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l-Ergothioneine prevents cystine lithiasis in the Slc7a9−/− mouse model of cystinuria Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Methods Destination: mk:H1_2 Children: Item: Title: 2.1 Mice treatments Destination: mk:H2_1 Item: Title: 2.2 Cystine calculi detection by X-ray Destination: mk:H2_2 Item: Title: 2.3 Sample collection Destination: mk:H2_3 Item: Title: 2.4 L-Erg and S-Met-L-Erg determination Destination: mk:H2_4 Item: Title: 2.5 Cystine analysis Destination: mk:H2_5 Item: Title: 2.6 Electron microscopy Destination: mk:H2_6 Item: Title: 2.7 GSH and GSSG determination Destination: mk:H2_7 Item: Title: 2.8 Mitochondrial respirometry Destination: mk:H2_8 Item: Title: 2.9 Mitochondrial respiratory chain enzymatic activities Destination: mk:H2_9 Item: Title: 2.10 Statistical analysis Destination: mk:H2_10 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Determination of L-Erg dose Destination: mk:H2_11 Item: Title: 3.2 Long-term L-Erg treatment prevents cystine lithiasis and delays its onset Destination: mk:H2_12 Item: Title: 3.3 L-Erg treatment increases urinary cystine solubility without affecting metabolic parameters or chelating cysteine Destination: mk:H2_13 Item: Title: 3.4 High-dose L-Erg treatment prevents cystine lithiasis Destination: mk:H2_14 Item: Title: 3.5 L-Erg metabolism is essential for treatment effectiveness Destination: mk:H2_15 Item: Title: 3.6 Long-term L-Erg treatment ameliorates oxidative damage in cystinuric mice Destination: mk:H2_16 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: Funding Destination: mk:H1_5 Item: Title: Authors’ contribution Destination: mk:H1_6 Item: Title: Declaration of competing interest Destination: mk:HH1_3 Item: Title: Data availability Destination: datalink4 Item: Title: Acknowledgements Destination: mk:HH1_5 Item: Title: Appendix A Supplementary data Destination: mk:H1_7 Item: Title: References Destination: mk:HH2_1 Info: Title: The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9−/− mouse model of cystinuria Author: Clara Mayayo-Vallverdú Subject: Redox Biology, 64 (2023) 102801. doi:10.1016/j.redox.2023.102801 Keywords: Cystinuria,l-Ergothioneine,Cystine lithiasis,Antioxidant,Oxidative stress,Treatment Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Jul 05 14:40:24 CEST 2023 ModDate: Wed Jul 05 16:34:38 CEST 2023 ID: 0x54a017b438fd030b6b7d9517873749d0, 0x92c03ce4a08673c466e9c6e05eee9eb5 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: HWOCRT+CharisSIL-BoldItalic Encoding: Identity-H ToUnicode: true Font: 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Redox Biology, 64 (2023) 102801. doi:10.1016/j.redox.2023.102801 Cystinuria l-Ergothioneine Cystine lithiasis Antioxidant Oxidative stress Treatment The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9−/− mouse model of cystinuria Clara Mayayo-Vallverdú Miguel López de Heredia Esther Prat Laura González Meritxell Espino Guarch Clara Vilches Lourdes Muñoz Miguel A. Asensi Carmen Serra Amadeu Llebaria Mercedes Casado Rafael Artuch Gloria Garrabou Pablo M. Garcia-Roves Federico V. Pallardó Virginia Nunes VoR 5th July 2023 Acrobat Distiller 8.1.0 (Windows) Cystinuria,l-Ergothioneine,Cystine lithiasis,Antioxidant,Oxidative stress,Treatment 5th July 2023 7.0 10.1016/j.redox.2023.102801 noindex journal © 2023 The Authors. 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