c87655d180eeee7b2ece68b70eadaf01 302814.pdf 8d8b89aca99ee2fbb6e13899c383d0bd67e7e97b 302814.pdf 24514ddf5e70346769f119f8cd84bb666819422f4ed05f88a7a4b4bcd3eba8fb 302814.pdf Title: Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN‐derived networks and highlights causal links in Alzheimer's disease Subject: Alzheimer's & Dementia 2023.19:3350-3364 Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Sat Aug 5 15:29:43 2023 CEST ModDate: Thu Nov 14 08:42:43 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2476896 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PFDHBF+Lato-Regular Type 1C WinAnsi yes yes no 58 0 PFDHHE+Lato-Bold Type 1C WinAnsi yes yes no 59 0 PFDHLD+Lato-Italic Type 1C WinAnsi yes yes no 60 0 PFDIBC+STIXTwoMath Type 1C Custom yes yes yes 61 0 PFDICC+STIXTwoText-Italic Type 1C Custom yes yes yes 62 0 Times-Roman Type 1 WinAnsi no no no 5 0 PFDIJB+Lato-Black Type 1C WinAnsi yes yes no 74 0 PFDLAD+STIX-Regular Type 1C Custom yes yes yes 89 0 PFDLOO+Lato-BoldItalic Type 1C WinAnsi yes yes no 119 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-11-15 02:49:00 CET RepresentationInformation: 302814.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-11-14 09:52:56 CET Size: 2476896 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'alz12961-supitem-0001' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'alz12961-supitem-0003' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'alz12961-supitem-0002' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12961-supitem-0001' cannot be found ID: PDF-HUL-122 Offset: 2454183 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12961-supitem-0003' cannot be found ID: PDF-HUL-122 Offset: 2454183 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12961-supitem-0002' cannot be found ID: PDF-HUL-122 Offset: 2454183 MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer’s disease Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | INTRODUCTION Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Participants: EMIF-AD MBD study Destination: subsection..1.2.1 Item: Title: 2.2 | Omics analyses Destination: subsection..1.2.2 Children: Item: Title: 2.2.1 | CSF proteomics Destination: subsubsection..1.2.2.1 Item: Title: 2.2.2 | Plasma proteomics Destination: subsubsection..1.2.2.2 Item: Title: 2.2.3 | Plasma metabolomics Destination: subsubsection..1.2.2.3 Item: Title: 2.2.4 | SNP genotyping Destination: subsubsection..1.2.2.4 Item: Title: 2.3 | Statistical analysis Destination: subsection..1.2.3 Children: Item: Title: 2.3.1 | Weighted Gene Correlation Network Analysis (WGCNA) Destination: subsubsection..1.2.3.1 Item: Title: 2.3.2 | Pathway enrichment analysis Destination: subsubsection..1.2.3.2 Item: Title: 2.3.3 | AD PRS calculation Destination: subsubsection..1.2.3.3 Item: Title: 2.3.4 | Association of AD PRS and AT(N) with modules and hubs Destination: subsubsection..1.2.3.4 Item: Title: 2.3.5 | Partial correlation network Destination: subsubsection..1.2.3.5 Item: Title: 2.3.6 | Mendelian randomization Destination: subsubsection..1.2.3.6 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Subject demographics Destination: subsection..1.3.1 Item: Title: 3.2 | Co-expression network analysis of individual omics modalities reveals modules linked to AD endophenotypes Destination: subsection..1.3.2 Item: Title: 3.3 | Correlation of individual omics modules with the AT(N) framework Destination: subsection..1.3.3 Item: Title: 3.4 | Association between AT(N) framework-related modules and AD PRS Destination: subsection..1.3.4 Item: Title: 3.5 | Association of hub proteins/metabolites with AT(N) markers and AD PRS Destination: subsection..1.3.5 