
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 529, 641, 545, 649
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 366, 611, 382, 619
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 510, 611, 561, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 601, 390, 609
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 378, 571, 394, 579
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 334, 530, 351, 538
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 519, 510, 536, 518
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 381, 500, 457, 508
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 512, 470, 529, 478
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 334, 419, 350, 427
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 417, 419, 513, 427
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 441, 388, 458, 396
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 355, 358, 371, 366
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 437, 358, 504, 366
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 372, 318, 389, 326
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 334, 287, 351, 295
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 420, 287, 543, 295
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 433, 257, 449, 265
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 398, 227, 414, 235
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 388, 207, 404, 215
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 393, 176, 410, 184
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 471, 176, 541, 184
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 399, 126, 415, 134
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 513, 126, 561, 134
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 116, 364, 124
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 485, 96, 501, 104
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 464, 76, 561, 84
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 66, 508, 74
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 351, 35, 367, 43
       Flags: Print
       Destination: 1
    Page: 
     Label: 9
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 110, 712, 126, 720
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 150, 682, 167, 690
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 135, 652, 152, 660
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 72, 611, 88, 619
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 168, 611, 266, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 255, 581, 272, 589
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 131, 571, 205, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 158, 530, 175, 538
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 236, 500, 253, 508
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 282, 459, 298, 467
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 206, 418, 222, 426
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 268, 378, 284, 386
       Flags: Print
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 131, 368, 192, 376
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 72, 317, 88, 325
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 222, 286, 239, 294
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 88, 276, 185, 284
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 189, 185, 205, 193
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 139, 164, 156, 172
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 254, 144, 271, 152
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 131, 134, 218, 142
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 72, 53, 88, 61
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 172, 53, 245, 61
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 433, 652, 449, 660
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 517, 652, 561, 660
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 642, 359, 650
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 545, 612, 561, 620
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 407, 562, 424, 570
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 511, 562, 561, 570
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 552, 407, 560
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 409, 512, 425, 520
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 486, 512, 560, 520
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 472, 351, 480
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 420, 472, 515, 480
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 518, 442, 534, 450
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 369, 392, 385, 400
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 409, 362, 425, 370
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 495, 362, 561, 370
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 508, 332, 524, 340
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 367, 322, 482, 330
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 394, 292, 410, 300
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 494, 292, 561, 300
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 282, 369, 290
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 252, 351, 260
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 403, 252, 473, 260
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 454, 202, 471, 210
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 552, 202, 561, 210
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 192, 419, 200
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 518, 132, 534, 140
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 505, 102, 522, 110
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 353, 82, 476, 90
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 499, 62, 516, 70
       Flags: Print
       Destination: 1
  Checksum: b2c69fcc
   Type: CRC32
  Checksum: 931509085e87d0edfe008d836190ad3b
   Type: MD5
  Checksum: 363716ce67ee23139d0f90ae01e7ff5c8c161c86
   Type: SHA-1
  Checksum: f50839213541f3a2c6f6aecc3bf1ab08f0f4add81a85f8e7de5334fc6000ab3b
   Type: SHA-256