d2d570bf7aeeb9613e62faed2d72cff3 303442.pdf 241f1e66e4270b88d7c9df8598abf291704d901f 303442.pdf 78490f49929e1573e5239738529a3f21ebc7fddb9ea218fe445059011ab3f2de 303442.pdf Title: Myostatin and follistatin as monitoring and prognostic biomarkers in dysferlinopathy Subject: Neuromuscular Disorders, 33 (2023) 199-207. doi:10.1016/j.nmd.2023.01.001 Keywords: "Myostatin"; "Follistatin"; "Muscular dystrophy"; "Dysferlinopathy"; "Limb girdle muscular dystrophy R2"; "Miyoshi myopathy" Author: Ursula Moore Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sat Jan 21 10:05:05 2023 CET ModDate: Sat Jan 21 10:05:33 2023 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.245 x 793.92 pts Page rot: 0 File size: 865073 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EDJNAM+GulliverSCOsF Type 1C Custom yes yes yes 1019 0 EDJMML+MTSY Type 1C Custom yes yes yes 1024 0 EDJMMM+Gulliver-Italic Type 1C Custom yes yes yes 1029 0 EDJFBL+Gulliver Type 1C Custom yes yes yes 1034 0 EDJFIK+UniversLTStd Type 1C Custom yes yes yes 1039 0 EDJFBM+dummy-space Type 1C WinAnsi yes yes no 1044 0 EDJNEM+RMTMI Type 1C Custom yes yes yes 180 0 EDJNCM+Gulliver-Bold Type 1C Custom yes yes yes 185 0 EDJNLK+TimesNewRomanPSMT-00 Type 1C Custom yes yes yes 45 0 EDJONE+MTSYB Type 1C Custom yes yes yes 73 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-11-23 02:45:47 CET RepresentationInformation: 303442.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-11-22 09:18:47 CET Size: 865073 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1120 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: English Outlines: Item: Title: Myostatin and follistatin as monitoring and prognostic biomarkers in dysferlinopathy Destination: chapter..1 Children: Item: Title: 1 Introduction Destination: section..1 Item: Title: 2 Methods Destination: section..2 Children: Item: Title: 2.1 Subjects Destination: subsection..2.1 Item: Title: 2.2 Samples Destination: subsection..2.2 Item: Title: 2.3 Ethical approval Destination: subsection..2.3 Item: Title: 2.4 Myostatin and follistatin quantification Destination: subsection..2.4 Item: Title: 2.5 MRI Destination: subsection..2.5 Item: Title: 2.6 Statistical analysis Destination: subsection..2.6 Children: Item: Title: 2.6.1 Cross-sectional analysis Destination: subsubsection..2.6.1 Item: Title: 2.6.2 Longitudinal analysis Destination: subsubsection..2.6.2 Item: Title: 2.6.3 Prognostic capability Destination: subsubsection..2.6.3 Item: Title: 2.6.4 Sub-cohort analysis Destination: subsubsection..2.6.4 Item: Title: 3 Results Destination: section..3 Children: Item: Title: 3.1 Subjects Destination: subsection..3.1 Item: Title: 3.2 Cross-sectional analysis Destination: subsection..3.2 Item: Title: 3.3 Longitudinal assessment Destination: subsection..3.3 Item: Title: 3.4 Predicting loss of ambulation Destination: subsection..3.4 Item: Title: 3.5 Predicting functional decline Destination: subsection..3.5 Item: Title: 4 Discussion Destination: section..4 Item: Title: 6 Conclusion Destination: section..5 Item: Title: Declaration of Competing Interest Destination: section..6 Item: Title: Acknowledgements Destination: section..7 Item: Title: Supplementary materials Destination: section..8 Item: Title: References Destination: section..9 Info: Title: Myostatin and follistatin as monitoring and prognostic biomarkers in dysferlinopathy Author: Ursula Moore Subject: Neuromuscular Disorders, 33 (2023) 199-207. doi:10.1016/j.nmd.2023.01.001 Keywords: "Myostatin"; "Follistatin"; "Muscular dystrophy"; "Dysferlinopathy"; "Limb girdle muscular dystrophy R2"; "Miyoshi myopathy" Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sat Jan 21 10:35:05 CET 2023 ModDate: Sat Jan 21 10:35:33 CET 2023 ID: 0xa70dfe1a7b71fc51ee460a77a4589f3d, 