2a182e74f26377078a1fbf43056154b8 302851.pdf 4dfdb05145d1b71ce5f3d8c9335ca811873406b6 302851.pdf b604c83e9ad1ba74b377014b0f0bad0e8959748e8224d8bd1a96693e4e120bd3 302851.pdf Title: Meteorin-like levels are associated with active brown adipose tissue in early infancy Subject: Introduction: Meteorin-like (METRNL) is a hormonal factor released by several tissues, including thermogenically active brown and beige adipose tissues Keywords: meteorin-like (METRNL), brown adipose tissue (BAT), brown adipokine, infancy, thermogenesis Author: Cristina Garcia-Beltran Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon Feb 27 03:42:05 2023 CET ModDate: Mon Feb 27 07:13:56 2023 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.389 x 841.89 pts (A4) Page rot: 0 File size: 1078284 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IOECFK+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 383 0 IOECFL+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 384 0 IOECFM+AdvPSA18C Type 1C WinAnsi yes yes no 385 0 IOECFN+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 386 0 IOECFO+AdvPSA323 Type 1C WinAnsi yes yes no 387 0 IOECGP+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 388 0 IOECHA+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 389 0 IOECHB+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 401 0 IOEFKO+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 404 0 IOEGBO+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 217 0 IOEGBP+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 202 0 IOEGCA+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 205 0 IOEGDB+AdvTT58d178b9+03 Type 1C Custom yes yes yes 207 0 IOEGDC+AdvOT1ef757c0+22 Type 1C Custom yes yes no 223 0 IOEGAM+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 211 0 IOEGBN+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 212 0 IOEGIB+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 224 0 IOEGJB+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 225 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 229 0 IOFEDA+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 233 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-11-22 02:47:47 CET RepresentationInformation: 302851.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-11-21 11:37:14 CET Size: 1078284 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 468 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Meteorin-like levels are associated with active brown adipose tissue in early infancy Destination: bmark_1208850454 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Materials and methods Destination: s2 Children: Item: Title: 2.1 Study population and ethics Destination: s2_1 Item: Title: 2.2 Clinical and endocrine-metabolic assessments Destination: s2_2 Item: Title: 2.3 Body composition and BAT activity assessment Destination: s2_3 Item: Title: 2.4 Cell cultures of neonatal beige adipocytes Destination: s2_4 Item: Title: 2.5 RNA isolation and qRT-PCR analyses Destination: s2_5 Item: Title: 2.6 Statistics Destination: s2_6 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 METRNL levels in the first year of life Destination: s3_1 Item: Title: 3.2 Correlations between METRNL levels and clinical, endocrine-metabolic and body composition variables Destination: s3_2 Item: Title: 3.3 Correlations between METRNL concentrations and parameters of BAT activity Destination: s3_3 Item: Title: 3.4 METRNL expression in neonatal and adult tissues Destination: s3_4 Item: Title: 3.5 Activation of neonatal brown/beige adipocytes leads to increased METRNL expression and secretion of METRNL Destination: s3_5 Item: Title: 4 Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Title: Meteorin-like levels are associated with active brown adipose tissue in early infancy Author: Cristina Garcia-Beltran Subject: Introduction: Meteorin-like (METRNL) is a hormonal factor released by several tissues, including thermogenically active brown and beige adipose tissues Keywords: meteorin-like (METRNL), brown adipose tissue (BAT), brown adipokine, infancy, thermogenesis Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon Feb 27 03:42:05 CET 2023 ModDate: Mon Feb 27 07:13:56 CET 2023 ID: 0x50230a0519a0004921ae7a15ab277bb3, 0x30c77854cf013741b9d5351e3235d5bd Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2126 