9e9f7388654efaae04bac4d85698bcf1 303456.pdf 34f873a4c2aaead4d1d8aa21d14c5cbc34f1186a 303456.pdf e5cc9f97a2925bbc0fd0eb466696c1e010455da3484962d35020078795b6cc0a 303456.pdf Title: Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized double-blinded placebo-controlled phase III trials Author: Andrew Blauvelt; Jacob P. Thyssen; Emma Guttman-Yassky; Thomas Bieber; Esther Serra-Baldrich; Eric Simpson; David Rosmarin; Hany Elmaraghy; Eric Meskimen; Chitra R. Natalie; Zhuqing Liu; Chenjia Xu; Evangeline Pierce; MaryAnn Morgan-Cox; Esther Garcia Gil; Jonathan I. Silverberg Creator: Adobe InDesign 17.4 (Windows) Producer: Adobe PDF Library 16.0.7; modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Sat May 20 06:44:10 2023 CEST ModDate: Tue Nov 26 08:19:56 2024 CET Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 938103 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FPQIQO+UniversLTStd-LightObl Type 1C Custom yes yes yes 87 0 POUVAU+UniversLTStd-Light Type 1C Custom yes yes yes 27 0 SIKSQO+UniversLTStd-Bold Type 1C Custom yes yes yes 30 0 GIIYEM+UniversLTStd-BoldCn Type 1C WinAnsi yes yes yes 1397 0 ZFANKA+UniversLTStd-Cn Type 1C WinAnsi yes yes yes 1398 0 PDXFAU+UniversLTStd-CnObl Type 1C WinAnsi yes yes yes 1399 0 IDEOIV+ArialMT TrueType WinAnsi yes yes no 1 0 IWEAGI+EuclidSymbol CID TrueType Identity-H yes yes yes 31 0 MABOKA+UniversLTStd-Obl Type 1C WinAnsi yes yes yes 28 0 NWNZYY+UniversLTStd Type 1C Custom yes yes yes 29 0 FNKYQO+UniversLTStd-Light-SC700 Type 1C WinAnsi yes yes yes 65 0 WCZWUG+UniversLTStd-BoldObl Type 1C WinAnsi yes yes yes 88 0 RSMSCQ+EuclidSymbol-Bold CID TrueType Identity-H yes yes yes 89 0 QTXMOS+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 107 0 QTXMOS+Arial-BoldMT Type 1C WinAnsi yes yes no 108 0 QTXMOS+Helvetica-Bold Type 1C WinAnsi yes yes no 109 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-11-27 02:49:52 CET RepresentationInformation: 303456.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-11-26 09:51:21 CET Size: 938103 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 1439 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized double-blinded placebo-controlled phase III trials Children: Item: Title: Patients and methods Children: Item: Title: Outcomes and assessments Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Maintenance primary population efficacy outcomes Item: Title: Safety Item: Title: Discussion Children: Item: Title: Acknowledgments Item: Title: Funding sources Item: Title: Conflicts of interest Item: Title: Data availability Item: Title: Ethics statement Item: Title: Supporting Information Item: Title: References Info: Title: Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized double-blinded placebo-controlled phase III trials Author: Andrew Blauvelt; Jacob P. Thyssen; Emma Guttman-Yassky; Thomas Bieber; Esther Serra-Baldrich; Eric Simpson; David Rosmarin; Hany Elmaraghy; Eric Meskimen; Chitra R. Natalie; Zhuqing Liu; Chenjia Xu; Evangeline Pierce; MaryAnn Morgan-Cox; Esther Garcia Gil; Jonathan I. Silverberg Creator: Adobe InDesign 17.4 (Windows) Producer: Adobe PDF Library 16.0.7; modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Sat May 20 07:14:10 CEST 2023 ModDate: Tue Nov 26 08:19:56 CET 2024 ID: 0x6a9614c93ba32ee19e3b2df463cf8af7, 0xa15be920ea5b7bea669851464b9b251c Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: RSMSCQ+EuclidSymbol-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: IWEAGI+EuclidSymbol Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: FNKYQO+UniversLTStd-Light-SC700 FontSubset: true FirstChar: 65 LastChar: 86 FontDescriptor: FontName: FNKYQO+UniversLTStd-Light-SC700 Flags: Nonsymbolic FontBBox: -151, -250, 1000, 957 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: QTXMOS+Arial-BoldItalicMT FontSubset: true FirstChar: 110 LastChar: 110 FontDescriptor: FontName: QTXMOS+Arial-BoldItalicMT Flags: Nonsymbolic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: QTXMOS+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: QTXMOS+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: QTXMOS+Helvetica-Bold FontSubset: true FirstChar: 40 