a7e74978c2cca32d84b805efbf5bbb0f 301725.pdf 5698eeb3f91f0eeb4bc0f5093c05958993f28e97 301725.pdf 6620d87297ddb14428624c92eed162138b719093591af81a25d03daecb30eed3 301725.pdf Title: Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality Subject: Scientific Reports, https://doi.org/10.1038/s41598-023-35951-6 Author: Virginia Actis Dato Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue May 30 04:22:31 2023 CEST ModDate: Tue May 30 16:14:26 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 4152062 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FPMMGN+Wingdings-Regular Type 1C WinAnsi yes yes yes 429 0 MinionPro-Regular Type 1C Custom yes no yes 49 0 CAHEFZ+Corbel-BoldItalic CID TrueType Identity-H yes yes yes 430 0 Corbel-BoldItalic2 TrueType WinAnsi yes no yes 431 0 CCIJFZ+Corbel-Bold CID TrueType Identity-H yes yes yes 51 0 Corbel2 TrueType WinAnsi yes no yes 52 0 NABHDD+Corbel CID TrueType Identity-H yes yes yes 53 0 Corbel3 CID TrueType Identity-H yes no yes 469 0 RINICV+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 50 0 MinionPro-It Type 1C Custom yes no yes 90 0 Corbel4 TrueType WinAnsi yes no yes 94 0 MinionPro-Bold Type 1C Custom yes no yes 130 0 TimesNewRomanPSMT2 TrueType WinAnsi yes no yes 258 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-30 02:50:04 CET RepresentationInformation: 301725.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-29 14:07:05 CET Size: 4152062 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 503 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality Children: Item: Title: Materials and methods Children: Item: Title: HL-1 cardiomyocyte culture. Item: Title: LDL isolation and aggregation. Item: Title: mRNA purification and library preparation. Item: Title: Transcriptomic analysis. Item: Title: Epifluorescence microscopy. Item: Title: Real time-PCR. Item: Title: Mouse model. Item: Title: Cryosection of heart tissue. Item: Title: Statistical analysis. Item: Title: Results and discussion Item: Title: Conclusion Children: Item: Title: Limitations. Item: Title: References Info: Title: Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality Author: Virginia Actis Dato Subject: Scientific Reports, https://doi.org/10.1038/s41598-023-35951-6 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue May 30 04:52:31 CEST 2023 ModDate: Tue May 30 16:14:26 CEST 2023 ID: 0x9a7108ceb0281924a55868fab2156b86, 0x84a5a7ad1ed4907d183e1a673b1cd1fb Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 1428 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 2029 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1500 ImageHeight: 1316 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1428 ImageHeight: 2599 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1519 ImageHeight: 2599 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: RINICV+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: CCIJFZ+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: NABHDD+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: CAHEFZ+Corbel-BoldItalic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FPMMGN+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: FPMMGN+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: TimesNewRomanPSMT2 FirstChar: 32 LastChar: 121 FontDescriptor: FontName: TimesNewRomanPSMT2 Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-BoldItalic2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-BoldItalic2 Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: RINICV+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RINICV+TimesNewRomanPSMT Flags: Serif, Symbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Font: BaseFont: KMBVCJ+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KMBVCJ+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: CCIJFZ+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CCIJFZ+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Font: BaseFont: CAHEFZ+Corbel-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CAHEFZ+Corbel-BoldItalic Flags: Symbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true XMP: 2023-05-30T07:52:31+05:30 Springer 2023-05-30T16:14:26+02:00 2023-05-30T16:14:26+02:00 application/pdf https://doi.org/10.1038/s41598-023-35951-6 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-023-35951-6 Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality Virginia Actis Dato María C. Paz Federico E. Rey María C. Sánchez Vicenta Llorente-Cortés Gustavo A. Chiabrando Danilo G. Ceschin 10.1038/s41598-023-35951-6 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-023-35951-6 10.1038/s41598-023-35951-6 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-023-35951-6 noindex springer.com springerlink.com VoR uuid:ab7cffb1-abb2-4aaa-832f-8cdbae897d7f uuid:d64210f6-48cd-4309-8ca0-8aaeed138f2b default 1 converted uuid:38cca906-96a5-4cc4-a316-e325c9a9cef8 converted to PDF/A-2b pdfToolbox 2023-05-30T07:53:14+05:30 converted uuid:43e6fd70-f3b9-45e8-aa72-b80b8dfcbc15 converted to PDF/A-2b pdfToolbox 2023-05-30T07:53:50+05:30 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 368, 219, 370, 207 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 373, 219, 376, 207 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 481, 675, 556, 658 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 255, 734, 258, 722 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 180, 714, 183, 702 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 418, 704, 421, 692 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 424, 704, 430, 692 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 331, 694, 337, 682 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 450, 684, 456, 672 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 263, 664, 269, 652 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 270, 664, 276, 652 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 341, 654, 346, 642 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 347, 654, 353, 642 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 468, 644, 474, 632 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 177, 624, 182, 612 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 340, 604, 346, 592 