0x46f69c0686262d35d0101bf22722f1fb Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 249 ImageHeight: 273 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 118 ImageHeight: 118 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 223 ImageHeight: 297 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1800 ImageHeight: 509 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1001 ImageHeight: 602 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1001 ImageHeight: 588 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1014 ImageHeight: 584 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: EDJMML+MTSY FontSubset: true FirstChar: 2 LastChar: 177 FontDescriptor: FontName: EDJMML+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EDJFBM+dummy-space FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: EDJFBM+dummy-space Flags: Nonsymbolic FontBBox: 0, 0, 0, 0 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EDJNEM+RMTMI FontSubset: true FirstChar: 2 LastChar: 62 FontDescriptor: FontName: EDJNEM+RMTMI Flags: Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EDJMMM+Gulliver-Italic FontSubset: true FirstChar: 40 LastChar: 244 FontDescriptor: FontName: EDJMMM+Gulliver-Italic Flags: Serif, Symbolic, Italic FontBBox: -141, -211, 1053, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EDJNCM+Gulliver-Bold FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: EDJNCM+Gulliver-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -150, -211, 1131, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EDJONE+MTSYB FontSubset: true FirstChar: 2 LastChar: 138 FontDescriptor: FontName: EDJONE+MTSYB Flags: Symbolic, ForceBold FontBBox: -16, -935, 1043, 896 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EDJFBL+Gulliver FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: EDJFBL+Gulliver Flags: Serif, Symbolic FontBBox: -115, -211, 1042, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EDJNAM+GulliverSCOsF FontSubset: true FirstChar: 97 LastChar: 116 FontDescriptor: FontName: EDJNAM+GulliverSCOsF Flags: Serif, Symbolic FontBBox: -115, -211, 1407, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EDJNLK+TimesNewRomanPSMT-00 FontSubset: true FirstChar: 176 LastChar: 176 FontDescriptor: FontName: EDJNLK+TimesNewRomanPSMT-00 Flags: Serif, Symbolic FontBBox: -77, -216, 936, 877 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EDJFIK+UniversLTStd FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: EDJFIK+UniversLTStd Flags: Symbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2023-01-21T14:35:05+05:30 Elsevier 2023-01-21T14:35:33+05:30 2023-01-21T14:35:33+05:30 Acrobat Distiller 10.0.0 (Windows) "Myostatin"; "Follistatin"; "Muscular dystrophy"; "Dysferlinopathy"; "Limb girdle muscular dystrophy R2"; "Miyoshi myopathy" application/pdf doi:10.1016/j.nmd.2023.01.001 Elsevier B.V. Neuromuscular Disorders, 33 (2023) 199-207. doi:10.1016/j.nmd.2023.01.001 Myostatin Follistatin Muscular dystrophy Dysferlinopathy Limb girdle muscular dystrophy R2 Miyoshi myopathy Myostatin and follistatin as monitoring and prognostic biomarkers in dysferlinopathy Ursula Moore Esther Fernández-Simón Marianela Schiava Dan Cox Heather Gordish-Dressman Meredith K. James Anna Mayhew Ian Wilson Michela Guglieri Laura Rufibach Andrew Blamire Pierre G. Carlier Madoka Mori-Yoshimura John W. Day Kristi J. Jones Diana X. Bharucha-Goebel Emmanuelle Salort-Campana Alan Pestronk Maggie C. Walter Carmen Paradas Tanya Stojkovic Elena Bravver Elena Pegoraro Jerry R. Mendell Kate Bushby Jordi Diaz-Manera Volker Straub The Jain COS Consortium uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:e9dee054-e1ee-4bc5-9e9d-e81e41323832 journal © 2023 The Authors. Published by Elsevier B.V. Neuromuscular Disorders 0960-8966 33 2 10.1016/j.nmd.2023.01.001 https://doi.org/10.1016/j.nmd.2023.01.001 