LastChar: 101 FontDescriptor: FontName: QTXMOS+Helvetica-Bold Flags: Nonsymbolic FontBBox: -172, -247, 1000, 966 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GIIYEM+UniversLTStd-BoldCn FontSubset: true FirstChar: 32 LastChar: 114 FontDescriptor: FontName: GIIYEM+UniversLTStd-BoldCn Flags: Nonsymbolic FontBBox: -83, -250, 1000, 969 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: ZFANKA+UniversLTStd-Cn FontSubset: true FirstChar: 32 LastChar: 252 FontDescriptor: FontName: ZFANKA+UniversLTStd-Cn Flags: Nonsymbolic FontBBox: -166, -250, 1000, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: FPQIQO+UniversLTStd-LightObl FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: FPQIQO+UniversLTStd-LightObl Flags: Nonsymbolic, Italic FontBBox: -151, -274, 1144, 957 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PDXFAU+UniversLTStd-CnObl FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: PDXFAU+UniversLTStd-CnObl Flags: Nonsymbolic, Italic FontBBox: -172, -270, 1064, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: WCZWUG+UniversLTStd-BoldObl FontSubset: true FirstChar: 110 LastChar: 110 FontDescriptor: FontName: WCZWUG+UniversLTStd-BoldObl Flags: Nonsymbolic, Italic FontBBox: -173, -270, 1148, 938 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: POUVAU+UniversLTStd-Light FontSubset: true FirstChar: 29 LastChar: 233 FontDescriptor: FontName: POUVAU+UniversLTStd-Light Flags: Nonsymbolic FontBBox: -151, -250, 1000, 957 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MABOKA+UniversLTStd-Obl FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: MABOKA+UniversLTStd-Obl Flags: Nonsymbolic, Italic FontBBox: -174, -272, 1145, 947 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: NWNZYY+UniversLTStd FontSubset: true FirstChar: 30 LastChar: 122 FontDescriptor: FontName: NWNZYY+UniversLTStd Flags: Nonsymbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SIKSQO+UniversLTStd-Bold FontSubset: true FirstChar: 30 LastChar: 122 FontDescriptor: FontName: SIKSQO+UniversLTStd-Bold Flags: Nonsymbolic FontBBox: -167, -250, 995, 938 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: IDEOIV+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: IDEOIV+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: RSMSCQ+EuclidSymbol-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RSMSCQ+EuclidSymbol-Bold Flags: Symbolic FontBBox: -186, -308, 1102, 960 FontFile2: true Font: BaseFont: IWEAGI+EuclidSymbol CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IWEAGI+EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1083, 950 FontFile2: true XMP: en application/pdf Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized double-blinded placebo-controlled phase III trials Andrew Blauvelt; Jacob P. Thyssen; Emma Guttman-Yassky; Thomas Bieber; Esther Serra-Baldrich; Eric Simpson; David Rosmarin; Hany Elmaraghy; Eric Meskimen; Chitra R. Natalie; Zhuqing Liu; Chenjia Xu; Evangeline Pierce; MaryAnn Morgan-Cox; Esther Garcia Gil; Jonathan I. Silverberg Oxford University Press 2023-05-20T10:14:10+05:30 2024-11-26T07:19:56+00:00 2024-11-26T07:19:56+00:00 Adobe InDesign 17.4 (Windows) uuid:de428148-cb6e-4996-a53c-12b09823180e xmp.did:2aecd8bd-cbd3-4539-b083-9de383973cbe xmp.id:fc353a97-ebde-fc42-9515-e624a90e1a39 proof:pdf converted from application/pdf to application/pdf Adobe InDesign 17.4 (Windows) / 2023-05-20T10:14:10+05:30 xmp.iid:856769fa-3c67-b14b-9cde-13a1b18848be xmp.did:4ef6a9d1-f5b0-3846-960b-84d21a67a404 xmp.did:2aecd8bd-cbd3-4539-b083-9de383973cbe default True Adobe PDF Library 16.0.7; modified using iTextSharp 4.1.6 by 1T3XT False Pages: Page: Label: 740 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 279, 566, 291, 554 Annotation: Subtype: Link Rect: 177, 430, 305, 420 Thumb: true Page: Label: 741 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 281, 631, 284, 620 ActionDest: 138 Annotation: Subtype: Link Rect: 288, 631, 291, 620 ActionDest: 138 Annotation: Subtype: Link Rect: 128, 598, 131, 587 ActionDest: 138 Annotation: Subtype: Link Rect: 132, 598, 136, 587 ActionDest: 144 Annotation: Subtype: Link Rect: 139, 598, 143, 587 ActionDest: 