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 510, 604, 516, 592 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 444, 492, 449, 480 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 451, 492, 456, 480 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 475, 462, 478, 450 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 230, 400, 233, 388 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 234, 400, 240, 388 Flags: Print AppearanceDictionary: true Destination: 245 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 459, 724, 554, 712 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 714, 272, 702 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 396, 704, 402, 692 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 335, 694, 341, 682 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 382, 684, 387, 672 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 484, 674, 490, 662 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 193, 644, 199, 632 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 339, 594, 345, 582 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 199, 574, 205, 562 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 185, 420, 188, 408 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 179, 198, 185, 186 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 202, 178, 208, 166 Flags: Print AppearanceDictionary: true Destination: 265 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 504, 640, 510, 628 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 511, 640, 517, 628 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 281, 630, 287, 618 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 290, 630, 295, 618 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 297, 630, 302, 618 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 305, 630, 311, 618 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 234, 610, 237, 598 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 238, 610, 241, 598 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 199, 590, 205, 578 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 208, 590, 214, 578 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 213, 580, 218, 568 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 229, 510, 233, 498 Flags: Print AppearanceDictionary: true Destination: 97 Annotation: Subtype: Link Rect: 288, 490, 292, 478 Flags: Print AppearanceDictionary: true Destination: 97 Annotation: Subtype: Link Rect: 174, 480, 179, 468 Flags: Print AppearanceDictionary: true Destination: 97 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 174, 714, 179, 702 Flags: Print AppearanceDictionary: true Destination: 97 Annotation: Subtype: Link Rect: 298, 664, 302, 652 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 342, 654, 346, 642 Flags: Print AppearanceDictionary: true Destination: 135 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 543, 734, 547, 722 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 539, 714, 545, 702 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 546, 714, 552, 702 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 471, 704, 477, 692 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 478, 704, 484, 692 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 506, 684, 512, 672 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 264, 654, 270, 642 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 395, 584, 401, 572 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 530, 534, 535, 522 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 324, 514, 327, 502 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 313, 504, 319, 492 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 465, 504, 554, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 494, 274, 482 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 442, 494, 554, 482 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 484, 255, 472 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 400, 484, 554, 472 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 474, 216, 462 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 366, 474, 554, 462 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 464, 187, 452 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 246, 374, 252, 362 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 209, 314, 214, 302 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 216, 174, 221, 162 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 255, 134, 259, 122 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 408, 54, 412, 42 Flags: Print AppearanceDictionary: true Destination: 233 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 221, 311, 224, 299 Flags: Print AppearanceDictionary: true Destination: 245 Annotation: Subtype: Link Rect: 341, 301, 347, 289 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 350, 301, 355, 289 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 522, 301, 528, 289 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 498, 261, 504, 249 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 518, 241, 524, 229 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 525, 241, 531, 229 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 222, 221, 228, 209 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 175, 141, 179, 129 Flags: Print AppearanceDictionary: true Destination: 239 Thumb: true Page: Sequence: 8 Thumb: true Page: Sequence: 9 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 330, 532, 536, 520 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 464, 522, 554, 510 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 512, 266, 500 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 499, 244, 554, 231 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 233, 260, 221 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 351, 204, 443, 191 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 358, 93, 517, 81 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 5ab9c604 Type: CRC32 Checksum: a7e74978c2cca32d84b805efbf5bbb0f Type: MD5 Checksum: 5698eeb3f91f0eeb4bc0f5093c05958993f28e97 Type: SHA-1 Checksum: 6620d87297ddb14428624c92eed162138b719093591af81a25d03daecb30eed3 Type: SHA-256