199 207 199-207 February 2023 7.0 2010-04-23 true 10.1016/j.nmd.2023.01.001 noindex sciencedirect.com elsevier.com sciencedirect.com elsevier.com VoR true 2010-04-23 10.1016/j.nmd.2023.01.001 sciencedirect.com elsevier.com True http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 199 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 229, 749, 366, 758 Annotation: Subtype: Link Rect: 321, 720, 374, 731 Annotation: Subtype: Link Rect: 277, 665, 393, 676 Annotation: Subtype: Link Rect: 498, 593, 528, 604 Annotation: Subtype: Link Rect: 104, 571, 111, 585 Destination: 1006 Annotation: Subtype: Link Rect: 236, 571, 242, 585 Destination: 1006 Annotation: Subtype: Link Rect: 336, 571, 342, 585 Destination: 1006 Annotation: Subtype: Link Rect: 388, 571, 394, 585 Destination: 1006 Annotation: Subtype: Link Rect: 171, 558, 178, 572 Destination: 1006 Annotation: Subtype: Link Rect: 177, 558, 183, 572 Destination: 1006 Annotation: Subtype: Link Rect: 279, 558, 286, 572 Destination: 1006 Annotation: Subtype: Link Rect: 361, 558, 368, 572 Destination: 1006 Annotation: Subtype: Link Rect: 426, 558, 433, 572 Destination: 1006 Annotation: Subtype: Link Rect: 119, 545, 125, 559 Destination: 1006 Annotation: Subtype: Link Rect: 203, 545, 209, 559 Destination: 1006 Annotation: Subtype: Link Rect: 294, 545, 300, 559 Destination: 1006 Annotation: Subtype: Link Rect: 384, 545, 389, 559 Destination: 1006 Annotation: Subtype: Link Rect: 159, 532, 165, 546 Destination: 1006 Annotation: Subtype: Link Rect: 232, 532, 239, 546 Destination: 1006 Annotation: Subtype: Link Rect: 309, 532, 314, 546 Destination: 1006 Annotation: Subtype: Link Rect: 448, 532, 453, 546 Destination: 1006 Annotation: Subtype: Link Rect: 452, 532, 459, 546 Destination: 1006 Annotation: Subtype: Link Rect: 180, 519, 185, 533 Destination: 1006 Annotation: Subtype: Link Rect: 258, 519, 268, 533 Destination: 1006 Annotation: Subtype: Link Rect: 357, 519, 364, 533 Destination: 1006 Annotation: Subtype: Link Rect: 448, 519, 455, 533 Destination: 1006 Annotation: Subtype: Link Rect: 113, 506, 120, 520 Destination: 1006 Annotation: Subtype: Link Rect: 192, 506, 199, 520 Destination: 1006 Annotation: Subtype: Link Rect: 277, 506, 282, 520 Destination: 1006 Annotation: Subtype: Link Rect: 367, 506, 373, 520 Destination: 1006 Annotation: Subtype: Link Rect: 439, 506, 445, 520 Destination: 1006 Annotation: Subtype: Link Rect: 127, 494, 133, 507 Destination: 1006 Annotation: Subtype: Link Rect: 133, 494, 138, 507 Destination: 1006 Annotation: Subtype: Link Rect: 137, 494, 144, 507 Destination: 1006 Annotation: Subtype: Link Rect: 216, 494, 222, 507 Destination: 1006 Annotation: Subtype: Link Rect: 221, 494, 228, 507 Destination: 1006 Annotation: Subtype: Link Rect: 95, 83, 186, 92 Annotation: Subtype: Link Rect: 36, 57, 161, 66 Annotation: Subtype: Link Rect: 404, 48, 556, 57 Page: Label: 200 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 385, 660, 556, 670 Annotation: Subtype: Link Rect: 154, 549, 176, 560 Destination: 131 Annotation: Subtype: Link Rect: 227, 496, 239, 507 Destination: 131 Annotation: Subtype: Link Rect: 253, 475, 265, 486 Destination: 131 Annotation: Subtype: Link Rect: 113, 402, 125, 413 Destination: 131 Annotation: Subtype: Link Rect: 90, 371, 102, 382 Destination: 131 Annotation: Subtype: Link Rect: 147, 329, 160, 340 Destination: 131 Annotation: Subtype: Link Rect: 237, 277, 250, 288 Destination: 131 Annotation: Subtype: Link Rect: 36, 245, 49, 256 Destination: 131 Annotation: Subtype: Link Rect: 237, 224, 253, 235 Destination: 131 Annotation: Subtype: Link Rect: 248, 214, 264, 225 Destination: 131 Annotation: Subtype: Link Rect: 75, 193, 91, 204 Destination: 131 Annotation: Subtype: Link Rect: 68, 182, 84, 193 Destination: 131 Annotation: Subtype: Link Rect: 225, 