Item: Title: 3.6 | Hub molecules integration in MCI conversion Destination: subsection..1.3.6 Item: Title: 3.7 | Causal links of hub proteins/metabolites with AD Destination: subsection..1.3.7 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICT OF INTEREST Destination: section*.6 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: section*.8 Item: Title: ETHICS STATEMENT Destination: section*.10 Item: Title: REFERENCES Destination: section*.12 Item: Title: SUPPORTING INFORMATION Destination: section*.14 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1505 ImageHeight: 1136 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1929 ImageHeight: 2482 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1864 ImageHeight: 2602 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1440 ImageHeight: 2504 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: PFDLOO+Lato-BoldItalic FontSubset: true FirstChar: 65 LastChar: 112 FontDescriptor: FontName: PFDLOO+Lato-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -110, -250, 1049, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PFDLAD+STIX-Regular FontSubset: true FirstChar: 2 LastChar: 143 FontDescriptor: FontName: PFDLAD+STIX-Regular Flags: Symbolic FontBBox: 63, -103, 629, 676 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PFDHBF+Lato-Regular FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: PFDHBF+Lato-Regular Flags: Nonsymbolic FontBBox: -94, -183, 1117, 919 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PFDIJB+Lato-Black FontSubset: true FirstChar: 49 LastChar: 88 FontDescriptor: FontName: PFDIJB+Lato-Black Flags: Nonsymbolic, ForceBold FontBBox: -83, -179, 1167, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PFDHHE+Lato-Bold FontSubset: true FirstChar: 37 LastChar: 243 FontDescriptor: FontName: PFDHHE+Lato-Bold Flags: Nonsymbolic, ForceBold FontBBox: -89, -181, 1143, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PFDHLD+Lato-Italic FontSubset: true FirstChar: 38 LastChar: 146 FontDescriptor: FontName: PFDHLD+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -115, -250, 1024, 919 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PFDIBC+STIXTwoMath FontSubset: true FirstChar: 2 LastChar: 215 FontDescriptor: FontName: PFDIBC+STIXTwoMath Flags: Symbolic FontBBox: 43, -40, 876, 558 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PFDICC+STIXTwoText-Italic FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: PFDICC+STIXTwoText-Italic Flags: Symbolic, Italic FontBBox: -893, -367, 1298, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdfdoi:10.1002/alz.12961 10.1002/alz.12961https://doi.org/10.1002/alz.12961 2023-02-15truealz-journals.onlinelibrary.wiley.com10.1002/alz.12961 alz-journals.onlinelibrary.wiley.comtrue10.1002/alz.129612023-02-15 VoR Pages: Page: Label: 3350 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 79, 578, 86, 586 Destination: 321 Annotation: Subtype: Link Rect: 141, 578, 148, 586 Destination: 321 Annotation: Subtype: Link Rect: 251, 578, 258, 586 Destination: 321 Annotation: Subtype: Link Rect: 258, 578, 264, 586 Destination: 321 Annotation: Subtype: Link Rect: 265, 578, 271, 586 Destination: 321 Annotation: Subtype: Link Rect: 376, 578, 383, 586 Destination: 321 Annotation: Subtype: Link Rect: 472, 578, 479, 586 Destination: 321 Annotation: Subtype: Link Rect: 124, 561, 131, 568 Destination: 321 Annotation: Subtype: Link Rect: 231, 560, 238, 568 Destination: 321 Annotation: Subtype: Link Rect: 359, 561, 366, 568 Destination: 321 Annotation: Subtype: Link Rect: 472, 561, 478, 568 Destination: 321 Annotation: Subtype: Link Rect: 479, 560, 490, 568 Destination: 321 Annotation: Subtype: Link Rect: 490, 561, 502, 568 Destination: 321 Annotation: Subtype: Link Rect: 120, 543, 127, 550 Destination: 321 Annotation: Subtype: Link Rect: 277, 543, 288, 550 Destination: 321 Annotation: Subtype: Link Rect: 288, 543, 299, 550 Destination: 321 Annotation: Subtype: Link Rect: 406, 543, 417, 550 Destination: 321 Annotation: Subtype: Link Rect: 417, 543, 428, 550 Destination: 321 Annotation: Subtype: Link Rect: 144, 525, 155, 532 Destination: 321 Annotation: Subtype: Link Rect: 155, 525, 166, 532 Destination: 321 Annotation: Subtype: Link Rect: 265, 525, 276, 532 Destination: 321 Annotation: Subtype: Link Rect: 365, 525, 376, 532 Destination: 321 Annotation: Subtype: Link Rect: 460, 525, 471, 532 Destination: 321 Annotation: Subtype: Link Rect: 471, 525, 482, 532 Destination: 321 Annotation: Subtype: Link Rect: 155, 507, 166, 515 Destination: 321 Annotation: Subtype: Link Rect: 283, 507, 295, 515 Destination: 51 Annotation: Subtype: Link Rect: 409, 507, 420, 515 Destination: 51 Annotation: Subtype: Link Rect: 420, 507, 431, 515 Destination: 51 Annotation: Subtype: Link Rect: 142, 489, 153, 497 Destination: 51 Annotation: Subtype: Link Rect: 153, 489, 164, 497 Destination: 51 Annotation: Subtype: Link Rect: 165, 489, 176, 497 Destination: 51 Annotation: Subtype: Link Rect: 176, 489, 187, 497 Destination: 51 Annotation: Subtype: Link Rect: 306, 489, 312, 497 Destination: 321 Annotation: Subtype: Link Rect: 313, 489, 319, 497 Destination: 321 Annotation: Subtype: Link Rect: 433, 489, 439, 497 Destination: 321 Annotation: Subtype: Link Rect: 440, 489, 451, 497 Destination: 51 Annotation: Subtype: Link Rect: 114, 471, 120, 479 Destination: 321 Annotation: Subtype: Link Rect: 120, 471, 132, 479 Destination: 51 Annotation: Subtype: Link Rect: 286, 471, 292, 479 Destination: 321 Annotation: Subtype: Link Rect: 399, 471, 406, 479 Destination: 321 Annotation: Subtype: Link Rect: 170, 453, 176, 461 Destination: 321 Annotation: Subtype: Link Rect: 177, 453, 183, 461 Destination: 321 Annotation: Subtype: Link Rect: 210, 72, 393, 79 Annotation: Subtype: Link Rect: 78, 29, 183, 37 Annotation: Subtype: Link Rect: 519, 782, 595, 767 Thumb: true Page: Label: 3351 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 64, 540, 165, 548 Annotation: Subtype: Link Rect: 74, 147, 80, 153 Destination: 223 Annotation: Subtype: Link Rect: 120, 108, 125, 115 Destination: 223 Annotation: Subtype: Link Rect: 537, 160, 550, 166 Destination: 223 Annotation: Subtype: Link Rect: 358, 147, 370, 153 Destination: 223 Annotation: Subtype: Link Rect: 468, 108, 483, 114 Destination: 223 Thumb: true Page: Label: 3352 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 253, 648, 260, 656 Destination: 84 Annotation: Subtype: Link Rect: 217, 375, 289, 383 Annotation: Subtype: Link Rect: 44, 362, 84, 370 Annotation: Subtype: Link Rect: 155, 340, 164, 346 Destination: 228 Annotation: Subtype: Link Rect: 119, 159, 128, 165 Destination: 228 Annotation: Subtype: Link Rect: 343, 366, 352, 372 Destination: 228 Annotation: Subtype: Link Rect: 348, 264, 355, 272 Destination: 84 Annotation: Subtype: Link Rect: 435, 193, 444, 200 Destination: 228 Annotation: Subtype: Link Rect: 440, 55, 449, 61 Destination: 228 Thumb: true Page: Label: 3353 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 230, 302, 239, 308 Destination: 228 Annotation: Subtype: Link Rect: 224, 224, 233, 230 Destination: 228 Annotation: Subtype: Link Rect: 81, 133, 90, 140 Destination: 228 Annotation: Subtype: Link Rect: 430, 277, 439, 283 Destination: 228 Thumb: true Page: Label: 3354 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 133, 634, 232, 642 Annotation: Subtype: Link Rect: 214, 560, 223, 567 Destination: 228 Annotation: Subtype: Link Rect: 46, 531, 127, 538 Annotation: Subtype: Link Rect: 62, 457, 71, 463 Destination: 228 Annotation: Subtype: Link Rect: 77, 431, 86, 437 Destination: 228 Annotation: Subtype: Link Rect: 173, 418, 182, 424 Destination: 228 Annotation: Subtype: Link Rect: 234, 366, 243, 372 Destination: 228 Annotation: Subtype: Link Rect: 237, 211, 246, 217 Destination: 228 Annotation: Subtype: Link Rect: 234, 55, 243, 61 Destination: 228 Annotation: Subtype: Link Rect: 305, 647, 392, 656 Destination: null Annotation: Subtype: Link Rect: 449, 547, 458, 554 Destination: 228 Annotation: Subtype: Link Rect: 530, 547, 539, 554 Destination: 228 Annotation: Subtype: Link Rect: 532, 478, 550, 487 Destination: null Annotation: Subtype: Link Rect: 305, 465, 379, 474 Destination: null Annotation: Subtype: Link Rect: 326, 363, 332, 371 Destination: 116 Annotation: Subtype: Link Rect: 519, 130, 531, 138 Destination: 125 Annotation: Subtype: Link Rect: 349, 78, 360, 86 Destination: 125 Thumb: true Page: Label: 3355 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 104, 183, 116, 191 Destination: 125 Annotation: Subtype: Link Rect: 113, 105, 125, 113 Destination: 125 Annotation: Subtype: Link Rect: 333, 170, 345, 178 Destination: 125 Annotation: Subtype: Link Rect: 419, 173, 428, 179 Destination: 228 Annotation: Subtype: Link Rect: 403, 53, 415, 61 Destination: 125 Thumb: true Page: Label: 3356 Sequence: 7 Thumb: true Page: Label: 3357 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 141, 687, 154, 695 Destination: 125 Annotation: Subtype: Link Rect: 273, 674, 285, 682 Destination: 125 Annotation: Subtype: Link Rect: 214, 557, 225, 565 Destination: 125 Annotation: Subtype: Link Rect: 142, 493, 153, 500 Destination: null Annotation: Subtype: Link Rect: 231, 480, 241, 487 Destination: null Annotation: Subtype: Link Rect: 146, 311, 158, 319 Destination: 157 Annotation: Subtype: Link Rect: 159, 311, 167, 319 Destination: 157 Annotation: Subtype: Link Rect: 208, 298, 221, 306 Destination: 157 Annotation: Subtype: Link Rect: 222, 298, 229, 306 Destination: 157 Annotation: Subtype: Link Rect: 277, 301, 286, 308 Destination: 228 Annotation: Subtype: Link Rect: 111, 272, 123, 280 Destination: 157 Annotation: Subtype: Link Rect: 124, 272, 130, 280 Destination: 157 Annotation: Subtype: Link Rect: 74, 247, 85, 254 Destination: null Annotation: Subtype: Link Rect: 305, 700, 316, 708 Destination: null Annotation: Subtype: Link Rect: 332, 557, 344, 565 Destination: 157 Annotation: Subtype: Link Rect: 365, 557, 387, 565 Destination: null Annotation: Subtype: Link Rect: 517, 467, 529, 474 Destination: 157 Annotation: Subtype: Link Rect: 305, 454, 316, 462 Destination: null Annotation: Subtype: Link Rect: 305, 428, 316, 436 Destination: null Annotation: Subtype: Link Rect: 397, 311, 408, 319 Destination: null Annotation: Subtype: Link Rect: 332, 182, 344, 190 Destination: 162 Annotation: Subtype: Link Rect: 365, 182, 380, 190 Destination: null Annotation: Subtype: Link Rect: 513, 156, 529, 164 Destination: null Annotation: Subtype: Link Rect: 534, 65, 546, 73 Destination: 162 Thumb: true Page: Label: 3358 Sequence: 9 Thumb: true Page: Label: 3359 Sequence: 10 Thumb: true Page: Label: 3360 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 111, 619, 119, 625 Destination: 228 Annotation: Subtype: Link Rect: 111, 605, 119, 610 Destination: 228 Annotation: Subtype: Link Rect: 111, 590, 119, 596 Destination: 228 Annotation: Subtype: Link Rect: 111, 576, 119, 581 Destination: 228 Annotation: Subtype: Link Rect: 111, 561, 119, 567 Destination: 228 Annotation: Subtype: Link Rect: 111, 547, 119, 553 Destination: 228 Annotation: Subtype: Link Rect: 236, 544, 241, 549 Destination: 167 Annotation: Subtype: Link Rect: 116, 530, 124, 534 Destination: 167 Annotation: Subtype: Link Rect: 124, 532, 132, 538 Destination: 232 Annotation: Subtype: Link Rect: 236, 530, 247, 534 Destination: 167 Annotation: Subtype: Link Rect: 110, 515, 118, 520 Destination: 167 Annotation: Subtype: Link Rect: 118, 518, 126, 524 Destination: 232 Annotation: Subtype: Link Rect: 157, 427, 169, 435 Destination: 162 Annotation: Subtype: Link Rect: 114, 337, 126, 345 Destination: 162 Annotation: Subtype: Link Rect: 150, 337, 166, 345 Destination: null Annotation: Subtype: Link Rect: 192, 246, 208, 254 Destination: null Annotation: Subtype: Link Rect: 162, 104, 177, 111 Destination: null Annotation: Subtype: Link Rect: 333, 376, 345, 383 Destination: 162 Annotation: Subtype: Link Rect: 369, 376, 384, 383 Destination: null Annotation: Subtype: Link Rect: 332, 350, 343, 358 Destination: 162 Annotation: Subtype: Link Rect: 375, 210, 384, 216 Destination: 228 Annotation: Subtype: Link Rect: 459, 184, 468, 191 Destination: 228 Annotation: Subtype: Link Rect: 492, 181, 499, 189 Destination: 167 Annotation: Subtype: Link Rect: 404, 142, 415, 150 Destination: null Annotation: Subtype: Link Rect: 368, 130, 383, 137 Destination: null Annotation: Subtype: Link Rect: 493, 65, 509, 73 Destination: null Thumb: true Page: Label: 3361 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 135, 700, 142, 708 Destination: 167 Annotation: Subtype: Link Rect: 171, 700, 189, 708 Destination: null Annotation: Subtype: Link Rect: 66, 674, 82, 682 Destination: null Annotation: Subtype: Link Rect: 230, 560, 239, 567 Destination: 228 Annotation: Subtype: Link Rect: 202, 431, 211, 437 Destination: 228 Annotation: Subtype: Link Rect: 217, 379, 226, 385 Destination: 228 Annotation: Subtype: Link Rect: 279, 379, 288, 385 Destination: 228 Annotation: Subtype: Link Rect: 157, 366, 166, 372 Destination: 228 Annotation: Subtype: Link Rect: 251, 366, 260, 372 Destination: 228 Annotation: Subtype: Link Rect: 174, 288, 183, 295 Destination: 228 Annotation: Subtype: Link Rect: 271, 288, 280, 295 Destination: 228 Annotation: Subtype: Link Rect: 279, 223, 288, 230 Destination: 228 Annotation: Subtype: Link Rect: 136, 211, 145, 217 Destination: 228 Annotation: Subtype: Link Rect: 432, 664, 441, 670 Destination: 228 Annotation: Subtype: Link Rect: 361, 586, 380, 592 Destination: 228 Annotation: Subtype: Link Rect: 517, 572, 535, 580 Destination: 228 Annotation: Subtype: Link Rect: 358, 560, 367, 567 Destination: 228 Annotation: Subtype: Link Rect: 407, 431, 416, 437 Destination: 228 Annotation: Subtype: Link Rect: 356, 392, 365, 398 Destination: 228 Annotation: Subtype: Link Rect: 352, 324, 359, 332 Destination: 167 Annotation: Subtype: Link Rect: 431, 262, 439, 269 Destination: 228 Annotation: Subtype: Link Rect: 509, 249, 518, 256 Destination: 228 Annotation: Subtype: Link Rect: 360, 236, 369, 243 Destination: 228 Thumb: true Page: Label: 3362 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 510, 543, 550, 552 Destination: null Annotation: Subtype: Link Rect: 305, 530, 348, 539 Destination: null Thumb: true Page: Label: 3363 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 384, 160, 491, 167 Thumb: true Page: Label: 3364 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 318, 662, 440, 670 Thumb: true Checksum: 7fdfe09a Type: CRC32 Checksum: c87655d180eeee7b2ece68b70eadaf01 Type: MD5 Checksum: 8d8b89aca99ee2fbb6e13899c383d0bd67e7e97b Type: SHA-1 Checksum: 24514ddf5e70346769f119f8cd84bb666819422f4ed05f88a7a4b4bcd3eba8fb Type: SHA-256