7414ba4966071e66037f50c9291585c4 MED_VIGex.pdf 2a3bebde7ef7dc72ed7fef8c6dc5ff3d8af352f3 MED_VIGex.pdf 275c1515b5400bf5e7c28b075151cc92e6c80f192514313d18dc4480e2e60e01 MED_VIGex.pdf Title: A pan-cancer clinical platform to predict immunotherapy outcomes and prioritize immuno-oncology combinations in early-phase trials Subject: Med, 4 (2023) 710-732. doi:10.1016/j.medj.2023.07.006 Author: Alberto Hernando-Calvo Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Oct 9 19:13:09 2023 CEST ModDate: Fri Nov 15 16:43:57 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 24 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 5050686 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FGNJBJ+AdvPSA5BC Type 1C WinAnsi yes yes no 2181 0 FGNJBK+AdvPSA5CD Type 1C WinAnsi yes yes no 2183 0 FGNJBL+AdvPSA5B8 Type 1C MacRoman yes yes no 2185 0 FGNLBA+AdvPSA5B9 Type 1C WinAnsi yes yes no 2187 0 FGNLBB+AdvPSSym Type 1C WinAnsi yes yes no 2189 0 FGNLDB+Helvetica-Bold Type 1C WinAnsi yes yes no 2191 0 FGNLDC+AdvPSA5CF Type 1C WinAnsi yes yes no 2193 0 FGNJBJ+AdvPSA5BC Type 1C MacRoman yes yes no 1691 0 FGNJBK+AdvPSA5CD Type 1C Custom yes yes no 1688 0 FGNJBL+AdvPSA5B8 Type 1C MacRoman yes yes no 1696 0 FGGHNE+AdvPSA5BA Type 1C WinAnsi yes yes no 1695 0 FGNLBA+AdvPSA5B9 Type 1C WinAnsi yes yes no 1697 0 FGNLBB+AdvPSSym Type 1C WinAnsi yes yes no 1692 0 FGNLDB+Helvetica-Bold Type 1C WinAnsi yes yes no 1689 0 FGNLDC+AdvPSA5CF Type 1C WinAnsi yes yes no 1693 0 FGGLGE+AdvPSA5BD Type 1C WinAnsi yes yes no 1708 0 FGGLGD+AdvP4C4E74 Type 1C Custom yes yes no 1707 0 FGGNKI+AdvPSA5CE Type 1C WinAnsi yes yes no 1713 0 FGHAEI+AdvPS4731B1 Type 1C WinAnsi yes yes no 1720 0 FGHCMK+AdvPS4721B4 Type 1C WinAnsi yes yes no 1723 0 FGHDFI+AdvPS480274 Type 1C WinAnsi yes yes no 1733 0 FGHDFJ+AdvPSMPi6 Type 1C WinAnsi yes yes no 1735 0 FGHEAG+AdvP4C4E59 Type 1C Custom yes yes yes 1743 0 FGHEDF+AdvPS3F4C13 Type 1C WinAnsi yes yes no 1750 0 FGHEEG+AdvPS44A44B Type 1C WinAnsi yes yes no 1749 0 FGHFAD+AdvP4C4E46 Type 1C Custom yes yes yes 1760 0 FGHFAE+AdvP4C4E51 Type 1C WinAnsi yes yes no 1758 0 FGHFDD+AdvHelN-L Type 1C WinAnsi yes yes no 1765 0 FGHFDE+AdvP7DED Type 1C WinAnsi yes yes no 1769 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-11-16 02:44:29 CET RepresentationInformation: MED_VIGex.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-11-15 16:44:13 CET Size: 5050686 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'sec4' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec4' cannot be found ID: PDF-HUL-122 Offset: 5039909 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: A pan-cancer clinical platform to predict immunotherapy outcomes and prioritize immuno-oncology combinations in early-phase ... Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: Development of the VIGex signature Destination: slink1 Item: Title: VIGex categorizes samples according to the immunogenicity of the tumor microenvironment Destination: slink2 Item: Title: VIGex identifies patients deriving clinical benefit in early-phase immuno-oncology trials Destination: slink3 Item: Title: A composite immune gene signature prioritizes immuno-oncology combinations in early-phase clinical trials Destination: slink4 Item: Title: Discussion Destination: flink3 Children: Item: Title: Limitations of the study Destination: slink5 Item: Title: Supplemental information Destination: falink4 Item: Title: Acknowledgments Destination: acklink1 Item: Title: Author contributions Destination: flink5 Item: Title: Declaration of interests Destination: flink6 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink7 Children: Item: Title: Key resources table Destination: slink6 Item: Title: Resource availability Destination: slink7 Children: Item: Title: Lead contact Destination: tlink1 Item: Title: Materials availability Destination: tlink2 Item: Title: Data and code availability Destination: tlink3 Item: Title: Experimental models and study participant details Destination: slink8 Item: Title: Method details Destination: slink9 Children: Item: Title: VHIO molecular profiling Destination: tlink4 Item: Title: VIGex inter-laboratory validation Destination: tlink5 Item: Title: Publicly available datasets of patients treated with immunotherapy in the metanalysis Destination: tlink6 Item: Title: VIGex and tumor mutational burden computation in the metanalysis Destination: tlink7 Item: Title: Quantification and statistical analysis Destination: slink10 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png CompressionScheme: 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ImageWidth: 14 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 