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Type 1C WinAnsi yes yes no 860 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-26 02:46:22 CEST RepresentationInformation: 301715.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-25 13:13:11 CEST Size: 7688899 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Improperly formed date ID: PDF-HUL-133 Offset: 7670786 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1015 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: Excitatory synapses are lost in Alzheimer’s disease Destination: slink1 Item: Title: Oligomeric, misfolded, and phosphorylated tau species accumulate in postsynaptic terminals of AD cases Destination: slink2 Item: Title: Synaptic oligomeric tau precedes the presence of neurofibrillary tangles Destination: slink3 Item: Title: Indirect evidence of transsynaptic transmission of tau aggregates Destination: slink4 Item: Title: Discussion Destination: flink3 Children: Item: Title: Synaptic loss and synaptic tau Destination: slink5 Item: Title: Conclusions Destination: slink6 Item: Title: Supplemental information Destination: falink4 Item: Title: Acknowledgments Destination: acklink1 Item: Title: Author contributions Destination: acklink2 Item: Title: Declaration of interests Destination: acklink3 Item: Title: Acknowledgments Destination: acklink4 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink5 Children: Item: Title: Key resources table Destination: slink7 Item: Title: Resource availability Destination: slink8 Children: Item: Title: Lead contact Destination: tlink1 Item: Title: Materials availability Destination: tlink2 Item: Title: Data and code availability Destination: tlink3 Item: Title: Experimental model and subject details Destination: slink9 Children: Item: Title: Human brain tissue Destination: tlink4 Item: Title: Mouse brain tissue Destination: tlink5 Item: Title: Method details Destination: slink10 Children: Item: Title: Array tomography Destination: tlink6 Item: Title: Immunogold-electron microscopy Destination: tlink7 Item: Title: Direct STORM acquisition and image reconstruction Destination: tlink8 Item: Title: DNA-PAINT Destination: tlink9 Item: Title: DNA-PAINT analysis Destination: tlink10 Item: Title: Immunohistochemistry Destination: tlink11 Item: Title: Synaptoneurosome isolation and western blot analysis Destination: tlink12 Item: Title: Study design Destination: tlink13 Item: Title: Quantification and statistical analysis Destination: slink11 Info: Title: Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread 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WinAnsiEncoding Font: BaseFont: KAHEPJ+AdvPSA189 FontSubset: true FirstChar: 30 LastChar: 151 FontDescriptor: FontName: KAHEPJ+AdvPSA189 Flags: Nonsymbolic FontBBox: -156, -208, 1072, 802 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KBDKCB+Helvetica-Bold FontSubset: true FirstChar: 108 LastChar: 108 FontDescriptor: FontName: KBDKCB+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KAKGIH+AdvPS4721B4 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: KAKGIH+AdvPS4721B4 Flags: Nonsymbolic FontBBox: 0, -208, 843, 697 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.neuron.2023.04.020 Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain Martí Colom-Cadena Caitlin Davies Sònia Sirisi Ji-Eun Lee Elizabeth M. Simzer Makis Tzioras Marta Querol-Vilaseca Érika Sánchez-Aced Ya Yin Chang Kristjan Holt Robert I. McGeachan Jamie Rose Jane Tulloch Lewis Wilkins Colin Smith Teodora Andrian Olivia Belbin Sílvia Pujals Mathew H. Horrocks Alberto Lleó Tara L. Spires-Jones Alzheimer synapse tau Neuron, 111 (2023) 2170-2189. doi:10.1016/j.neuron.2023.04.020 The Author(s) journal Neuron © 2023 The Author(s). 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