52282a08c6f2dbb55029c321967a1777 301718.pdf 3e4dc56db3a4c528cd7071cec60a44c408dbe592 301718.pdf c3a072d9c769ed00a2bceb061f01520bb5ad155a13c2ab07ec6ebf16fa002b48 301718.pdf Title: Calibration of a three-state cell death model for cardiomyocytes and its application in radiofrequency ablation Subject: Physiological Measurement, 44(2023) 065003. doi:10.1088/1361-6579/acdcdd Keywords: thermal damage; cardiomyocytes; radiofrequency ablation; computer simulation Creator: IOPP Producer: iText® 5.5.13.3 ©2000-2022 iText Group NV (AGPL-version) CreationDate: Fri Jun 23 15:14:23 2023 CEST ModDate: Mon Oct 28 10:04:31 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595 x 842 pts (A4) Page rot: 0 File size: 1447506 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Helvetica Type 1 WinAnsi no no no 14 0 Helvetica-Bold Type 1 WinAnsi no no no 15 0 XXQVOD+ArialUnicodeMS CID TrueType Identity-H yes yes yes 16 0 DCCGHH+AdvTTab7e17fd Type 1C WinAnsi yes yes no 131 0 DCCGGE+AdvOT5e4d79fc Type 1C WinAnsi yes yes no 132 0 DCCGGC+AdvOTb49d9406 Type 1C WinAnsi yes yes no 133 0 DCCGEA+AdvOT77db9845 Type 1C WinAnsi yes yes no 134 0 DCCGHG+AdvOT77db9845+20 Type 1C WinAnsi yes yes no 135 0 DCCGEB+AdvTT25d87263 Type 1C WinAnsi yes yes no 136 0 DCCGDN+AdvOT255b5711.I Type 1C WinAnsi yes yes no 137 0 DCCGDP+AdvOTb0c9bf5d Type 1C WinAnsi yes yes no 138 0 DCCGGD+AdvOTf5828f90 Type 1C WinAnsi yes yes no 139 0 DCCGHF+AdvOT255b5711.I+fb Type 1C Custom yes yes yes 140 0 DCCGGF+AdvOT77db9845+fb Type 1C Custom yes yes yes 141 0 DCCGDO+AdvOT3bbb1fa6.B Type 1C WinAnsi yes yes no 142 0 DCCHCJ+AdvTTab7e17fd+22 Type 1C Custom yes yes yes 172 0 DCCGPI+Minion-Regular Type 1C WinAnsi yes yes no 173 0 DCCHCK+AdvTTab7e17fd+03 Type 1C Custom yes yes yes 174 0 DCCGOG+EuclidExtra CID TrueType Identity-H yes yes yes 175 0 DCCHAJ+STIXGeneral-Regular Type 1C Custom yes yes yes 176 0 DCCGOH+EuclidSymbol CID TrueType Identity-H yes yes yes 177 0 DCCGOI+Minion-Italic Type 1C WinAnsi yes yes no 178 0 DCCHFL+AdvTT691e30a0 Type 1C WinAnsi yes yes no 228 0 DCCHFK+AdvTT426b32fa Type 1C Custom yes yes yes 229 0 DCCPCM+AdvOT3bbb1fa6.B+fb Type 1C Custom yes yes yes 320 0 DCCPDN+EuclidSymbol-Italic CID TrueType Identity-H yes yes yes 313 0 DCDAAC+STIXTwoMath Type 1C Custom yes yes yes 340 0 DCCPJO+AdvTTec1d2308.I+03 Type 1C Custom yes yes yes 358 0 DCCPIN+Minion-BoldItalic Type 1C WinAnsi yes yes no 365 0 DCCPMD+AdvTTbdf32688.BI+03 Type 1C Custom yes yes yes 344 0 DCCPKB+AdvOT8e84d3f8.BI Type 1C WinAnsi yes yes no 348 0 DCCPHM+EuclidSymbol-Bold CID TrueType Identity-H yes yes yes 337 0 DCCPKA+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 350 0 DCCPLC+EuclidSymbol-BoldItalic CID TrueType Identity-H yes yes yes 334 0 DCCPIO+Minion-Semibold Type 1C WinAnsi yes yes no 362 0 DCCPJP+AdvTTcca15adf.B+03 Type 1C Custom yes yes yes 352 0 DCDBIK+AdvOTdd3b7348.I+20 Type 1C WinAnsi yes yes no 216 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-29 02:45:27 CET RepresentationInformation: 301718.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-28 11:38:25 CET Size: 1447506 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 619 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: 1. Introduction Destination: A1 Item: Title: 2. Materials and methods Destination: A2 Item: Title: 3. Results Destination: A3 Children: Item: Title: 3.1. Model calibration I: physiological response Destination: B1 Item: Title: 3.2. Model calibration II: lesion size assessment Destination: B2 Item: Title: 3.3. Thermal latency effect in HPSD ablations