12 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 13 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 12 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 22 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 11 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 11 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 2 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 2 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 141 ImageHeight: 127 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 141 ImageHeight: 127 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 141 ImageHeight: 127 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 141 ImageHeight: 126 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 140 ImageHeight: 127 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 141 ImageHeight: 126 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 141 ImageHeight: 126 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 141 ImageHeight: 127 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 140 ImageHeight: 126 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 3 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 3 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 23 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 69 ImageHeight: 68 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 23 ImageHeight: 111 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 879 ImageHeight: 588 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 282 ImageHeight: 921 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 980 ImageHeight: 790 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 698 ImageHeight: 717 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 980 ImageHeight: 133 BitsPerSample: 8 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ImageHeight: 416 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 596 ImageHeight: 504 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 503 ImageHeight: 554 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 260 ImageHeight: 976 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 252 ImageHeight: 968 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 518 ImageHeight: 419 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: 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ImageWidth: 1057 ImageHeight: 151 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 530 ImageHeight: 600 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 687 ImageHeight: 467 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 276 ImageHeight: 467 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 680 ImageHeight: 478 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 273 ImageHeight: 478 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: 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FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FGHEAG+AdvP4C4E59 FontSubset: true FirstChar: 2 LastChar: 125 FontDescriptor: FontName: FGHEAG+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FGNLDC+AdvPSA5CF FontSubset: true FirstChar: 65 LastChar: 83 FontDescriptor: FontName: FGNLDC+AdvPSA5CF Flags: Nonsymbolic FontBBox: -156, -239, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FGHEEG+AdvPS44A44B FontSubset: true FirstChar: 71 LastChar: 71 FontDescriptor: FontName: FGHEEG+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FGHEDF+AdvPS3F4C13 FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: FGHEDF+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FGNJBK+AdvPSA5CD FontSubset: true FirstChar: 25 LastChar: 180 FontDescriptor: FontName: FGNJBK+AdvPSA5CD Flags: Nonsymbolic FontBBox: -156, -239, 1000, 781 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: FGNLDB+Helvetica-Bold FontSubset: true FirstChar: 65 LastChar: 108 FontDescriptor: FontName: FGNLDB+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FGNJBJ+AdvPSA5BC FontSubset: true FirstChar: 45 LastChar: 222 FontDescriptor: FontName: FGNJBJ+AdvPSA5BC Flags: Nonsymbolic FontBBox: -156, -239, 1135, 791 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: FGNLBB+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: FGNLBB+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FGNLDC+AdvPSA5CF FontSubset: true FirstChar: 65 LastChar: 83 FontDescriptor: FontName: FGNLDC+AdvPSA5CF 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-239, 1166, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FGGNKI+AdvPSA5CE FontSubset: true FirstChar: 48 LastChar: 90 FontDescriptor: FontName: FGGNKI+AdvPSA5CE Flags: Nonsymbolic FontBBox: -166, -239, 