144 Annotation: Subtype: Link Rect: 113, 576, 116, 565 ActionDest: 144 Annotation: Subtype: Link Rect: 117, 576, 124, 565 ActionDest: 144 Annotation: Subtype: Link Rect: 68, 521, 74, 510 ActionDest: 144 Annotation: Subtype: Link Rect: 75, 521, 81, 510 ActionDest: 144 Annotation: Subtype: Link Rect: 116, 499, 122, 488 ActionDest: 144 Annotation: Subtype: Link Rect: 285, 466, 291, 455 ActionDest: 144 Annotation: Subtype: Link Rect: 193, 400, 199, 389 ActionDest: 144 Annotation: Subtype: Link Rect: 200, 400, 207, 389 ActionDest: 144 Annotation: Subtype: Link Rect: 77, 367, 83, 356 ActionDest: 144 Annotation: Subtype: Link Rect: 85, 367, 91, 356 ActionDest: 144 Annotation: Subtype: Link Rect: 171, 334, 177, 323 ActionDest: 144 Annotation: Subtype: Link Rect: 190, 290, 196, 279 ActionDest: 144 Annotation: Subtype: Link Rect: 268, 224, 291, 213 Annotation: Subtype: Link Rect: 48, 213, 58, 202 Annotation: Subtype: Link Rect: 80, 213, 176, 202 Annotation: Subtype: Link Rect: 138, 114, 144, 103 ActionDest: 144 Annotation: Subtype: Link Rect: 539, 444, 550, 433 Annotation: Subtype: Link Rect: 328, 433, 425, 422 Annotation: Subtype: Link Rect: 420, 213, 427, 202 ActionDest: 144 Annotation: Subtype: Link Rect: 452, 81, 458, 70 ActionDest: 144 Thumb: true Page: Label: 742 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 89, 543, 95, 532 ActionDest: 144 Annotation: Subtype: Link Rect: 207, 235, 217, 224 Annotation: Subtype: Link Rect: 239, 235, 285, 224 Annotation: Subtype: Link Rect: 42, 224, 90, 213 Annotation: Subtype: Link Rect: 467, 554, 478, 543 Annotation: Subtype: Link Rect: 501, 554, 547, 543 Annotation: Subtype: Link Rect: 303, 543, 351, 532 Annotation: Subtype: Link Rect: 516, 477, 527, 466 Annotation: Subtype: Link Rect: 303, 466, 399, 455 Annotation: Subtype: Link Rect: 385, 312, 390, 301 ActionDest: 84 Annotation: Subtype: Link Rect: 516, 224, 527, 213 Annotation: Subtype: Link Rect: 303, 213, 399, 202 Annotation: Subtype: Link Rect: 515, 103, 526, 92 Annotation: Subtype: Link Rect: 303, 92, 400, 81 Thumb: true Page: Label: 743 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 79, 268, 84, 257 ActionDest: 104 Annotation: Subtype: Link Rect: 128, 268, 133, 257 ActionDest: 123 Annotation: Subtype: Link Rect: 211, 169, 217, 158 ActionDest: 123 Annotation: Subtype: Link Rect: 160, 59, 171, 48 Annotation: Subtype: Link Rect: 193, 59, 286, 48 Annotation: Subtype: Link Rect: 448, 334, 489, 323 Annotation: Subtype: Link Rect: 541, 334, 552, 323 Annotation: Subtype: Link Rect: 309, 323, 337, 312 Annotation: Subtype: Link Rect: 360, 323, 455, 312 Annotation: Subtype: Link Rect: 336, 235, 347, 224 Annotation: Subtype: Link Rect: 369, 235, 465, 224 Annotation: Subtype: Link Rect: 422, 125, 427, 114 ActionDest: 133 Thumb: true Page: Label: 744 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 124, 191, 135, 180 Annotation: Subtype: Link Rect: 157, 191, 253, 180 Annotation: Subtype: Link Rect: 63, 59, 70, 48 ActionDest: 144 Thumb: true Page: Label: 745 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 173, 378, 180, 367 ActionDest: 144 Annotation: Subtype: Link Rect: 273, 356, 280, 345 ActionDest: 144 Annotation: Subtype: Link Rect: 282, 356, 288, 345 ActionDest: 144 Annotation: Subtype: Link Rect: 275, 235, 281, 224 ActionDest: 144 Annotation: Subtype: Link Rect: 284, 235, 291, 224 ActionDest: 144 Annotation: Subtype: Link Rect: 96, 180, 102, 169 ActionDest: 144 Thumb: true Page: Label: 746 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 67, 259, 73, 250 ActionDest: 144 Thumb: true Page: Label: 747 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 486, 422, 543, 411 Annotation: Subtype: Link Rect: 356, 235, 456, 224 Thumb: true Page: Label: 748 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 365, 620, 520, 610 Annotation: Subtype: Link Rect: 426, 320, 547, 310 Annotation: Subtype: Link Rect: 317, 310, 371, 300 Thumb: true Checksum: 8aa0d9ae Type: CRC32 Checksum: 9e9f7388654efaae04bac4d85698bcf1 Type: MD5 Checksum: 34f873a4c2aaead4d1d8aa21d14c5cbc34f1186a Type: SHA-1 Checksum: e5cc9f97a2925bbc0fd0eb466696c1e010455da3484962d35020078795b6cc0a Type: SHA-256