Destination: B3 Item: Title: 3.4. Repeated HPSD ablations Destination: B4 Item: Title: 3.5. Ablation with catheter movement Destination: B5 Item: Title: 4. Discussion Destination: A4 Item: Title: Acknowledgments Destination: A5 Item: Title: Data availability statement Destination: A6 Item: Title: Conflict of interest Destination: A7 Item: Title: Appendix A. Destination: A8 Item: Title: Appendix B. Destination: A9 Children: Item: Title: B.1. Computational domain Destination: B6 Item: Title: B.2. RFA model Destination: B7 Item: Title: B.3. Catheter movement Destination: B8 Item: Title: B.4. Parameters Destination: B9 Item: Title: References Destination: A10 Info: Title: Calibration of a three-state cell death model for cardiomyocytes and its application in radiofrequency ablation Subject: Physiological Measurement, 44(2023) 065003. doi:10.1088/1361-6579/acdcdd Keywords: thermal damage; cardiomyocytes; radiofrequency ablation; computer simulation Creator: IOPP Producer: iText® 5.5.13.3 ©2000-2022 iText Group NV (AGPL-version) CreationDate: Fri Jun 23 15:44:23 CEST 2023 ModDate: Mon Oct 28 10:04:31 CET 2024 ID: 0x1b8be1fe8bb29670e74b27e84c07ad21, 0x07d84e3b0bd0436ca0b21fd1d5f5a20b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 232 ImageHeight: 85 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 749 ImageHeight: 472 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 955 ImageHeight: 400 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1720 ImageHeight: 450 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1720 ImageHeight: 1004 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1502 ImageHeight: 1251 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 346 ImageHeight: 675 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 617 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 776 ImageHeight: 405 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 636 ImageHeight: 668 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 998 ImageHeight: 977 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: DCCGOH+EuclidSymbol Encoding: Identity-H ToUnicode: true Font: BaseFont: DCCPHM+EuclidSymbol-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: DCCPDN+EuclidSymbol-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: DCCPLC+EuclidSymbol-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: DCCGOG+EuclidExtra Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: DCCPCM+AdvOT3bbb1fa6.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DCCPCM+AdvOT3bbb1fa6.B+fb Flags: Symbolic FontBBox: 9, 0, 552, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCGHH+AdvTTab7e17fd FontSubset: true FirstChar: 42 LastChar: 176 FontDescriptor: FontName: DCCGHH+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCGGE+AdvOT5e4d79fc FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: DCCGGE+AdvOT5e4d79fc Flags: Serif, Nonsymbolic FontBBox: -20, -250, 958, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCGGC+AdvOTb49d9406 FontSubset: true FirstChar: 65 LastChar: 86 FontDescriptor: FontName: DCCGGC+AdvOTb49d9406 Flags: Nonsymbolic FontBBox: -72, -250, 770, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCGEA+AdvOT77db9845 FontSubset: true FirstChar: 37 LastChar: 243 FontDescriptor: FontName: DCCGEA+AdvOT77db9845 Flags: Serif, Nonsymbolic FontBBox: -41, -250, 937, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCGHG+AdvOT77db9845+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: DCCGHG+AdvOT77db9845+20 Flags: Nonsymbolic FontBBox: -135, -135, 1093, 708 