13383998362714afcb194a69e43243e1 301719.pdf 319a8ec3e37ecb7fd8e7e559c252713ee241a2d8 301719.pdf c2b8139c0deeed3c15a157bab943034e2a56a228a01b6429b5296b2849fc3b18 301719.pdf Title: Targeting mitochondrial stress with Szeto‐Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress Subject: British J Pharmacology 2023.180:2230-2249 Keywords: 10.1111/bph.16077 and ageing; antioxidants; hypertension; in vivo; inflammation; small molecules; translational pharmacology; vascular pharmacology Author: Miquel Navas‐Madroñal, Rafael Almendra‐Pegueros, Lidia Puertas‐Umbert, Francesc Jiménez‐Altayó, Josep Julve, Belén Pérez, Marta Consegal‐Pérez, Modar Kassan, José Martínez‐González, Cristina Rodriguez, María Galán Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 23.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Mon Jul 24 09:05:19 2023 CEST ModDate: Mon Oct 28 10:04:52 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 5929994 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BMEONC+AdvTT6071803a.B Type 1C WinAnsi yes yes no 106 0 BMEOND+AdvP4C4E59 Type 1C Custom yes yes yes 153 0 BMEPEB+AdvTTa9c1b374 Type 1C WinAnsi yes yes no 107 0 BMEPFC+AdvTTa9c1b374+20 Type 1C WinAnsi yes yes no 108 0 BMEPFD+AdvP4C4E74 Type 1C Custom yes yes yes 154 0 BMFKCC+AdvTTeb5f0e55.I Type 1C WinAnsi yes yes no 155 0 BMFKIA+AdvTT0459e7ca.B Type 1C WinAnsi yes yes no 105 0 Times-Roman Type 1 WinAnsi no no no 2 0 BMGFHO+AdvTTa9c1b374+03 Type 1C Custom yes yes yes 152 0 BMHBCI+AdvTT9c438aa4.BI Type 1C WinAnsi yes yes no 181 0 BMHBDJ+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 182 0 BMHBCH+AdvTTa9c1b374+22 Type 1C Custom yes yes yes 183 0 BMHBDK+AdvOT8244d044.BI+03 Type 1C Custom yes yes yes 184 0 BMHBEK+AdvOTdd3b7348.I+03 Type 1C Custom yes yes yes 185 0 BMHNDC+AdvOT582d4acf Type 1C WinAnsi yes yes no 212 0 BMHNED+AdvTTa9c1b374+21 Type 1C WinAnsi yes yes no 213 0 BMJGAM+AdvTTfac587ca.B Type 1C WinAnsi yes yes no 233 0 BNGMNF+AdvP4C4E40 Type 1C WinAnsi yes yes no 404 0 BNKLHF+AdvTTa9c1b374+01 Type 1C Custom yes yes no 494 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-29 02:45:24 CET RepresentationInformation: 301719.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-28 11:38:37 CET Size: 5929994 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Targeting mitochondrial stress with Szeto-Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endop... Destination: atl_BPH_16077_ Children: Item: Title: 1 INTRODUCTION Destination: HeadingBPH_16077bph16077-sec-0009 Item: Title: What is already known Destination: HeadingBPH_16077bph16077-sec-0006 Item: Title: What does this study add Destination: HeadingBPH_16077bph16077-sec-0007 Item: Title: What is the clinical significance Destination: HeadingBPH_16077bph16077-sec-0008 Item: Title: 2 METHODS Destination: HeadingBPH_16077bph16077-sec-0010 Children: Item: Title: 2.1 Animal handling Destination: HeadingBPH_16077bph16077-sec-0011 Item: Title: 2.2 Non-invasive measurement of systolic blood pressure Destination: HeadingBPH_16077bph16077-sec-0012 Item: Title: 2.3 Basic measurements of ultrasound recording for abdominal aortas Destination: HeadingBPH_16077bph16077-sec-0013 Item: Title: 2.4 Basic measurements of cardiac function by echocardiography (M-mode and Doppler) Destination: HeadingBPH_16077bph16077-sec-0014 Item: Title: 2.5 Total mRNA and protein isolation from tissues Destination: HeadingBPH_16077bph16077-sec-0015 Item: Title: 2.6 Real-time PCR Destination: HeadingBPH_16077bph16077-sec-0016 Item: Title: 2.7 Immunohistochemistry, immunofluorescence and histology Destination: HeadingBPH_16077bph16077-sec-0017 Item: Title: 2.8 Determination of the lipid profile in plasma Destination: HeadingBPH_16077bph16077-sec-0018 Item: Title: 2.9 ROS quantification in plasma Destination: HeadingBPH_16077bph16077-sec-0019 Item: Title: 2.10 Gelatin zymography Destination: HeadingBPH_16077bph16077-sec-0020 Item: Title: 2.11 Western blot (WB) Destination: HeadingBPH_16077bph16077-sec-0021 Item: Title: 2.12 Statistical analysis Destination: HeadingBPH_16077bph16077-sec-0022 Item: Title: 2.13 Materials Destination: HeadingBPH_16077bph16077-sec-0023 Item: Title: 2.14 Nomenclature of targets and ligands Destination: HeadingBPH_16077bph16077-sec-0025 Item: Title: 3 RESULTS Destination: HeadingBPH_16077bph16077-sec-0026 Children: Item: Title: 3.1 The mitochondria-targeted peptide SS31 reduces abdominal aorta aneurysm formation through a decrease in vascular remod... Destination: HeadingBPH_16077bph16077-sec-0027 Item: Title: 3.2 SS31 decreases vascular remodelling, ROS and inflammation and modulates ER stress in abdominal aorta Destination: HeadingBPH_16077bph16077-sec-0028 Item: Title: 3.3 ER stress inhibition in AngII-infused ApoE-/- mice prevents AAA through an attenuation of vascular remodelling and inf... Destination: HeadingBPH_16077bph16077-sec-0029 Item: Title: 3.4 CHOP deficiency reduces AngII-induced AAA formation in ApoE-/- mice Destination: HeadingBPH_16077bph16077-sec-0030 Item: Title: 3.5 Hypertensive cardiac hypertrophy and dysfunction were improved by SS31 and ER stress inhibition Destination: HeadingBPH_16077bph16077-sec-0031 Item: Title: 4 DISCUSSION Destination: HeadingBPH_16077bph16077-sec-0032 Item: Title: AUTHOR CONTRIBUTIONS Destination: HeadingBPH_16077bph16077-sec-0038 Item: Title: ACKNOWLEDGEMENTS Destination: HeadingBPH_16077bph16077-sec-0033 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: HeadingBPH_16077bph16077-sec-0034 Item: Title: DECLARATION OF TRANSPARENCY AND SCIENTIFIC RIGOUR Destination: HeadingBPH_16077bph16077-sec-0035 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: HeadingBPH_16077bph16077-sec-0037 Item: Title: REFERENCES Destination: HeadingBPH_16077bph16077-bibl-00011 Filters: FilterPipeline: FlateDecode FilterPipeline: 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