b5e9b1f2a6de6292c492e13234f6acc7 303844.pdf e18ca96fae70186f0b632c86f2969bcfa8f4d385 303844.pdf 7b2de6c374017f8b5762ccd9c2144b28f751e99dd9218ec1ea3efe322d418226 303844.pdf Title: Adjuvant Osimertinib vs. Placebo in Completely Resected Stage IA2-IA3 EGFR-Mutated NSCLC: ADAURA2 Subject: Clinical Lung Cancer, 24 (2023) 376-380. doi:10.1016/j.cllc.2023.02.002 Keywords: "Adjuvant"; "Early-stage"; "Resectable"; "Tyrosine kinase inhibitor"; "Targeted therapy" Author: Yasuhiro Tsutani Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Mon May 8 22:47:50 2023 CEST ModDate: Mon May 8 22:48:07 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 5 Encrypted: no Page size: 594 x 783 pts Page rot: 0 File size: 566836 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PCCJKO+FuturaStd-CondensedLight Type 1C Custom yes yes yes 687 0 PCCJEM+HelveticaLTStd-Light Type 1C Custom yes yes yes 692 0 PCCJEK+MTSY Type 1C Custom yes yes yes 697 0 PCCJDJ+HelveticaLTStd-Bold Type 1C Custom yes yes yes 702 0 PCCJKN+FuturaStd-Condensed Type 1C Custom yes yes yes 707 0 PCCJDK+HelveticaLTStd-Roman Type 1C Custom yes yes yes 712 0 PCCIKJ+HelveticaNeueLTStd-BdEx Type 1C Custom yes yes yes 717 0 PCCJBJ+AGaramond-Regular Type 1C Custom yes yes no 722 0 PCCJEL+HelveticaLTStd-Obl Type 1C Custom yes yes yes 726 0 PCCJKM+Futura-DemiBold Type 1C Custom yes yes yes 731 0 PCCJIM+RMTMI Type 1C Custom yes yes yes 736 0 PCCIKK+dummy-space Type 1C WinAnsi yes yes no 741 0 PCCKEM+FuturaStd-CondensedBold Type 1C Custom yes yes yes 105 0 PCCJLP+AGaramond-BoldItalic Type 1C WinAnsi yes yes no 110 0 PCCKFO+HelveticaLTStd-BoldCond Type 1C Custom yes yes yes 113 0 PCCKFP+HelveticaLTStd-LightCond Type 1C Custom yes yes yes 29 0 PCCKGA+TimesNewRomanPSMT-20 Type 1C Custom yes yes yes 34 0 PCCKEN+AGaramond-Bold Type 1C WinAnsi yes yes no 118 0 PCCLLI+CMSY10 Type 1C Custom yes yes yes 52 0 PCCMNC+AGaramond-Italic Type 1C WinAnsi yes yes no 66 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-04 02:48:27 CET RepresentationInformation: 303844.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-03 10:18:13 CET Size: 566836 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'tb1fn1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tb2fn1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tb1fn2' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb1fn2' cannot be found ID: PDF-HUL-122 Offset: 507363 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb1fn1' cannot be found ID: PDF-HUL-122 Offset: 507363 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb2fn1' cannot be found ID: PDF-HUL-122 Offset: 507363 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 794 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: English Outlines: Item: Title: Adjuvant Osimertinib vs. Placebo in Completely Resected Stage IA2-IA3 EGFR-Mutated NSCLC: ADAURA2 Destination: chapter..1 Children: Item: Title: Introduction Destination: section..1 Item: Title: Patients and Methods Destination: section..2 Children: Item: Title: Objectives Destination: subsection..2.1 Item: Title: Key Eligibility Criteria Destination: subsection..2.2 Item: Title: Study Design Destination: subsection..2.3 Item: Title: Statistical Analysis Destination: subsection..2.4 Item: Title: Discussion Destination: section..3 Item: Title: Conclusion Destination: section..4 Item: Title: Disclosure Destination: section..5 Item: Title: CRediT authorship contribution statement Destination: section..6 Item: Title: Acknowledgments Destination: section..7 Item: Title: References Destination: section..8 Info: Title: Adjuvant Osimertinib vs. Placebo in Completely Resected Stage IA2-IA3 EGFR-Mutated NSCLC: ADAURA2 Author: Yasuhiro Tsutani Subject: Clinical Lung Cancer, 24 (2023) 376-380. doi:10.1016/j.cllc.2023.02.002 Keywords: "Adjuvant"; "Early-stage"; "Resectable"; "Tyrosine kinase inhibitor"; "Targeted therapy" Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Mon May 08 23:17:50 CEST 2023 ModDate: Mon May 08 