4a6d747820960875269d6939ea1ea1e9 301316.pdf 16b19d2e298405b7f109e62ad6ac447c89afc22e 301316.pdf babaf427a2783918dbfb80e0fd8cc0ee2a8acf63c00cb2befa3572bc31bea02c 301316.pdf Title: SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe Subject: DOI: 10.1093/eurheartj/ehad260; European Heart Journal, 44, 28, 2023-05-29.; Abstract: Aims: To develop and validate a recalibrated prediction model (SCORE2-Diabetes) to estimate the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. Methods and results: SCORE2-Diabetes was developed by extending SCORE2 algorithms using individual-participant data from four large-scale datasets comprising 229 460 participants (43 706 CVD events) with type 2 diabetes and without previous CVD. Sex-specific competing risk-adjusted models were used including conventional risk factors (i.e. age, smoking, systolic blood pressure, total, and HDL-cholesterol), as well as diabetes-related variables (i.e. age at diabetes diagnosis, glycated haemoglobin [HbA1c] and creatinine-based estimated glomerular filtration rate [eGFR]). Models were recalibrated to CVD incidence in four European risk regions. External validation included 217 036 further individuals (38 602 CVD eve Keywords: Prediction model; Diabetes; Cardiovascular diseases Author: SCORE2-Diabetes Working Group and the ESC Cardiovascular Risk Collaboration Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Thu Jul 20 16:39:00 2023 CEST ModDate: Fri Jul 21 05:59:53 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1088085 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CXGNCJ+GillSansNova-Book CID TrueType Identity-H yes yes yes 1474 0 QFDFGA+GillSansNova-Bold CID TrueType Identity-H yes yes yes 1477 0 SYMSUG+GillSansNova-BookItalic CID TrueType Identity-H yes yes yes 1480 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true Font: BaseFont: MHKAWD+GillSansNova-Heavy CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MHKAWD+GillSansNova-Heavy Flags: Nonsymbolic, ForceBold FontBBox: -504, -287, 1375, 966 FontFile2: true XMP: uuid:37d27cf5-652c-43cc-b96a-e6374ee5f52a uuid:B3821137-A0B4-207D-B6AF-1DF361A94CEF True Prediction model; Diabetes; Cardiovascular diseases PDFlib+PDI 9.0.7p3 (C++/Win64) application/pdf 10.1093/eurheartj/ehad260 en Oxford University Press SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe SCORE2-Diabetes Working Group and the ESC Cardiovascular Risk Collaboration DOI: 10.1093/eurheartj/ehad260; European Heart Journal, 44, 28, 2023-05-29.; Abstract: Aims: To develop and validate a recalibrated prediction model (SCORE2-Diabetes) to estimate the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. Methods and results: SCORE2-Diabetes was developed by extending SCORE2 algorithms using individual-participant data from four large-scale datasets comprising 229 460 participants (43 706 CVD events) with type 2 diabetes and without previous CVD. Sex-specific competing risk-adjusted models were used including conventional risk factors (i.e. age, smoking, systolic blood pressure, total, and HDL-cholesterol), as well as diabetes-related variables (i.e. age at diabetes diagnosis, glycated haemoglobin [HbA1c] and creatinine-based estimated glomerular filtration rate [eGFR]). Models were recalibrated to CVD incidence in four European risk regions. External validation included 217 036 further individuals (38 602 CVD eve © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. Prediction model Diabetes Cardiovascular diseases Journal European Heart Journal © The Author(s) 2023. 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