ImageHeight: 909 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2009 ImageHeight: 691 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2599 ImageHeight: 873 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 886 ImageHeight: 679 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2515 ImageHeight: 935 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: IOECFL+AdvTTd3a5f740+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: IOECFL+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOEGIB+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IOEGIB+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOECFM+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: IOECFM+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOEGJB+AdvTT749c1f5a.I FontSubset: true FirstChar: 69 LastChar: 84 FontDescriptor: FontName: IOEGJB+AdvTT749c1f5a.I Flags: Nonsymbolic FontBBox: -145, -208, 989, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOECFN+AdvTT9b12cd41 FontSubset: true FirstChar: 40 LastChar: 241 FontDescriptor: FontName: IOECFN+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOECFO+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: IOECFO+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOECGP+AdvTT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: IOECGP+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOECHA+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IOECHA+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-Bd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOFEDA+AdvOT1ef757c0+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: IOFEDA+AdvOT1ef757c0+01 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: IOEGBP+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: IOEGBP+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOEGCA+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: IOEGCA+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOEGDB+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: IOEGDB+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOECHB+AdvTTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 118 FontDescriptor: FontName: IOECHB+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOEGAM+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: IOEGAM+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOEFKO+AdvTT9b12cd41+20 FontSubset: true FirstChar: 134 LastChar: 150 FontDescriptor: FontName: IOEFKO+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOEGBN+AdvOT3f84ef53 FontSubset: true FirstChar: 68 LastChar: 109 FontDescriptor: FontName: IOEGBN+AdvOT3f84ef53 Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOEGBO+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IOEGBO+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IOECFK+AdvTTd3a5f740 FontSubset: true FirstChar: 42 LastChar: 241 FontDescriptor: FontName: IOECFK+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOEGDC+AdvOT1ef757c0+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: IOEGDC+AdvOT1ef757c0+22 Flags: Nonsymbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: Acrobat Distiller 7.0 (Windows) meteorin-like (METRNL), brown adipose tissue (BAT), brown adipokine, infancy, thermogenesis 2023-02-27T10:42:05+08:00 2023-02-27T14:13:56+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2023-02-27T14:13:56+08:00 application/pdf Meteorin-like levels are associated with active brown adipose tissue in early infancy Cristina Garcia-Beltran Artur Navarro-Gascon Abel López-Bermejo Tania Quesada-López Francis de&nbsp Zegher Lourdes Ibáñez Francesc Villarroya Introduction: Meteorin-like (METRNL) is a hormonal factor released by several tissues, including thermogenically active brown and beige adipose tissues meteorin-like (METRNL) brown adipose tissue (BAT) brown adipokine infancy thermogenesis uuid:77364871-97c2-42e6-b577-a1987165d3eb uuid:85643a37-cd4c-4ddc-b7d7-435ccea831fe Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 449, 707 Annotation: Subtype: Link Rect: 222, 661, 504, 682 Annotation: Subtype: Link Rect: 222, 636, 511, 657 Annotation: Subtype: Link Rect: 49, 34, 135, 41 Annotation: Subtype: Link Rect: 500, 34, 545, 41 Annotation: Subtype: Link Rect: 49, 691, 125, 706 Annotation: Subtype: Link Rect: 60, 547, 117, 554 Annotation: Subtype: Link Rect: 60, 527, 129, 534 Annotation: Subtype: Link Rect: 49, 331, 156, 338 Annotation: Subtype: Link Rect: 49, 272, 168, 279 Annotation: Subtype: Link Rect: 49, 263, 74, 270 Annotation: Subtype: Link Rect: 454, 802, 510, 809 Annotation: Subtype: Link Rect: 471, 793, 519, 800 Annotation: Subtype: Link Rect: 451, 783, 541, 790 Annotation: Subtype: Link Rect: 49, 797, 240, 814 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 199, 503, 204, 512 Destination: 138 Annotation: Subtype: Link Rect: 84, 465, 88, 474 Destination: 138 Annotation: Subtype: Link Rect: 109, 390, 113, 399 Destination: 138 Annotation: Subtype: Link Rect: 211, 365, 215, 374 Destination: 138 Annotation: Subtype: Link Rect: 222, 365, 226, 374 Destination: 138 Annotation: Subtype: Link Rect: 52, 340, 57, 349 Destination: 138 Annotation: Subtype: Link Rect: 62, 340, 66, 349 Destination: 138 Annotation: Subtype: Link Rect: 238, 340, 243, 349 Destination: 138 Annotation: Subtype: Link Rect: 248, 340, 252, 349 Destination: 138 Annotation: Subtype: Link Rect: 127, 303, 136, 312 Destination: 138 Annotation: Subtype: Link Rect: 140, 303, 149, 312 Destination: 138 Annotation: Subtype: Link Rect: 259, 228, 267, 237 Destination: 138 Annotation: Subtype: Link Rect: 132, 190, 140, 199 Destination: 138 Annotation: Subtype: Link Rect: 277, 178, 285, 187 Destination: 138 Annotation: Subtype: Link Rect: 128, 78, 137, 87 Destination: 138 Annotation: Subtype: Link Rect: 142, 78, 150, 87 Destination: 138 Annotation: Subtype: Link Rect: 335, 390, 426, 399 Destination: 138 Annotation: Subtype: Link Rect: 307, 352, 316, 361 Destination: 138 Annotation: Subtype: Link Rect: 321, 352, 329, 361 Destination: 138 Annotation: Subtype: Link Rect: 308, 165, 410, 174 Destination: 138 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 278, 756, 287, 765 Destination: 138 Annotation: Subtype: Link Rect: 52, 744, 137, 753 Destination: 138 Annotation: Subtype: Link Rect: 201, 656, 206, 665 Destination: 138 Annotation: Subtype: Link Rect: 210, 656, 219, 665 Destination: 138 Annotation: Subtype: Link Rect: 277, 467, 285, 476 Destination: 138 Annotation: Subtype: Link Rect: 172, 379, 181, 388 Destination: 138 Annotation: Subtype: Link Rect: 187, 379, 195, 388 Destination: 138 Annotation: Subtype: Link Rect: 163, 228, 172, 237 Destination: 138 Annotation: Subtype: Link Rect: 152, 215, 161, 224 Destination: 138 Annotation: Subtype: Link Rect: 277, 69, 285, 78 Destination: 138 Annotation: Subtype: Link Rect: 308, 744, 316, 753 Destination: 138 Annotation: Subtype: Link Rect: 323, 744, 332, 753 Destination: 138 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 63, 650, 153, 659 Destination: 138 Annotation: Subtype: Link Rect: 178, 613, 186, 622 Destination: 138 Annotation: Subtype: Link Rect: 190, 613, 199, 622 Destination: 138 Annotation: Subtype: Link Rect: 237, 525, 267, 534 Destination: 48 Annotation: Subtype: Link Rect: 234, 391, 290, 400 Destination: 138 Annotation: Subtype: Link Rect: 49, 379, 78, 388 Destination: 138 Annotation: Subtype: Link Rect: 49, 354, 135, 363 Destination: 138 Annotation: Subtype: Link Rect: 52, 316, 90, 325 Destination: 74 Annotation: Subtype: Link Rect: 52, 291, 90, 300 Destination: 74 Annotation: Subtype: Link Rect: 402, 666, 411, 675 Destination: 138 Annotation: Subtype: Link Rect: 455, 641, 543, 650 Destination: 138 Annotation: Subtype: Link Rect: 304, 604, 340, 613 Destination: 74 Annotation: Subtype: Link Rect: 488, 604, 523, 613 Destination: 74 Annotation: Subtype: Link Rect: 326, 441, 356, 450 Destination: 106 Annotation: Subtype: Link Rect: 494, 341, 503, 350 Destination: 138 Annotation: Subtype: Link Rect: 429, 316, 468, 325 Destination: 106 Annotation: Subtype: Link Rect: 446, 279, 540, 288 Destination: 138 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 113, 540, 148, 549 Destination: 106 Annotation: Subtype: Link Rect: 134, 415, 139, 424 Destination: 138 Annotation: Subtype: Link Rect: 52, 340, 61, 349 Destination: 138 Annotation: Subtype: Link Rect: 448, 565, 456, 574 Destination: 138 Annotation: Subtype: Link Rect: 409, 503, 417, 512 Destination: 138 Annotation: Subtype: Link Rect: 435, 478, 443, 487 Destination: 138 Annotation: Subtype: Link Rect: 483, 465, 491, 474 Destination: 138 Annotation: Subtype: Link Rect: 395, 428, 