161, 235, 172 Destination: 131 Annotation: Subtype: Link Rect: 235, 161, 246, 172 Destination: 131 Annotation: Subtype: Link Rect: 169, 141, 180, 152 Destination: 131 Annotation: Subtype: Link Rect: 180, 141, 190, 152 Destination: 131 Annotation: Subtype: Link Rect: 98, 130, 108, 141 Destination: 131 Annotation: Subtype: Link Rect: 108, 130, 119, 141 Destination: 131 Annotation: Subtype: Link Rect: 209, 99, 225, 110 Destination: 131 Annotation: Subtype: Link Rect: 244, 57, 260, 68 Destination: 131 Annotation: Subtype: Link Rect: 93, 46, 109, 57 Destination: 131 Annotation: Subtype: Link Rect: 305, 602, 322, 613 Destination: 131 Annotation: Subtype: Link Rect: 440, 602, 456, 613 Destination: 131 Annotation: Subtype: Link Rect: 350, 592, 360, 603 Destination: 131 Annotation: Subtype: Link Rect: 360, 592, 371, 603 Destination: 131 Annotation: Subtype: Link Rect: 371, 592, 382, 603 Destination: 131 Annotation: Subtype: Link Rect: 453, 529, 470, 540 Destination: 131 Annotation: Subtype: Link Rect: 394, 497, 405, 508 Destination: 131 Annotation: Subtype: Link Rect: 404, 497, 416, 508 Destination: 131 Annotation: Subtype: Link Rect: 526, 477, 557, 487 Destination: 131 Annotation: Subtype: Link Rect: 433, 445, 450, 456 Destination: 131 Annotation: Subtype: Link Rect: 305, 372, 322, 383 Destination: 131 Annotation: Subtype: Link Rect: 400, 361, 431, 372 Destination: 131 Annotation: Subtype: Link Rect: 523, 330, 540, 341 Destination: 131 Annotation: Subtype: Link Rect: 479, 151, 492, 162 Destination: 131 Annotation: Subtype: Link Rect: 382, 130, 399, 141 Destination: 131 Annotation: Subtype: Link Rect: 504, 88, 521, 99 Destination: 131 Page: Label: 201 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 36, 557, 53, 568 Destination: 131 Annotation: Subtype: Link Rect: 178, 418, 195, 429 Destination: 131 Annotation: Subtype: Link Rect: 189, 120, 206, 131 Destination: 131 Annotation: Subtype: Link Rect: 111, 110, 177, 117 Annotation: Subtype: Link Rect: 75, 46, 92, 57 Destination: 131 Page: Label: 202 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 205, 539, 221, 550 Destination: 131 Annotation: Subtype: Link Rect: 60, 383, 128, 390 Annotation: Subtype: Link Rect: 124, 308, 148, 319 Destination: 81 Annotation: Subtype: Link Rect: 482, 643, 504, 654 Destination: 69 Annotation: Subtype: Link Rect: 524, 549, 554, 560 Destination: 69 Annotation: Subtype: Link Rect: 341, 455, 370, 466 Destination: 69 Annotation: Subtype: Link Rect: 518, 413, 547, 424 Destination: 69 Annotation: Subtype: Link Rect: 523, 360, 554, 371 Destination: 69 Annotation: Subtype: Link Rect: 478, 245, 500, 256 Destination: 81 Annotation: Subtype: Link Rect: 518, 203, 547, 214 Destination: 69 Annotation: Subtype: Link Rect: 401, 141, 430, 152 Destination: 69 Page: Label: 203 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 141, 307, 165, 316 Destination: 69 Page: Label: 204 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 139, 99, 163, 110 Destination: 81 Annotation: Subtype: Link Rect: 308, 203, 338, 214 Destination: 69 Annotation: Subtype: Link Rect: 492, 193, 514, 204 Destination: 81 Annotation: Subtype: Link Rect: 308, 151, 330, 162 Destination: 81 Page: Label: 205 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 39, 433, 50, 444 Destination: 131 Annotation: Subtype: Link Rect: 50, 433, 60, 444 Destination: 131 Annotation: Subtype: Link Rect: 245, 402, 251, 413 Destination: 131 Annotation: Subtype: Link Rect: 251, 402, 262, 413 Destination: 131 Annotation: Subtype: Link Rect: 229, 392, 246, 403 Destination: 131 Annotation: Subtype: Link Rect: 114, 371, 126, 382 Destination: 131 Annotation: Subtype: Link Rect: 89, 350, 101, 361 Destination: 131 Annotation: Subtype: Link Rect: 166, 235, 173, 246 Destination: 131 Annotation: Subtype: Link Rect: 173, 235, 196, 246 