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCGEB+AdvTT25d87263 FontSubset: true FirstChar: 47 LastChar: 47 FontDescriptor: FontName: DCCGEB+AdvTT25d87263 Flags: Nonsymbolic FontBBox: -20, -250, 1052, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCGDN+AdvOT255b5711.I FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: DCCGDN+AdvOT255b5711.I Flags: Nonsymbolic FontBBox: -93, -250, 989, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCGDP+AdvOTb0c9bf5d FontSubset: true FirstChar: 40 LastChar: 41 FontDescriptor: FontName: DCCGDP+AdvOTb0c9bf5d Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCGGD+AdvOTf5828f90 FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: DCCGGD+AdvOTf5828f90 Flags: Nonsymbolic FontBBox: -52, -250, 739, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCGHF+AdvOT255b5711.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DCCGHF+AdvOT255b5711.I+fb Flags: Symbolic FontBBox: -93, -239, 531, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCGGF+AdvOT77db9845+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DCCGGF+AdvOT77db9845+fb Flags: Symbolic FontBBox: 19, 0, 531, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCGDO+AdvOT3bbb1fa6.B FontSubset: true FirstChar: 45 LastChar: 122 FontDescriptor: FontName: DCCGDO+AdvOT3bbb1fa6.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 958, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCDAAC+STIXTwoMath FontSubset: true FirstChar: 2 LastChar: 7 FontDescriptor: FontName: DCDAAC+STIXTwoMath Flags: Serif, Symbolic FontBBox: 121, 0, 463, 1274 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCPMD+AdvTTbdf32688.BI+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DCCPMD+AdvTTbdf32688.BI+03 Flags: Symbolic FontBBox: 9, -208, 1156, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCDBIK+AdvOTdd3b7348.I+20 FontSubset: true FirstChar: 151 LastChar: 151 FontDescriptor: FontName: DCDBIK+AdvOTdd3b7348.I+20 Flags: Nonsymbolic FontBBox: -968, -250, 1427, 1020 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCPKB+AdvOT8e84d3f8.BI FontSubset: true FirstChar: 75 LastChar: 75 FontDescriptor: FontName: DCCPKB+AdvOT8e84d3f8.BI Flags: Nonsymbolic FontBBox: -93, -250, 1020, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCPKA+AdvOT8608a8d1 FontSubset: true FirstChar: 183 LastChar: 183 FontDescriptor: FontName: DCCPKA+AdvOT8608a8d1 Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCPJP+AdvTTcca15adf.B+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DCCPJP+AdvTTcca15adf.B+03 Flags: Symbolic FontBBox: 0, -208, 1041, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCHFL+AdvTT691e30a0 FontSubset: true FirstChar: 215 LastChar: 215 FontDescriptor: FontName: DCCHFL+AdvTT691e30a0 Flags: Nonsymbolic FontBBox: -31, -250, 1020, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCHFK+AdvTT426b32fa FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DCCHFK+AdvTT426b32fa Flags: Symbolic FontBBox: 0, -458, 1281, 1000 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCPJO+AdvTTec1d2308.I+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DCCPJO+AdvTTec1d2308.I+03 Flags: Symbolic FontBBox: 9, -208, 1041, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCPIO+Minion-Semibold FontSubset: true FirstChar: 84 LastChar: 118 FontDescriptor: FontName: DCCPIO+Minion-Semibold Flags: Serif, Nonsymbolic, ForceBold FontBBox: -146, -250, 1126, 830 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCHCJ+AdvTTab7e17fd+22 FontSubset: true FirstChar: 2 LastChar: 21 FontDescriptor: FontName: DCCHCJ+AdvTTab7e17fd+22 Flags: Symbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCGPI+Minion-Regular FontSubset: true FirstChar: 44 LastChar: 117 FontDescriptor: FontName: DCCGPI+Minion-Regular Flags: Serif, Nonsymbolic FontBBox: -141, -250, 1104, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCPIN+Minion-BoldItalic FontSubset: true FirstChar: 75 LastChar: 75 FontDescriptor: FontName: DCCPIN+Minion-BoldItalic Flags: Serif, Nonsymbolic, Italic, ForceBold FontBBox: -189, -250, 1148, 821 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DCCHCK+AdvTTab7e17fd+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: DCCHCK+AdvTTab7e17fd+03 Flags: Symbolic FontBBox: 0, -208, 864, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCHAJ+STIXGeneral-Regular FontSubset: true FirstChar: 40 LastChar: 183 FontDescriptor: FontName: DCCHAJ+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DCCGOI+Minion-Italic FontSubset: true FirstChar: 65 LastChar: 116 FontDescriptor: FontName: DCCGOI+Minion-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -139, -250, 1101, 812 FontFile3: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: DCCPLC+EuclidSymbol-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DCCPLC+EuclidSymbol-BoldItalic Flags: Symbolic, Italic FontBBox: -176, -308, 1181, 950 FontFile2: true Font: BaseFont: DCCGOH+EuclidSymbol CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DCCGOH+EuclidSymbol Flags: Symbolic FontBBox: -166, -252, 1083, 950 FontFile2: true Font: BaseFont: DCCPHM+EuclidSymbol-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DCCPHM+EuclidSymbol-Bold Flags: Symbolic FontBBox: -186, -308, 1102, 960 FontFile2: true Font: BaseFont: DCCGOG+EuclidExtra CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DCCGOG+EuclidExtra Flags: Serif, Symbolic FontBBox: -126, -327, 1573, 962 FontFile2: true Font: BaseFont: DCCPDN+EuclidSymbol-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DCCPDN+EuclidSymbol-Italic Flags: Symbolic, Italic FontBBox: -166, -276, 1152, 950 FontFile2: true XMP: IOP Publishing Physiological Measurement, 44(2023) 065003. doi:10.1088/1361-6579/acdcdd thermal damage cardiomyocytes radiofrequency ablation computer simulation Calibration of a three-state cell death model for cardiomyocytes and its application in radiofrequency ablation iop.org iop.org Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 71, 581, 116, 588 Annotation: Subtype: Link Rect: 422, 700, 514, 706 Annotation: Subtype: Link Rect: 422, 692, 526, 698 Annotation: Subtype: Link Rect: 422, 660, 551, 667 Annotation: Subtype: Link Rect: 422, 652, 534, 659 Annotation: Subtype: Link Rect: 422, 644, 533, 651 Annotation: Subtype: Link Rect: 422, 621, 555, 627 Annotation: Subtype: Link Rect: 422, 613, 431, 619 Annotation: Subtype: Link Rect: 438, 613, 440, 619 Annotation: Subtype: Link Rect: 440, 613, 553, 619 Annotation: Subtype: Link Rect: 37, 51, 557, 387 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 411, 806, 552, 814 Annotation: Subtype: Link Rect: 181, 647, 184, 656 Destination: 500 Annotation: Subtype: Link Rect: 268, 647, 271, 656 Destination: 500 Annotation: Subtype: Link Rect: 333, 647, 336, 656 Destination: 500 Annotation: Subtype: Link Rect: 443, 647, 446, 656 Destination: 500 Annotation: Subtype: Link Rect: 446, 647, 451, 656 Destination: 500 Annotation: Subtype: Link Rect: 144, 576, 234, 584 Annotation: Subtype: Link Rect: 145, 213, 164, 223 Destination: 69 Annotation: Subtype: Link Rect: 327, 200, 346, 210 Destination: 69 Annotation: Subtype: Link