23:18:07 CEST 2023 ID: 0x4f010e13d792b7eda27970354d4ccfd8, 0x2a1f04a38f55a0be6db429800dc0e49e Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: PCCJIM+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: PCCJIM+RMTMI Flags: Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCKGA+TimesNewRomanPSMT-20 FontSubset: true FirstChar: 3 LastChar: 128 FontDescriptor: FontName: PCCKGA+TimesNewRomanPSMT-20 Flags: Symbolic FontBBox: -210, -216, 1066, 865 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCMNC+AGaramond-Italic FontSubset: true FirstChar: 65 LastChar: 120 FontDescriptor: FontName: PCCMNC+AGaramond-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -182, -285, 1150, 851 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PCCJKN+FuturaStd-Condensed FontSubset: true FirstChar: 67 LastChar: 117 FontDescriptor: FontName: PCCJKN+FuturaStd-Condensed Flags: Symbolic FontBBox: -157, -216, 894, 969 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCIKK+dummy-space FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: PCCIKK+dummy-space Flags: Nonsymbolic FontBBox: 0, 0, 0, 0 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PCCJDK+HelveticaLTStd-Roman FontSubset: true FirstChar: 37 LastChar: 147 FontDescriptor: FontName: PCCJDK+HelveticaLTStd-Roman Flags: Symbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCKEM+FuturaStd-CondensedBold FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: PCCKEM+FuturaStd-CondensedBold Flags: Symbolic, ForceBold FontBBox: -140, -261, 1195, 990 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCIKJ+HelveticaNeueLTStd-BdEx FontSubset: true FirstChar: 65 LastChar: 119 FontDescriptor: FontName: PCCIKJ+HelveticaNeueLTStd-BdEx Flags: Symbolic, ForceBold FontBBox: -145, -213, 1163, 984 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCJLP+AGaramond-BoldItalic FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: PCCJLP+AGaramond-BoldItalic Flags: Serif, Nonsymbolic, Italic, ForceBold FontBBox: -183, -285, 1166, 862 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PCCJKO+FuturaStd-CondensedLight FontSubset: true FirstChar: 36 LastChar: 169 FontDescriptor: FontName: PCCJKO+FuturaStd-CondensedLight Flags: Symbolic FontBBox: -125, -221, 896, 961 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCKFO+HelveticaLTStd-BoldCond FontSubset: true FirstChar: 49 LastChar: 121 FontDescriptor: FontName: PCCKFO+HelveticaLTStd-BoldCond Flags: Symbolic, ForceBold FontBBox: -169, -250, 1091, 991 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCJBJ+AGaramond-Regular FontSubset: true FirstChar: 30 LastChar: 174 FontDescriptor: FontName: PCCJBJ+AGaramond-Regular Flags: Serif, Nonsymbolic FontBBox: -183, -269, 1099, 851 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PCCJEM+HelveticaLTStd-Light FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: PCCJEM+HelveticaLTStd-Light Flags: Symbolic FontBBox: -164, -250, 1000, 979 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCLLI+CMSY10 FontSubset: true FirstChar: 129 LastChar: 129 FontDescriptor: FontName: PCCLLI+CMSY10 Flags: Symbolic, Italic FontBBox: -29, -960, 1116, 775 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCJEL+HelveticaLTStd-Obl FontSubset: true FirstChar: 44 LastChar: 117 FontDescriptor: FontName: PCCJEL+HelveticaLTStd-Obl Flags: Symbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCKEN+AGaramond-Bold FontSubset: true FirstChar: 45 LastChar: 150 FontDescriptor: FontName: PCCKEN+AGaramond-Bold Flags: Serif, Nonsymbolic, ForceBold FontBBox: -158, -269, 1147, 862 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PCCJEK+MTSY FontSubset: true FirstChar: 2 LastChar: 61 FontDescriptor: FontName: PCCJEK+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCJKM+Futura-DemiBold FontSubset: true FirstChar: 51 LastChar: 55 FontDescriptor: FontName: PCCJKM+Futura-DemiBold Flags: Symbolic FontBBox: -153, -250, 1139, 930 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCKFP+HelveticaLTStd-LightCond