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Title:           Impact of Molnupiravir Treatment on Patient-Reported COVID-19 Symptoms in the Phase 3 MOVe-OUT Trial: A Randomized, Placebo-Controlled Trial
Subject:         DOI: 10.1093/cid/ciad409; Clinical Infectious Diseases, 77, 11, 2023-07-19.; Abstract:  Background: Molnupiravir is an orally administered antiviral authorized for COVID-19 treatment in adults at high risk of progression to severe disease. Here, we report secondary and post hoc analyses of participants’ self-reported symptoms in the MOVe-OUT trial, which evaluated molnupiravir initiated within 5 days of symptom onset in nonhospitalized, unvaccinated adults with mild-to-moderate, laboratory-confirmed COVID-19. Methods: Eligible participants completed a 15-item symptom diary daily from day 1 (randomization) through day 29, rating symptom severity as “none,” “mild,” “moderate,” or “severe”; loss of smell and loss of taste were rated as “yes” or “no.” Time to sustained symptom resolution/improvement was defined as the number of days from randomization to the first of 3 consecutive days of reduced severity, without subsequent relapse. Time to symptom progression was defined as the number 
Keywords:        SARS-CoV-2; antiviral; β-D-N4-hydroxycytidine; clinical trial; public health
Author:          Yanfen Guan
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   Type: CRC32
  Checksum: 0af3d7d5ec37a2ff1b5593e7c0f4d985
   Type: MD5
  Checksum: e58887b88a3c755996b9f5079102ba33b27d1a32
   Type: SHA-1
  Checksum: ad64d68af8210012c77ae566aeeb713bf187d0e74550c4ddb67b429db9e25513
   Type: SHA-256