Rect: 382, 200, 401, 210 Destination: 69 Annotation: Subtype: Link Rect: 323, 174, 342, 184 Destination: 69 Annotation: Subtype: Link Rect: 374, 174, 393, 184 Destination: 69 Annotation: Subtype: Link Rect: 380, 148, 399, 158 Destination: 69 Annotation: Subtype: Link Rect: 266, 122, 285, 132 Destination: 491 Annotation: Subtype: Link Rect: 275, 109, 294, 119 Destination: 69 Annotation: Subtype: Link Rect: 352, 109, 371, 119 Destination: 491 Annotation: Subtype: Link Rect: 448, 109, 467, 119 Destination: 491 Annotation: Subtype: Link Rect: 502, 109, 521, 119 Destination: 491 Annotation: Subtype: Link Rect: 393, 96, 412, 106 Destination: 491 Annotation: Subtype: Link Rect: 447, 96, 466, 106 Destination: 69 Annotation: Subtype: Link Rect: 353, 70, 372, 80 Destination: 69 Annotation: Subtype: Link Rect: 409, 70, 429, 80 Destination: 69 Annotation: Subtype: Link Rect: 41, 711, 97, 721 Annotation: Subtype: Link Rect: 97, 711, 97, 721 Annotation: Subtype: Link Rect: 84, 546, 106, 553 Annotation: Subtype: Link Rect: 42, 538, 111, 545 Annotation: Subtype: Link Rect: 42, 530, 60, 537 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 119, 758, 138, 768 Destination: 491 Annotation: Subtype: Link Rect: 338, 745, 357, 755 Destination: 69 Annotation: Subtype: Link Rect: 388, 745, 407, 755 Destination: 69 Annotation: Subtype: Link Rect: 443, 745, 462, 755 Destination: 69 Annotation: Subtype: Link Rect: 243, 720, 262, 730 Destination: 69 Annotation: Subtype: Link Rect: 211, 708, 230, 718 Destination: 491 Annotation: Subtype: Link Rect: 400, 696, 419, 705 Destination: 69 Annotation: Subtype: Link Rect: 346, 671, 365, 681 Destination: 69 Annotation: Subtype: Link Rect: 119, 646, 138, 656 Destination: 69 Annotation: Subtype: Link Rect: 212, 646, 231, 656 Destination: 69 Annotation: Subtype: Link Rect: 289, 646, 312, 656 Destination: 69 Annotation: Subtype: Link Rect: 316, 646, 340, 656 Destination: 69 Annotation: Subtype: Link Rect: 406, 608, 425, 618 Destination: 69 Annotation: Subtype: Link Rect: 495, 596, 514, 606 Destination: 69 Annotation: Subtype: Link Rect: 339, 583, 358, 593 Destination: 69 Annotation: Subtype: Link Rect: 291, 546, 310, 556 Destination: 491 Annotation: Subtype: Link Rect: 341, 546, 361, 556 Destination: 69 Annotation: Subtype: Link Rect: 237, 534, 257, 544 Destination: 69 Annotation: Subtype: Link Rect: 180, 496, 199, 506 Destination: 69 Annotation: Subtype: Link Rect: 375, 471, 394, 481 Destination: 491 Annotation: Subtype: Link Rect: 426, 471, 445, 481 Destination: 69 Annotation: Subtype: Link Rect: 383, 446, 402, 456 Destination: 491 Annotation: Subtype: Link Rect: 453, 446, 472, 456 Destination: 69 Annotation: Subtype: Link Rect: 446, 434, 465, 444 Destination: 69 Annotation: Subtype: Link Rect: 415, 422, 434, 432 Destination: 69 Annotation: Subtype: Link Rect: 314, 409, 333, 419 Destination: 69 Annotation: Subtype: Link Rect: 463, 329, 482, 339 Destination: 69 Annotation: Subtype: Link Rect: 250, 233, 254, 243 Destination: 30 Annotation: Subtype: Link Rect: 401, 122, 420, 132 Destination: 491 Annotation: Subtype: Link Rect: 289, 97, 308, 107 Destination: 69 Annotation: Subtype: Link Rect: 458, 60, 477, 70 Destination: 69 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 167, 601, 186, 611 Destination: 491 Annotation: Subtype: Link Rect: 217, 601, 237, 611 Destination: 69 Annotation: Subtype: Link Rect: 228, 576, 247, 586 Destination: 69 Annotation: Subtype: Link Rect: 416, 563, 435, 573 Destination: 69 Annotation: Subtype: Link Rect: 177, 551, 196, 561 Destination: 