399, 437 Destination: 138 Annotation: Subtype: Link Rect: 403, 428, 412, 437 Destination: 138 Annotation: Subtype: Link Rect: 413, 365, 422, 374 Destination: 138 Annotation: Subtype: Link Rect: 471, 353, 475, 362 Destination: 138 Annotation: Subtype: Link Rect: 442, 340, 446, 349 Destination: 138 Annotation: Subtype: Link Rect: 307, 328, 312, 337 Destination: 138 Annotation: Subtype: Link Rect: 316, 328, 325, 337 Destination: 138 Annotation: Subtype: Link Rect: 352, 265, 361, 274 Destination: 138 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 196, 439, 205, 448 Destination: 138 Annotation: Subtype: Link Rect: 153, 339, 161, 348 Destination: 138 Annotation: Subtype: Link Rect: 133, 314, 142, 323 Destination: 138 Annotation: Subtype: Link Rect: 147, 314, 155, 323 Destination: 138 Annotation: Subtype: Link Rect: 169, 289, 177, 298 Destination: 187 Annotation: Subtype: Link Rect: 520, 476, 529, 485 Destination: 187 Annotation: Subtype: Link Rect: 534, 476, 542, 485 Destination: 187 Annotation: Subtype: Link Rect: 536, 339, 540, 348 Destination: 138 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 164, 619, 173, 628 Destination: 138 Annotation: Subtype: Link Rect: 177, 619, 186, 628 Destination: 138 Annotation: Subtype: Link Rect: 253, 419, 262, 428 Destination: 187 Annotation: Subtype: Link Rect: 265, 344, 274, 353 Destination: 187 Annotation: Subtype: Link Rect: 78, 269, 87, 278 Destination: 187 Annotation: Subtype: Link Rect: 92, 269, 100, 278 Destination: 187 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 304, 641, 545, 650 Annotation: Subtype: Link Rect: 304, 628, 404, 637 Annotation: Subtype: Link Rect: 215, 545, 290, 552 Annotation: Subtype: Link Rect: 177, 518, 249, 525 Annotation: Subtype: Link Rect: 62, 491, 115, 498 Annotation: Subtype: Link Rect: 62, 456, 139, 463 Annotation: Subtype: Link Rect: 265, 429, 290, 436 Annotation: Subtype: Link Rect: 49, 421, 81, 428 Annotation: Subtype: Link Rect: 265, 394, 290, 401 Annotation: Subtype: Link Rect: 49, 386, 102, 393 Annotation: Subtype: Link Rect: 263, 359, 290, 366 Annotation: Subtype: Link Rect: 49, 351, 99, 358 Annotation: Subtype: Link Rect: 158, 324, 221, 331 Annotation: Subtype: Link Rect: 97, 297, 166, 304 Annotation: Subtype: Link Rect: 153, 270, 235, 277 Annotation: Subtype: Link Rect: 196, 243, 247, 250 Annotation: Subtype: Link Rect: 185, 216, 269, 223 Annotation: Subtype: Link Rect: 62, 189, 123, 196 Annotation: Subtype: Link Rect: 72, 162, 150, 169 Annotation: Subtype: Link Rect: 215, 143, 285, 150 Annotation: Subtype: Link Rect: 191, 116, 255, 123 Annotation: Subtype: Link Rect: 107, 89, 188, 96 Annotation: Subtype: Link Rect: 327, 529, 396, 536 Annotation: Subtype: Link Rect: 369, 494, 442, 501 Annotation: Subtype: Link Rect: 522, 467, 545, 474 Annotation: Subtype: Link Rect: 304, 459, 365, 466 Annotation: Subtype: Link Rect: 387, 424, 441, 431 Annotation: Subtype: Link Rect: 349, 389, 403, 396 Annotation: Subtype: Link Rect: 520, 362, 545, 369 Annotation: Subtype: Link Rect: 304, 354, 342, 361 Annotation: Subtype: Link Rect: 317, 319, 398, 326 Annotation: Subtype: Link Rect: 522, 292, 545, 299 Annotation: Subtype: Link Rect: 304, 284, 361, 291 Annotation: Subtype: Link Rect: 522, 257, 545, 264 Annotation: Subtype: Link Rect: 304, 249, 343, 256 Annotation: Subtype: Link Rect: 317, 214, 393, 221 Annotation: Subtype: Link Rect: 489, 187, 545, 194 Annotation: Subtype: Link Rect: 304, 179, 326, 186 Annotation: Subtype: Link Rect: 406, 152, 473, 159 Annotation: Subtype: Link Rect: 373, 117, 445, 124 Annotation: Subtype: Link Rect: 349, 90, 403, 97 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 148, 742, 224, 749 Annotation: Subtype: Link Rect: 133, 723, 188, 730 Annotation: Subtype: Link Rect: 62, 696, 138, 703 Annotation: Subtype: Link Rect: 127, 669, 192, 676 Annotation: Subtype: Link Rect: 373, 742, 434, 749 Annotation: Subtype: Link Rect: 521, 715, 545, 722 Annotation: Subtype: Link Rect: 304, 707, 352, 714 Annotation: Subtype: Link Rect: 317, 670, 393, 677 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: be9e3478 Type: CRC32 Checksum: 2a182e74f26377078a1fbf43056154b8 Type: MD5 Checksum: 4dfdb05145d1b71ce5f3d8c9335ca811873406b6 Type: SHA-1 Checksum: b604c83e9ad1ba74b377014b0f0bad0e8959748e8224d8bd1a96693e4e120bd3 Type: SHA-256