1031, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FGHAEI+AdvPS4731B1 FontSubset: true FirstChar: 37 LastChar: 82 FontDescriptor: FontName: FGHAEI+AdvPS4731B1 Flags: Nonsymbolic FontBBox: 0, -208, 1572, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FGHCMK+AdvPS4721B4 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: FGHCMK+AdvPS4721B4 Flags: Nonsymbolic FontBBox: 0, -208, 843, 697 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.medj.2023.07.006 A pan-cancer clinical platform to predict immunotherapy outcomes and prioritize immuno-oncology combinations in early-phase trials Alberto Hernando-Calvo Maria Vila-Casadesús Yacine Bareche Alberto Gonzalez-Medina Farnoosh Abbas-Aghababazadeh Deborah Lo Giacco Agatha Martin Omar Saavedra Irene Brana Maria Vieito Roberta Fasani John Stagg Francesco Mancuso Benjamin Haibe-Kains Ming Han Roger Berche Trevor J. Pugh Oriol Mirallas Jose Jimenez Nadia Saoudi Gonzalez Claudia Valverde Eva Muñoz-Couselo Cristina Suarez Marc Diez Elena Élez Jaume Capdevila Ana Oaknin Cristina Saura Teresa Macarulla Joan Carles Galceran Enriqueta Felip Rodrigo Dienstmann Philippe L. Bedard Paolo Nuciforo Joan Seoane Josep Tabernero Elena Garralda Ana Vivancos immunotherapy immunooncology predictive biomarkers IFNg activation tumor microenvironment Med, 4 (2023) 710-732. doi:10.1016/j.medj.2023.07.006 The Authors journal Med © 2023 The Authors. Published by Elsevier Inc. 2666-6340 4 10 13 October 2023 2023-10-13 710-727.e5 710 727.e5 10.1016/j.medj.2023.07.006 https://doi.org/10.1016/j.medj.2023.07.006 2010-04-23 true 10.1016/j.medj.2023.07.006 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.medj.2023.07.006 noindex true 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-10-09T22:43:09+05:30 2024-11-15T16:43:57+01:00 2024-11-15T16:43:57+01:00 True Acrobat Distiller 8.1.0 (Windows) uuid:e4e20e66-ac0d-4e82-93ef-5dcb7f43feba uuid:7a5bfa73-538e-4f39-8501-1da44280b665 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 710 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 404, 448, 466, 455 Annotation: Subtype: Link Rect: 404, 60, 521, 66 Annotation: Subtype: Link Rect: 528, 16, 544, 32 Page: Label: 711 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 180, 578, 184, 589 Destination: 17 Annotation: Subtype: Link Rect: 186, 578, 190, 589 Destination: 17 Annotation: Subtype: Link Rect: 192, 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Annotation: Subtype: Link Rect: 235, 548, 366, 555 Annotation: Subtype: Link Rect: 235, 534, 377, 541 Annotation: Subtype: Link Rect: 235, 526, 365, 533 Annotation: Subtype: Link Rect: 235, 518, 292, 525 Annotation: Subtype: Link Rect: 235, 504, 378, 511 Annotation: Subtype: Link Rect: 235, 496, 375, 503 Annotation: Subtype: Link Rect: 235, 488, 378, 495 Annotation: Subtype: Link Rect: 235, 480, 363, 487 Annotation: Subtype: Link Rect: 235, 472, 366, 479 Annotation: Subtype: Link Rect: 235, 464, 260, 471 Annotation: Subtype: Link Rect: 235, 450, 363, 457 Annotation: Subtype: Link Rect: 235, 442, 365, 449 Annotation: Subtype: Link Rect: 235, 434, 378, 441 Annotation: Subtype: Link Rect: 235, 426, 377, 433 Annotation: Subtype: Link Rect: 235, 418, 369, 425 Annotation: Subtype: Link Rect: 235, 410, 370, 417 Annotation: Subtype: Link Rect: 235, 402, 265, 409 Annotation: Subtype: Link Rect: 235, 388, 367, 395 Annotation: Subtype: Link Rect: 235, 380, 378, 387 Annotation: Subtype: Link Rect: 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Annotation: Subtype: Link Rect: 521, 243, 544, 250 Annotation: Subtype: Link Rect: 401, 235, 519, 242 Annotation: Subtype: Link Rect: 401, 219, 530, 226 Annotation: Subtype: Link Rect: 401, 211, 536, 218 Annotation: Subtype: Link Rect: 401, 203, 426, 210 Annotation: Subtype: Link Rect: 401, 188, 538, 195 Annotation: Subtype: Link Rect: 401, 180, 512, 187 Annotation: Subtype: Link Rect: 401, 172, 528, 179 Annotation: Subtype: Link Rect: 401, 164, 426, 171 Annotation: Subtype: Link Rect: 401, 148, 525, 155 Annotation: Subtype: Link Rect: 401, 140, 533, 147 Annotation: Subtype: Link Rect: 401, 132, 499, 139 Annotation: Subtype: Link Rect: 401, 116, 535, 123 Annotation: Subtype: Link Rect: 401, 108, 532, 115 Annotation: Subtype: Link Rect: 401, 100, 544, 107 Annotation: Subtype: Link Rect: 401, 92, 445, 99 Page: Label: 727.e1 Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 114, 191, 189, 199 Annotation: Subtype: Link Rect: 222, 121, 358, 129 Annotation: Subtype: Link Rect: 197, 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2a3bebde7ef7dc72ed7fef8c6dc5ff3d8af352f3 Type: SHA-1 Checksum: 275c1515b5400bf5e7c28b075151cc92e6c80f192514313d18dc4480e2e60e01 Type: SHA-256