69 Annotation: Subtype: Link Rect: 197, 501, 209, 511 Destination: 188 Annotation: Subtype: Link Rect: 314, 501, 319, 511 Destination: 188 Annotation: Subtype: Link Rect: 215, 463, 234, 473 Destination: 69 Annotation: Subtype: Link Rect: 494, 438, 513, 448 Destination: 69 Annotation: Subtype: Link Rect: 464, 413, 483, 423 Destination: 69 Annotation: Subtype: Link Rect: 457, 375, 476, 385 Destination: 69 Annotation: Subtype: Link Rect: 310, 363, 329, 373 Destination: 69 Annotation: Subtype: Link Rect: 358, 337, 377, 347 Destination: 69 Annotation: Subtype: Link Rect: 215, 268, 220, 277 Destination: 188 Annotation: Subtype: Link Rect: 412, 211, 431, 221 Destination: 69 Annotation: Subtype: Link Rect: 509, 192, 528, 202 Destination: 69 Annotation: Subtype: Link Rect: 164, 161, 183, 171 Destination: 491 Annotation: Subtype: Link Rect: 315, 123, 335, 133 Destination: 69 Annotation: Subtype: Link Rect: 386, 123, 405, 133 Destination: 69 Annotation: Subtype: Link Rect: 160, 98, 165, 108 Destination: 254 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 199, 390, 218, 400 Destination: 69 Annotation: Subtype: Link Rect: 269, 390, 288, 400 Destination: 69 Annotation: Subtype: Link Rect: 288, 314, 293, 324 Destination: 501 Annotation: Subtype: Link Rect: 174, 301, 193, 311 Destination: 69 Annotation: Subtype: Link Rect: 327, 288, 331, 298 Destination: 254 Annotation: Subtype: Link Rect: 419, 237, 438, 247 Destination: 69 Annotation: Subtype: Link Rect: 349, 224, 368, 234 Destination: 69 Annotation: Subtype: Link Rect: 139, 211, 144, 221 Destination: 295 Annotation: Subtype: Link Rect: 507, 185, 526, 195 Destination: 69 Annotation: Subtype: Link Rect: 186, 159, 205, 169 Destination: 69 Annotation: Subtype: Link Rect: 394, 146, 413, 156 Destination: 69 Annotation: Subtype: Link Rect: 269, 94, 288, 104 Destination: 69 Annotation: Subtype: Link Rect: 298, 81, 317, 91 Destination: 69 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 145, 268, 150, 278 Destination: 295 Annotation: Subtype: Link Rect: 211, 99, 230, 109 Destination: 69 Annotation: Subtype: Link Rect: 122, 73, 141, 83 Destination: 69 Annotation: Subtype: Link Rect: 143, 61, 148, 71 Destination: 324 Annotation: Subtype: Link Rect: 458, 453, 473, 461 Destination: 69 Annotation: Subtype: Link Rect: 247, 444, 262, 452 Destination: 69 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 377, 329, 383, 339 Destination: 501 Annotation: Subtype: Link Rect: 417, 329, 421, 339 Destination: 370 Annotation: Subtype: Link Rect: 490, 98, 509, 108 Destination: 69 Annotation: Subtype: Link Rect: 136, 60, 155, 70 Destination: 69 Annotation: Subtype: Link Rect: 504, 60, 523, 70 Destination: 491 Annotation: Subtype: Link Rect: 146, 48, 165, 58 Destination: 69 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 119, 480, 138, 490 Destination: 69 Annotation: Subtype: Link Rect: 415, 480, 420, 490 Destination: 30 Annotation: Subtype: Link Rect: 228, 467, 247, 477 Destination: 69 Annotation: Subtype: Link Rect: 350, 442, 369, 452 Destination: 69 Annotation: Subtype: Link Rect: 151, 416, 170, 426 Destination: 491 Annotation: Subtype: Link Rect: 206, 416, 225, 426 Destination: 69 Annotation: Subtype: Link Rect: 276, 416, 295, 426 Destination: 69 Annotation: Subtype: Link Rect: 218, 391, 237, 401 Destination: 69 Annotation: Subtype: Link Rect: 241, 391, 260, 401 Destination: 69 Annotation: Subtype: Link Rect: 136, 378, 155, 388 Destination: 69 Annotation: Subtype: Link Rect: 201, 378, 220, 388 Destination: 69 Annotation: Subtype: Link Rect: 