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Microbiol. 13:1187999 Keywords: HIV, integrase strand transfer inhibitors (INSTI), real-world study, raltegravir, elvitegravir, dolutegravir Author: José Ramón Santos CreationDate: Wed Jun 21 09:35:39 2023 CEST ModDate: Wed Jun 21 09:35:39 2023 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 1716073 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JEOMIG+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 2002 0 JEOMJH+AdvPSA18C Type 1C WinAnsi yes yes no 2003 0 JEOMJI+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 2004 0 JEOMJJ+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 2005 0 JEOMJK+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 2011 0 JEOMJL+AdvPSA323 Type 1C WinAnsi yes yes no 2012 0 JEOMJM+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 2013 0 JEOMJN+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 2014 0 JEPAFH+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 2017 0 JEPALI+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 271 0 JEPALJ+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 287 0 JEPALK+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 288 0 JEPAMK+AdvTT58d178b9+03 Type 1C Custom yes yes yes 279 0 JEPAML+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 284 0 JEPALG+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 266 0 JEPALH+AdvTT9b12cd41+22 Type 1C Custom yes yes yes 275 0 JEPAOL+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 296 0 JEPAPM+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 295 0 JEPBBM+AdvOT46dcae81 Type 1C WinAnsi yes yes no 306 0 JEPBBN+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 304 0 JEPBCO+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 305 0 JEPBCP+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 299 0 JEPBFP+AdvOTb65e897d.B+22 Type 1C Custom yes yes yes 309 0 JEPGJA+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 310 0 JFAHAM+AdvOTd877c31c+03 Type 1C Custom yes yes yes 313 0 JFAHAN+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 314 0 JFAHCN+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 318 0 JFAHEN+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 319 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-19 02:43:53 CEST RepresentationInformation: 301686.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-18 09:23:07 CEST Size: 1716073 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'B27' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B27' cannot be found ID: PDF-HUL-122 Offset: 1695450 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 2079 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study Destination: bmark_1662744767 Children: Item: Title: Introduction Destination: s1 Item: Title: Material and methods Destination: s2 Children: Item: Title: Study design Destination: s2_1 Item: Title: Data and assessments Destination: s2_2 Item: Title: Statistical analysis Destination: s2_3 Item: Title: Ethics Destination: s2_4 Item: Title: Results Destination: s3 Children: Item: Title: Study population Destination: s3_1 Item: Title: Effectiveness outcomes: virological failure Destination: s3_2 Item: Title: Genotypic resistance analysis Destination: s3_3 Item: Title: Immunological parameters Destination: s3_4 Item: Title: Cox proportional hazard regression models Destination: s3_5 Item: Title: Safety Destination: s3_6 Item: Title: Discussion Destination: s4 Item: Title: INSTINCT study group Destination: s5 Item: Title: Data availability statement Destination: s6 Item: Title: Ethics statement Destination: s7 Item: Title: Group members of INSTINCT study group Destination: s8 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Title: Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study Author: José Ramón Santos Subject: Santos JR, Casadellà M, Noguera-Julian M, Micán-Rivera R, Domingo P, Antela A, Portilla J, Sanz J, Montero-Alonso M, Navarro J, Masiá M, Valcarce-Pardeiro N, Ocampo A, Pérez-Martínez L, García-Vallecillos C, Vivancos MJ, Imaz A, Iribarren JA, Hernández-Quero J, Villar-García J, Barrufet P, Paredes Rand INSTINCT study group (2023) Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study. 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José Antonio Iribarren José Hernández-Quero Judit Villar-García Pilar Barrufet Roger Paredes INSTINCT study group Santos JR, Casadellà M, Noguera-Julian M, Micán-Rivera R, Domingo P, Antela A, Portilla J, Sanz J, Montero-Alonso M, Navarro J, Masiá M, Valcarce-Pardeiro N, Ocampo A, Pérez-Martínez L, García-Vallecillos C, Vivancos MJ, Imaz A, Iribarren JA, Hernández-Quero J, Villar-García J, Barrufet P, Paredes Rand INSTINCT study group (2023) Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study. Front. Cell. Infect. Microbiol. 13:1187999 Copyright © 2023 Santos, Casadellà, Noguera-Julian, Micán-Rivera, Domingo, Antela, Portilla, Sanz, Montero-Alonso, Navarro, Masiá, Valcarce-Pardeiro, Ocampo, Pérez-Martínez, García-Vallecillos, Vivancos, Imaz, Iribarren, Hernández-Quero, Villar-García, Barrufet, Paredes and INSTINCT study group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. 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