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Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Adipose tissue and cancer development in the obese setting Destination: mk:H1_2 Children: Item: Title: 2.1 White and brown adipose tissue Destination: mk:H2_1 Item: Title: 2.2 Metabolic syndrome and its role in cancer development Destination: mk:H2_2 Item: Title: 3 Lipid metabolism in cancer cells in the obese setting Destination: mk:H1_3 Children: Item: Title: 3.1 Intrinsic regulation of lipid metabolism in cancer cells Destination: mk:H2_3 Item: Title: 3.2 Exogenous lipid supply to cancer cells Destination: mk:H2_4 Item: Title: 3.3 Adipose tumor microenvironment tends to be hypoxic Destination: mk:H2_5 Item: Title: 3.4 Obesity and intracellular lipid metabolism in cancer cells Destination: mk:H2_6 Item: Title: 4 Cancer-associated host cells in the obese setting Destination: mk:H1_4 Children: Item: Title: 4.1 Adipose tissue macrophages, tumor-associated macrophages, and tumor growth Destination: mk:H2_7 Item: Title: 4.2 Tumorigenic cancer-associated fibroblast Destination: mk:H2_8 Item: Title: 4.3 Endothelial cells and angiogenesis Destination: mk:H2_9 Item: Title: 4.4 CD8+ cytotoxic T cells Destination: mk:H2_10 Item: Title: 5 Potential therapeutic strategies Destination: mk:H1_5 Children: Item: Title: 5.1 Nutritional interventions Destination: mk:H2_11 Item: Title: 5.2 Drugs targeted to regulate fatty acid metabolism Destination: mk:H2_12 Item: Title: 5.3 Statins Destination: mk:H2_13 Item: Title: 5.4 Oral antidiabetic drugs Destination: mk:H2_14 Item: Title: 6 Concluding remarks Destination: mk:H1_6 Item: Title: Funding Source Destination: mk:H1_7 Item: Title: CRediT authorship contribution statement Destination: mk:H1_8 Item: Title: Declaration of Competing Interest Destination: mk:HH1_3 Item: Title: Data Availability Destination: datalink4 Item: Title: Acknowledgments Destination: mk:HH1_5 Item: Title: References Destination: mk:HH2_1 Info: Title: Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism Author: Miriam Lee-Rueckert Subject: Seminars in Cancer Biology, 93 (2023) 36-51. doi:10.1016/j.semcancer.2023.05.002 Keywords: "Adipocytes, cancer",Cholesterol,"Fibroblasts, fatty acids",Lipids,Macrophages,Obesity,Tumor microenvironment Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Dec 20 08:27:39 CET 2023 ModDate: Wed Dec 20 09:43:56 CET 2023 ID: 0x5b80af13516d80d271426d30f88c7a3e, 0xcce4f8d04bc0916db7f7b02e29b8bb88 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: 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Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JDTVDB+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: SCGYEE+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SCGYEE+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true XMP: application/pdf 10.1016/j.semcancer.2023.05.002 Elsevier Ltd Seminars in Cancer Biology, 93 (2023) 36-51. doi:10.1016/j.semcancer.2023.05.002 Adipocytes, cancer Cholesterol Fibroblasts, fatty acids Lipids Macrophages Obesity Tumor microenvironment Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism Miriam Lee-Rueckert Marina Canyelles Mireia Tondo Noemi Rotllan Petri T. Kovanen Vicenta Llorente-Cortes Joan Carles Escolà-Gil journal Seminars in Cancer Biology © 2023 The Authors. Published by Elsevier Ltd. 1044-579X 93 1 August 2023 2023-08-01 36-51 36 51 10.1016/j.semcancer.2023.05.002 https://doi.org/10.1016/j.semcancer.2023.05.002 2010-04-23 true 10.1016/j.semcancer.2023.05.002 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by/4.0/ VoR 10.1016/j.semcancer.2023.05.002 noindex 2010-04-23 true 20th December 2023 sciencedirect.com elsevier.com Elsevier 2023-12-20T08:43:56 2023-12-20T07:27:39 2023-12-20T08:43:56 True 20th December 2023 Acrobat Distiller 8.1.0 (Windows) "Adipocytes, cancer",Cholesterol,"Fibroblasts, fatty acids",Lipids,Macrophages,Obesity,Tumor microenvironment uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 36 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 137, 559, 144, 569 Flags: Print Destination: 1977 Annotation: Subtype: Link Rect: 144, 554, 238, 565 Flags: Print Destination: 1977 Annotation: Subtype: Link Rect: 238, 559, 245, 569 Flags: Print Destination: 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