398, 378, 417, 388 Destination: 69 Annotation: Subtype: Link Rect: 421, 378, 440, 388 Destination: 69 Annotation: Subtype: Link Rect: 209, 301, 228, 311 Destination: 69 Annotation: Subtype: Link Rect: 136, 225, 159, 235 Destination: 69 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 142, 678, 153, 688 Destination: 501 Annotation: Subtype: Link Rect: 205, 665, 224, 675 Destination: 69 Annotation: Subtype: Link Rect: 325, 639, 348, 649 Destination: 69 Annotation: Subtype: Link Rect: 352, 639, 376, 649 Destination: 69 Annotation: Subtype: Link Rect: 489, 639, 513, 649 Destination: 69 Annotation: Subtype: Link Rect: 237, 600, 261, 610 Destination: 69 Annotation: Subtype: Link Rect: 139, 561, 158, 571 Destination: 69 Annotation: Subtype: Link Rect: 277, 472, 296, 482 Destination: 69 Annotation: Subtype: Link Rect: 523, 460, 543, 470 Destination: 491 Annotation: Subtype: Link Rect: 194, 436, 213, 446 Destination: 69 Annotation: Subtype: Link Rect: 376, 397, 396, 407 Destination: 69 Annotation: Subtype: Link Rect: 397, 140, 416, 150 Destination: 69 Annotation: Subtype: Link Rect: 368, 75, 387, 85 Destination: 69 Annotation: Subtype: Link Rect: 463, 362, 478, 370 Destination: 69 Annotation: Subtype: Link Rect: 266, 353, 282, 361 Destination: 69 Annotation: Subtype: Link Rect: 452, 315, 467, 323 Destination: 69 Annotation: Subtype: Link Rect: 528, 315, 547, 323 Destination: 69 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 410, 618, 429, 628 Destination: 69 Annotation: Subtype: Link Rect: 511, 594, 530, 604 Destination: 69 Annotation: Subtype: Link Rect: 150, 582, 154, 592 Destination: 498 Annotation: Subtype: Link Rect: 122, 570, 188, 580 Annotation: Subtype: Link Rect: 501, 520, 511, 530 Destination: 491 Annotation: Subtype: Link Rect: 446, 507, 465, 517 Destination: 491 Annotation: Subtype: Link Rect: 470, 495, 490, 505 Destination: 69 Annotation: Subtype: Link Rect: 242, 470, 261, 480 Destination: 491 Annotation: Subtype: Link Rect: 309, 470, 328, 480 Destination: 69 Annotation: Subtype: Link Rect: 387, 457, 406, 467 Destination: 491 Annotation: Subtype: Link Rect: 454, 457, 473, 467 Destination: 69 Annotation: Subtype: Link Rect: 288, 445, 299, 455 Destination: 491 Annotation: Subtype: Link Rect: 213, 407, 232, 417 Destination: 491 Annotation: Subtype: Link Rect: 389, 407, 400, 417 Destination: 491 Annotation: Subtype: Link Rect: 399, 334, 418, 344 Destination: 69 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 496, 450, 515, 460 Destination: 69 Annotation: Subtype: Link Rect: 175, 437, 179, 447 Destination: 498 Annotation: Subtype: Link Rect: 269, 437, 274, 447 Destination: 498 Annotation: Subtype: Link Rect: 229, 425, 241, 435 Destination: 324 Annotation: Subtype: Link Rect: 470, 388, 489, 398 Destination: 69 Annotation: Subtype: Link Rect: 149, 375, 154, 385 Destination: 498 Annotation: Subtype: Link Rect: 165, 375, 170, 385 Destination: 498 Annotation: Subtype: Link Rect: 122, 363, 188, 373 Annotation: Subtype: Link Rect: 330, 325, 350, 335 Destination: 69 Annotation: Subtype: Link Rect: 417, 325, 436, 335 Destination: 69 Annotation: Subtype: Link Rect: 214, 243, 240, 251 Annotation: Subtype: Link Rect: 322, 223, 340, 231 Annotation: Subtype: Link Rect: 322, 223, 344, 231 Annotation: Subtype: Link Rect: 322, 223, 352, 231 Annotation: Subtype: Link Rect: 218, 203, 240, 211 Annotation: Subtype: Link Rect: 218, 203, 244, 211 Annotation: Subtype: Link Rect: 218, 203, 251, 211 Annotation: Subtype: Link Rect: 289, 183, 310, 191 Annotation: Subtype: Link Rect: 289, 