FontSubset: true FirstChar: 37 LastChar: 147 FontDescriptor: FontName: PCCKFP+HelveticaLTStd-LightCond Flags: Symbolic FontBBox: -170, -250, 1000, 986 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCCJDJ+HelveticaLTStd-Bold FontSubset: true FirstChar: 58 LastChar: 121 FontDescriptor: FontName: PCCJDJ+HelveticaLTStd-Bold Flags: Symbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2023-05-09T02:17:50+05:30 Elsevier 2023-05-09T02:18:07+05:30 2023-05-09T02:18:07+05:30 Acrobat Distiller 10.0.0 (Windows) "Adjuvant"; "Early-stage"; "Resectable"; "Tyrosine kinase inhibitor"; "Targeted therapy" application/pdf doi:10.1016/j.cllc.2023.02.002 Elsevier Inc. Clinical Lung Cancer, 24 (2023) 376-380. doi:10.1016/j.cllc.2023.02.002 Adjuvant Early-stage Resectable Tyrosine kinase inhibitor Targeted therapy Adjuvant Osimertinib vs. Placebo in Completely Resected Stage IA2-IA3 EGFR-Mutated NSCLC: ADAURA2 Yasuhiro Tsutani Jonathan W. Goldman Sanja Dacic Yasushi Yatabe Margarita Majem Xiangning Huang Allen Chen Toon van der Gronde Jie He uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:468e461e-ad41-4620-be3f-f2a785336739 journal © 2023 The Authors. Published by Elsevier Inc. Clinical Lung Cancer 1525-7304 24 4 10.1016/j.cllc.2023.02.002 https://doi.org/10.1016/j.cllc.2023.02.002 376 380 376-380 June 2023 7.0 2010-04-23 true 10.1016/j.cllc.2023.02.002 noindex sciencedirect.com elsevier.com sciencedirect.com elsevier.com VoR true 2010-04-23 10.1016/j.cllc.2023.02.002 sciencedirect.com elsevier.com True http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 376 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 460, 719, 541, 731 Annotation: Subtype: Link Rect: 185, 603, 192, 621 Destination: 674 Annotation: Subtype: Link Rect: 328, 603, 336, 621 Destination: 674 Annotation: Subtype: Link Rect: 408, 603, 416, 621 Destination: 674 Annotation: Subtype: Link Rect: 504, 603, 512, 621 Destination: 674 Annotation: Subtype: Link Rect: 160, 586, 167, 604 Destination: 674 Annotation: Subtype: Link Rect: 275, 586, 283, 604 Destination: 674 Annotation: Subtype: Link Rect: 353, 586, 361, 604 Destination: 674 Annotation: Subtype: Link Rect: 489, 586, 497, 604 Destination: 674 Annotation: Subtype: Link Rect: 533, 586, 541, 604 Destination: 674 Annotation: Subtype: Link Rect: 323, 336, 527, 348 Annotation: Subtype: Link Rect: 246, 266, 252, 277 Destination: 64 Annotation: Subtype: Link Rect: 252, 266, 257, 277 Destination: 64 Annotation: Subtype: Link Rect: 98, 72, 154, 81 Annotation: Subtype: Link Rect: 533, 291, 539, 302 Destination: 64 Annotation: Subtype: Link Rect: 319, 255, 329, 267 Destination: 64 Annotation: Subtype: Link Rect: 351, 219, 356, 231 Destination: 64 Annotation: Subtype: Link Rect: 356, 219, 362, 231 Destination: 64 Annotation: Subtype: Link Rect: 425, 207, 430, 219 Destination: 64 Annotation: Subtype: Link Rect: 403, 160, 408, 171 Destination: 64 Annotation: Subtype: Link Rect: 474, 112, 480, 123 Destination: 64 Annotation: Subtype: Link Rect: 480, 112, 488, 123 Destination: 64 Annotation: Subtype: Link Rect: 536, 76, 541, 87 Destination: 64 Annotation: Subtype: Link Rect: 411, 37, 539, 47 Annotation: Subtype: Link Rect: 430, 27, 541, 37 Page: Label: 377 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 165, 677, 174, 689 Destination: 64 Annotation: Subtype: Link Rect: 218, 594, 234, 605 Destination: 64 Annotation: Subtype: Link Rect: 268, 534, 276, 545 Destination: 64 Annotation: Subtype: Link Rect: 73, 486, 82, 498 Destination: 64 Annotation: Subtype: Link Rect: 108, 426, 116, 438 Destination: 64 Annotation: Subtype: Link Rect: 180, 403, 188, 414 Destination: 64 Annotation: Subtype: Link Rect: 188, 403, 197, 414 Destination: 64 Annotation: Subtype: Link Rect: 197, 403, 205, 414 Destination: 64 Annotation: Subtype: Link Rect: 221, 241, 249, 252 Destination: 27 Annotation: Subtype: Link Rect: 255, 198, 286, 210 Destination: 27 Annotation: Subtype: Link Rect: 212, 138, 220, 150 Destination: 64 Annotation: Subtype: Link Rect: 398, 701, 430, 712 Destination: 46 Annotation: Subtype: Link Rect: 451, 581, 460, 592 Destination: 64 Annotation: Subtype: Link Rect: 369, 509, 397, 521 Destination: 27 Annotation: Subtype: Link Rect: 371, 246, 377, 257 Destination: 64 Annotation: Subtype: Link Rect: 377, 246, 382, 257 Destination: 64 Annotation: Subtype: Link Rect: 323, 210, 331, 222 Destination: 64 Annotation: Subtype: Link Rect: 489, 198, 497, 210 Destination: 64 Annotation: Subtype: Link Rect: 415, 186, 424, 198 Destination: 64 Annotation: Subtype: Link Rect: 333, 127, 338, 138 Destination: 64 Annotation: Subtype: Link Rect: 338, 127, 347, 138 Destination: 64 Annotation: Subtype: Link Rect: 335, 79, 343, 90 Destination: 64 Annotation: Subtype: Link Rect: 343, 79, 352, 90 Destination: 64 Annotation: Subtype: Link Rect: 447, 67, 456, 78 Destination: 64 Page: Label: 378 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 170, 688, 175, 699 Destination: null Annotation: Subtype: Link Rect: 450, 534, 456, 545 Destination: null Annotation: Subtype: Link Rect: 191, 346, 195, 356 Destination: null Annotation: Subtype: Link Rect: 68, 98, 77, 109 Destination: 64 Annotation: Subtype: Link Rect: 77, 98, 85, 109 Destination: 64 Annotation: Subtype: Link Rect: 282, 74, 290, 85 Destination: 64 Annotation: Subtype: Link Rect: 398, 146, 406, 157 Destination: 64 Page: Label: 379 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 279, 390, 288, 401 Destination: 64 Annotation: Subtype: Link Rect: 220, 366, 236, 377 Destination: 64 Annotation: Subtype: Link Rect: 227, 330, 233, 341 Destination: 64 Annotation: Subtype: Link Rect: 279, 306, 288, 318 Destination: 64 Annotation: Subtype: Link Rect: 94, 270, 103, 282 Destination: 64 Annotation: Subtype: Link Rect: 103, 270, 111, 282 Destination: 64 Annotation: Subtype: Link Rect: 132, 234, 140, 246 Destination: 64 Page: Label: 380 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 58, 426, 115, 438 Destination: 64 Annotation: Subtype: Link Rect: 76, 380, 173, 387 Annotation: Subtype: Link Rect: 44, 335, 295, 355 Annotation: Subtype: Link Rect: 44, 319, 294, 339 Annotation: Subtype: Link Rect: 44, 295, 295, 323 Annotation: Subtype: Link Rect: 44, 272, 295, 299 Annotation: Subtype: Link Rect: 44, 248, 295, 275 Annotation: Subtype: Link Rect: 44, 224, 295, 251 Annotation: Subtype: Link Rect: 44, 200, 295, 227 Annotation: Subtype: Link Rect: 44, 176, 295, 203 Annotation: Subtype: Link Rect: 44, 152, 295, 179 Annotation: Subtype: Link Rect: 44, 128, 295, 155 Annotation: Subtype: Link Rect: 317, 710, 562, 738 Annotation: Subtype: Link Rect: 317, 686, 562, 714 Annotation: Subtype: Link Rect: 317, 662, 562, 690 Annotation: Subtype: Link Rect: 317, 647, 562, 666 Annotation: Subtype: Link Rect: 317, 615, 562, 650 Annotation: Subtype: Link Rect: 317, 591, 562, 618 Annotation: Subtype: Link Rect: 317, 567, 562, 594 Annotation: Subtype: Link Rect: 317, 551, 562, 570 Annotation: Subtype: Link Rect: 317, 520, 562, 540 Annotation: Subtype: Link Rect: 317, 479, 562, 507 Annotation: Subtype: Link Rect: 317, 455, 562, 483 Annotation: Subtype: Link Rect: 317, 431, 562, 459 Annotation: Subtype: Link Rect: 317, 415, 562, 435 Annotation: Subtype: Link Rect: 317, 391, 562, 419 Annotation: Subtype: Link Rect: 317, 376, 562, 395 Annotation: Subtype: Link Rect: 317, 352, 562, 379 Annotation: Subtype: Link Rect: 317, 329, 562, 349 Annotation: Subtype: Link Rect: 317, 312, 562, 331 Annotation: Subtype: Link Rect: 317, 288, 562, 315 Annotation: Subtype: Link Rect: 317, 256, 562, 291 Annotation: Subtype: Link Rect: 317, 232, 562, 260 Annotation: Subtype: Link Rect: 317, 192, 562, 236 Annotation: Subtype: Link Rect: 317, 168, 562, 196 Annotation: Subtype: Link Rect: 317, 152, 562, 172 Checksum: 21e4275e Type: CRC32 Checksum: b5e9b1f2a6de6292c492e13234f6acc7 Type: MD5 Checksum: e18ca96fae70186f0b632c86f2969bcfa8f4d385 Type: SHA-1 Checksum: 7b2de6c374017f8b5762ccd9c2144b28f751e99dd9218ec1ea3efe322d418226 Type: SHA-256