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indirect destination - referenced object 'cor1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found ID: PDF-HUL-122 Offset: 849997 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 849997 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 931 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Patients and methods Destination: flink2 Children: Item: Title: Study design, participant selection, and recorded parameters Destination: slink1 Item: Title: Data pre-processing and exploration Destination: slink2 Item: Title: Development of MLMs Destination: slink3 Item: Title: Feature selection for MLMs: recursive feature elimination Destination: slink4 Item: Title: Robust estimation of classification performance using 5-fold cross-validation Destination: slink5 Item: Title: External model validation Destination: slink6 Item: Title: Extraction of LR coefficients Destination: slink7 Item: Title: Prediction of HVPG value with regression Destination: slink8 Item: Title: Results Destination: flink3 Children: Item: Title: Patient characteristics Destination: slink9 Item: Title: Selection of widely available parameters for assessment of PH severity Destination: slink10 Item: Title: Performance of the Vienna-trained MLMs in external validation Destination: slink11 Item: Title: Evaluation of the overall performance of the MLMs in the merged cACLD cohort Destination: slink12 Item: Title: Contribution of disease activity and aetiology to model performance Destination: slink13 Item: Title: Balancing datasets does not significantly improve the predictive power Destination: slink14 Item: Title: The formula for prediction of severe PH with LR Destination: slink15 Item: Title: Discussion Destination: flink4 Item: Title: Abbreviations Destination: flink5 Item: Title: Financial support Destination: flink6 Item: Title: Conflict of interest Destination: flink7 Item: Title: Authors' contributions Destination: flink8 Item: Title: Data availability statement Destination: flink9 Item: Title: Supplementary data Destination: flink10 Item: Title: References Destination: blink1 Info: Title: Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis Author: Jiří Reiniš Subject: Journal of Hepatology, 78 (2023) 390-400. doi:10.1016/j.jhep.2022.09.012 Creator: Elsevier Producer: 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FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EJNMBJ+AdvOT3a037357.I+fb Flags: Symbolic FontBBox: 19, 0, 562, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EJNMBI+AdvOT3a037357.I+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: EJNMBI+AdvOT3a037357.I+20 Flags: Nonsymbolic FontBBox: -156, -145, 1010, 718 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.jhep.2022.09.012 Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis Jiří Reiniš Oleksandr Petrenko Benedikt Simbrunner Benedikt S. Hofer Filippo Schepis Marco Scoppettuolo Dario Saltini Federica Indulti Tomas Guasconi Agustin Albillos Luis Téllez Càndid Villanueva Anna Brujats Juan Carlos Garcia-Pagan Valeria Perez-Campuzano Virginia Hernández-Gea Pierre-Emmanuel Rautou Lucile Moga Thomas Vanwolleghem Wilhelmus J. Kwanten Sven Francque Jonel Trebicka Wenyi Gu Philip G. Ferstl Lise Lotte Gluud Flemming Bendtsen Søren Møller Stefan Kubicek Mattias Mandorfer Thomas Reiberger hepatic venous pressure gradient machine learning non-invasive testing Journal of Hepatology, 78 (2023) 390-400. doi:10.1016/j.jhep.2022.09.012 The Authors journal Journal of Hepatology © 2022 The Authors. 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