183, 314, 191 Annotation: Subtype: Link Rect: 289, 183, 318, 191 Annotation: Subtype: Link Rect: 139, 163, 164, 171 Annotation: Subtype: Link Rect: 139, 163, 167, 171 Annotation: Subtype: Link Rect: 139, 163, 175, 171 Annotation: Subtype: Link Rect: 297, 143, 326, 151 Annotation: Subtype: Link Rect: 334, 123, 371, 131 Annotation: Subtype: Link Rect: 270, 103, 291, 111 Annotation: Subtype: Link Rect: 270, 103, 295, 111 Annotation: Subtype: Link Rect: 270, 103, 303, 111 Annotation: Subtype: Link Rect: 287, 83, 305, 91 Annotation: Subtype: Link Rect: 422, 73, 444, 81 Annotation: Subtype: Link Rect: 422, 73, 448, 81 Annotation: Subtype: Link Rect: 422, 73, 456, 81 Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 197, 751, 215, 759 Annotation: Subtype: Link Rect: 455, 731, 492, 739 Annotation: Subtype: Link Rect: 407, 711, 444, 719 Annotation: Subtype: Link Rect: 462, 691, 495, 699 Annotation: Subtype: Link Rect: 270, 671, 292, 679 Annotation: Subtype: Link Rect: 270, 671, 296, 679 Annotation: Subtype: Link Rect: 270, 671, 300, 679 Annotation: Subtype: Link Rect: 464, 661, 490, 669 Annotation: Subtype: Link Rect: 464, 661, 494, 669 Annotation: Subtype: Link Rect: 464, 661, 501, 669 Annotation: Subtype: Link Rect: 196, 631, 214, 639 Annotation: Subtype: Link Rect: 491, 621, 513, 629 Annotation: Subtype: Link Rect: 491, 621, 516, 629 Annotation: Subtype: Link Rect: 491, 621, 524, 629 Annotation: Subtype: Link Rect: 517, 601, 546, 609 Annotation: Subtype: Link Rect: 139, 591, 262, 599 Annotation: Subtype: Link Rect: 456, 571, 485, 579 Annotation: Subtype: Link Rect: 343, 552, 361, 560 Annotation: Subtype: Link Rect: 343, 552, 365, 560 Annotation: Subtype: Link Rect: 343, 552, 376, 560 Annotation: Subtype: Link Rect: 354, 532, 384, 540 Annotation: Subtype: Link Rect: 182, 512, 204, 520 Annotation: Subtype: Link Rect: 182, 512, 208, 520 Annotation: Subtype: Link Rect: 182, 512, 216, 520 Annotation: Subtype: Link Rect: 301, 492, 326, 500 Annotation: Subtype: Link Rect: 301, 492, 330, 500 Annotation: Subtype: Link Rect: 301, 492, 342, 500 Annotation: Subtype: Link Rect: 281, 472, 307, 480 Annotation: Subtype: Link Rect: 281, 472, 311, 480 Annotation: Subtype: Link Rect: 281, 472, 315, 480 Annotation: Subtype: Link Rect: 209, 452, 242, 460 Annotation: Subtype: Link Rect: 244, 432, 262, 440 Annotation: Subtype: Link Rect: 244, 432, 266, 440 Annotation: Subtype: Link Rect: 244, 432, 274, 440 Annotation: Subtype: Link Rect: 416, 412, 441, 420 Annotation: Subtype: Link Rect: 416, 412, 445, 420 Annotation: Subtype: Link Rect: 416, 412, 453, 420 Annotation: Subtype: Link Rect: 244, 392, 262, 400 Annotation: Subtype: Link Rect: 398, 372, 420, 380 Annotation: Subtype: Link Rect: 398, 372, 424, 380 Annotation: Subtype: Link Rect: 398, 372, 432, 380 Annotation: Subtype: Link Rect: 201, 352, 223, 360 Annotation: Subtype: Link Rect: 201, 352, 227, 360 Annotation: Subtype: Link Rect: 201, 352, 235, 360 Annotation: Subtype: Link Rect: 435, 332, 460, 340 Annotation: Subtype: Link Rect: 435, 332, 464, 340 Annotation: Subtype: Link Rect: 435, 332, 472, 340 Annotation: Subtype: Link Rect: 313, 312, 339, 320 Annotation: Subtype: Link Rect: 208, 283, 230, 291 Annotation: Subtype: Link Rect: 208, 283, 234, 291 Annotation: Subtype: Link Rect: 208, 283, 245, 291 Thumb: true Checksum: 853e3e13 Type: CRC32 Checksum: 52282a08c6f2dbb55029c321967a1777 Type: MD5 Checksum: 3e4dc56db3a4c528cd7071cec60a44c408dbe592 Type: SHA-1 Checksum: c3a072d9c769ed00a2bceb061f01520bb5ad155a13c2ab07ec6ebf16fa002b48 Type: SHA-256