Destination: 131 Annotation: Subtype: Link Rect: 103, 99, 120, 110 Destination: 131 Annotation: Subtype: Link Rect: 479, 706, 490, 717 Destination: 131 Annotation: Subtype: Link Rect: 490, 706, 501, 717 Destination: 131 Annotation: Subtype: Link Rect: 480, 695, 496, 706 Destination: 131 Annotation: Subtype: Link Rect: 339, 685, 355, 696 Destination: 131 Annotation: Subtype: Link Rect: 494, 675, 510, 686 Destination: 131 Annotation: Subtype: Link Rect: 454, 664, 471, 675 Destination: 131 Annotation: Subtype: Link Rect: 347, 643, 363, 654 Destination: 131 Annotation: Subtype: Link Rect: 429, 643, 445, 654 Destination: 131 Annotation: Subtype: Link Rect: 386, 633, 403, 644 Destination: 131 Annotation: Subtype: Link Rect: 429, 633, 446, 644 Destination: 131 Annotation: Subtype: Link Rect: 527, 633, 543, 644 Destination: 171 Annotation: Subtype: Link Rect: 360, 256, 370, 267 Destination: 131 Annotation: Subtype: Link Rect: 370, 256, 382, 267 Destination: 171 Annotation: Subtype: Link Rect: 399, 204, 415, 215 Destination: 131 Annotation: Subtype: Link Rect: 305, 152, 322, 162 Destination: 131 Annotation: Subtype: Link Rect: 487, 141, 498, 152 Destination: 131 Annotation: Subtype: Link Rect: 498, 141, 521, 152 Destination: 171 Annotation: Subtype: Link Rect: 517, 131, 534, 142 Destination: 131 Page: Label: 206 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 36, 643, 53, 654 Destination: 131 Annotation: Subtype: Link Rect: 104, 323, 125, 334 Annotation: Subtype: Link Rect: 170, 270, 270, 277 Annotation: Subtype: Link Rect: 25, 213, 294, 240 Annotation: Subtype: Link Rect: 25, 189, 294, 216 Annotation: Subtype: Link Rect: 25, 165, 294, 192 Annotation: Subtype: Link Rect: 25, 141, 294, 168 Annotation: Subtype: Link Rect: 25, 117, 294, 144 Annotation: Subtype: Link Rect: 25, 94, 294, 120 Annotation: Subtype: Link Rect: 25, 62, 294, 97 Annotation: Subtype: Link Rect: 25, 46, 294, 65 Annotation: Subtype: Link Rect: 320, 702, 579, 737 Annotation: Subtype: Link Rect: 320, 686, 579, 705 Annotation: Subtype: Link Rect: 320, 662, 579, 689 Annotation: Subtype: Link Rect: 320, 631, 579, 665 Annotation: Subtype: Link Rect: 320, 615, 579, 635 Annotation: Subtype: Link Rect: 320, 583, 579, 618 Annotation: Subtype: Link Rect: 320, 559, 579, 586 Annotation: Subtype: Link Rect: 320, 527, 579, 562 Annotation: Subtype: Link Rect: 320, 503, 579, 530 Annotation: Subtype: Link Rect: 320, 479, 579, 506 Annotation: Subtype: Link Rect: 320, 447, 579, 482 Annotation: Subtype: Link Rect: 320, 431, 579, 450 Annotation: Subtype: Link Rect: 320, 407, 579, 434 Annotation: Subtype: Link Rect: 320, 391, 579, 410 Annotation: Subtype: Link Rect: 320, 368, 579, 394 Annotation: Subtype: Link Rect: 320, 328, 579, 371 Annotation: Subtype: Link Rect: 320, 304, 579, 331 Annotation: Subtype: Link Rect: 320, 272, 579, 307 Annotation: Subtype: Link Rect: 321, 265, 499, 274 Annotation: Subtype: Link Rect: 320, 232, 579, 267 Annotation: Subtype: Link Rect: 320, 208, 579, 235 Annotation: Subtype: Link Rect: 320, 168, 579, 187 Annotation: Subtype: Link Rect: 320, 144, 579, 171 Annotation: Subtype: Link Rect: 320, 112, 579, 147 Annotation: Subtype: Link Rect: 320, 81, 579, 115 Annotation: Subtype: Link Rect: 320, 49, 579, 84 Page: Label: 207 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 25, 710, 294, 737 Annotation: Subtype: Link Rect: 25, 686, 294, 713 Annotation: Subtype: Link Rect: 25, 654, 294, 689 Annotation: Subtype: Link Rect: 25, 631, 294, 657 Annotation: Subtype: Link Rect: 320, 702, 579, 737 Annotation: Subtype: Link Rect: 320, 670, 579, 705 Checksum: 51e8b101 Type: CRC32 Checksum: d2d570bf7aeeb9613e62faed2d72cff3 Type: MD5 Checksum: 241f1e66e4270b88d7c9df8598abf291704d901f Type: SHA-1 Checksum: 78490f49929e1573e5239738529a3f21ebc7fddb9ea218fe445059011ab3f2de Type: SHA-256