f2af83dde030b6cf3aa4d1edf259d4cb 301140.pdf 08db056957188539c8e44f65070825ddf1d6e842 301140.pdf b56f8a8e653245983a9b6d99ef65ab2821029f9814451a96dffb62921c5f184a 301140.pdf Title: Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society Subject: DOI: 10.1093/eurheartj/ehad472; European Heart Journal, 44, 39, 2023-08-23.; Abstract: Cardiovascular disease is the leading cause of death in women and men globally, with most due to atherosclerotic cardiovascular disease (ASCVD). Despite progress during the last 30 years, ASCVD mortality is now increasing, with the fastest relative increase in middle-aged women. Missed or delayed diagnosis and undertreatment do not fully explain this burden of disease. Sex-specific factors, such as hypertensive disorders of pregnancy, premature menopause (especially primary ovarian insufficiency), and polycystic ovary syndrome are also relevant, with good evidence that these are associated with greater cardiovascular risk. This position statement from the European Atherosclerosis Society focuses on these factors, as well as sex-specific effects on lipids, including lipoprotein(a), over the life course in women which impact ASCVD risk. Women are also disproportionately impacted (in relative terms) by diabetes, chronic kidney disease, and auto-immune inflammatory disease. All these effects are compounded by sociocultural components related to gender. This panel stresses the need to identify and treat modifiable cardiovascular risk factors earlier in women, especially for those at risk due to sex-specific conditions, to reduce the unacceptably high burden of ASCVD in women. Keywords: Women; Atherosclerotic cardiovascular disease; Sex-specific risk; Lipids; Cholesterol; Triglycerides; Lipoprotein(a) Author: Jeanine E. Roeters van Lennep Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Fri Oct 13 05:38:49 2023 CEST ModDate: Fri Oct 13 10:14:18 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1924673 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZWZDAU+GillSansNova-Bold CID TrueType Identity-H yes yes yes 3197 0 KQETCA+GillSansNova-Book CID TrueType Identity-H yes yes yes 3200 0 STPLGN+GillSansNova-BookItalic CID TrueType Identity-H yes yes yes 3203 0 NFEMNX+GillSansNova-Heavy CID TrueType Identity-H yes yes yes 3206 0 MBMTDA+STIXGeneral-Regular Type 1C Custom yes yes yes 334 0 QJBIYH+GillSansNova-Book CID TrueType Identity-H yes yes yes 198 0 AGZLIN+GillSansNova-Book TrueType WinAnsi yes yes no 200 0 KIXTST+GillSansNova-Medium TrueType WinAnsi yes yes no 202 0 YSKNLI+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 414 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-01 02:43:41 CEST RepresentationInformation: 301140.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-30 11:17:32 CEST Size: 1924673 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - 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Destination: secehad472-s1 Children: Item: Title: Gender Destination: secehad472-s2 Item: Title: Does cardiovascular risk prediction differ in women? Destination: secehad472-s2.1 Item: Title: Are there sex-related differences in the pathogenesis of atherosclerosis? Destination: secehad472-s2.2 Item: Title: Does sex impact atherothrombosis risk? Destination: secehad472-s2.3 Item: Title: Does atherosclerotic cardiovascular disease presentation differ in women? Destination: secehad472-s3 Children: Item: Title: Ischaemic heart disease Destination: secehad472-s3.1 Item: Title: Stroke Destination: secehad472-s3.2 Item: Title: Peripheral artery disease Destination: secehad472-s3.3 Item: Title: Cardiovascular risk factors in women: focus on lipids Destination: secehad472-s4 Children: Item: Title: Familial hypercholesterolaemia Destination: secehad472-s4.1 Item: Title: Triglyceride-rich lipoproteins Destination: secehad472-s5 Item: Title: Lipoprotein(a) Destination: secehad472-s6 Item: Title: Call to action for women and atherosclerotic cardiovascular disease Destination: secehad472-s7 Item: Title: Acknowledgements Destination: acknow Item: Title: secehad472-s8 Destination: secehad472-s8 Item: Title: Declarations Destination: secehad472-s9 Children: Item: Title: Disclosure of Interest Destination: secehad472-s10 Item: Title: Data Availability Destination: secehad472-s11 Item: Title: Funding Destination: secehad472-s12 Item: Title: References Destination: secref1 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1154 ImageHeight: 1338 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1170 ImageHeight: 710 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1266 ImageHeight: 1113 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 983 ImageHeight: 1016 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1166 ImageHeight: 401 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1166 ImageHeight: 395 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: KQETCA+GillSansNova-Book Encoding: Identity-H ToUnicode: true Font: BaseFont: STPLGN+GillSansNova-BookItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: NFEMNX+GillSansNova-Heavy Encoding: Identity-H ToUnicode: true Font: BaseFont: ZWZDAU+GillSansNova-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: YSKNLI+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MBMTDA+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 9 FontDescriptor: FontName: MBMTDA+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: STPLGN+GillSansNova-BookItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: STPLGN+GillSansNova-BookItalic Flags: Nonsymbolic, Italic FontBBox: -316, -235, 1219, 950 FontFile2: true Font: BaseFont: NFEMNX+GillSansNova-Heavy CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NFEMNX+GillSansNova-Heavy Flags: Nonsymbolic, ForceBold FontBBox: -504, -287, 1375, 966 FontFile2: true Font: BaseFont: ZWZDAU+GillSansNova-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ZWZDAU+GillSansNova-Bold Flags: Nonsymbolic, ForceBold FontBBox: -476, -276, 1276, 961 FontFile2: true Font: BaseFont: YSKNLI+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YSKNLI+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Font: BaseFont: KQETCA+GillSansNova-Book CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KQETCA+GillSansNova-Book Flags: Nonsymbolic FontBBox: -420, -251, 1219, 950 FontFile2: true XMP: uuid:ded8611e-2bc5-4816-a75e-eaa0eee434fd uuid:D9BA795F-9BE6-BAA6-CC13-02864AE79ADA True Women; Atherosclerotic cardiovascular disease; Sex-specific risk; Lipids; Cholesterol; Triglycerides; Lipoprotein(a) PDFlib+PDI 9.0.7p3 (C++/Win64) application/pdf 10.1093/eurheartj/ehad472 en Oxford University Press Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society Jeanine E. Roeters van Lennep Lale S. Tokgözoğlu Lina Badimon Sandra M. Dumanski Martha Gulati Connie N. Hess Kirsten B. Holven Maryam Kavousi Meral Kayıkçıoğlu Esther Lutgens Erin D. Michos Eva Prescott Jane K. Stock Anne Tybjaerg-Hansen Marieke J.H. Wermer Marianne Benn DOI: 10.1093/eurheartj/ehad472; European Heart Journal, 44, 39, 2023-08-23.; Abstract: Cardiovascular disease is the leading cause of death in women and men globally, with most due to atherosclerotic cardiovascular disease (ASCVD). Despite progress during the last 30 years, ASCVD mortality is now increasing, with the fastest relative increase in middle-aged women. Missed or delayed diagnosis and undertreatment do not fully explain this burden of disease. Sex-specific factors, such as hypertensive disorders of pregnancy, premature menopause (especially primary ovarian insufficiency), and polycystic ovary syndrome are also relevant, with good evidence that these are associated with greater cardiovascular risk. This position statement from the European Atherosclerosis Society focuses on these factors, as well as sex-specific effects on lipids, including lipoprotein(a), over the life course in women which impact ASCVD risk. Women are also disproportionately impacted (in relative terms) by diabetes, chronic kidney disease, and auto-immune inflammatory disease. All these effects are compounded by sociocultural components related to gender. This panel stresses the need to identify and treat modifiable cardiovascular risk factors earlier in women, especially for those at risk due to sex-specific conditions, to reduce the unacceptably high burden of ASCVD in women. © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. Women Atherosclerotic cardiovascular disease Sex-specific risk Lipids Cholesterol Triglycerides Lipoprotein(a) Journal European Heart Journal © The Author(s) 2023. 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