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Destination: s2_7 Item: Title: RT-qPCR assay Destination: s2_8 Item: Title: Data analysis Destination: s2_9 Item: Title: Statistical analysis Destination: s2_10 Item: Title: Results Destination: s3 Children: Item: Title: DRG cells show histological alterations before and during the development of autoimmune diabetes Destination: s3_1 Item: Title: DRG cells from NOD mice display gene transcriptional dysfunctions Destination: s3_2 Item: Title: Gene expression of DRG cells is shaped by mouse genetic background but not age-related Destination: s3_3 Item: Title: Genes related to inflammation, and protein synthesis and folding are the most DEGs Destination: s3_4 Item: Title: Peripheral blood leukocytes from NOD mice also show gene expression defects Destination: s3_5 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Keywords: type 1 diabetes, dorsal root ganglion, NOD mouse/mice, neurodegeneration, parasympathetic function, neural regulation, autoimmune diseases/disorders ID: 0x14090c7124de6b168fec402755095dd9, 0x9ed4c92c0be62b418649345bef023406 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1966 ImageHeight: 2207 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1974 ImageHeight: 1951 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: 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Front. Endocrinol. 14:1176566 Copyright © 2023 Corral-Pujol, Arpa, Rosell-Mases, Egia-Mendikute, Mora, Stratmann, Sanchez, Casanovas, Esquerda, Mauricio, Vives-Pi and Verdaguer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. type 1 diabetes dorsal root ganglion NOD mouse/mice neurodegeneration parasympathetic function neural regulation autoimmune diseases/disorders NOD mouse dorsal root ganglia display morphological and gene expression defects before and during autoimmune diabetes development type 1 diabetes, dorsal root ganglion, NOD mouse/mice, neurodegeneration, parasympathetic function, neural regulation, autoimmune diseases/disorders True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 701, 530, 722 Annotation: Subtype: Link Rect: 222, 676, 532, 697 Annotation: Subtype: Link Rect: 222, 651, 478, 672 Annotation: Subtype: Link Rect: 222, 626, 462, 647 Annotation: Subtype: Link Rect: 222, 601, 436, 622 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 706, 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